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Urinary Tract Infections (UTIs): Oxolinic acid is effective against urinary tract infections caused by susceptible strains of bacteria, including Escherichia coli, Proteus mirabilis, Klebsiella species, Enterobacter species, and other gram-negative bacteria. It is particularly useful in treating uncomplicated lower urinary tract infections such as cystitis.
Prostatitis: Oxolinic acid may also be used in the treatment of bacterial prostatitis, which is an inflammation of the prostate gland often caused by bacterial infection. It can help eradicate the bacteria responsible for the infection and alleviate symptoms such as pain, urinary frequency, and discomfort.
Gastrointestinal Infections: In some cases, oxolinic acid may be prescribed for the treatment of gastrointestinal infections caused by susceptible bacteria. However, its use in this context is less common compared to other antibiotics.
Other Infections: Oxolinic acid may also be used to treat other bacterial infections caused by susceptible organisms, though its use is primarily limited to urinary tract infections and prostatitis.
Mechanism of Action: Oxolinic acid works by inhibiting the bacterial DNA gyrase enzyme, thereby interfering with the replication and transcription of bacterial DNA. This ultimately leads to bacterial cell death and eradication of the infection.
Dosage and Administration: The dosage of oxolinic acid depends on the severity of the infection, the specific bacteria causing the infection, and the patient's renal function. It is typically administered orally in the form of tablets or capsules. The dosage regimen should be determined by a healthcare professional based on individual factors.
Adverse Effects: Common side effects of oxolinic acid may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain. Additionally, allergic reactions and skin rashes may occur in some individuals. Rare but serious adverse effects may include tendon rupture, central nervous system effects (such as dizziness or confusion), and photosensitivity reactions.
Precautions: Oxolinic acid should be used with caution in patients with a history of tendon disorders, as it may increase the risk of tendon rupture. It should also be used cautiously in patients with epilepsy or other seizure disorders, as quinolone antibiotics may lower the seizure threshold.
Drug Interactions: Oxolinic acid may interact with certain medications, supplements, or herbal products, potentially affecting its efficacy or increasing the risk of adverse effects. It is important to inform a healthcare professional about all medications being taken before starting treatment with oxolinic acid.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
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