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🍽️ trifluoperazine dihydrochloride,(prescription)

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  1. Schizophrenia and Psychotic Disorders:

    • Trifluoperazine dihydrochloride belongs to the class of medications known as typical antipsychotics or first-generation antipsychotics.
    • It is used for the management of schizophrenia, a chronic mental disorder characterized by distorted thinking, hallucinations, delusions, and abnormal social behavior.
    • Trifluoperazine helps alleviate symptoms by blocking dopamine receptors in the brain, thereby reducing the activity of dopamine, a neurotransmitter associated with psychosis.
    • It may also be prescribed for other psychotic disorders, including schizoaffective disorder and psychotic depression.
  2. Adjunctive Therapy:

    • In some cases, trifluoperazine dihydrochloride may be used as an adjunctive therapy alongside other medications or psychosocial interventions to enhance the overall management of psychiatric conditions.
  3. Dosage and Administration:

    • Trifluoperazine dihydrochloride is available in various formulations, including tablets and oral solution.
    • The dosage and frequency of administration depend on the patient's age, weight, medical condition, and response to treatment.
    • It is typically taken orally with or without food, as directed by a healthcare provider.
    • Dosage adjustments may be necessary based on individual patient factors and the severity of symptoms.
  4. Adverse Effects:

    • Common side effects of trifluoperazine dihydrochloride may include drowsiness, dizziness, dry mouth, blurred vision, constipation, urinary retention, weight gain, and extrapyramidal symptoms such as tremors, muscle stiffness, and tardive dyskinesia.
    • Some patients may experience orthostatic hypotension, a sudden drop in blood pressure upon standing up, which can cause dizziness or fainting.
    • Rare but serious adverse effects may include neuroleptic malignant syndrome (NMS), a potentially life-threatening condition characterized by fever, altered mental status, muscle rigidity, and autonomic dysfunction.
  5. Contraindications and Precautions:

    • Trifluoperazine dihydrochloride is contraindicated in patients with a known hypersensitivity to trifluoperazine or other phenothiazine derivatives.
    • It should be used with caution in elderly patients, individuals with cardiovascular disease, hepatic impairment, or renal insufficiency.
    • Trifluoperazine may lower the seizure threshold, so caution is advised in patients with a history of seizures or epilepsy.
  6. Drug Interactions:

    • Trifluoperazine may interact with other medications, including central nervous system depressants, anticholinergic drugs, antihypertensive agents, and certain antibiotics.
    • Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking to avoid potential interactions.
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βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of trifluoperazine dihydrochloride,(prescription) On Probiotics

Rank Probiotic Impact
species Bacteroides uniformis Reduces
species Lacticaseibacillus paracasei Reduces
species Parabacteroides distasonis Reduces

Bacteria Impacted by trifluoperazine dihydrochloride,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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πŸ““ Direct Citations πŸ‘ͺπŸ‘Ά Indirect Citations Taxonomy Rank Effect
0 1 Dorea genus Decreases
0 1 Roseburia genus Decreases
0 1 Parabacteroides genus Decreases
0 1 Ruminococcus genus Decreases
0 1 Agathobacter genus Decreases
0 1 Bacteroides genus Decreases
0 1 Bilophila genus Decreases
0 1 Clostridioides genus Decreases
0 1 Collinsella genus Decreases
0 1 Coprococcus genus Decreases
0 1 Fusobacterium genus Decreases
0 1 Lachnospira genus Decreases
0 1 Lacrimispora genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Odoribacter genus Decreases
0 1 Phocaeicola genus Decreases
0 1 Streptococcus genus Decreases
0 1 Segatella genus Decreases
0 1 Blautia genus Decreases
0 1 Lacticaseibacillus genus Decreases
1 0 Agathobacter rectalis species Decreases
1 0 Bacteroides fragilis species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
1 0 Bacteroides uniformis species Decreases
1 0 Bilophila wadsworthia species Decreases
1 0 Blautia obeum species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Dorea formicigenerans species Decreases
1 0 Lachnospira eligens species Decreases
1 0 Lacrimispora saccharolytica species Decreases
1 0 Lacticaseibacillus paracasei species Decreases
1 0 Parabacteroides distasonis species Decreases
1 0 Phocaeicola vulgatus species Decreases
1 0 Roseburia hominis species Decreases
1 0 Roseburia intestinalis species Decreases
1 0 Ruminococcus bromii species Decreases
1 0 Segatella copri species Decreases
1 0 Coprococcus comes species Decreases
1 0 Parabacteroides merdae species Decreases
1 0 Odoribacter splanchnicus species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Streptococcus salivarius species Decreases
1 0 Mediterraneibacter gnavus species Decreases
1 0 Fusobacterium nucleatum species Decreases
0 1 Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases
0 1 Fusobacterium nucleatum subsp. nucleatum subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases

Impact of trifluoperazine dihydrochloride,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.9 0.9
Acne 0.6 0.6
ADHD 3 0.3 9
Age-Related Macular Degeneration and Glaucoma 1.1 0.4 1.75
Allergic Rhinitis (Hay Fever) 1.8 0.3 5
Allergies 3.8 2.4 0.58
Allergy to milk products 1.2 0.7 0.71
Alopecia (Hair Loss) 1.6 1.6
Alzheimer's disease 4.1 5.7 -0.39
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.4 0.3 7
Ankylosing spondylitis 3.1 1.2 1.58
Anorexia Nervosa 1.2 3 -1.5
Antiphospholipid syndrome (APS) 1.5 0.3 4
Asthma 3.4 1.1 2.09
Atherosclerosis 1.8 2 -0.11
Atrial fibrillation 3.5 2.2 0.59
Autism 5.8 7.6 -0.31
Autoimmune Disease 0.3 0.5 -0.67
Barrett esophagus cancer 0.3 0.3 0
benign prostatic hyperplasia 0.3 -0.3
Biofilm 0.4 0.4
Bipolar Disorder 1.3 1.1 0.18
Brain Trauma 0.6 1.1 -0.83
Breast Cancer 0.1 0.1
Cancer (General) 0.6 0.6 0
Carcinoma 3.2 2.3 0.39
Celiac Disease 2.7 2.6 0.04
Cerebral Palsy 0.6 1.3 -1.17
Chronic Fatigue Syndrome 2.6 6.1 -1.35
Chronic Kidney Disease 1.8 2.3 -0.28
Chronic Lyme 0.2 0.8 -3
Chronic Obstructive Pulmonary Disease (COPD) 0.9 1.7 -0.89
Chronic Urticaria (Hives) 0.3 1.2 -3
Coagulation / Micro clot triggering bacteria 0.7 1.3 -0.86
Cognitive Function 3.3 1.1 2
Colorectal Cancer 4.5 1.7 1.65
Constipation 1.5 0.7 1.14
Coronary artery disease 1.2 2.7 -1.25
COVID-19 5.9 9.4 -0.59
Crohn's Disease 6.5 5.5 0.18
Cushing's Syndrome (hypercortisolism) 0.9 -0.9
cystic fibrosis 1 -1
deep vein thrombosis 1.9 1.4 0.36
Denture Wearers Oral Shifts 0.4 0.4
Depression 7.3 7.3 0
Dermatomyositis 0.3 0.3
Eczema 0.6 1 -0.67
Endometriosis 2 1.7 0.18
Eosinophilic Esophagitis 0.3 0.3 0
Epilepsy 1.9 1.1 0.73
erectile dysfunction 0.6 0.6
Fibromyalgia 1.9 1.8 0.06
Functional constipation / chronic idiopathic constipation 4 3.2 0.25
gallstone disease (gsd) 2.1 0.8 1.63
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.5 1.2 0.25
Generalized anxiety disorder 1.4 0.9 0.56
Glioblastoma 0.3 -0.3
Gout 0.9 0.6 0.5
Graves' disease 1.3 2.7 -1.08
Gulf War Syndrome 0.7 1.2 -0.71
Halitosis 0.9 0.3 2
Hashimoto's thyroiditis 2.7 0.9 2
Heart Failure 2.5 1.6 0.56
hemorrhagic stroke 1.3 1.3
Hidradenitis Suppurativa 1.4 1.4
High Histamine/low DAO 0.5 0.3 0.67
hypercholesterolemia (High Cholesterol) 0.3 0.3
hyperglycemia 0.1 0.9 -8
Hyperlipidemia (High Blood Fats) 0.6 0.3 1
hypersomnia 0.7 -0.7
hypertension (High Blood Pressure 2.8 4.8 -0.71
Hypothyroidism 0.4 -0.4
Hypoxia 1.3 0.6 1.17
IgA nephropathy (IgAN) 1.6 3 -0.88
Inflammatory Bowel Disease 3.8 8.4 -1.21
Insomnia 1.7 2.1 -0.24
Intelligence 1.2 0.6 1
Intracranial aneurysms 1.4 0.6 1.33
Irritable Bowel Syndrome 4.1 3.9 0.05
ischemic stroke 1.4 1.1 0.27
Liver Cirrhosis 5.3 2.9 0.83
Long COVID 4.2 7.3 -0.74
Low bone mineral density 1.1 -1.1
Lung Cancer 0.3 1 -2.33
Mast Cell Issues / mastitis 0.3 0.6 -1
ME/CFS with IBS 0.3 1.8 -5
ME/CFS without IBS 0.4 2.1 -4.25
membranous nephropathy 0.3 0.3
Menopause 0.3 0.5 -0.67
Metabolic Syndrome 5.9 6.1 -0.03
Mood Disorders 6.1 5.5 0.11
multiple chemical sensitivity [MCS] 0.4 0.1 3
Multiple Sclerosis 3.6 5.9 -0.64
Multiple system atrophy (MSA) 0.6 0.4 0.5
myasthenia gravis 0.3 0.5 -0.67
neuropathic pain 2.4 -2.4
Neuropathy (all types) 0.4 1.2 -2
neuropsychiatric disorders (PANDAS, PANS) 0.6 0.6
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 3.9 3.3 0.18
NonCeliac Gluten Sensitivity 0.7 0.3 1.33
Obesity 7 5.4 0.3
obsessive-compulsive disorder 4.5 2.8 0.61
Osteoarthritis 1.4 0.9 0.56
Osteoporosis 1.1 1.3 -0.18
pancreatic cancer 0.6 0.3 1
Parkinson's Disease 5.4 6.3 -0.17
Polycystic ovary syndrome 5.9 2.7 1.19
Postural orthostatic tachycardia syndrome 0.3 -0.3
Premenstrual dysphoric disorder 0.4 0.4 0
primary biliary cholangitis 0.9 1.5 -0.67
Primary sclerosing cholangitis 1.3 2.4 -0.85
Psoriasis 2.5 3.4 -0.36
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 6.2 3.9 0.59
Rosacea 0.3 0.5 -0.67
Schizophrenia 3.8 2.3 0.65
scoliosis 0.3 1.2 -3
Sjögren syndrome 1.7 2.3 -0.35
Sleep Apnea 1.9 1.6 0.19
Slow gastric motility / Gastroparesis 0.6 0.6
Small Intestinal Bacterial Overgrowth (SIBO) 1.2 1.2
Stress / posttraumatic stress disorder 2.1 1.8 0.17
Systemic Lupus Erythematosus 3 2.2 0.36
Tic Disorder 1.5 1.5 0
Tourette syndrome 0.9 0.3 2
Type 1 Diabetes 2.8 2.3 0.22
Type 2 Diabetes 6.4 5.6 0.14
Ulcerative colitis 3.3 6.2 -0.88
Unhealthy Ageing 3.5 2.2 0.59
Vitiligo 2.2 0.7 2.14

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