🍽️ 4-aminosalicylic acid (antibiotic)

Antibacterial Activity: 4-Aminosalicylic acid works by inhibiting the growth of Mycobacterium tuberculosis, the bacteria that cause TB. It interferes with bacterial cell wall synthesis, ultimately leading to bacterial cell death. When used as part of a multidrug regimen, 4-aminosalicylic acid can help to treat TB infections and prevent the development of drug resistance.

Side Effects: Like other antibiotics, 4-aminosalicylic acid can cause side effects. Common side effects may include nausea, vomiting, diarrhea, stomach pain, headache, dizziness, and skin rash. Some individuals may also experience allergic reactions, including severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis, although these are rare.

Hypersensitivity Reactions: 4-Aminosalicylic acid can cause hypersensitivity reactions in some individuals, particularly those with a history of allergies to sulfa drugs or related medications. Hypersensitivity reactions may include rash, itching, swelling, difficulty breathing, and anaphylaxis. Patients with a known allergy to 4-aminosalicylic acid or sulfa drugs should avoid medications containing 4-aminosalicylic acid.

Renal Impairment: 4-Aminosalicylic acid is primarily excreted by the kidneys, so patients with renal impairment may require dosage adjustments or closer monitoring to prevent drug accumulation and potential toxicity. Kidney function should be assessed before starting treatment with 4-aminosalicylic acid, and dosage adjustments may be necessary in patients with impaired renal function.

Drug Interactions: 4-Aminosalicylic acid may interact with other medications, potentially increasing the risk of side effects or reducing the effectiveness of other drugs. It's important for patients to inform their healthcare providers about all medications, supplements, and herbal products they are taking before starting treatment with 4-aminosalicylic acid.