🍽️ zileuton,(prescription)

Asthma Treatment: Zileuton is primarily used for the management of asthma, particularly in cases where symptoms are not adequately controlled by other asthma medications such as bronchodilators or corticosteroids. It works by inhibiting the enzyme 5-lipoxygenase, which is involved in the production of leukotrienes, substances that contribute to inflammation and bronchoconstriction in the airways.

Improvement of Asthma Symptoms: Zileuton helps to reduce inflammation in the airways and decrease bronchoconstriction, leading to improved airflow and relief of asthma symptoms such as wheezing, coughing, chest tightness, and shortness of breath.

Prevention of Asthma Attacks: By reducing airway inflammation and constriction, zileuton helps to prevent asthma exacerbations and reduce the frequency and severity of asthma attacks. It is often used as a long-term maintenance treatment to control asthma symptoms and minimize the need for rescue medications.

Zyflo CR Formulation: Zyflo CR (controlled-release) is an extended-release formulation of zileuton that allows for once-daily dosing, providing continuous asthma symptom control throughout the day. This formulation may improve treatment adherence and convenience for patients.

Adverse Effects: Like any medication, zileuton may cause adverse effects in some individuals. Common side effects include headache, gastrointestinal disturbances (such as nausea, vomiting, diarrhea, and abdominal pain), liver function abnormalities (elevated liver enzymes), and insomnia. These side effects are usually mild to moderate in severity and often resolve with continued use or dose adjustment.

Liver Function Monitoring: Due to the risk of liver toxicity, liver function tests should be performed regularly during zileuton treatment to monitor for signs of liver dysfunction. Patients should be advised to report any symptoms of liver injury, such as jaundice (yellowing of the skin or eyes), dark urine, or abdominal pain, to their healthcare provider promptly.

Drug Interactions: Zileuton may interact with other medications, particularly those metabolized by the cytochrome P450 enzyme system. Concurrent use of zileuton with certain drugs, such as warfarin (an anticoagulant) or theophylline (a bronchodilator), may require dose adjustments or close monitoring to prevent adverse effects or drug interactions.

Contraindications: Zileuton is contraindicated in patients with active liver disease or liver function abnormalities. It should not be used in individuals with a history of allergic reactions to zileuton or any of its components.