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🍽️ pyrazinamide (antibiotic)

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  1. Treatment of Tuberculosis (TB): Pyrazinamide is a key component of first-line anti-tuberculosis therapy. It is used in combination with other drugs such as isoniazid, rifampicin, and ethambutol for the treatment of both drug-susceptible and drug-resistant TB infections.

  2. Bactericidal Activity: Pyrazinamide exhibits bactericidal activity against Mycobacterium tuberculosis, the bacterium that causes TB. It works by disrupting the synthesis of mycolic acids, which are essential components of the bacterial cell wall. This disrupts cell wall integrity and leads to bacterial death.

  3. Sterilizing Effect: Pyrazinamide is particularly effective against dormant or slowly replicating bacteria, which are often present in TB lesions. It plays a crucial role in shortening the duration of TB treatment by targeting these persistent bacteria and reducing the risk of relapse.

  4. Combination Therapy: Pyrazinamide is usually administered as part of a multidrug regimen for TB treatment. The combination of multiple drugs with different mechanisms of action helps prevent the development of drug resistance and improves treatment outcomes.

  5. Side Effects: Common side effects of pyrazinamide may include gastrointestinal disturbances such as nausea, vomiting, and abdominal pain. Hepatotoxicity (liver toxicity) and hyperuricemia (elevated uric acid levels) are less common but potentially serious adverse effects associated with pyrazinamide use.

  6. Monitoring: Patients receiving pyrazinamide therapy should be closely monitored for signs of hepatotoxicity, including jaundice, elevated liver enzymes, and liver function abnormalities. Regular monitoring of serum uric acid levels may also be necessary to detect hyperuricemia and prevent associated complications such as gout.

  7. Dosage and Administration: Pyrazinamide is typically administered orally in the form of tablets or capsules. The dosage and duration of treatment depend on factors such as the severity of the TB infection, the patient's weight, and the presence of drug resistance. Treatment regimens are often guided by national or international TB treatment guidelines.

  8. Drug Interactions: Pyrazinamide may interact with other medications, including antacids, rifampicin, and other drugs metabolized by the liver. Clinicians should review the patient's medication profile and consider potential interactions when prescribing pyrazinamide.

  9. Pregnancy and Lactation: The safety of pyrazinamide use during pregnancy and lactation is not well established. Pregnant or breastfeeding women should discuss the risks and benefits of pyrazinamide therapy with their healthcare provider.

  10. Adherence to Treatment: Adherence to the prescribed TB treatment regimen, including pyrazinamide, is crucial for successful treatment outcomes and the prevention of drug resistance. Patients should be educated about the importance of completing the full course of treatment as directed by their healthcare provider.

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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of pyrazinamide (antibiotic) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Akkermansia muciniphila Reduces
species Anaerobutyricum hallii Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium bifidum Reduces
species Bifidobacterium breve Reduces
species Bifidobacterium catenulatum Reduces
species Bifidobacterium longum Reduces
species Blautia wexlerae Reduces
species Christensenella minuta Reduces
species Escherichia coli Reduces
species Faecalibacterium prausnitzii Reduces
species Lactococcus cremoris Reduces
species Veillonella atypica Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by pyrazinamide (antibiotic)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Akkermansiaceae family Decreases
0 1 Veillonella genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Collinsella genus Decreases
0 1 Roseburia genus Decreases
0 1 Blautia genus Decreases
0 1 Dorea genus Decreases
0 1 Ruminococcus genus Decreases
1 0 Akkermansia genus Decreases
0 1 Lachnospira genus Decreases
0 1 Bacteroides genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Odoribacter genus Decreases
0 1 Clostridioides genus Decreases
0 1 Parabacteroides genus Decreases
0 1 Eggerthella genus Decreases
0 1 Parolsenella genus Decreases
0 1 Escherichia genus Decreases
0 1 Lacrimispora genus Decreases
0 1 Enterocloster genus Decreases
0 1 Coprococcus genus Decreases
0 1 Clostridium genus Decreases
0 1 Agathobacter genus Decreases
0 1 environmental samples no rank Decreases
0 1 unclassified Akkermansia no rank Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
1 0 Ruminococcus bromii species Decreases
1 0 Akkermansia muciniphila species Decreases
1 0 Bacteroides xylanisolvens species Decreases
1 0 Bifidobacterium adolescentis species Decreases
1 0 Bifidobacterium longum species Decreases
1 0 Blautia obeum species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Dorea formicigenerans species Decreases
1 0 Roseburia hominis species Decreases
1 0 Veillonella parvula species Decreases
1 0 Lachnospira eligens species Decreases
1 0 Bacteroides ovatus species Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Odoribacter splanchnicus species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Parabacteroides merdae species Decreases
1 0 Eggerthella lenta species Decreases
0 1 Veillonella rodentium species Decreases
1 0 Escherichia coli species Decreases
0 1 Veillonella dispar species Decreases
0 1 Bacteroides luhongzhouii species Decreases
0 1 Bifidobacterium breve species Decreases
0 1 Veillonella sp. S12025-13 species Decreases
0 1 Bifidobacterium angulatum species Decreases
0 1 Veillonella nakazawae species Decreases
0 1 Coprococcus catus species Decreases
0 1 Parolsenella catena species Decreases
1 0 Lacrimispora saccharolytica species Decreases
0 1 Dorea longicatena species Decreases
0 1 Anaerobutyricum hallii species Decreases
0 1 Veillonella rogosae species Decreases
0 1 Bacteroides sp. D2 species Decreases
0 1 Parolsenella massiliensis species Decreases
0 1 Wansuia hejianensis species Decreases
0 1 Blautia sp. SC05B48 species Decreases
0 1 Eggerthella guodeyinii species Decreases
0 1 Eubacterium ventriosum species Decreases
0 1 Butyrivibrio crossotus species Decreases
0 1 Collinsella stercoris species Decreases
0 1 Ligilactobacillus ruminis species Decreases
0 1 Komagataeibacter oboediens species Decreases
0 1 Bacteroides sp. DH3716P species Decreases
0 1 Bacteroides sp. M10 species Decreases
0 1 Subdoligranulum variabile species Decreases
0 1 Eubacterium sp. MSJ-33 species Decreases
0 1 Faecalibacillus intestinalis species Decreases
0 1 Veillonella atypica species Decreases
0 1 Wujia chipingensis species Decreases
0 1 Clostridium sp. M62/1 species Decreases
0 1 Intestinibaculum porci species Decreases
0 1 Clostridium sp. SY8519 species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
0 1 Roseburia rectibacter species Decreases
0 1 Pseudobutyrivibrio xylanivorans species Decreases
0 1 Blautia liquoris species Decreases
0 1 [Ruminococcus] lactaris species Decreases
0 1 Coprococcus eutactus species Decreases
0 1 Faecalibacterium duncaniae species Decreases
0 1 Vescimonas fastidiosa species Decreases
0 1 Qiania dongpingensis species Decreases
0 1 Christensenella minuta species Decreases
0 1 Bacteroides faecium species Decreases
0 1 Bifidobacterium catenulatum species Decreases
0 1 Novisyntrophococcus fermenticellae species Decreases
0 1 Massilistercora timonensis species Decreases
0 1 Bacillus paralicheniformis species Decreases
0 1 Anaerostipes hadrus species Decreases
0 1 Adlercreutzia equolifaciens species Decreases
0 1 Faecalitalea cylindroides species Decreases
0 1 Catenibacterium mitsuokai species Decreases
0 1 Ruminococcus gauvreauii species Decreases
0 1 Roseburia intestinalis species Decreases
0 1 Maliibacterium massiliense species Decreases
0 1 Ruminococcus bicirculans (ex Wegman et al. 2014) species Decreases
0 1 Simiaoa sunii species Decreases
0 1 Vescimonas coprocola species Decreases
0 1 Ruminococcus champanellensis species Decreases
0 1 [Clostridium] hylemonae species Decreases
0 1 Barnesiella viscericola species Decreases
0 1 Coprococcus sp. ART55/1 species Decreases
0 1 Monoglobus pectinilyticus species Decreases
0 1 Alistipes megaguti species Decreases
0 1 Faecalibacterium sp. I3-3-33 species Decreases
0 1 Faecalibacterium sp. I4-1-79 species Decreases
0 1 Faecalibacterium sp. I2-3-92 species Decreases
0 1 Shigella dysenteriae species Decreases
0 1 Bifidobacterium bifidum species Decreases
0 1 Lachnoanaerobaculum gingivalis species Decreases
0 1 Faecalibacterium sp. IP-3-29 species Decreases
0 1 Actinomyces oris species Decreases
0 1 Catenibacterium sp. co_0103 species Decreases
0 1 Parafannyhessea umbonata species Decreases
0 1 Faecalibacterium prausnitzii species Decreases
0 1 Faecalibacterium sp. I4-3-84 species Decreases
0 1 Lachnoclostridium phocaeense species Decreases
0 1 Faecalibacterium sp. IP-1-18 species Decreases
0 1 Actinomyces naeslundii species Decreases
0 1 Bacteroides caecimuris species Decreases
0 1 Marvinbryantia formatexigens species Decreases
0 1 Longicatena caecimuris species Decreases
0 1 Fannyhessea vaginae species Decreases
0 1 Alistipes sp. dk3624 species Decreases
0 1 Mageeibacillus indolicus species Decreases
0 1 Actinomyces sp. oral taxon 169 species Decreases
0 1 Shigella flexneri species Decreases
0 1 Streptococcus gordonii species Decreases
0 1 Butyricimonas virosa species Decreases
0 1 Clostridium cadaveris species Decreases
0 1 Faecalibacterium sp. HTF-F species Decreases
0 1 Escherichia albertii species Decreases
0 1 Treponema peruense species Decreases
0 1 Oscillibacter hominis species Decreases
0 1 Coprobacter fastidiosus species Decreases
0 1 Mogibacterium diversum species Decreases
0 1 Flintibacter sp. KGMB00164 species Decreases
0 1 Gordonibacter urolithinfaciens species Decreases
0 1 Parvimonas micra species Decreases
0 1 Alistipes finegoldii species Decreases
0 1 Faecalibacterium sp. I3-3-89 species Decreases
0 1 Intestinimonas butyriciproducens species Decreases
0 1 Blautia wexlerae species Decreases
0 1 Streptococcus suis species Decreases
0 1 Corynebacterium durum species Decreases
0 1 Olsenella sp. oral taxon 807 species Decreases
0 1 Solibaculum mannosilyticum species Decreases
0 1 Eubacterium sp. c-25 species Decreases
0 1 Streptococcus mutans species Decreases
0 1 Akkermansia glycaniphila species Decreases
0 1 Akkermansia massiliensis species Decreases
0 1 Candidatus Akkermansia intestinavium species Decreases
0 1 [Eubacterium] hominis species Decreases
0 1 Lactococcus cremoris species Decreases
0 1 Treponema denticola species Decreases
0 1 Arabiibacter massiliensis species Decreases
0 1 Alistipes onderdonkii species Decreases
0 1 Faecalibaculum rodentium species Decreases
0 1 Anaerotruncus colihominis species Decreases
0 1 Eubacterium limosum species Decreases
0 1 Enterococcus cecorum species Decreases
0 1 Butyricimonas faecalis species Decreases
1 0 Enterocloster bolteae species Decreases
1 0 Coprococcus comes species Decreases
1 0 Clostridium perfringens species Decreases
1 0 Agathobacter rectalis species Decreases
0 1 Bifidobacterium longum subsp. infantis subspecies Decreases
0 1 Bifidobacterium longum subsp. longum subspecies Decreases
0 1 Bifidobacterium longum subsp. suillum subspecies Decreases
0 1 Bifidobacterium longum subsp. suis subspecies Decreases

Impact of pyrazinamide (antibiotic) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.1 0.1
Acne 0.4 -0.4
ADHD 3.4 0.6 4.67
Age-Related Macular Degeneration and Glaucoma 0.9 0.2 3.5
Allergic Rhinitis (Hay Fever) 2 2.6 -0.3
Allergies 6.2 3.4 0.82
Allergy to milk products 1.9 1.2 0.58
Alopecia (Hair Loss) 1.1 0.1 10
Alzheimer's disease 4.7 4.6 0.02
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.8 1.2 1.33
Ankylosing spondylitis 3.3 0.9 2.67
Anorexia Nervosa 1.4 2.1 -0.5
Antiphospholipid syndrome (APS) 0.5 0.5
Asthma 4.3 3.2 0.34
Atherosclerosis 2 1.4 0.43
Atrial fibrillation 2.9 1.1 1.64
Autism 6.6 6.8 -0.03
Autoimmune Disease 0.6 0.8 -0.33
Barrett esophagus cancer 0.5 0.5
benign prostatic hyperplasia 0.1 0.3 -2
Biofilm 0.9 0.9
Bipolar Disorder 1.3 1.5 -0.15
Brain Trauma 1 1.5 -0.5
Breast Cancer 0.2 0.2
Cancer (General) 0.7 1.5 -1.14
Carcinoma 3 2.7 0.11
Celiac Disease 1.9 3.9 -1.05
Cerebral Palsy 1.5 1.4 0.07
Chronic Fatigue Syndrome 4.1 4.8 -0.17
Chronic Kidney Disease 3.3 2.4 0.38
Chronic Lyme 0.5 0.7 -0.4
Chronic Obstructive Pulmonary Disease (COPD) 0.8 1.2 -0.5
Chronic Urticaria (Hives) 0.8 0.7 0.14
Coagulation / Micro clot triggering bacteria 0.6 1.1 -0.83
Cognitive Function 2 1.1 0.82
Colorectal Cancer 3.6 1.9 0.89
Constipation 1 0.8 0.25
Coronary artery disease 1.3 2.3 -0.77
COVID-19 8.6 9.7 -0.13
Crohn's Disease 4.7 5.2 -0.11
Cushing's Syndrome (hypercortisolism) 0.3 -0.3
cystic fibrosis 0.4 2.1 -4.25
d-lactic acidosis (one form of brain fog) 0.2 0.2
deep vein thrombosis 0.7 1 -0.43
Denture Wearers Oral Shifts 0.8 0.8
Depression 6.5 8 -0.23
Dermatomyositis 0.4 -0.4
Eczema 0.7 1.1 -0.57
Endometriosis 2.2 2 0.1
Eosinophilic Esophagitis 0.5 -0.5
Epilepsy 2.5 2.7 -0.08
erectile dysfunction 0.4 0.4 0
Fibromyalgia 2.7 0.9 2
Functional constipation / chronic idiopathic constipation 3.5 2.8 0.25
gallstone disease (gsd) 2.1 1.1 0.91
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.6 1.5 -1.5
Generalized anxiety disorder 1.6 1.7 -0.06
giant cell arteritis 0 0
Gout 1.5 0.4 2.75
Graves' disease 2.1 3.3 -0.57
Gulf War Syndrome 0.4 1.5 -2.75
Halitosis 0.8 0.8
Hashimoto's thyroiditis 3.7 2 0.85
Heart Failure 2.3 2.2 0.05
hemorrhagic stroke 0.6 0.6
Hidradenitis Suppurativa 0.6 0.5 0.2
High Histamine/low DAO 0.7 0.8 -0.14
hypercholesterolemia (High Cholesterol) 0.5 0.6 -0.2
hyperglycemia 1.2 2.4 -1
Hyperlipidemia (High Blood Fats) 1.2 0.4 2
hypersomnia 0.8 -0.8
hypertension (High Blood Pressure 4.8 5.2 -0.08
Hypothyroidism 0.3 1.1 -2.67
Hypoxia 1.7 1.7
IgA nephropathy (IgAN) 1.2 3.5 -1.92
Inflammatory Bowel Disease 5.5 8 -0.45
Insomnia 1.7 3.2 -0.88
Intelligence 0.8 0.1 7
Intracranial aneurysms 1.2 0.4 2
Irritable Bowel Syndrome 5.8 4.5 0.29
ischemic stroke 3 0.9 2.33
Liver Cirrhosis 5.3 3.6 0.47
Long COVID 4.2 8 -0.9
Low bone mineral density 1 -1
Lung Cancer 0.1 2.1 -20
Lymphoma 0.1 0.1
Mast Cell Issues / mastitis 0.1 0.8 -7
ME/CFS with IBS 0.1 2.7 -26
ME/CFS without IBS 0.9 1.9 -1.11
Menopause 2.2 0.7 2.14
Metabolic Syndrome 4.9 6.6 -0.35
Mood Disorders 7.4 6.5 0.14
multiple chemical sensitivity [MCS] 0.8 0.5 0.6
Multiple Sclerosis 4.8 3.8 0.26
Multiple system atrophy (MSA) 1.6 1.2 0.33
myasthenia gravis 0.1 0.4 -3
neuropathic pain 0.2 3 -14
Neuropathy (all types) 0.9 1.4 -0.56
neuropsychiatric disorders (PANDAS, PANS) 0.5 0.5
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 3.8 5.5 -0.45
NonCeliac Gluten Sensitivity 2.4 0.7 2.43
Obesity 8.8 6.3 0.4
obsessive-compulsive disorder 4.3 2.9 0.48
Osteoarthritis 1.2 1.6 -0.33
Osteoporosis 1.8 1.9 -0.06
pancreatic cancer 0.3 0.3
Parkinson's Disease 7.2 4.2 0.71
Polycystic ovary syndrome 4 3.1 0.29
Postural orthostatic tachycardia syndrome 0 0.5 0
Premenstrual dysphoric disorder 1.2 0.2 5
primary biliary cholangitis 0.8 0.4 1
Primary sclerosing cholangitis 1.8 2 -0.11
Psoriasis 3.4 1.6 1.13
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 6.4 3.2 1
Rosacea 1.3 0.5 1.6
Schizophrenia 6 3.2 0.88
scoliosis 0.4 0.9 -1.25
sensorineural hearing loss 0.3 0.3
Sjögren syndrome 2.3 2.4 -0.04
Sleep Apnea 1.6 1.3 0.23
Slow gastric motility / Gastroparesis 1.3 0.4 2.25
Small Intestinal Bacterial Overgrowth (SIBO) 1 0.6 0.67
Stress / posttraumatic stress disorder 2.2 3 -0.36
Systemic Lupus Erythematosus 2.1 2.3 -0.1
Tic Disorder 0.6 1.5 -1.5
Tourette syndrome 0.7 0.3 1.33
Type 1 Diabetes 2.9 3.5 -0.21
Type 2 Diabetes 5.1 5.2 -0.02
Ulcerative colitis 3 5.2 -0.73
Unhealthy Ageing 2.5 1.7 0.47
Vitiligo 1.6 1.1 0.45

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