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Migraine Prophylaxis: Flunarizine is effective in reducing the frequency, severity, and duration of migraine attacks. It is commonly prescribed for individuals with recurrent migraines to prevent the onset of headaches and associated symptoms such as nausea, vomiting, and sensitivity to light and sound.
Vestibular Disorders: Flunarizine is also used to manage various vestibular disorders, including vertigo and Meniere's disease. It helps alleviate symptoms such as dizziness, spinning sensation (vertigo), imbalance, and nausea by stabilizing the inner ear and reducing abnormal sensory input to the brain.
Calcium Channel Blocker: Flunarizine acts as a calcium channel blocker, primarily targeting calcium channels in neuronal membranes. By inhibiting calcium influx into cells, particularly in cerebral and vascular tissues, flunarizine exerts its therapeutic effects, including vasodilation and suppression of neuronal excitability.
Preventive Therapy: Flunarizine is typically used as a preventive therapy rather than an acute treatment for migraine attacks. It is taken on a regular basis, often as a long-term prophylactic measure, to reduce the frequency and severity of migraine episodes over time.
Dosage and Administration: Flunarizine is available in oral tablet form and is usually taken once daily. The dosage may vary depending on the individual's age, medical condition, and response to treatment. It is important to follow the prescribed dosage and instructions provided by a healthcare professional.
Side Effects: Common side effects of flunarizine may include drowsiness, fatigue, weight gain, increased appetite, and gastrointestinal disturbances such as nausea and abdominal discomfort. These side effects are usually mild and transient but may necessitate dose adjustment or discontinuation of the medication in some cases.
Central Nervous System Effects: Flunarizine may cause central nervous system (CNS) side effects, including sedation, depression, and extrapyramidal symptoms such as tremors and dystonia. Patients should be advised to exercise caution when operating machinery or engaging in activities requiring mental alertness until they know how the medication affects them.
Cardiovascular Effects: Flunarizine may rarely cause cardiovascular side effects, including changes in heart rate, blood pressure, and electrocardiogram (ECG) parameters. It should be used with caution in individuals with preexisting cardiovascular conditions, and cardiac function should be monitored periodically during treatment.
Contraindications: Flunarizine is contraindicated in individuals with a history of hypersensitivity to the drug or its components. It should be avoided in patients with severe depression, Parkinson's disease, or a history of movement disorders such as tardive dyskinesia.
Drug Interactions: Flunarizine may interact with other medications, including central nervous system depressants, antihypertensive drugs, and selective serotonin reuptake inhibitors (SSRIs), leading to additive CNS effects or changes in blood pressure. It is important to inform healthcare providers about all medications being taken to avoid potential interactions.
Rank | Probiotic | Impact |
---|---|---|
species | Anaerobutyricum hallii | Reduces |
species | Bacteroides uniformis | Reduces |
species | Blautia hansenii | Reduces |
species | Blautia wexlerae | Reduces |
species | Christensenella minuta | Reduces |
species | Enterococcus faecium | Reduces |
species | Lacticaseibacillus paracasei | Reduces |
species | Lactococcus cremoris | Reduces |
species | Parabacteroides distasonis | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
π Direct Citations | πͺπΆ Indirect Citations | Taxonomy | Rank | Effect |
---|---|---|---|---|
0 | 1 | Lachnospira | genus | Decreases |
0 | 1 | Agathobacter | genus | Decreases |
0 | 1 | Phocaeicola | genus | Decreases |
0 | 1 | Mediterraneibacter | genus | Decreases |
0 | 1 | Blautia | genus | Decreases |
0 | 1 | Lacticaseibacillus | genus | Decreases |
0 | 1 | Bacteroides | genus | Decreases |
0 | 1 | Eggerthella | genus | Decreases |
0 | 1 | Clostridioides | genus | Decreases |
0 | 1 | Lacrimispora | genus | Decreases |
0 | 1 | Segatella | genus | Decreases |
0 | 1 | Roseburia | genus | Decreases |
0 | 1 | Parabacteroides | genus | Decreases |
0 | 1 | Collinsella | genus | Decreases |
0 | 1 | Dorea | genus | Decreases |
0 | 1 | Coprococcus | genus | Decreases |
0 | 1 | Thomasclavelia | genus | Decreases |
0 | 1 | Streptococcus | genus | Decreases |
0 | 1 | Clostridium | genus | Decreases |
0 | 1 | Clostridium perfringens A | no rank | Decreases |
0 | 1 | Clostridium perfringens B | no rank | Decreases |
0 | 1 | Clostridium perfringens C | no rank | Decreases |
0 | 1 | Clostridium perfringens CPE | no rank | Decreases |
0 | 1 | Clostridium perfringens D | no rank | Decreases |
0 | 1 | Clostridium perfringens E | no rank | Decreases |
1 | 0 | Eggerthella lenta | species | Decreases |
1 | 0 | Bacteroides fragilis | species | Decreases |
1 | 0 | Clostridioides difficile | species | Decreases |
1 | 0 | Lacrimispora saccharolytica | species | Decreases |
1 | 0 | Parabacteroides merdae | species | Decreases |
1 | 0 | [Ruminococcus] torques | species | Decreases |
1 | 0 | Agathobacter rectalis | species | Decreases |
1 | 0 | Bacteroides uniformis | species | Decreases |
1 | 0 | Blautia obeum | species | Decreases |
1 | 0 | Lachnospira eligens | species | Decreases |
1 | 0 | Lacticaseibacillus paracasei | species | Decreases |
1 | 0 | Mediterraneibacter gnavus | species | Decreases |
1 | 0 | Phocaeicola vulgatus | species | Decreases |
1 | 0 | Roseburia intestinalis | species | Decreases |
1 | 0 | Segatella copri | species | Decreases |
1 | 0 | Bacteroides thetaiotaomicron | species | Decreases |
1 | 0 | Parabacteroides distasonis | species | Decreases |
1 | 0 | Collinsella aerofaciens | species | Decreases |
1 | 0 | Dorea formicigenerans | species | Decreases |
1 | 0 | Coprococcus comes | species | Decreases |
1 | 0 | Thomasclavelia ramosa | species | Decreases |
1 | 0 | Streptococcus parasanguinis | species | Decreases |
1 | 0 | Streptococcus salivarius | species | Decreases |
0 | 1 | Bacteroides humanifaecis | species | Decreases |
0 | 1 | Eggerthella guodeyinii | species | Decreases |
0 | 1 | Bacteroides sp. CACC 737 | species | Decreases |
0 | 1 | Parolsenella catena | species | Decreases |
0 | 1 | Segatella bryantii | species | Decreases |
0 | 1 | Coprococcus catus | species | Decreases |
0 | 1 | Dorea longicatena | species | Decreases |
0 | 1 | Anaerobutyricum hallii | species | Decreases |
0 | 1 | Leyella stercorea | species | Decreases |
0 | 1 | Wansuia hejianensis | species | Decreases |
0 | 1 | Streptococcus sp. FDAARGOS_192 | species | Decreases |
0 | 1 | Blautia sp. SC05B48 | species | Decreases |
0 | 1 | Ligilactobacillus ruminis | species | Decreases |
0 | 1 | Butyrivibrio crossotus | species | Decreases |
0 | 1 | Bacteroides sp. A1C1 | species | Decreases |
0 | 1 | Komagataeibacter oboediens | species | Decreases |
0 | 1 | Subdoligranulum variabile | species | Decreases |
0 | 1 | Streptococcus sp. LPB0220 | species | Decreases |
0 | 1 | Streptococcus sp. HSISM1 | species | Decreases |
0 | 1 | Roseburia rectibacter | species | Decreases |
0 | 1 | Eubacterium ventriosum | species | Decreases |
0 | 1 | Clostridium sp. M62/1 | species | Decreases |
0 | 1 | Bacteroides sp. HF-162 | species | Decreases |
0 | 1 | Clostridium sp. SY8519 | species | Decreases |
0 | 1 | Blautia argi | species | Decreases |
0 | 1 | Blautia liquoris | species | Decreases |
0 | 1 | Eubacterium sp. MSJ-33 | species | Decreases |
0 | 1 | Coprococcus eutactus | species | Decreases |
0 | 1 | [Ruminococcus] lactaris | species | Decreases |
0 | 1 | Faecalibacterium duncaniae | species | Decreases |
0 | 1 | Bacillus paralicheniformis | species | Decreases |
0 | 1 | Massilistercora timonensis | species | Decreases |
0 | 1 | Christensenella minuta | species | Decreases |
0 | 1 | Pseudobutyrivibrio xylanivorans | species | Decreases |
0 | 1 | Faecalitalea cylindroides | species | Decreases |
0 | 1 | Qiania dongpingensis | species | Decreases |
0 | 1 | Novisyntrophococcus fermenticellae | species | Decreases |
0 | 1 | Parabacteroides johnsonii | species | Decreases |
0 | 1 | Faecalibacillus intestinalis | species | Decreases |
0 | 1 | Wujia chipingensis | species | Decreases |
0 | 1 | Vescimonas fastidiosa | species | Decreases |
0 | 1 | Intestinibaculum porci | species | Decreases |
0 | 1 | [Clostridium] hylemonae | species | Decreases |
0 | 1 | Maliibacterium massiliense | species | Decreases |
0 | 1 | Coprococcus sp. ART55/1 | species | Decreases |
0 | 1 | Catenibacterium mitsuokai | species | Decreases |
0 | 1 | Lachnoanaerobaculum gingivalis | species | Decreases |
0 | 1 | Anaerostipes hadrus | species | Decreases |
0 | 1 | Hungatella hathewayi | species | Decreases |
0 | 1 | Faecalibacterium sp. I2-3-92 | species | Decreases |
0 | 1 | Faecalibacterium sp. I4-1-79 | species | Decreases |
0 | 1 | Longicatena caecimuris | species | Decreases |
0 | 1 | Parolsenella massiliensis | species | Decreases |
0 | 1 | Marvinbryantia formatexigens | species | Decreases |
0 | 1 | Parvimonas micra | species | Decreases |
0 | 1 | Faecalibacterium sp. IP-3-29 | species | Decreases |
0 | 1 | Blautia parvula | species | Decreases |
0 | 1 | Faecalibacterium sp. HTF-F | species | Decreases |
0 | 1 | Actinomyces oris | species | Decreases |
0 | 1 | Ruminococcus gauvreauii | species | Decreases |
0 | 1 | Prevotella intermedia | species | Decreases |
0 | 1 | Mogibacterium diversum | species | Decreases |
0 | 1 | Catenibacterium sp. co_0103 | species | Decreases |
0 | 1 | Ruminococcus champanellensis | species | Decreases |
0 | 1 | Lachnoclostridium phocaeense | species | Decreases |
0 | 1 | Clostridium cadaveris | species | Decreases |
0 | 1 | Adlercreutzia equolifaciens | species | Decreases |
0 | 1 | Adlercreutzia hattorii | species | Decreases |
0 | 1 | Amedibacterium intestinale | species | Decreases |
0 | 1 | Blautia hansenii | species | Decreases |
0 | 1 | Actinomyces naeslundii | species | Decreases |
0 | 1 | Ruminococcus bicirculans (ex Wegman et al. 2014) | species | Decreases |
0 | 1 | Collinsella stercoris | species | Decreases |
0 | 1 | Streptococcus suis | species | Decreases |
0 | 1 | Lactococcus cremoris | species | Decreases |
0 | 1 | Faecalibacterium sp. I3-3-89 | species | Decreases |
0 | 1 | Treponema peruense | species | Decreases |
0 | 1 | Simiaoa sunii | species | Decreases |
0 | 1 | Leyella lascolaii | species | Decreases |
0 | 1 | Vescimonas coprocola | species | Decreases |
0 | 1 | Faecalibacterium sp. IP-1-18 | species | Decreases |
0 | 1 | Blautia producta | species | Decreases |
0 | 1 | Corynebacterium durum | species | Decreases |
0 | 1 | Faecalibacterium sp. I3-3-33 | species | Decreases |
0 | 1 | Faecalibacterium sp. I4-3-84 | species | Decreases |
0 | 1 | Olsenella sp. oral taxon 807 | species | Decreases |
0 | 1 | Mageeibacillus indolicus | species | Decreases |
0 | 1 | Monoglobus pectinilyticus | species | Decreases |
0 | 1 | Solibaculum mannosilyticum | species | Decreases |
0 | 1 | Blautia wexlerae | species | Decreases |
0 | 1 | Gordonibacter urolithinfaciens | species | Decreases |
1 | 0 | Roseburia hominis | species | Decreases |
0 | 1 | Eubacterium sp. c-25 | species | Decreases |
0 | 1 | Blautia pseudococcoides | species | Decreases |
0 | 1 | [Clostridium] scindens | species | Decreases |
0 | 1 | Acutalibacter muris | species | Decreases |
0 | 1 | Enterococcus faecium | species | Decreases |
0 | 1 | Oscillibacter hominis | species | Decreases |
0 | 1 | Bacteroides luhongzhouii | species | Decreases |
0 | 1 | Paraprevotella clara | species | Decreases |
0 | 1 | Prevotella bivia | species | Decreases |
0 | 1 | Flintibacter sp. KGMB00164 | species | Decreases |
0 | 1 | Arabiibacter massiliensis | species | Decreases |
0 | 1 | Enterococcus cecorum | species | Decreases |
0 | 1 | Fannyhessea vaginae | species | Decreases |
0 | 1 | Actinomyces sp. oral taxon 169 | species | Decreases |
0 | 1 | [Eubacterium] hominis | species | Decreases |
1 | 0 | Clostridium perfringens | species | Decreases |
0 | 1 | Lacticaseibacillus paracasei subsp. paracasei | subspecies | Decreases |
0 | 1 | Lacticaseibacillus paracasei subsp. tolerans | subspecies | Decreases |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
Abdominal Aortic Aneurysm | 0.5 | 0.5 | |
ADHD | 1.8 | 0.9 | 1 |
Age-Related Macular Degeneration and Glaucoma | 0.7 | 0.3 | 1.33 |
Allergic Rhinitis (Hay Fever) | 2.2 | 0.6 | 2.67 |
Allergies | 4.2 | 0.9 | 3.67 |
Allergy to milk products | 0.8 | 0.8 | 0 |
Alopecia (Hair Loss) | 1.5 | 0.1 | 14 |
Alzheimer's disease | 3.3 | 5.1 | -0.55 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1.7 | 1.7 | |
Ankylosing spondylitis | 2.9 | 1.5 | 0.93 |
Anorexia Nervosa | 0.9 | 2.9 | -2.22 |
Antiphospholipid syndrome (APS) | 1.2 | 1.2 | |
Asthma | 3.8 | 0.8 | 3.75 |
Atherosclerosis | 1.5 | 0.9 | 0.67 |
Atrial fibrillation | 3.3 | 1.8 | 0.83 |
Autism | 7.1 | 6.1 | 0.16 |
Autoimmune Disease | 0.1 | 0.3 | -2 |
Barrett esophagus cancer | 0.1 | -0.1 | |
benign prostatic hyperplasia | 0.4 | -0.4 | |
Biofilm | 1 | 1 | |
Bipolar Disorder | 1 | 0.8 | 0.25 |
Brain Trauma | 0.5 | 0.6 | -0.2 |
Cancer (General) | 0.8 | -0.8 | |
Carcinoma | 2 | 1.5 | 0.33 |
Celiac Disease | 2.4 | 1.8 | 0.33 |
Cerebral Palsy | 0.5 | 1.1 | -1.2 |
Chronic Fatigue Syndrome | 3.8 | 5.2 | -0.37 |
Chronic Kidney Disease | 3.5 | 2.7 | 0.3 |
Chronic Lyme | 0.7 | 0.6 | 0.17 |
Chronic Obstructive Pulmonary Disease (COPD) | 0.9 | 1.1 | -0.22 |
Chronic Urticaria (Hives) | 0.2 | 1.2 | -5 |
Coagulation / Micro clot triggering bacteria | 0.4 | 0.9 | -1.25 |
Cognitive Function | 1.2 | 0.5 | 1.4 |
Colorectal Cancer | 4.7 | 2 | 1.35 |
Constipation | 1.5 | 0.7 | 1.14 |
Coronary artery disease | 1.6 | 2.9 | -0.81 |
COVID-19 | 7 | 10 | -0.43 |
Crohn's Disease | 5.7 | 4.6 | 0.24 |
Cushing's Syndrome (hypercortisolism) | 1 | -1 | |
cystic fibrosis | 1.1 | -1.1 | |
deep vein thrombosis | 0.9 | 0.8 | 0.13 |
Denture Wearers Oral Shifts | 0.4 | 0.4 | |
Depression | 7.6 | 6.7 | 0.13 |
Dermatomyositis | 0.1 | 0.1 | |
Eczema | 0.8 | 1.2 | -0.5 |
Endometriosis | 1.7 | 1 | 0.7 |
Eosinophilic Esophagitis | 0.1 | -0.1 | |
Epilepsy | 2.1 | 1.7 | 0.24 |
erectile dysfunction | 0.4 | 0.4 | |
Fibromyalgia | 2.8 | 1.9 | 0.47 |
Functional constipation / chronic idiopathic constipation | 3.4 | 3.6 | -0.06 |
gallstone disease (gsd) | 2.4 | 0.3 | 7 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 1.3 | 1.7 | -0.31 |
Generalized anxiety disorder | 2.1 | 0.7 | 2 |
giant cell arteritis | 0 | 0 | |
Glioblastoma | 0.1 | -0.1 | |
Gout | 0.5 | 0.2 | 1.5 |
Graves' disease | 0.9 | 1.8 | -1 |
Gulf War Syndrome | 0.8 | 1.2 | -0.5 |
Halitosis | 0.5 | 0.1 | 4 |
Hashimoto's thyroiditis | 2.8 | 1.5 | 0.87 |
Heart Failure | 2.9 | 1.5 | 0.93 |
hemorrhagic stroke | 0.5 | 0.5 | |
Hidradenitis Suppurativa | 1 | 1 | |
High Histamine/low DAO | 0.4 | 0.4 | |
hypercholesterolemia (High Cholesterol) | 0 | 0.1 | 0 |
hyperglycemia | 0.3 | 1.1 | -2.67 |
Hyperlipidemia (High Blood Fats) | 0.2 | 0.2 | 0 |
hypersomnia | 0.7 | -0.7 | |
hypertension (High Blood Pressure | 3.4 | 3.3 | 0.03 |
Hypothyroidism | 0.1 | 1 | -9 |
Hypoxia | 1 | 1 | |
IgA nephropathy (IgAN) | 1.1 | 3.4 | -2.09 |
Inflammatory Bowel Disease | 5.8 | 7 | -0.21 |
Insomnia | 1.8 | 2.2 | -0.22 |
Intelligence | 1.2 | 0.6 | 1 |
Intracranial aneurysms | 1.2 | 0.5 | 1.4 |
Irritable Bowel Syndrome | 4.3 | 3.3 | 0.3 |
ischemic stroke | 1.2 | 1.1 | 0.09 |
Liver Cirrhosis | 3.9 | 1.2 | 2.25 |
Long COVID | 5.8 | 5.4 | 0.07 |
Low bone mineral density | 1.2 | -1.2 | |
Lung Cancer | 0.9 | -0.9 | |
Mast Cell Issues / mastitis | 0.1 | 0.2 | -1 |
ME/CFS with IBS | 0.2 | 2.4 | -11 |
ME/CFS without IBS | 2.1 | 1.7 | 0.24 |
membranous nephropathy | 0.1 | 0.1 | |
Menopause | 0.3 | 0.3 | 0 |
Metabolic Syndrome | 4.4 | 4.2 | 0.05 |
Mood Disorders | 6.8 | 5.9 | 0.15 |
multiple chemical sensitivity [MCS] | 0.4 | 0.4 | 0 |
Multiple Sclerosis | 4.1 | 5.4 | -0.32 |
Multiple system atrophy (MSA) | 0.4 | 0.4 | 0 |
myasthenia gravis | 0.1 | 0.3 | -2 |
neuropathic pain | 0.3 | 1.5 | -4 |
Neuropathy (all types) | 0.9 | 0.6 | 0.5 |
neuropsychiatric disorders (PANDAS, PANS) | 0.1 | 0.1 | |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 3.4 | 3.1 | 0.1 |
NonCeliac Gluten Sensitivity | 1.4 | 0.4 | 2.5 |
Obesity | 5.8 | 5.8 | 0 |
obsessive-compulsive disorder | 4.8 | 3.6 | 0.33 |
Osteoarthritis | 2.9 | 0.7 | 3.14 |
Osteoporosis | 1 | 1.2 | -0.2 |
pancreatic cancer | 0.1 | 0.1 | 0 |
Parkinson's Disease | 5.7 | 6.6 | -0.16 |
Polycystic ovary syndrome | 5.3 | 1.3 | 3.08 |
Postural orthostatic tachycardia syndrome | 0 | 0.2 | 0 |
Premenstrual dysphoric disorder | 0.7 | 0.3 | 1.33 |
primary biliary cholangitis | 0.4 | 1 | -1.5 |
Primary sclerosing cholangitis | 1.2 | 2.9 | -1.42 |
Psoriasis | 2.2 | 2.7 | -0.23 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 5.2 | 3 | 0.73 |
Rosacea | 0.6 | 0.3 | 1 |
Schizophrenia | 3.5 | 2.1 | 0.67 |
scoliosis | 0.3 | 0.6 | -1 |
sensorineural hearing loss | 0.3 | 0.3 | |
Sjögren syndrome | 1.4 | 2.4 | -0.71 |
Sleep Apnea | 0.9 | 1.6 | -0.78 |
Slow gastric motility / Gastroparesis | 0.4 | 0.4 | |
Small Intestinal Bacterial Overgrowth (SIBO) | 0.8 | 0.8 | |
Stress / posttraumatic stress disorder | 1.2 | 2 | -0.67 |
Systemic Lupus Erythematosus | 3.1 | 1.9 | 0.63 |
Tic Disorder | 0.7 | 1.5 | -1.14 |
Tourette syndrome | 0.4 | 0.4 | 0 |
Type 1 Diabetes | 2.5 | 2.1 | 0.19 |
Type 2 Diabetes | 6.1 | 4.7 | 0.3 |
Ulcerative colitis | 4.2 | 5.3 | -0.26 |
Unhealthy Ageing | 4.6 | 1.3 | 2.54 |
Vitiligo | 2 | 0.7 | 1.86 |
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