🍽️ pimethixene maleate,(prescription)

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Anxiety Disorders: Pimethixene maleate is occasionally used off-label as an adjunctive treatment for anxiety disorders. Its sedative properties can help alleviate symptoms of anxiety and promote relaxation. However, it is not typically considered a first-line treatment for anxiety disorders due to the availability of other medications with more established efficacy and safety profiles.
Insomnia: Pimethixene maleate's sedative effects make it useful in the management of insomnia, particularly in cases where sleep disturbances are secondary to anxiety or other conditions. It can help induce sleep and improve sleep continuity, leading to better overall sleep quality.
Allergic Reactions: As an antihistamine, pimethixene maleate can be used to alleviate symptoms associated with allergic reactions, such as itching, hives, and allergic rhinitis. Its antihistaminic properties help block the action of histamine, a chemical involved in allergic responses, thereby reducing symptoms of allergy.
Nausea and Vomiting: Pimethixene maleate's antiemetic properties may make it useful in managing nausea and vomiting, particularly in cases where these symptoms are related to motion sickness, vertigo, or medication side effects. Its ability to block certain neurotransmitter receptors in the brain can help alleviate nausea and suppress the vomiting reflex.
Preoperative Anxiety: Pimethixene maleate is sometimes used as a preoperative medication to reduce anxiety and induce sedation in patients undergoing surgical procedures. By promoting relaxation and sedation, it can help alleviate preoperative apprehension and facilitate a smoother induction of anesthesia.
Side Effects: Common side effects associated with pimethixene maleate include drowsiness, sedation, dizziness, blurred vision, dry mouth, constipation, urinary retention, and cognitive impairment. These side effects are typical of medications with sedative and anticholinergic properties and may vary in intensity depending on individual sensitivity and dosage.
Contraindications: Pimethixene maleate is contraindicated in individuals with known hypersensitivity to the drug or its components, as well as in individuals with narrow-angle glaucoma, urinary retention, severe liver impairment, or certain cardiovascular conditions. It should be used with caution in the elderly and in individuals with respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD).
Drug Interactions: Pimethixene maleate may interact with other medications that have sedative or CNS depressant effects, including alcohol, benzodiazepines, opioids, and certain antidepressants. Concurrent use of these medications may potentiate sedation and increase the risk of adverse effects.

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Data Contradictions — Limits of Certainity

Impacted of pimethixene maleate,(prescription) On Probiotics

Rank	Probiotic	Impact
genus	Bifidobacterium	Reduces
species	Akkermansia muciniphila	Reduces
species	Bacteroides uniformis	Reduces
species	Bifidobacterium adolescentis	Reduces
species	Bifidobacterium longum	Reduces
species	Escherichia coli	Reduces
species	Parabacteroides distasonis	Reduces
subspecies	Bifidobacterium longum subsp. infantis	Reduces
subspecies	Bifidobacterium longum subsp. longum	Reduces

Bacteria Impacted by pimethixene maleate,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations	👪👶 Indirect Citations	Taxonomy	Rank	Effect
0	1	Akkermansiaceae	family	Decreases
0	1	Escherichia	genus	Decreases
0	1	Dorea	genus	Decreases
0	1	Roseburia	genus	Decreases
0	1	Parabacteroides	genus	Decreases
1	0	Akkermansia	genus	Decreases
0	1	Ruminococcus	genus	Decreases
0	1	Agathobacter	genus	Decreases
0	1	Bacteroides	genus	Decreases
0	1	Bifidobacterium	genus	Decreases
0	1	Clostridioides	genus	Decreases
0	1	Collinsella	genus	Decreases
0	1	Eggerthella	genus	Decreases
0	1	Lachnospira	genus	Decreases
0	1	Odoribacter	genus	Decreases
0	1	Phocaeicola	genus	Decreases
0	1	Veillonella	genus	Decreases
0	1	Clostridium	genus	Decreases
0	1	Segatella	genus	Decreases
0	1	Enterocloster	genus	Decreases
0	1	Blautia	genus	Decreases
0	1	Escherichia coli O25:H16	no rank	Decreases
0	1	Clostridium perfringens A	no rank	Decreases
0	1	Clostridium perfringens C	no rank	Decreases
0	1	Clostridium perfringens CPE	no rank	Decreases
0	1	environmental samples	no rank	Decreases
0	1	Escherichia coli O145:H34	no rank	Decreases
0	1	Escherichia coli O16:H48	no rank	Decreases
0	1	unclassified Akkermansia	no rank	Decreases
0	1	Clostridium perfringens D	no rank	Decreases
0	1	Escherichia coli O141:H4	no rank	Decreases
0	1	Clostridium perfringens B	no rank	Decreases
0	1	Escherichia coli O139:H1	no rank	Decreases
0	1	Clostridium perfringens E	no rank	Decreases
0	1	Escherichia coli O80:H26	no rank	Decreases
0	1	Escherichia coli O158:H23	no rank	Decreases
0	1	Escherichia coli O84:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H4	no rank	Decreases
0	1	Escherichia coli O2:K1:H7	no rank	Decreases
0	1	Escherichia coli O78:H51	no rank	Decreases
0	1	Escherichia coli O18ac:H14	no rank	Decreases
0	1	Escherichia coli O85:H1	no rank	Decreases
0	1	Escherichia coli O7:H15	no rank	Decreases
0	1	Escherichia coli O68:H12	no rank	Decreases
0	1	Escherichia coli O55:H7	no rank	Decreases
0	1	Escherichia coli O1:K1:H7	no rank	Decreases
0	1	Escherichia coli O15:H12	no rank	Decreases
0	1	Escherichia coli O170:H18	no rank	Decreases
0	1	Escherichia coli O155:H21	no rank	Decreases
0	1	Escherichia coli O19:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H5	no rank	Decreases
0	1	Escherichia coli O20:H12	no rank	Decreases
0	1	Escherichia coli O111	serogroup	Decreases
0	1	Escherichia coli O121	serogroup	Decreases
0	1	Escherichia coli O155	serogroup	Decreases
0	1	Escherichia coli O177	serogroup	Decreases
0	1	Escherichia coli O26	serogroup	Decreases
0	1	Escherichia coli O3	serogroup	Decreases
0	1	Escherichia coli O5	serogroup	Decreases
0	1	Escherichia coli O86	serogroup	Decreases
0	1	Escherichia coli O91	serogroup	Decreases
0	1	Escherichia coli O103	serogroup	Decreases
0	1	Escherichia coli O78	serogroup	Decreases
0	1	Escherichia coli O43	serogroup	Decreases
0	1	Escherichia coli O119	serogroup	Decreases
0	1	Escherichia coli O157	serogroup	Decreases
0	1	Escherichia coli O145	serogroup	Decreases
0	1	Escherichia coli O1:HNT	serotype	Decreases
0	1	Escherichia coli O10:K5(L):H4	serotype	Decreases
0	1	Escherichia coli O103:H11	serotype	Decreases
0	1	Escherichia coli O103:H25	serotype	Decreases
0	1	Escherichia coli O104:H21	serotype	Decreases
0	1	Escherichia coli O111:H11	serotype	Decreases
0	1	Escherichia coli O111:H8	serotype	Decreases
0	1	Escherichia coli O112ac:H19	serotype	Decreases
0	1	Escherichia coli O114:H49	serotype	Decreases
0	1	Escherichia coli O118:H16	serotype	Decreases
0	1	Escherichia coli O121:H7	serotype	Decreases
0	1	Escherichia coli O123:H11	serotype	Decreases
0	1	Escherichia coli O127:H27	serotype	Decreases
0	1	Escherichia coli O127:H6	serotype	Decreases
0	1	Escherichia coli O128:H2	serotype	Decreases
0	1	Escherichia coli O128ac:H12	serotype	Decreases
0	1	Escherichia coli O145:H25	serotype	Decreases
0	1	Escherichia coli O145:NM	serotype	Decreases
0	1	Escherichia coli O146:H21	serotype	Decreases
0	1	Escherichia coli O153:H2	serotype	Decreases
0	1	Escherichia coli O156:H25	serotype	Decreases
0	1	Escherichia coli O157:H43	serotype	Decreases
0	1	Escherichia coli O157:NM	serotype	Decreases
0	1	Escherichia coli O165:H25	serotype	Decreases
0	1	Escherichia coli O174:H2	serotype	Decreases
0	1	Escherichia coli O174:H21	serotype	Decreases
0	1	Escherichia coli O174:H8	serotype	Decreases
0	1	Escherichia coli O176:H45	serotype	Decreases
0	1	Escherichia coli O177:NM	serotype	Decreases
0	1	Escherichia coli O26:H1	serotype	Decreases
0	1	Escherichia coli O28ac:NM	serotype	Decreases
0	1	Escherichia coli O29:H4	serotype	Decreases
0	1	Escherichia coli O32:H37	serotype	Decreases
0	1	Escherichia coli O6:H16:CFA/II	serotype	Decreases
0	1	Escherichia coli O69:H11	serotype	Decreases
0	1	Escherichia coli O78:H12	serotype	Decreases
0	1	Escherichia coli O79:H7	serotype	Decreases
0	1	Escherichia coli O81:NM	serotype	Decreases
0	1	Escherichia coli O86:H34	serotype	Decreases
0	1	Escherichia coli O91:H14	serotype	Decreases
0	1	Escherichia coli O91:NM	serotype	Decreases
0	1	Escherichia coli ONT:H33	serotype	Decreases
0	1	Escherichia coli O100:H21	serotype	Decreases
0	1	Escherichia coli O121:H19	serotype	Decreases
0	1	Escherichia coli O157:H7	serotype	Decreases
0	1	Escherichia coli O16:H6	serotype	Decreases
0	1	Escherichia coli O89m:H9	serotype	Decreases
0	1	Escherichia coli O111:H-	serotype	Decreases
0	1	Escherichia coli O113:H21	serotype	Decreases
0	1	Escherichia coli H20	serotype	Decreases
0	1	Escherichia coli O150:H6	serotype	Decreases
0	1	Escherichia coli O111:NM	serotype	Decreases
0	1	Escherichia coli O112ab:H8	serotype	Decreases
0	1	Escherichia coli O99:H6	serotype	Decreases
0	1	Escherichia coli O26:H11	serotype	Decreases
0	1	Escherichia coli O145:H28	serotype	Decreases
0	1	Escherichia coli O126:H45	serotype	Decreases
0	1	Escherichia coli O2:H6	serotype	Decreases
0	1	Escherichia coli O7:H4	serotype	Decreases
0	1	Escherichia coli O1:H42	serotype	Decreases
0	1	Escherichia coli O25:NM	serotype	Decreases
0	1	Escherichia coli O25:H1	serotype	Decreases
0	1	Escherichia coli O7:K1	serotype	Decreases
0	1	Escherichia coli O125ac:K+:H10	serotype	Decreases
0	1	Escherichia coli O6:K2:H1	serotype	Decreases
0	1	Escherichia coli O152:H23	serotype	Decreases
0	1	Escherichia coli O15:H18	serotype	Decreases
0	1	Escherichia coli O39:NM	serotype	Decreases
0	1	Escherichia coli O44:H18	serotype	Decreases
0	1	Escherichia coli O2:K2:H1	serotype	Decreases
0	1	Escherichia coli O8:H8	serotype	Decreases
0	1	Escherichia coli O89m:H10	serotype	Decreases
0	1	Escherichia coli O10:H32	serotype	Decreases
0	1	Escherichia coli O6:H16	serotype	Decreases
0	1	Escherichia coli O157:H-	serotype	Decreases
0	1	Escherichia coli O45:H2	serotype	Decreases
0	1	Escherichia coli O103:H2	serotype	Decreases
0	1	Escherichia coli O167:H26	serotype	Decreases
0	1	Escherichia coli O104:H4	serotype	Decreases
0	1	Escherichia coli O83:H1	serotype	Decreases
0	1	Escherichia coli O9:H10	serotype	Decreases
0	1	Escherichia coli O78:H4	serotype	Decreases
0	1	Escherichia coli O139:H28	serotype	Decreases
1	0	Bifidobacterium longum	species	Decreases
1	0	Dorea formicigenerans	species	Decreases
1	0	Bifidobacterium adolescentis	species	Decreases
1	0	Agathobacter rectalis	species	Decreases
1	0	Akkermansia muciniphila	species	Decreases
1	0	Bacteroides caccae	species	Decreases
1	0	Bacteroides fragilis	species	Decreases
1	0	Bacteroides ovatus	species	Decreases
1	0	Bacteroides thetaiotaomicron	species	Decreases
1	0	Bacteroides uniformis	species	Decreases
1	0	Blautia obeum	species	Decreases
1	0	Clostridioides difficile	species	Decreases
1	0	Collinsella aerofaciens	species	Decreases
1	0	Lachnospira eligens	species	Decreases
1	0	Odoribacter splanchnicus	species	Decreases
1	0	Parabacteroides distasonis	species	Decreases
1	0	Parabacteroides merdae	species	Decreases
1	0	Phocaeicola vulgatus	species	Decreases
1	0	Segatella copri	species	Decreases
1	0	Veillonella parvula	species	Decreases
1	0	Ruminococcus bromii	species	Decreases
1	0	Roseburia hominis	species	Decreases
1	0	Clostridium perfringens	species	Decreases
0	1	Akkermansia massiliensis	species	Decreases
0	1	Candidatus Akkermansia intestinavium	species	Decreases
1	0	Enterocloster bolteae	species	Decreases
1	0	Eggerthella lenta	species	Decreases
1	0	Escherichia coli	species	Decreases
0	1	Akkermansia glycaniphila	species	Decreases
0	1	Bifidobacterium longum subsp. longum	subspecies	Decreases
0	1	Bifidobacterium longum subsp. infantis	subspecies	Decreases
0	1	Bifidobacterium longum subsp. suis	subspecies	Decreases
0	1	Bifidobacterium longum subsp. suillum	subspecies	Decreases

Impact of pimethixene maleate,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition	Positive Impact	Negative Impact	Benefit Ratio Impact
Abdominal Aortic Aneurysm	0.6		0.6
Acne	0.3	0.3	0
ADHD	4.9	0.6	7.17
Age-Related Macular Degeneration and Glaucoma	1.1	0.4	1.75
Allergic Rhinitis (Hay Fever)	2.5	2.1	0.19
Allergies	6.7	4.2	0.6
Allergy to milk products	1.7	1.6	0.06
Alopecia (Hair Loss)	1.6		1.6
Alzheimer's disease	6.5	5.8	0.12
Amyotrophic lateral sclerosis (ALS) Motor Neuron	4	1	3
Ankylosing spondylitis	4.4	0.9	3.89
Anorexia Nervosa	1.4	2.9	-1.07
Antiphospholipid syndrome (APS)	0.7		0.7
Asthma	4.4	3.1	0.42
Atherosclerosis	1.8	2.4	-0.33
Atrial fibrillation	3.5	2.8	0.25
Autism	9.3	10.2	-0.1
Autoimmune Disease	0.9	1	-0.11
Barrett esophagus cancer	0.3		0.3
benign prostatic hyperplasia	0.6	0.3	1
Biofilm	0.3		0.3
Bipolar Disorder	2.1	1.4	0.5
Brain Trauma	0.6	1.4	-1.33
Breast Cancer	0.3	0.3	0
Cancer (General)	0.6	2.6	-3.33
Carcinoma	3.5	2.6	0.35
Celiac Disease	2.1	4	-0.9
Cerebral Palsy	1.5	1.3	0.15
Chronic Fatigue Syndrome	4.1	6	-0.46
Chronic Kidney Disease	4	2.1	0.9
Chronic Lyme	0.6	0.8	-0.33
Chronic Obstructive Pulmonary Disease (COPD)	0.3	1.1	-2.67
Chronic Urticaria (Hives)	1.1	1.8	-0.64
Coagulation / Micro clot triggering bacteria	1.1	1	0.1
Cognitive Function	3.3	1.3	1.54
Colorectal Cancer	7.1	2.2	2.23
Constipation	2.1	1.3	0.62
Coronary artery disease	1.5	2.7	-0.8
COVID-19	10.1	11.9	-0.18
Crohn's Disease	7.4	6.2	0.19
Cushing's Syndrome (hypercortisolism)		0.9	-0.9
cystic fibrosis	0.7	1.9	-1.71
d-lactic acidosis (one form of brain fog)	0.1		0.1
deep vein thrombosis	2.7	1.1	1.45
Denture Wearers Oral Shifts	0.6		0.6
Depression	10.3	9.1	0.13
Dermatomyositis		0.3	-0.3
Eczema	1.1	1.7	-0.55
Endometriosis	2.4	1.8	0.33
Eosinophilic Esophagitis		0.3	-0.3
Epilepsy	3	2.8	0.07
erectile dysfunction	1.1	0.3	2.67
Fibromyalgia	3.1	2	0.55
Functional constipation / chronic idiopathic constipation	5.2	4	0.3
gallstone disease (gsd)	3.2	1.3	1.46
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	1.5	0.9	0.67
Generalized anxiety disorder	1.8	2.4	-0.33
giant cell arteritis		0.2	-0.2
Gout	1.6	0.9	0.78
Graves' disease	1.9	2.7	-0.42
Gulf War Syndrome	0.3	2.5	-7.33
Halitosis	0.6		0.6
Hashimoto's thyroiditis	3.4	1.3	1.62
Heart Failure	3.1	2.3	0.35
hemorrhagic stroke	1		1
Hidradenitis Suppurativa	0.6	0.3	1
High Histamine/low DAO	1.1	0.6	0.83
hypercholesterolemia (High Cholesterol)	0.5	0.6	-0.2
hyperglycemia	1.9	2.2	-0.16
Hyperlipidemia (High Blood Fats)	1	0.3	2.33
hypersomnia		0.4	-0.4
hypertension (High Blood Pressure	4.8	5.8	-0.21
Hypothyroidism	0.4	0.7	-0.75
Hypoxia	3.2	0.9	2.56
IgA nephropathy (IgAN)	1.3	4.9	-2.77
Inflammatory Bowel Disease	7.1	9.5	-0.34
Insomnia	1.3	3.2	-1.46
Intelligence	1.1	0.6	0.83
Intracranial aneurysms	1.2	0.6	1
Irritable Bowel Syndrome	7.3	5.7	0.28
ischemic stroke	2.9	1.7	0.71
Liver Cirrhosis	6.6	4.2	0.57
Long COVID	5.9	8.4	-0.42
Low bone mineral density		0.8	-0.8
Lung Cancer	1.2	1.6	-0.33
Lymphoma	0.6		0.6
Mast Cell Issues / mastitis	0.6	0.6	0
ME/CFS with IBS	0.4	1.8	-3.5
ME/CFS without IBS	0.7	2.4	-2.43
Menopause	1.9	1	0.9
Metabolic Syndrome	6.5	8.3	-0.28
Mood Disorders	10.6	7.7	0.38
multiple chemical sensitivity [MCS]	0.7	0.1	6
Multiple Sclerosis	6.2	6.2	0
Multiple system atrophy (MSA)	1.5	0.7	1.14
myasthenia gravis	0.6	0.7	-0.17
neuropathic pain	0.3	3.4	-10.33
Neuropathy (all types)	0.8	2.8	-2.5
neuropsychiatric disorders (PANDAS, PANS)	0.3		0.3
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	4.8	5.7	-0.19
NonCeliac Gluten Sensitivity	1.9	0.6	2.17
Obesity	10.4	7.3	0.42
obsessive-compulsive disorder	6.1	3.1	0.97
Osteoarthritis	1.8	1.3	0.38
Osteoporosis	2.5	1.6	0.56
pancreatic cancer	0.3		0.3
Parkinson's Disease	7.9	5.6	0.41
Polycystic ovary syndrome	6.4	3	1.13
Postural orthostatic tachycardia syndrome	0.2	0.3	-0.5
Premenstrual dysphoric disorder	0.7	0.4	0.75
primary biliary cholangitis	0.9	1.1	-0.22
Primary sclerosing cholangitis	1.8	2.3	-0.28
Psoriasis	3.5	3.7	-0.06
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	7.5	4.1	0.83
Rosacea	0.6	1	-0.67
Schizophrenia	6.5	3.2	1.03
scoliosis	0.1	0.9	-8
Sjögren syndrome	2.9	3.2	-0.1
Sleep Apnea	1.6	1.6	0
Slow gastric motility / Gastroparesis	0.9	0.3	2
Small Intestinal Bacterial Overgrowth (SIBO)	0.8	0.7	0.14
Stress / posttraumatic stress disorder	2.8	2.6	0.08
Systemic Lupus Erythematosus	3.1	1.8	0.72
Tic Disorder	1.2	1.8	-0.5
Tourette syndrome	1	0.3	2.33
Type 1 Diabetes	4.2	4.2	0
Type 2 Diabetes	7.7	8.1	-0.05
Ulcerative colitis	5.3	8	-0.51
Unhealthy Ageing	3.5	2.6	0.35
Vitiligo	2.2	1.3	0.69

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