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🍽️ flunarizine dihydrochloride,(prescription)

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  1. Migraine Prophylaxis: Flunarizine is effective in reducing the frequency, severity, and duration of migraine attacks. It is commonly prescribed for individuals with recurrent migraines to prevent the onset of headaches and associated symptoms such as nausea, vomiting, and sensitivity to light and sound.

  2. Vestibular Disorders: Flunarizine is also used to manage various vestibular disorders, including vertigo and Meniere's disease. It helps alleviate symptoms such as dizziness, spinning sensation (vertigo), imbalance, and nausea by stabilizing the inner ear and reducing abnormal sensory input to the brain.

  3. Calcium Channel Blocker: Flunarizine acts as a calcium channel blocker, primarily targeting calcium channels in neuronal membranes. By inhibiting calcium influx into cells, particularly in cerebral and vascular tissues, flunarizine exerts its therapeutic effects, including vasodilation and suppression of neuronal excitability.

  4. Preventive Therapy: Flunarizine is typically used as a preventive therapy rather than an acute treatment for migraine attacks. It is taken on a regular basis, often as a long-term prophylactic measure, to reduce the frequency and severity of migraine episodes over time.

  5. Dosage and Administration: Flunarizine is available in oral tablet form and is usually taken once daily. The dosage may vary depending on the individual's age, medical condition, and response to treatment. It is important to follow the prescribed dosage and instructions provided by a healthcare professional.

  6. Side Effects: Common side effects of flunarizine may include drowsiness, fatigue, weight gain, increased appetite, and gastrointestinal disturbances such as nausea and abdominal discomfort. These side effects are usually mild and transient but may necessitate dose adjustment or discontinuation of the medication in some cases.

  7. Central Nervous System Effects: Flunarizine may cause central nervous system (CNS) side effects, including sedation, depression, and extrapyramidal symptoms such as tremors and dystonia. Patients should be advised to exercise caution when operating machinery or engaging in activities requiring mental alertness until they know how the medication affects them.

  8. Cardiovascular Effects: Flunarizine may rarely cause cardiovascular side effects, including changes in heart rate, blood pressure, and electrocardiogram (ECG) parameters. It should be used with caution in individuals with preexisting cardiovascular conditions, and cardiac function should be monitored periodically during treatment.

  9. Contraindications: Flunarizine is contraindicated in individuals with a history of hypersensitivity to the drug or its components. It should be avoided in patients with severe depression, Parkinson's disease, or a history of movement disorders such as tardive dyskinesia.

  10. Drug Interactions: Flunarizine may interact with other medications, including central nervous system depressants, antihypertensive drugs, and selective serotonin reuptake inhibitors (SSRIs), leading to additive CNS effects or changes in blood pressure. It is important to inform healthcare providers about all medications being taken to avoid potential interactions.

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βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of flunarizine dihydrochloride,(prescription) On Probiotics

Rank Probiotic Impact
species Anaerobutyricum hallii Reduces
species Bacteroides uniformis Reduces
species Blautia hansenii Reduces
species Blautia wexlerae Reduces
species Christensenella minuta Reduces
species Enterococcus faecium Reduces
species Lacticaseibacillus paracasei Reduces
species Lactococcus cremoris Reduces
species Parabacteroides distasonis Reduces

Bacteria Impacted by flunarizine dihydrochloride,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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πŸ““ Direct Citations πŸ‘ͺπŸ‘Ά Indirect Citations Taxonomy Rank Effect
0 1 Lachnospira genus Decreases
0 1 Agathobacter genus Decreases
0 1 Phocaeicola genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Blautia genus Decreases
0 1 Lacticaseibacillus genus Decreases
0 1 Bacteroides genus Decreases
0 1 Eggerthella genus Decreases
0 1 Clostridioides genus Decreases
0 1 Lacrimispora genus Decreases
0 1 Segatella genus Decreases
0 1 Roseburia genus Decreases
0 1 Parabacteroides genus Decreases
0 1 Collinsella genus Decreases
0 1 Dorea genus Decreases
0 1 Coprococcus genus Decreases
0 1 Thomasclavelia genus Decreases
0 1 Streptococcus genus Decreases
0 1 Clostridium genus Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
1 0 Eggerthella lenta species Decreases
1 0 Bacteroides fragilis species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Lacrimispora saccharolytica species Decreases
1 0 Parabacteroides merdae species Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Agathobacter rectalis species Decreases
1 0 Bacteroides uniformis species Decreases
1 0 Blautia obeum species Decreases
1 0 Lachnospira eligens species Decreases
1 0 Lacticaseibacillus paracasei species Decreases
1 0 Mediterraneibacter gnavus species Decreases
1 0 Phocaeicola vulgatus species Decreases
1 0 Roseburia intestinalis species Decreases
1 0 Segatella copri species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
1 0 Parabacteroides distasonis species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Dorea formicigenerans species Decreases
1 0 Coprococcus comes species Decreases
1 0 Thomasclavelia ramosa species Decreases
1 0 Streptococcus parasanguinis species Decreases
1 0 Streptococcus salivarius species Decreases
0 1 Bacteroides humanifaecis species Decreases
0 1 Eggerthella guodeyinii species Decreases
0 1 Bacteroides sp. CACC 737 species Decreases
0 1 Parolsenella catena species Decreases
0 1 Segatella bryantii species Decreases
0 1 Coprococcus catus species Decreases
0 1 Dorea longicatena species Decreases
0 1 Anaerobutyricum hallii species Decreases
0 1 Leyella stercorea species Decreases
0 1 Wansuia hejianensis species Decreases
0 1 Streptococcus sp. FDAARGOS_192 species Decreases
0 1 Blautia sp. SC05B48 species Decreases
0 1 Ligilactobacillus ruminis species Decreases
0 1 Butyrivibrio crossotus species Decreases
0 1 Bacteroides sp. A1C1 species Decreases
0 1 Komagataeibacter oboediens species Decreases
0 1 Subdoligranulum variabile species Decreases
0 1 Streptococcus sp. LPB0220 species Decreases
0 1 Streptococcus sp. HSISM1 species Decreases
0 1 Roseburia rectibacter species Decreases
0 1 Eubacterium ventriosum species Decreases
0 1 Clostridium sp. M62/1 species Decreases
0 1 Bacteroides sp. HF-162 species Decreases
0 1 Clostridium sp. SY8519 species Decreases
0 1 Blautia argi species Decreases
0 1 Blautia liquoris species Decreases
0 1 Eubacterium sp. MSJ-33 species Decreases
0 1 Coprococcus eutactus species Decreases
0 1 [Ruminococcus] lactaris species Decreases
0 1 Faecalibacterium duncaniae species Decreases
0 1 Bacillus paralicheniformis species Decreases
0 1 Massilistercora timonensis species Decreases
0 1 Christensenella minuta species Decreases
0 1 Pseudobutyrivibrio xylanivorans species Decreases
0 1 Faecalitalea cylindroides species Decreases
0 1 Qiania dongpingensis species Decreases
0 1 Novisyntrophococcus fermenticellae species Decreases
0 1 Parabacteroides johnsonii species Decreases
0 1 Faecalibacillus intestinalis species Decreases
0 1 Wujia chipingensis species Decreases
0 1 Vescimonas fastidiosa species Decreases
0 1 Intestinibaculum porci species Decreases
0 1 [Clostridium] hylemonae species Decreases
0 1 Maliibacterium massiliense species Decreases
0 1 Coprococcus sp. ART55/1 species Decreases
0 1 Catenibacterium mitsuokai species Decreases
0 1 Lachnoanaerobaculum gingivalis species Decreases
0 1 Anaerostipes hadrus species Decreases
0 1 Hungatella hathewayi species Decreases
0 1 Faecalibacterium sp. I2-3-92 species Decreases
0 1 Faecalibacterium sp. I4-1-79 species Decreases
0 1 Longicatena caecimuris species Decreases
0 1 Parolsenella massiliensis species Decreases
0 1 Marvinbryantia formatexigens species Decreases
0 1 Parvimonas micra species Decreases
0 1 Faecalibacterium sp. IP-3-29 species Decreases
0 1 Blautia parvula species Decreases
0 1 Faecalibacterium sp. HTF-F species Decreases
0 1 Actinomyces oris species Decreases
0 1 Ruminococcus gauvreauii species Decreases
0 1 Prevotella intermedia species Decreases
0 1 Mogibacterium diversum species Decreases
0 1 Catenibacterium sp. co_0103 species Decreases
0 1 Ruminococcus champanellensis species Decreases
0 1 Lachnoclostridium phocaeense species Decreases
0 1 Clostridium cadaveris species Decreases
0 1 Adlercreutzia equolifaciens species Decreases
0 1 Adlercreutzia hattorii species Decreases
0 1 Amedibacterium intestinale species Decreases
0 1 Blautia hansenii species Decreases
0 1 Actinomyces naeslundii species Decreases
0 1 Ruminococcus bicirculans (ex Wegman et al. 2014) species Decreases
0 1 Collinsella stercoris species Decreases
0 1 Streptococcus suis species Decreases
0 1 Lactococcus cremoris species Decreases
0 1 Faecalibacterium sp. I3-3-89 species Decreases
0 1 Treponema peruense species Decreases
0 1 Simiaoa sunii species Decreases
0 1 Leyella lascolaii species Decreases
0 1 Vescimonas coprocola species Decreases
0 1 Faecalibacterium sp. IP-1-18 species Decreases
0 1 Blautia producta species Decreases
0 1 Corynebacterium durum species Decreases
0 1 Faecalibacterium sp. I3-3-33 species Decreases
0 1 Faecalibacterium sp. I4-3-84 species Decreases
0 1 Olsenella sp. oral taxon 807 species Decreases
0 1 Mageeibacillus indolicus species Decreases
0 1 Monoglobus pectinilyticus species Decreases
0 1 Solibaculum mannosilyticum species Decreases
0 1 Blautia wexlerae species Decreases
0 1 Gordonibacter urolithinfaciens species Decreases
1 0 Roseburia hominis species Decreases
0 1 Eubacterium sp. c-25 species Decreases
0 1 Blautia pseudococcoides species Decreases
0 1 [Clostridium] scindens species Decreases
0 1 Acutalibacter muris species Decreases
0 1 Enterococcus faecium species Decreases
0 1 Oscillibacter hominis species Decreases
0 1 Bacteroides luhongzhouii species Decreases
0 1 Paraprevotella clara species Decreases
0 1 Prevotella bivia species Decreases
0 1 Flintibacter sp. KGMB00164 species Decreases
0 1 Arabiibacter massiliensis species Decreases
0 1 Enterococcus cecorum species Decreases
0 1 Fannyhessea vaginae species Decreases
0 1 Actinomyces sp. oral taxon 169 species Decreases
0 1 [Eubacterium] hominis species Decreases
1 0 Clostridium perfringens species Decreases
0 1 Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases

Impact of flunarizine dihydrochloride,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.5 0.5
ADHD 1.8 0.9 1
Age-Related Macular Degeneration and Glaucoma 0.7 0.3 1.33
Allergic Rhinitis (Hay Fever) 2.2 0.6 2.67
Allergies 4.2 0.9 3.67
Allergy to milk products 0.8 0.8 0
Alopecia (Hair Loss) 1.5 0.1 14
Alzheimer's disease 3.3 5.1 -0.55
Amyotrophic lateral sclerosis (ALS) Motor Neuron 1.7 1.7
Ankylosing spondylitis 2.9 1.5 0.93
Anorexia Nervosa 0.9 2.9 -2.22
Antiphospholipid syndrome (APS) 1.2 1.2
Asthma 3.8 0.8 3.75
Atherosclerosis 1.5 0.9 0.67
Atrial fibrillation 3.3 1.8 0.83
Autism 7.1 6.1 0.16
Autoimmune Disease 0.1 0.3 -2
Barrett esophagus cancer 0.1 -0.1
benign prostatic hyperplasia 0.4 -0.4
Biofilm 1 1
Bipolar Disorder 1 0.8 0.25
Brain Trauma 0.5 0.6 -0.2
Cancer (General) 0.8 -0.8
Carcinoma 2 1.5 0.33
Celiac Disease 2.4 1.8 0.33
Cerebral Palsy 0.5 1.1 -1.2
Chronic Fatigue Syndrome 3.8 5.2 -0.37
Chronic Kidney Disease 3.5 2.7 0.3
Chronic Lyme 0.7 0.6 0.17
Chronic Obstructive Pulmonary Disease (COPD) 0.9 1.1 -0.22
Chronic Urticaria (Hives) 0.2 1.2 -5
Coagulation / Micro clot triggering bacteria 0.4 0.9 -1.25
Cognitive Function 1.2 0.5 1.4
Colorectal Cancer 4.7 2 1.35
Constipation 1.5 0.7 1.14
Coronary artery disease 1.6 2.9 -0.81
COVID-19 7 10 -0.43
Crohn's Disease 5.7 4.6 0.24
Cushing's Syndrome (hypercortisolism) 1 -1
cystic fibrosis 1.1 -1.1
deep vein thrombosis 0.9 0.8 0.13
Denture Wearers Oral Shifts 0.4 0.4
Depression 7.6 6.7 0.13
Dermatomyositis 0.1 0.1
Eczema 0.8 1.2 -0.5
Endometriosis 1.7 1 0.7
Eosinophilic Esophagitis 0.1 -0.1
Epilepsy 2.1 1.7 0.24
erectile dysfunction 0.4 0.4
Fibromyalgia 2.8 1.9 0.47
Functional constipation / chronic idiopathic constipation 3.4 3.6 -0.06
gallstone disease (gsd) 2.4 0.3 7
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.3 1.7 -0.31
Generalized anxiety disorder 2.1 0.7 2
giant cell arteritis 0 0
Glioblastoma 0.1 -0.1
Gout 0.5 0.2 1.5
Graves' disease 0.9 1.8 -1
Gulf War Syndrome 0.8 1.2 -0.5
Halitosis 0.5 0.1 4
Hashimoto's thyroiditis 2.8 1.5 0.87
Heart Failure 2.9 1.5 0.93
hemorrhagic stroke 0.5 0.5
Hidradenitis Suppurativa 1 1
High Histamine/low DAO 0.4 0.4
hypercholesterolemia (High Cholesterol) 0 0.1 0
hyperglycemia 0.3 1.1 -2.67
Hyperlipidemia (High Blood Fats) 0.2 0.2 0
hypersomnia 0.7 -0.7
hypertension (High Blood Pressure 3.4 3.3 0.03
Hypothyroidism 0.1 1 -9
Hypoxia 1 1
IgA nephropathy (IgAN) 1.1 3.4 -2.09
Inflammatory Bowel Disease 5.8 7 -0.21
Insomnia 1.8 2.2 -0.22
Intelligence 1.2 0.6 1
Intracranial aneurysms 1.2 0.5 1.4
Irritable Bowel Syndrome 4.3 3.3 0.3
ischemic stroke 1.2 1.1 0.09
Liver Cirrhosis 3.9 1.2 2.25
Long COVID 5.8 5.4 0.07
Low bone mineral density 1.2 -1.2
Lung Cancer 0.9 -0.9
Mast Cell Issues / mastitis 0.1 0.2 -1
ME/CFS with IBS 0.2 2.4 -11
ME/CFS without IBS 2.1 1.7 0.24
membranous nephropathy 0.1 0.1
Menopause 0.3 0.3 0
Metabolic Syndrome 4.4 4.2 0.05
Mood Disorders 6.8 5.9 0.15
multiple chemical sensitivity [MCS] 0.4 0.4 0
Multiple Sclerosis 4.1 5.4 -0.32
Multiple system atrophy (MSA) 0.4 0.4 0
myasthenia gravis 0.1 0.3 -2
neuropathic pain 0.3 1.5 -4
Neuropathy (all types) 0.9 0.6 0.5
neuropsychiatric disorders (PANDAS, PANS) 0.1 0.1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 3.4 3.1 0.1
NonCeliac Gluten Sensitivity 1.4 0.4 2.5
Obesity 5.8 5.8 0
obsessive-compulsive disorder 4.8 3.6 0.33
Osteoarthritis 2.9 0.7 3.14
Osteoporosis 1 1.2 -0.2
pancreatic cancer 0.1 0.1 0
Parkinson's Disease 5.7 6.6 -0.16
Polycystic ovary syndrome 5.3 1.3 3.08
Postural orthostatic tachycardia syndrome 0 0.2 0
Premenstrual dysphoric disorder 0.7 0.3 1.33
primary biliary cholangitis 0.4 1 -1.5
Primary sclerosing cholangitis 1.2 2.9 -1.42
Psoriasis 2.2 2.7 -0.23
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 5.2 3 0.73
Rosacea 0.6 0.3 1
Schizophrenia 3.5 2.1 0.67
scoliosis 0.3 0.6 -1
sensorineural hearing loss 0.3 0.3
Sjögren syndrome 1.4 2.4 -0.71
Sleep Apnea 0.9 1.6 -0.78
Slow gastric motility / Gastroparesis 0.4 0.4
Small Intestinal Bacterial Overgrowth (SIBO) 0.8 0.8
Stress / posttraumatic stress disorder 1.2 2 -0.67
Systemic Lupus Erythematosus 3.1 1.9 0.63
Tic Disorder 0.7 1.5 -1.14
Tourette syndrome 0.4 0.4 0
Type 1 Diabetes 2.5 2.1 0.19
Type 2 Diabetes 6.1 4.7 0.3
Ulcerative colitis 4.2 5.3 -0.26
Unhealthy Ageing 4.6 1.3 2.54
Vitiligo 2 0.7 1.86

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