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🍽️ trazodone hydrochloride,(prescription)

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  1. Depression:

    • Trazodone is primarily indicated for the treatment of depression, including both the acute phase and the maintenance phase of major depressive disorder (MDD). It helps alleviate symptoms such as persistent sadness, loss of interest or pleasure in activities, changes in appetite or sleep patterns, and feelings of worthlessness or guilt.

  2. Anxiety Disorders:

    • Trazodone may be used off-label to manage symptoms of anxiety disorders such as generalized anxiety disorder (GAD), panic disorder, and social anxiety disorder (SAD). It can help reduce anxiety symptoms such as excessive worry, nervousness, and restlessness.

  3. Insomnia:

    • Trazodone is often prescribed off-label to treat insomnia, particularly in individuals with depression who experience sleep disturbances. It can help improve sleep quality and duration by promoting drowsiness and facilitating sleep onset.

  4. Sleep Disorders:

    • Trazodone may be used off-label in the treatment of certain sleep disorders, such as sleep disturbances associated with post-traumatic stress disorder (PTSD) and nightmares. It can help reduce the frequency and intensity of nightmares and improve overall sleep quality.

  5. Pain Management:

    • Trazodone may be used off-label to manage chronic pain conditions, particularly neuropathic pain. It can help alleviate pain symptoms and improve overall quality of life in individuals with conditions such as fibromyalgia, diabetic neuropathy, and chronic back pain.

  6. Adjunctive Therapy:

    • Trazodone may be used as an adjunctive treatment alongside other antidepressant medications or mood stabilizers to enhance therapeutic effects or manage specific symptoms. It may be prescribed in cases where standard antidepressant therapy alone is insufficient.

  7. Side Effects:

    • Common side effects of trazodone may include drowsiness, dizziness, dry mouth, blurred vision, constipation, and weight changes. Less common but potentially serious side effects may include serotonin syndrome (especially when used in combination with other serotonergic medications), priapism (prolonged erection), and orthostatic hypotension (drop in blood pressure upon standing).
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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of trazodone hydrochloride,(prescription) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Akkermansia muciniphila Reduces
species Bacteroides uniformis Reduces
species Bifidobacterium adolescentis Reduces

Bacteria Impacted by trazodone hydrochloride,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Akkermansiaceae family Decreases
0 1 Dorea genus Decreases
0 1 Roseburia genus Decreases
1 0 Akkermansia genus Decreases
0 1 Bacteroides genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Eggerthella genus Decreases
0 1 Fusobacterium genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Odoribacter genus Decreases
0 1 Veillonella genus Decreases
0 1 environmental samples no rank Decreases
0 1 unclassified Akkermansia no rank Decreases
1 0 Akkermansia muciniphila species Decreases
1 0 Eggerthella lenta species Decreases
1 0 Roseburia hominis species Decreases
1 0 Odoribacter splanchnicus species Decreases
1 0 Mediterraneibacter gnavus species Decreases
0 1 Akkermansia massiliensis species Decreases
0 1 Candidatus Akkermansia intestinavium species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Bifidobacterium adolescentis species Decreases
1 0 Bacteroides uniformis species Decreases
1 0 Veillonella parvula species Decreases
1 0 Bacteroides caccae species Decreases
1 0 Dorea formicigenerans species Decreases
1 0 Fusobacterium nucleatum species Decreases
0 1 Akkermansia glycaniphila species Decreases
0 1 Fusobacterium nucleatum subsp. nucleatum subspecies Decreases

Impact of trazodone hydrochloride,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.3 0.3
Acne 0.3 0.5 -0.67
ADHD 2.1 0.6 2.5
Age-Related Macular Degeneration and Glaucoma 1.1 1.1
Allergic Rhinitis (Hay Fever) 1.5 1 0.5
Allergies 2 2.2 -0.1
Allergy to milk products 0.9 0.6 0.5
Alopecia (Hair Loss) 0.6 0.6
Alzheimer's disease 3.3 2.5 0.32
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.3 0.6 2.83
Ankylosing spondylitis 1.9 0.9 1.11
Anorexia Nervosa 0.3 1.1 -2.67
Antiphospholipid syndrome (APS) 0.3 0.3
Asthma 3.2 2.7 0.19
Atherosclerosis 0.9 1.5 -0.67
Atrial fibrillation 1.4 0.6 1.33
Autism 5.1 3.9 0.31
Autoimmune Disease 0.3 0.8 -1.67
Barrett esophagus cancer 0.6 0.6
benign prostatic hyperplasia 0.3 -0.3
Biofilm 0.6 0.6
Bipolar Disorder 0.6 1.1 -0.83
Brain Trauma 0.3 1.1 -2.67
Breast Cancer 0.3 0.3
Cancer (General) 0.9 0.3 2
Carcinoma 2 1.4 0.43
Celiac Disease 0.9 2.2 -1.44
Cerebral Palsy 1.4 0.8 0.75
Chronic Fatigue Syndrome 2.5 1.9 0.32
Chronic Kidney Disease 2.1 1.3 0.62
Chronic Lyme 0.8 -0.8
Chronic Obstructive Pulmonary Disease (COPD) 0.6 1.1 -0.83
Chronic Urticaria (Hives) 0.3 0.6 -1
Coagulation / Micro clot triggering bacteria 0.5 -0.5
Cognitive Function 1.7 1.1 0.55
Colorectal Cancer 4.2 1.1 2.82
Constipation 0.3 0.5 -0.67
Coronary artery disease 0.3 1.4 -3.67
COVID-19 3.6 4.6 -0.28
Crohn's Disease 3.9 3.4 0.15
Cushing's Syndrome (hypercortisolism) 0.3 -0.3
cystic fibrosis 1.3 -1.3
deep vein thrombosis 1.1 0.8 0.38
Denture Wearers Oral Shifts 0.1 0.1
Depression 4.7 4.2 0.12
Dermatomyositis 0.3 -0.3
Eczema 0.9 0.5 0.8
Endometriosis 1.2 1.1 0.09
Eosinophilic Esophagitis 0.3 0.3 0
Epilepsy 1.4 1.7 -0.21
erectile dysfunction 0.9 0.3 2
Fibromyalgia 1.7 0.8 1.13
Functional constipation / chronic idiopathic constipation 0.9 1.4 -0.56
gallstone disease (gsd) 1.2 1.6 -0.33
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.6 0.6
Generalized anxiety disorder 1.7 1.6 0.06
Gout 0.9 0.5 0.8
Graves' disease 0.9 2 -1.22
Gulf War Syndrome 1.6 -1.6
Halitosis 0.9 0.9
Hashimoto's thyroiditis 3 1.3 1.31
Heart Failure 0.6 1.3 -1.17
hemorrhagic stroke 0.9 0.9
Hidradenitis Suppurativa 0.6 0.3 1
High Histamine/low DAO 0.5 0.3 0.67
hypercholesterolemia (High Cholesterol) 0.3 0.6 -1
hyperglycemia 0.7 1.7 -1.43
Hyperlipidemia (High Blood Fats) 0.8 0.8
hypertension (High Blood Pressure 2.5 2.8 -0.12
Hypothyroidism 0.5 0.6 -0.2
Hypoxia 1.7 0.3 4.67
IgA nephropathy (IgAN) 0.9 2 -1.22
Inflammatory Bowel Disease 3.6 3.3 0.09
Insomnia 1.2 2.2 -0.83
Intelligence 0.5 0.5
Intracranial aneurysms 0.6 0.3 1
Irritable Bowel Syndrome 4.1 2.7 0.52
ischemic stroke 1.4 0.8 0.75
Liver Cirrhosis 3.9 4 -0.03
Long COVID 2.9 3.2 -0.1
Low bone mineral density 0.5 -0.5
Lung Cancer 0.1 1.2 -11
Mast Cell Issues / mastitis 0 0.3 0
ME/CFS with IBS 0.6 -0.6
ME/CFS without IBS 1.2 1.2 0
Menopause 0.2 1 -4
Metabolic Syndrome 3.5 4.5 -0.29
Mood Disorders 4.9 2.8 0.75
multiple chemical sensitivity [MCS] 0.8 0.8
Multiple Sclerosis 3.1 1.1 1.82
Multiple system atrophy (MSA) 1.6 0.3 4.33
myasthenia gravis 0.5 -0.5
neuropathic pain 0.3 2.3 -6.67
Neuropathy (all types) 0.8 1 -0.25
neuropsychiatric disorders (PANDAS, PANS) 0.3 0.3
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2 2.7 -0.35
NonCeliac Gluten Sensitivity 1.5 0.6 1.5
Obesity 5.6 4.8 0.17
obsessive-compulsive disorder 0.8 2.6 -2.25
Osteoarthritis 0.8 1.1 -0.38
Osteoporosis 1.4 1.5 -0.07
pancreatic cancer 0.3 0.3
Parkinson's Disease 3.6 2.3 0.57
Polycystic ovary syndrome 1.7 1.9 -0.12
Postural orthostatic tachycardia syndrome 0.3 -0.3
Premenstrual dysphoric disorder 0.3 0.3
primary biliary cholangitis 0.9 0.5 0.8
Primary sclerosing cholangitis 1 0.3 2.33
Psoriasis 1.1 1.4 -0.27
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 2.8 2.6 0.08
Rosacea 0.5 0.8 -0.6
Schizophrenia 2.8 1.9 0.47
Sjögren syndrome 0.7 1.5 -1.14
Sleep Apnea 1.2 1.1 0.09
Slow gastric motility / Gastroparesis 0.6 0.3 1
Small Intestinal Bacterial Overgrowth (SIBO) 0.9 0.9
Stress / posttraumatic stress disorder 2.5 2.3 0.09
Systemic Lupus Erythematosus 1.8 1.1 0.64
Tic Disorder 0.3 0.9 -2
Tourette syndrome 1.1 0.3 2.67
Type 1 Diabetes 1.2 1.3 -0.08
Type 2 Diabetes 3.5 4 -0.14
Ulcerative colitis 1.6 3.4 -1.13
Unhealthy Ageing 2.3 1.6 0.44
Vitiligo 0.6 0.8 -0.33

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