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🍽️ 2-aminobenzenesulfonamide (antibiotic)

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  1. Antibacterial Activity: Sulfanilamide works by inhibiting the growth of bacteria by interfering with the synthesis of folic acid, which is essential for bacterial DNA synthesis and replication. It is effective against a range of bacterial infections, including urinary tract infections, respiratory tract infections, and skin infections caused by susceptible bacteria.

  2. Side Effects: Like other antibiotics, sulfanilamide can cause side effects. Common side effects may include nausea, vomiting, diarrhea, stomach pain, headache, dizziness, and skin rash. Some individuals may also experience allergic reactions, including severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis, although these are rare.

  3. Hypersensitivity Reactions: Sulfanilamide can cause hypersensitivity reactions in some individuals, particularly those with a history of allergies to sulfa drugs or related medications. Hypersensitivity reactions may include rash, itching, swelling, difficulty breathing, and anaphylaxis. Patients with a known allergy to sulfanilamide or sulfa drugs should avoid sulfanilamide-containing medications.

  4. Blood Disorders: Rarely, sulfanilamide can cause blood disorders such as agranulocytosis (severe depletion of white blood cells), hemolytic anemia (destruction of red blood cells), and thrombocytopenia (low platelet count). Patients should be monitored for signs of blood disorders while taking sulfanilamide, and treatment should be discontinued if these complications occur.

  5. Renal Impairment: Sulfanilamide is primarily excreted by the kidneys, so patients with renal impairment may require dosage adjustments or closer monitoring to prevent drug accumulation and potential toxicity. Kidney function should be assessed before starting treatment with sulfanilamide, and dosage adjustments may be necessary in patients with impaired renal function.

  6. Drug Interactions: Sulfanilamide may interact with other medications, potentially increasing the risk of side effects or reducing the effectiveness of other drugs. It's important for patients to inform their healthcare providers about all medications, supplements, and herbal products they are taking before starting treatment with sulfanilamide.

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Check for interactions on Supp.AI   |   πŸ“š PubMed Citations

βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of 2-aminobenzenesulfonamide (antibiotic) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Akkermansia muciniphila Reduces
species Anaerobutyricum hallii Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium bifidum Reduces
species Bifidobacterium breve Reduces
species Bifidobacterium catenulatum Reduces
species Bifidobacterium longum Reduces
species Lactococcus lactis Reduces
species Parabacteroides distasonis Reduces
species Veillonella atypica Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by 2-aminobenzenesulfonamide (antibiotic)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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πŸ““ Direct Citations πŸ‘ͺπŸ‘Ά Indirect Citations Taxonomy Rank Effect
0 1 Akkermansiaceae family Decreases
0 1 Enterocloster genus Decreases
0 1 Blautia genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Thomasclavelia genus Decreases
0 1 Veillonella genus Decreases
0 1 Eggerthella genus Decreases
0 1 Ruminococcus genus Decreases
0 1 Collinsella genus Decreases
0 1 Odoribacter genus Decreases
0 1 Lacrimispora genus Decreases
0 1 Agathobacter genus Decreases
0 1 Parabacteroides genus Decreases
0 1 Flavonifractor genus Decreases
0 1 Bacteroides genus Decreases
0 1 Dorea genus Decreases
0 1 Roseburia genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Streptococcus genus Decreases
0 1 Clostridioides genus Decreases
1 0 Akkermansia genus Decreases
0 1 Lachnospira genus Decreases
0 1 Phocaeicola genus Decreases
0 1 environmental samples no rank Decreases
0 1 unclassified Akkermansia no rank Decreases
1 0 Bifidobacterium adolescentis species Decreases
1 0 Bifidobacterium longum species Decreases
1 0 Blautia obeum species Decreases
1 0 Enterocloster bolteae species Decreases
1 0 Thomasclavelia ramosa species Decreases
1 0 Veillonella parvula species Decreases
1 0 Eggerthella lenta species Decreases
1 0 Ruminococcus bromii species Decreases
1 0 Bacteroides xylanisolvens species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Odoribacter splanchnicus species Decreases
1 0 Lacrimispora saccharolytica species Decreases
1 0 Agathobacter rectalis species Decreases
1 0 Parabacteroides distasonis species Decreases
0 1 Veillonella rodentium species Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Bacteroides ovatus species Decreases
1 0 Bacteroides caccae species Decreases
1 0 Roseburia hominis species Decreases
1 0 Dorea formicigenerans species Decreases
0 1 Veillonella dispar species Decreases
0 1 Bifidobacterium breve species Decreases
0 1 Bifidobacterium angulatum species Decreases
0 1 Veillonella sp. S12025-13 species Decreases
0 1 Veillonella nakazawae species Decreases
0 1 Eggerthella guodeyinii species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
0 1 Veillonella rogosae species Decreases
1 0 Streptococcus parasanguinis species Decreases
0 1 Flavonifractor plautii species Decreases
1 0 Roseburia intestinalis species Decreases
0 1 Veillonella atypica species Decreases
0 1 Bifidobacterium catenulatum species Decreases
0 1 Parolsenella catena species Decreases
0 1 Streptococcus sp. HSISM1 species Decreases
0 1 Streptococcus sp. LPB0220 species Decreases
0 1 Bacteroides luhongzhouii species Decreases
0 1 Bifidobacterium bifidum species Decreases
0 1 Actinomyces naeslundii species Decreases
0 1 Anaerobutyricum hallii species Decreases
0 1 Coprococcus catus species Decreases
0 1 Lactococcus lactis species Decreases
0 1 Gordonibacter urolithinfaciens species Decreases
0 1 Parolsenella massiliensis species Decreases
0 1 Blautia sp. SC05B48 species Decreases
0 1 Dorea longicatena species Decreases
0 1 Komagataeibacter oboediens species Decreases
0 1 Bacillus paralicheniformis species Decreases
0 1 Olsenella sp. oral taxon 807 species Decreases
0 1 Arabiibacter massiliensis species Decreases
0 1 Collinsella stercoris species Decreases
0 1 Blautia parvula species Decreases
0 1 Actinomyces oris species Decreases
0 1 Adlercreutzia equolifaciens species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Mediterraneibacter gnavus species Decreases
1 0 Akkermansia muciniphila species Decreases
1 0 Lachnospira eligens species Decreases
1 0 Phocaeicola vulgatus species Decreases
0 1 Akkermansia glycaniphila species Decreases
0 1 Akkermansia massiliensis species Decreases
0 1 Candidatus Akkermansia intestinavium species Decreases
0 1 Bifidobacterium longum subsp. infantis subspecies Decreases
0 1 Bifidobacterium longum subsp. longum subspecies Decreases
0 1 Bifidobacterium longum subsp. suillum subspecies Decreases
0 1 Bifidobacterium longum subsp. suis subspecies Decreases

Impact of 2-aminobenzenesulfonamide (antibiotic) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.2 0.2
Acne 0.3 -0.3
ADHD 2.7 0.4 5.75
Age-Related Macular Degeneration and Glaucoma 0.2 0.2 0
Allergic Rhinitis (Hay Fever) 1.3 2 -0.54
Allergies 3.9 1.7 1.29
Allergy to milk products 0.6 0.7 -0.17
Alopecia (Hair Loss) 1 1
Alzheimer's disease 2.1 3.4 -0.62
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.7 0.2 2.5
Ankylosing spondylitis 2.1 0.4 4.25
Anorexia Nervosa 1.2 1.3 -0.08
Antiphospholipid syndrome (APS) 0.4 0.4
Asthma 2.7 1.6 0.69
Atherosclerosis 0.9 0.6 0.5
Atrial fibrillation 1.9 0.9 1.11
Autism 4.3 4.1 0.05
Autoimmune Disease 0.4 0.4 0
Barrett esophagus cancer 0.3 0.1 2
benign prostatic hyperplasia 0.1 -0.1
Biofilm 0.7 0.7
Bipolar Disorder 0.9 0.8 0.13
Brain Trauma 0.6 0.7 -0.17
Cancer (General) 0.5 1.8 -2.6
Carcinoma 2 1.7 0.18
Celiac Disease 1.4 2.5 -0.79
Cerebral Palsy 0.8 0.8 0
Chronic Fatigue Syndrome 3.8 3.3 0.15
Chronic Kidney Disease 2.1 0.9 1.33
Chronic Lyme 0.1 0.2 -1
Chronic Obstructive Pulmonary Disease (COPD) 0.7 0.5 0.4
Chronic Urticaria (Hives) 0.4 0 0
Coagulation / Micro clot triggering bacteria 0.2 0.8 -3
Cognitive Function 1.2 0.7 0.71
Colorectal Cancer 1.9 0.9 1.11
Constipation 0.4 0.5 -0.25
Coronary artery disease 0.8 1.6 -1
COVID-19 6 6.9 -0.15
Crohn's Disease 3 2.5 0.2
Cushing's Syndrome (hypercortisolism) 0.2 -0.2
cystic fibrosis 1.6 -1.6
d-lactic acidosis (one form of brain fog) 0.1 0.1
deep vein thrombosis 0.1 0.5 -4
Denture Wearers Oral Shifts 0.7 0.7
Depression 5.8 4.4 0.32
Dermatomyositis 0.1 0.3 -2
Eczema 0.5 1 -1
Endometriosis 1.2 0.8 0.5
Eosinophilic Esophagitis 0.4 -0.4
Epilepsy 1.2 1.1 0.09
erectile dysfunction 0.1 0.3 -2
Fibromyalgia 2.1 0.4 4.25
Functional constipation / chronic idiopathic constipation 2.1 2 0.05
gallstone disease (gsd) 1.3 0.4 2.25
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.3 1 -2.33
Generalized anxiety disorder 1 1.2 -0.2
Glioblastoma 0.1 -0.1
Gout 1.1 0 0
Graves' disease 1.3 1.8 -0.38
Gulf War Syndrome 0.5 0.6 -0.2
Halitosis 0.5 0.1 4
Hashimoto's thyroiditis 2 0.8 1.5
Heart Failure 0.9 1.5 -0.67
hemorrhagic stroke 0.3 0.3
Hidradenitis Suppurativa 0.2 0.3 -0.5
High Histamine/low DAO 0.1 0.5 -4
hypercholesterolemia (High Cholesterol) 0.2 0 0
hyperglycemia 0.6 1.1 -0.83
Hyperlipidemia (High Blood Fats) 0.5 0.2 1.5
hypersomnia 0.1 0.6 -5
hypertension (High Blood Pressure 2 3.3 -0.65
Hypothyroidism 0.2 1 -4
Hypoxia 0.7 0.7
IgA nephropathy (IgAN) 0.8 1.8 -1.25
Inflammatory Bowel Disease 3.7 5.6 -0.51
Insomnia 1.2 1.6 -0.33
Intelligence 0.4 0.4
Intracranial aneurysms 0.9 0.2 3.5
Irritable Bowel Syndrome 3.4 1.8 0.89
ischemic stroke 2.2 0.4 4.5
Liver Cirrhosis 3.2 1.3 1.46
Long COVID 4.4 4.9 -0.11
Low bone mineral density 0.1 -0.1
Lung Cancer 0.3 0.9 -2
Mast Cell Issues / mastitis 0.1 0.5 -4
ME/CFS with IBS 0.7 1.6 -1.29
ME/CFS without IBS 1 1.2 -0.2
membranous nephropathy 0.1 0.1
Menopause 1.8 0.1 17
Metabolic Syndrome 3.1 4 -0.29
Mood Disorders 6.1 3.9 0.56
multiple chemical sensitivity [MCS] 0.4 0.4 0
Multiple Sclerosis 3.2 2.3 0.39
Multiple system atrophy (MSA) 0.5 0.9 -0.8
myasthenia gravis 0.1 0.1 0
neuropathic pain 0.2 1.2 -5
Neuropathy (all types) 0.8 0.6 0.33
neuropsychiatric disorders (PANDAS, PANS) 0.3 0.3
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2.3 3.7 -0.61
NonCeliac Gluten Sensitivity 1.3 0.4 2.25
Obesity 4.7 3.4 0.38
obsessive-compulsive disorder 2.2 1.8 0.22
Osteoarthritis 1.4 0.8 0.75
Osteoporosis 1 1 0
pancreatic cancer 0.3 0.1 2
Parkinson's Disease 3.6 3.3 0.09
Polycystic ovary syndrome 2.8 1.9 0.47
Postural orthostatic tachycardia syndrome 0.3 -0.3
Premenstrual dysphoric disorder 0.9 0.2 3.5
primary biliary cholangitis 0.5 0.3 0.67
Primary sclerosing cholangitis 1.6 1.9 -0.19
Psoriasis 1.9 1 0.9
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 3.8 2.1 0.81
Rosacea 1 0.1 9
Schizophrenia 4.3 1.6 1.69
scoliosis 0.2 -0.2
sensorineural hearing loss 0.1 0.1
Sjögren syndrome 1.9 1.9 0
Sleep Apnea 1 0.9 0.11
Slow gastric motility / Gastroparesis 0.6 0.3 1
Small Intestinal Bacterial Overgrowth (SIBO) 0.5 0.6 -0.2
Stress / posttraumatic stress disorder 0.8 1.4 -0.75
Systemic Lupus Erythematosus 1.7 1.6 0.06
Tic Disorder 0.5 0.6 -0.2
Tourette syndrome 0.2 0.1 1
Type 1 Diabetes 1.5 2.4 -0.6
Type 2 Diabetes 3.9 2.9 0.34
Ulcerative colitis 2.3 2.2 0.05
Unhealthy Ageing 1.9 1.1 0.73
Vitiligo 0.9 0.5 0.8

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