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🍽️ sulfadimethoxine (antibiotic)

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  1. Treatment of Bacterial Infections: Sulfadimethoxine is effective against a wide range of bacterial pathogens, including both gram-positive and gram-negative bacteria. It is commonly used to treat infections in poultry, cattle, swine, and other livestock caused by susceptible organisms.

  2. Coccidiosis Treatment and Prevention: Sulfadimethoxine is frequently used in the treatment and prevention of coccidiosis, a parasitic disease caused by protozoa of the genus Eimeria. Coccidiosis affects the gastrointestinal tract of animals, leading to diarrhea, weight loss, and reduced feed conversion efficiency. Sulfadimethoxine helps control the spread of coccidia and alleviate clinical signs of the disease.

  3. Mechanism of Action: Sulfadimethoxine works by inhibiting the synthesis of dihydrofolic acid, a precursor to folate, which is essential for bacterial growth. It acts as a competitive inhibitor of dihydropteroate synthase, an enzyme involved in the folate synthesis pathway. By interfering with folate production, sulfadimethoxine disrupts bacterial DNA synthesis and ultimately inhibits bacterial growth and reproduction.

  4. Broad Spectrum of Activity: Sulfadimethoxine exhibits a broad spectrum of activity against various bacterial pathogens commonly found in animals, including Escherichia coli, Salmonella spp., Pasteurella spp., Clostridium spp., and others. It is effective against both systemic and enteric infections in animals.

  5. Administration Route: Sulfadimethoxine is available in various formulations for oral or parenteral administration, including soluble powders, boluses, solutions, and injectable preparations. The choice of formulation and route of administration depends on the species of animal, the type of infection, and the severity of the disease.

  6. Dosage and Duration: The dosage and duration of sulfadimethoxine treatment vary depending on the specific condition being treated, the age and weight of the animal, and other factors. It is essential to follow the veterinarian's instructions carefully and complete the full course of treatment to ensure effective eradication of the infection and prevent the development of antimicrobial resistance.

  7. Adverse Effects: Common side effects of sulfadimethoxine in animals may include gastrointestinal disturbances (e.g., diarrhea, anorexia), allergic reactions (e.g., rash, itching), and hematological abnormalities (e.g., leukopenia, thrombocytopenia). Overdose or prolonged use of sulfadimethoxine may lead to adverse effects such as nephrotoxicity or hepatotoxicity.

  8. Withdrawal Periods: In food-producing animals, there may be specific withdrawal periods required after the administration of sulfadimethoxine to ensure that residues of the drug do not exceed safe levels in meat, milk, or eggs intended for human consumption. These withdrawal periods vary depending on the regulatory requirements in different jurisdictions.

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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of sulfadimethoxine (antibiotic) On Probiotics

Bacteria Impacted by sulfadimethoxine (antibiotic)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

Impact of sulfadimethoxine (antibiotic) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

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