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🍽️ etretinate,(prescription)

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  1. Psoriasis Treatment: Etretinate is indicated for the treatment of severe psoriasis, a chronic autoimmune skin condition characterized by thickened, red, and scaly patches of skin. It is typically prescribed when other treatments have failed to provide adequate relief.

  2. Retinoid Action: Etretinate works by modulating the growth and differentiation of skin cells. It reduces the proliferation of skin cells (keratinocytes) and promotes their normal differentiation, leading to a decrease in the formation of psoriatic plaques.

  3. Long Duration of Action: Etretinate has a long duration of action, which allows for less frequent dosing compared to some other psoriasis medications. This can improve treatment adherence and convenience for patients.

  4. Side Effects: Despite its effectiveness, etretinate is associated with several potential side effects, some of which can be serious. Common side effects include dry skin, dry mouth, dry eyes, itching, and hair loss. It can also cause nail changes, such as thickening or brittleness. Other potential side effects include headache, fatigue, joint pain, and muscle pain.

  5. Teratogenicity: Etretinate is highly teratogenic, meaning it can cause severe birth defects if taken during pregnancy. It has a long half-life, and even a single dose can remain in the body for an extended period. Due to this risk, etretinate is contraindicated in pregnant women and women of childbearing potential who are not using effective contraception. Additionally, women of childbearing age are advised to avoid becoming pregnant for several years after discontinuing etretinate therapy.

  6. Monitoring: Patients taking etretinate require close monitoring by a healthcare provider to assess treatment response and monitor for potential side effects. Regular blood tests, including liver function tests and lipid profiles, may be recommended to monitor for adverse effects on the liver and lipid metabolism.

  7. Sun Sensitivity: Etretinate can increase sensitivity to sunlight, so patients should take precautions to protect their skin from sun exposure, such as wearing protective clothing and using sunscreen.

  8. Drug Interactions: Etretinate may interact with other medications, including certain antibiotics and oral contraceptives. Patients should inform their healthcare provider about all medications they are taking to avoid potential interactions.

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Check for interactions on Supp.AI   |   📚 PubMed Citations

⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of etretinate,(prescription) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Anaerobutyricum hallii Reduces
species Bacteroides uniformis Reduces
species Bifidobacterium adolescentis Reduces
species Christensenella minuta Reduces
species Escherichia coli Reduces
species Faecalibacterium prausnitzii Reduces

Bacteria Impacted by etretinate,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Clostridium genus Decreases
0 1 Agathobacter genus Decreases
0 1 Roseburia genus Decreases
0 1 Clostridioides genus Decreases
0 1 Segatella genus Decreases
0 1 Lachnospira genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Parabacteroides genus Decreases
0 1 Leyella genus Decreases
0 1 Escherichia genus Decreases
0 1 Bacteroides genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Phocaeicola genus Decreases
0 1 Streptococcus genus Decreases
0 1 Coprococcus genus Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Agathobacter rectalis species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Clostridium perfringens species Decreases
1 0 Roseburia intestinalis species Decreases
1 0 Segatella copri species Decreases
1 0 Lachnospira eligens species Decreases
1 0 Bacteroides uniformis species Decreases
1 0 Parabacteroides merdae species Decreases
0 1 Segatella bryantii species Decreases
0 1 Leyella stercorea species Decreases
1 0 Escherichia coli species Decreases
0 1 Roseburia rectibacter species Decreases
0 1 Butyrivibrio crossotus species Decreases
0 1 Bacteroides humanifaecis species Decreases
0 1 Ligilactobacillus ruminis species Decreases
0 1 Coprococcus catus species Decreases
0 1 Pseudobutyrivibrio xylanivorans species Decreases
0 1 Dorea formicigenerans species Decreases
0 1 Dorea longicatena species Decreases
0 1 Prevotella intermedia species Decreases
0 1 Roseburia hominis species Decreases
0 1 Anaerobutyricum hallii species Decreases
0 1 Wansuia hejianensis species Decreases
0 1 Blautia obeum species Decreases
0 1 Wujia chipingensis species Decreases
0 1 [Ruminococcus] lactaris species Decreases
0 1 Bacteroides sp. CACC 737 species Decreases
0 1 Coprococcus eutactus species Decreases
0 1 Clostridium sp. M62/1 species Decreases
0 1 Subdoligranulum variabile species Decreases
0 1 Eubacterium sp. MSJ-33 species Decreases
0 1 Blautia sp. SC05B48 species Decreases
0 1 Clostridium sp. SY8519 species Decreases
0 1 Eubacterium ventriosum species Decreases
1 0 Bifidobacterium adolescentis species Decreases
0 1 Leyella lascolaii species Decreases
0 1 Faecalibacterium duncaniae species Decreases
0 1 Simiaoa sunii species Decreases
0 1 Amedibacterium intestinale species Decreases
0 1 Massilistercora timonensis species Decreases
0 1 Qiania dongpingensis species Decreases
0 1 Coprococcus sp. ART55/1 species Decreases
0 1 Lacrimispora saccharolytica species Decreases
0 1 Faecalibacterium sp. I4-1-79 species Decreases
0 1 Novisyntrophococcus fermenticellae species Decreases
0 1 Bacillus paralicheniformis species Decreases
0 1 Blautia liquoris species Decreases
0 1 Intestinibaculum porci species Decreases
0 1 Komagataeibacter oboediens species Decreases
1 0 Phocaeicola vulgatus species Decreases
0 1 Hungatella hathewayi species Decreases
0 1 Streptococcus pasteurianus species Decreases
0 1 Vescimonas fastidiosa species Decreases
0 1 Faecalibacterium sp. IP-3-29 species Decreases
0 1 Longicatena caecimuris species Decreases
0 1 Paraprevotella clara species Decreases
0 1 Marvinbryantia formatexigens species Decreases
0 1 [Clostridium] hylemonae species Decreases
0 1 Faecalibacterium sp. I3-3-89 species Decreases
0 1 Prevotella bivia species Decreases
0 1 Faecalibacterium sp. HTF-F species Decreases
0 1 Faecalibacterium sp. I2-3-92 species Decreases
0 1 Lachnoanaerobaculum gingivalis species Decreases
0 1 Faecalitalea cylindroides species Decreases
0 1 Christensenella minuta species Decreases
0 1 Faecalibacterium prausnitzii species Decreases
0 1 Faecalibacterium sp. I3-3-33 species Decreases
0 1 Catenibacterium mitsuokai species Decreases
0 1 Enterocloster clostridioformis species Decreases
0 1 Catenibacterium sp. co_0103 species Decreases
0 1 Faecalibacillus intestinalis species Decreases
0 1 Faecalibacterium sp. IP-1-18 species Decreases
0 1 Anaerostipes hadrus species Decreases
0 1 Ruminococcus bicirculans (ex Wegman et al. 2014) species Decreases
0 1 Prevotella dentalis species Decreases
0 1 Faecalibacterium sp. I4-3-84 species Decreases
0 1 [Clostridium] innocuum species Decreases
1 0 Streptococcus parasanguinis species Decreases
1 0 Coprococcus comes species Decreases
1 0 Mediterraneibacter gnavus species Decreases
1 0 Bacteroides caccae species Decreases
1 0 Bacteroides fragilis species Decreases

Impact of etretinate,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 0.1 -0.1
ADHD 1.5 0.3 4
Age-Related Macular Degeneration and Glaucoma 0.5 0.1 4
Allergic Rhinitis (Hay Fever) 1.1 0.6 0.83
Allergies 2 1.5 0.33
Allergy to milk products 0.8 0.5 0.6
Alopecia (Hair Loss) 0.1 -0.1
Alzheimer's disease 1.6 3.8 -1.37
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.9 0.2 3.5
Ankylosing spondylitis 1.3 0.4 2.25
Anorexia Nervosa 0.7 1.8 -1.57
Antiphospholipid syndrome (APS) 0.8 0.8
Asthma 1.8 0.8 1.25
Atherosclerosis 0.6 1.5 -1.5
Atrial fibrillation 1.1 1.6 -0.45
Autism 4 4 0
Autoimmune Disease 0.2 0.9 -3.5
Barrett esophagus cancer 0 0
benign prostatic hyperplasia 0.1 0.1 0
Biofilm 0.4 0.4
Bipolar Disorder 0.9 0.4 1.25
Brain Trauma 0.1 0.6 -5
Breast Cancer 0.2 0.2
Cancer (General) 0.7 -0.7
Carcinoma 0.4 0.3 0.33
Celiac Disease 1 0.5 1
Cerebral Palsy 0.7 0.5 0.4
Chronic Fatigue Syndrome 1.4 2.1 -0.5
Chronic Kidney Disease 1.9 2.3 -0.21
Chronic Lyme 0.6 0.5 0.2
Chronic Obstructive Pulmonary Disease (COPD) 0.3 0.7 -1.33
Chronic Urticaria (Hives) 0.8 0.7 0.14
Coagulation / Micro clot triggering bacteria 0.5 0.4 0.25
Cognitive Function 0.3 1 -2.33
Colorectal Cancer 2.2 1.8 0.22
Constipation 0.5 0.4 0.25
Coronary artery disease 0.9 1.4 -0.56
COVID-19 2.6 5 -0.92
Crohn's Disease 2.3 2.4 -0.04
Cushing's Syndrome (hypercortisolism) 0.2 -0.2
cystic fibrosis 0.3 0.6 -1
d-lactic acidosis (one form of brain fog) 0.2 0.2
deep vein thrombosis 0.4 0.5 -0.25
Denture Wearers Oral Shifts 0 0
Depression 2.8 3.9 -0.39
Dermatomyositis 0 0.1 0
Eczema 0.8 0.7 0.14
Endometriosis 0.8 0.9 -0.13
Eosinophilic Esophagitis 0 0
Epilepsy 1.3 0.5 1.6
erectile dysfunction 0.7 0.1 6
Fibromyalgia 1.5 1.8 -0.2
Functional constipation / chronic idiopathic constipation 2.1 2.6 -0.24
gallstone disease (gsd) 1 0.4 1.5
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.2 0.7 -2.5
Generalized anxiety disorder 0.5 0.7 -0.4
giant cell arteritis 0.5 -0.5
Glioblastoma 0 0
Gout 0.1 0.5 -4
Graves' disease 0.3 0.7 -1.33
Gulf War Syndrome 0.6 0.1 5
Halitosis 0.1 0 0
Hashimoto's thyroiditis 1.3 1.1 0.18
Heart Failure 2.3 1.3 0.77
hemorrhagic stroke 0.1 0.1
Hidradenitis Suppurativa 0.5 0.5
High Histamine/low DAO 1.7 0.1 16
hypercholesterolemia (High Cholesterol) 0.7 0.7
hyperglycemia 0.3 0.4 -0.33
Hyperlipidemia (High Blood Fats) 0.1 0.1
hypertension (High Blood Pressure 1.6 1.5 0.07
Hypothyroidism 0.1 0.1 0
Hypoxia 1.4 1.4
IgA nephropathy (IgAN) 0.2 2.9 -13.5
Inflammatory Bowel Disease 2.9 4.5 -0.55
Insomnia 0.3 1.2 -3
Intelligence 1.1 0.7 0.57
Intracranial aneurysms 0.3 0.2 0.5
Irritable Bowel Syndrome 2 2.2 -0.1
ischemic stroke 0.5 1 -1
Liver Cirrhosis 2.1 1.3 0.62
Long COVID 1.9 2.5 -0.32
Low bone mineral density 0.8 -0.8
Lung Cancer 0.1 0.2 -1
Lymphoma 0.1 0.1
Mast Cell Issues / mastitis 0.1 0.1 0
ME/CFS with IBS 0.5 1 -1
ME/CFS without IBS 0.8 0.4 1
membranous nephropathy 0 0
Menopause 0.3 0.4 -0.33
Metabolic Syndrome 1.8 2.2 -0.22
Mood Disorders 3.3 2.9 0.14
multiple chemical sensitivity [MCS] 0 0.1 0
Multiple Sclerosis 1.7 3.9 -1.29
Multiple system atrophy (MSA) 0.2 0.1 1
myasthenia gravis 0.1 0.9 -8
neuropathic pain 1.1 -1.1
Neuropathy (all types) 0 0.7 0
neuropsychiatric disorders (PANDAS, PANS) 0.2 0.2
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2.3 1.9 0.21
NonCeliac Gluten Sensitivity 0.1 0.1 0
Obesity 3.6 2.3 0.57
obsessive-compulsive disorder 2.3 1.9 0.21
Osteoarthritis 1.4 0.4 2.5
Osteoporosis 1 0.1 9
pancreatic cancer 0 0 0
Parkinson's Disease 3.3 4.1 -0.24
Polycystic ovary syndrome 2.1 1.1 0.91
Postural orthostatic tachycardia syndrome 0.5 0.1 4
Premenstrual dysphoric disorder 0.1 0.1 0
primary biliary cholangitis 0 0.9 0
Primary sclerosing cholangitis 0.8 1.2 -0.5
Psoriasis 1 1.8 -0.8
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 1.9 1.8 0.06
Rosacea 0.7 1 -0.43
Schizophrenia 2.3 1.5 0.53
scoliosis 0.4 0.5 -0.25
sensorineural hearing loss 0.1 0.1
Sjögren syndrome 1 1.2 -0.2
Sleep Apnea 0.1 0.5 -4
Slow gastric motility / Gastroparesis 0.3 0.1 2
Small Intestinal Bacterial Overgrowth (SIBO) 0.8 0.8
Stress / posttraumatic stress disorder 1.3 0.8 0.63
Systemic Lupus Erythematosus 1 0.8 0.25
Tic Disorder 0.2 1.1 -4.5
Tourette syndrome 0 0.1 0
Type 1 Diabetes 0.9 1.8 -1
Type 2 Diabetes 2 2.1 -0.05
Ulcerative colitis 2.3 3.2 -0.39
Unhealthy Ageing 1.7 1.2 0.42
Vitiligo 0.6 0.8 -0.33

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