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🍽️ tracazolate hydrochloride non-drug

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  1. GABA-A Receptor Modulation: Tracazolate hydrochloride acts as a positive allosteric modulator of the GABA-A receptor. GABA-A receptors are ion channels that mediate inhibitory neurotransmission in the central nervous system. Modulation of these receptors can affect neuronal excitability and synaptic transmission.

  2. Anxiolytic Effects: GABA-A receptor positive allosteric modulators like tracazolate hydrochloride have been investigated for their potential anxiolytic (anti-anxiety) effects. By enhancing the activity of GABA-A receptors, tracazolate hydrochloride may increase the inhibitory tone in the brain, leading to reduced anxiety and relaxation.

  3. Anticonvulsant Effects: Modulation of GABA-A receptors can also influence seizure activity in the brain. Some positive allosteric modulators of GABA-A receptors have demonstrated anticonvulsant properties in preclinical studies. Tracazolate hydrochloride may have potential as an anticonvulsant medication, although further research is needed to evaluate its efficacy and safety for this indication.

  4. Memory Enhancement: GABA-A receptor modulation has been linked to cognitive function and memory processes. Some positive allosteric modulators of GABA-A receptors have shown memory-enhancing effects in animal models. Tracazolate hydrochloride may have potential as a cognitive enhancer, although its effects on memory and learning would require further investigation.

  5. Potential Therapeutic Applications: While tracazolate hydrochloride has been primarily studied in preclinical research, its clinical development and therapeutic applications have been limited. More research would be needed to evaluate its efficacy, safety, and potential medical uses in humans. Additionally, the precise mechanisms of action and pharmacological effects of tracazolate hydrochloride require further elucidation.

  6. Side Effects: As with any pharmacological agent, tracazolate hydrochloride may have potential side effects. These could include sedation, dizziness, cognitive impairment, or other central nervous system effects. The safety profile of tracazolate hydrochloride would need to be thoroughly evaluated in clinical trials before it could be considered for medical use.

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Data Contradictions — Limits of Certainity

Impacted of tracazolate hydrochloride non-drug On Probiotics

Rank Probiotic Impact
species Anaerobutyricum hallii Reduces
species Blautia wexlerae Reduces
species Christensenella minuta Reduces
species Enterococcus faecium Reduces
species Escherichia coli Reduces
species Lactococcus cremoris Reduces
species Parabacteroides distasonis Reduces

Bacteria Impacted by tracazolate hydrochloride non-drug

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

🧙?

📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Mediterraneibacter genus Decreases
0 1 Roseburia genus Decreases
0 1 Blautia genus Decreases
0 1 Parabacteroides genus Decreases
0 1 Ruminococcus genus Decreases
0 1 Agathobacter genus Decreases
0 1 Clostridium genus Decreases
0 1 Phocaeicola genus Decreases
0 1 Streptococcus genus Decreases
0 1 Enterocloster genus Decreases
0 1 Bilophila genus Decreases
0 1 Escherichia genus Decreases
0 1 Coprococcus genus Decreases
0 1 Anaerostipes genus Decreases
0 1 Anaerobutyricum genus Decreases
0 1 Bacteroides genus Decreases
0 1 Eggerthella genus Decreases
0 1 Lachnospira genus Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Agathobacter rectalis species Decreases
1 0 Blautia obeum species Decreases
1 0 Parabacteroides distasonis species Decreases
1 0 Parabacteroides merdae species Decreases
1 0 Roseburia intestinalis species Decreases
1 0 Ruminococcus bromii species Decreases
1 0 Clostridium perfringens species Decreases
1 0 Phocaeicola vulgatus species Decreases
1 0 Streptococcus parasanguinis species Decreases
1 0 Enterocloster bolteae species Decreases
0 1 Streptococcus sp. HSISM1 species Decreases
0 1 Streptococcus sp. LPB0220 species Decreases
1 0 Bilophila wadsworthia species Decreases
1 0 Escherichia coli species Decreases
1 0 Coprococcus comes species Decreases
0 1 Anaerobutyricum hallii species Decreases
1 0 Bacteroides fragilis species Decreases
0 1 Blautia sp. SC05B48 species Decreases
0 1 Coprococcus catus species Decreases
0 1 Komagataeibacter oboediens species Decreases
0 1 Dorea longicatena species Decreases
0 1 Dorea formicigenerans species Decreases
0 1 Ligilactobacillus ruminis species Decreases
0 1 Wansuia hejianensis species Decreases
0 1 Butyrivibrio crossotus species Decreases
0 1 Blautia liquoris species Decreases
0 1 Roseburia rectibacter species Decreases
0 1 Faecalitalea cylindroides species Decreases
0 1 Christensenella minuta species Decreases
0 1 Lachnoanaerobaculum gingivalis species Decreases
0 1 Subdoligranulum variabile species Decreases
0 1 Qiania dongpingensis species Decreases
0 1 Anaerostipes hadrus species Decreases
0 1 Eubacterium ventriosum species Decreases
0 1 Clostridium sp. SY8519 species Decreases
0 1 Novisyntrophococcus fermenticellae species Decreases
0 1 Lacrimispora saccharolytica species Decreases
0 1 [Ruminococcus] lactaris species Decreases
0 1 Coprococcus eutactus species Decreases
0 1 Clostridium sp. M62/1 species Decreases
0 1 Longicatena caecimuris species Decreases
0 1 Streptococcus lactarius species Decreases
0 1 Bacillus paralicheniformis species Decreases
0 1 Maliibacterium massiliense species Decreases
0 1 Massilistercora timonensis species Decreases
0 1 Lactococcus cremoris species Decreases
0 1 Adlercreutzia equolifaciens species Decreases
0 1 Streptococcus gordonii species Decreases
0 1 Faecalibacterium duncaniae species Decreases
0 1 Parabacteroides johnsonii species Decreases
0 1 Eubacterium sp. MSJ-33 species Decreases
0 1 Coprococcus sp. ART55/1 species Decreases
0 1 Marvinbryantia formatexigens species Decreases
0 1 Clostridium cadaveris species Decreases
0 1 Blautia wexlerae species Decreases
0 1 Roseburia hominis species Decreases
0 1 Lachnoclostridium phocaeense species Decreases
0 1 Streptococcus suis species Decreases
0 1 Pseudobutyrivibrio xylanivorans species Decreases
0 1 Intestinibaculum porci species Decreases
0 1 Faecalibacillus intestinalis species Decreases
0 1 Actinomyces sp. oral taxon 169 species Decreases
0 1 [Clostridium] hylemonae species Decreases
0 1 Catenibacterium mitsuokai species Decreases
0 1 Ruminococcus gauvreauii species Decreases
0 1 Streptococcus salivarius species Decreases
0 1 Faecalibacterium sp. IP-3-29 species Decreases
0 1 Faecalibacterium sp. I2-3-92 species Decreases
0 1 Faecalibacterium sp. I4-1-79 species Decreases
0 1 Adlercreutzia hattorii species Decreases
1 0 Eggerthella lenta species Decreases
0 1 Streptococcus sp. FDAARGOS_192 species Decreases
0 1 Shigella dysenteriae species Decreases
0 1 Enterocloster clostridioformis species Decreases
0 1 Catenibacterium sp. co_0103 species Decreases
0 1 Solibaculum mannosilyticum species Decreases
0 1 Parvimonas micra species Decreases
0 1 Blautia parvula species Decreases
0 1 Faecalibacterium sp. HTF-F species Decreases
0 1 Streptococcus australis species Decreases
0 1 Wujia chipingensis species Decreases
0 1 Fannyhessea vaginae species Decreases
0 1 Mogibacterium diversum species Decreases
0 1 Shigella flexneri species Decreases
0 1 Eubacterium sp. c-25 species Decreases
0 1 Faecalibacterium sp. I3-3-89 species Decreases
0 1 Escherichia albertii species Decreases
0 1 Actinomyces oris species Decreases
0 1 Ruminococcus champanellensis species Decreases
0 1 Gordonibacter urolithinfaciens species Decreases
0 1 Streptococcus infantis species Decreases
0 1 Romboutsia ilealis species Decreases
0 1 Enterococcus cecorum species Decreases
0 1 Treponema peruense species Decreases
0 1 Eubacterium limosum species Decreases
0 1 Actinomyces naeslundii species Decreases
0 1 Acutalibacter muris species Decreases
0 1 Streptococcus sp. oral taxon 061 species Decreases
0 1 Vescimonas fastidiosa species Decreases
0 1 Streptococcus mutans species Decreases
0 1 Ruminococcus bicirculans (ex Wegman et al. 2014) species Decreases
0 1 Faecalibaculum rodentium species Decreases
0 1 Enterococcus faecium species Decreases
0 1 Amedibacterium intestinale species Decreases
0 1 Arabiibacter massiliensis species Decreases
0 1 Flavonifractor plautii species Decreases
1 0 Lachnospira eligens species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases

Impact of tracazolate hydrochloride non-drug on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.2 0.2
ADHD 1.8 0.5 2.6
Age-Related Macular Degeneration and Glaucoma 0.6 0.4 0.5
Allergic Rhinitis (Hay Fever) 1.6 1 0.6
Allergies 3.2 1.3 1.46
Allergy to milk products 1.1 0.8 0.38
Alopecia (Hair Loss) 1.3 0.1 12
Alzheimer's disease 2.4 5 -1.08
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.6 0.6 0
Ankylosing spondylitis 1.8 0.5 2.6
Anorexia Nervosa 1.7 2.6 -0.53
Antiphospholipid syndrome (APS) 1.1 0.1 10
Asthma 2.1 0.7 2
Atherosclerosis 1 1.3 -0.3
Atrial fibrillation 2.3 1.3 0.77
Autism 5.2 5 0.04
Autoimmune Disease 0.3 0.7 -1.33
Barrett esophagus cancer 0.2 -0.2
benign prostatic hyperplasia 0.1 0.1 0
Biofilm 0.9 0.9
Bipolar Disorder 1.4 1 0.4
Brain Trauma 0.3 0.9 -2
Breast Cancer 0.2 0.2
Cancer (General) 0.6 -0.6
Carcinoma 1.8 1.3 0.38
Celiac Disease 1.8 1.6 0.13
Cerebral Palsy 0.5 1.5 -2
Chronic Fatigue Syndrome 2.8 5.1 -0.82
Chronic Kidney Disease 1.4 2.2 -0.57
Chronic Lyme 0.5 -0.5
Chronic Obstructive Pulmonary Disease (COPD) 1.1 0.8 0.38
Chronic Urticaria (Hives) 0.8 0.2 3
Coagulation / Micro clot triggering bacteria 0.9 1.6 -0.78
Cognitive Function 1.1 0.9 0.22
Colorectal Cancer 4.7 1.9 1.47
Constipation 1.1 0.9 0.22
Coronary artery disease 1.6 2.2 -0.38
COVID-19 4.7 6.8 -0.45
Crohn's Disease 4.5 3.1 0.45
Cushing's Syndrome (hypercortisolism) 0.5 -0.5
cystic fibrosis 0.3 1 -2.33
d-lactic acidosis (one form of brain fog) 0.2 0.2
deep vein thrombosis 0.8 1.2 -0.5
Denture Wearers Oral Shifts 0.4 0.4
Depression 5.4 5.2 0.04
Dermatomyositis 0.2 0.2
Eczema 0.6 0.8 -0.33
Endometriosis 1.6 1.2 0.33
Eosinophilic Esophagitis 0.2 -0.2
Epilepsy 2 1.5 0.33
erectile dysfunction 0.4 0.4
Fibromyalgia 2.3 0.5 3.6
Functional constipation / chronic idiopathic constipation 3.1 2.9 0.07
gallstone disease (gsd) 2.3 0.5 3.6
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.8 1.4 -0.75
Generalized anxiety disorder 1.3 0.6 1.17
giant cell arteritis 0.2 -0.2
Glioblastoma 0.3 -0.3
Gout 0.7 0.4 0.75
Graves' disease 0.9 1.8 -1
Gulf War Syndrome 1 0.3 2.33
Halitosis 0.3 0.2 0.5
Hashimoto's thyroiditis 2.5 0.8 2.13
Heart Failure 1.8 2.2 -0.22
hemorrhagic stroke 0.4 0.4
Hidradenitis Suppurativa 0.4 0.4
High Histamine/low DAO 1.4 0.4 2.5
hypercholesterolemia (High Cholesterol) 0.5 0.1 4
hyperglycemia 0.6 0.9 -0.5
Hyperlipidemia (High Blood Fats) 0.1 0.1
hypersomnia 0.6 -0.6
hypertension (High Blood Pressure 3 2.3 0.3
Hypothyroidism 0.7 -0.7
Hypoxia 1.2 1.2
IgA nephropathy (IgAN) 1.2 1.1 0.09
Inflammatory Bowel Disease 3.1 6.8 -1.19
Insomnia 1.2 2 -0.67
Intelligence 0.7 0.7
Intracranial aneurysms 1.3 0.1 12
Irritable Bowel Syndrome 3.1 2.4 0.29
ischemic stroke 1.7 1 0.7
Liver Cirrhosis 3.8 1.8 1.11
Long COVID 3.4 4.2 -0.24
Low bone mineral density 0.9 -0.9
Lung Cancer 0.2 1.1 -4.5
Lymphoma 0.1 0.1
Mast Cell Issues / mastitis 0.3 0.5 -0.67
ME/CFS with IBS 0.8 1.7 -1.13
ME/CFS without IBS 0.8 1.1 -0.38
membranous nephropathy 0.2 0.2
Menopause 0.4 0.5 -0.25
Metabolic Syndrome 3.6 3.6 0
Mood Disorders 5.5 4.4 0.25
multiple chemical sensitivity [MCS] 0.3 0.4 -0.33
Multiple Sclerosis 3.6 4.9 -0.36
Multiple system atrophy (MSA) 0.5 0.8 -0.6
myasthenia gravis 0.3 0.7 -1.33
neuropathic pain 0.1 1.1 -10
Neuropathy (all types) 0.7 1 -0.43
neuropsychiatric disorders (PANDAS, PANS) 0.4 0.4
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2.5 2.9 -0.16
NonCeliac Gluten Sensitivity 0.6 0.1 5
Obesity 4.2 3.4 0.24
obsessive-compulsive disorder 3.3 1.9 0.74
Osteoarthritis 1.4 0.8 0.75
Osteoporosis 1.3 0.8 0.63
pancreatic cancer 0.2 0.2 0
Parkinson's Disease 4.7 4.7 0
Polycystic ovary syndrome 5.5 2.5 1.2
Postural orthostatic tachycardia syndrome 0.2 0.1 1
Premenstrual dysphoric disorder 0.4 0.4 0
primary biliary cholangitis 0.2 0.4 -1
Primary sclerosing cholangitis 1.4 3.2 -1.29
Psoriasis 1.9 2.2 -0.16
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 3.3 2.1 0.57
Rosacea 1.1 0.7 0.57
Schizophrenia 2.9 2.3 0.26
scoliosis 0.5 0.6 -0.2
sensorineural hearing loss 0.4 0.4
Sjögren syndrome 1.2 1.3 -0.08
Sleep Apnea 0.9 1.2 -0.33
Slow gastric motility / Gastroparesis 0.7 0.7
Small Intestinal Bacterial Overgrowth (SIBO) 1 1
Stress / posttraumatic stress disorder 1.5 1.2 0.25
Systemic Lupus Erythematosus 2 1.5 0.33
Tic Disorder 1.1 0.3 2.67
Tourette syndrome 0.2 0.1 1
Type 1 Diabetes 2.5 2.1 0.19
Type 2 Diabetes 4.7 3.4 0.38
Ulcerative colitis 3.1 3 0.03
Unhealthy Ageing 2.2 1.6 0.38
Vitiligo 1.3 0.9 0.44

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