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🍽️ griseofulvin,(prescription)

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  1. Antifungal Activity: Griseofulvin works by inhibiting the growth of fungi, specifically dermatophytes, which are responsible for causing various fungal infections of the skin, hair, and nails.

  2. Treatment of Dermatophytosis: Griseofulvin is commonly used to treat dermatophytosis, also known as ringworm, which can affect the skin, scalp, and nails. It is effective against infections caused by fungi such as Trichophyton, Microsporum, and Epidermophyton.

  3. Fungal Nail Infections: Griseofulvin is particularly useful in the treatment of fungal nail infections (onychomycosis), which can be challenging to treat due to the slow growth of nails and the difficulty of topical antifungal agents penetrating the nail plate.

  4. Topical and Oral Formulations: Griseofulvin is available in both topical and oral formulations. Oral griseofulvin is typically used for systemic fungal infections, while topical formulations are applied directly to the affected area for localized infections.

  5. Duration of Treatment: Treatment with griseofulvin may be prolonged, often lasting several weeks to months, depending on the severity and location of the fungal infection. Compliance with the prescribed treatment regimen is essential to achieve a successful outcome.

  6. Adverse Effects: Common side effects of griseofulvin may include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal pain. Other adverse effects may include headache, dizziness, fatigue, and allergic reactions such as rash or itching.

  7. Drug Interactions: Griseofulvin may interact with certain medications, including oral contraceptives, warfarin, phenobarbital, and cyclosporine, among others. It can decrease the effectiveness of hormonal contraceptives and increase the metabolism of other drugs, potentially leading to reduced efficacy or toxicity.

  8. Liver Function Monitoring: Patients taking griseofulvin may require periodic monitoring of liver function tests, as the medication can rarely cause liver toxicity or hepatitis. Individuals with pre-existing liver disease should use griseofulvin with caution and under close medical supervision.

  9. Photosensitivity: Griseofulvin may increase the risk of sunburn or photosensitivity reactions. Patients should be advised to avoid excessive sun exposure and use sun protection measures, such as wearing protective clothing and sunscreen, while taking the medication.

  10. Contraindications: Griseofulvin is contraindicated in individuals with known hypersensitivity to the drug or its components, as well as in pregnant women or women who may become pregnant, due to the risk of teratogenic effects.

  11. Pediatric Use: Griseofulvin is commonly used in pediatric patients for the treatment of fungal infections, particularly tinea capitis (scalp ringworm). Dosing may vary based on the child's age, weight, and the severity of the infection.

  12. Effectiveness: Griseofulvin is generally effective in treating fungal infections when used as prescribed. However, it may not be suitable for all types of fungal infections, and healthcare providers may consider alternative antifungal agents based on the specific diagnosis and patient factors.

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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of griseofulvin,(prescription) On Probiotics

Rank Probiotic Impact
species Akkermansia muciniphila Reduces
species Bacteroides uniformis Reduces
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces

Bacteria Impacted by griseofulvin,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Akkermansiaceae family Decreases
0 1 Lacticaseibacillus genus Decreases
0 1 Escherichia genus Decreases
0 1 Fusobacterium genus Decreases
0 1 Shigella genus Decreases
0 1 Lacrimispora genus Decreases
0 1 Roseburia genus Decreases
0 1 Bacteroides genus Decreases
0 1 Thomasclavelia genus Decreases
0 1 Streptococcus genus Decreases
0 1 Parabacteroides genus Decreases
1 0 Akkermansia genus Decreases
0 1 Bilophila genus Decreases
0 1 Clostridium genus Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 environmental samples no rank Decreases
0 1 unclassified Akkermansia no rank Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
1 0 Escherichia coli species Decreases
1 0 Lacticaseibacillus paracasei species Decreases
1 0 Fusobacterium nucleatum species Decreases
1 0 Lacrimispora saccharolytica species Decreases
1 0 Roseburia hominis species Decreases
0 1 Shigella dysenteriae species Decreases
0 1 Shigella flexneri species Decreases
0 1 Escherichia albertii species Decreases
0 1 Escherichia fergusonii species Decreases
1 0 Bacteroides fragilis species Decreases
0 1 Shigella boydii species Decreases
0 1 Shigella sonnei species Decreases
0 1 Eubacterium sp. MSJ-33 species Decreases
0 1 Escherichia marmotae species Decreases
0 1 Simiaoa sunii species Decreases
1 0 Bacteroides uniformis species Decreases
0 1 Escherichia sp. E4742 species Decreases
0 1 Wujia chipingensis species Decreases
1 0 Thomasclavelia ramosa species Decreases
0 1 Eubacterium ventriosum species Decreases
0 1 Faecalibacterium sp. IP-1-18 species Decreases
0 1 Ruminococcus bicirculans (ex Wegman et al. 2014) species Decreases
0 1 Butyrivibrio crossotus species Decreases
0 1 Clostridium sp. M62/1 species Decreases
0 1 Faecalibacterium sp. I3-3-33 species Decreases
0 1 Faecalibacterium sp. I4-3-84 species Decreases
0 1 Roseburia rectibacter species Decreases
0 1 Coprococcus catus species Decreases
0 1 Lachnospira eligens species Decreases
0 1 Oscillibacter hominis species Decreases
0 1 Roseburia intestinalis species Decreases
0 1 Clostridium sp. SY8519 species Decreases
0 1 Pseudobutyrivibrio xylanivorans species Decreases
0 1 Coprococcus comes species Decreases
0 1 Wansuia hejianensis species Decreases
0 1 Intestinibaculum porci species Decreases
0 1 Faecalibacterium duncaniae species Decreases
0 1 Mageeibacillus indolicus species Decreases
0 1 Monoglobus pectinilyticus species Decreases
1 0 Streptococcus salivarius species Decreases
1 0 Parabacteroides merdae species Decreases
1 0 Akkermansia muciniphila species Decreases
1 0 Bilophila wadsworthia species Decreases
1 0 Clostridium perfringens species Decreases
0 1 Akkermansia glycaniphila species Decreases
0 1 Akkermansia massiliensis species Decreases
0 1 Candidatus Akkermansia intestinavium species Decreases
0 1 Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases
0 1 Fusobacterium nucleatum subsp. nucleatum subspecies Decreases

Impact of griseofulvin,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0 0
ADHD 0.6 0.6
Age-Related Macular Degeneration and Glaucoma 0.3 0 0
Allergic Rhinitis (Hay Fever) 0.5 0.7 -0.4
Allergies 1.8 0.4 3.5
Allergy to milk products 0.8 0.6 0.33
Alopecia (Hair Loss) 0.1 -0.1
Alzheimer's disease 2 1.6 0.25
Amyotrophic lateral sclerosis (ALS) Motor Neuron 1 0.7 0.43
Ankylosing spondylitis 1.3 0.3 3.33
Anorexia Nervosa 0.1 0.6 -5
Antiphospholipid syndrome (APS) 0.8 0 0
Asthma 1.5 0.4 2.75
Atherosclerosis 1.2 0.3 3
Atrial fibrillation 0.4 0.7 -0.75
Autism 1.4 2.2 -0.57
Autoimmune Disease 0.5 0.2 1.5
Barrett esophagus cancer 0.2 0 0
benign prostatic hyperplasia 0.5 0.1 4
Biofilm 1.1 1.1
Bipolar Disorder 0.7 0.2 2.5
Brain Trauma 0 0.3 0
Breast Cancer 1.1 1.1
Cancer (General) 0.2 0.6 -2
Carcinoma 1.2 0.1 11
Celiac Disease 1.1 0.2 4.5
Cerebral Palsy 0.2 0.3 -0.5
Chronic Fatigue Syndrome 1.6 0.5 2.2
Chronic Kidney Disease 0.8 0.3 1.67
Chronic Lyme 0.3 -0.3
Chronic Obstructive Pulmonary Disease (COPD) 1 0.4 1.5
Chronic Urticaria (Hives) 1 0.3 2.33
Coagulation / Micro clot triggering bacteria 1.2 0.2 5
Cognitive Function 0.2 0.2 0
Colorectal Cancer 2.8 1 1.8
Constipation 0.6 0.2 2
Coronary artery disease 1.2 0.5 1.4
COVID-19 1.9 1.2 0.58
Crohn's Disease 2.9 1 1.9
Cushing's Syndrome (hypercortisolism) 0.1 -0.1
cystic fibrosis 0.9 0.3 2
d-lactic acidosis (one form of brain fog) 0.6 0.6
deep vein thrombosis 1.9 0.3 5.33
Denture Wearers Oral Shifts 0.6 0.6
Depression 3 2.3 0.3
Dermatomyositis 0 0
Eczema 0.8 0.4 1
Endometriosis 1.3 0.8 0.63
Eosinophilic Esophagitis 0.2 0 0
Epilepsy 1.8 0.3 5
erectile dysfunction 0.8 0.8
Fibromyalgia 0.4 0.4 0
Functional constipation / chronic idiopathic constipation 1.7 0.6 1.83
gallstone disease (gsd) 1.2 0.4 2
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.9 0 0
Generalized anxiety disorder 1.5 0.2 6.5
giant cell arteritis 0 0
Glioblastoma 0 0
Gout 0.2 0.2 0
Graves' disease 0.1 0.3 -2
Gulf War Syndrome 0 0.3 0
Halitosis 0.8 0 0
Hashimoto's thyroiditis 0.8 0.2 3
Heart Failure 1.9 0.2 8.5
hemorrhagic stroke 0.3 0.3
Hidradenitis Suppurativa 0.4 0.4
High Histamine/low DAO 0.8 0.8
hypercholesterolemia (High Cholesterol) 0.6 0.1 5
hyperglycemia 1.2 0.2 5
Hyperlipidemia (High Blood Fats) 0.1 0.1
hypersomnia 0 0
hypertension (High Blood Pressure 0.8 1.1 -0.38
Hypothyroidism 0 0
Hypoxia 0.2 0.2
IgA nephropathy (IgAN) 0.4 0.4 0
Inflammatory Bowel Disease 3.4 1.8 0.89
Insomnia 0.2 0.4 -1
Intelligence 0.9 0.9
Intracranial aneurysms 0.4 0.4
Irritable Bowel Syndrome 2.2 0.6 2.67
ischemic stroke 0.8 0.8 0
Liver Cirrhosis 2.2 1.3 0.69
Long COVID 1 0.8 0.25
Low bone mineral density 0.3 -0.3
Lung Cancer 0.5 0.1 4
Lymphoma 0.5 0.5
Mast Cell Issues / mastitis 1 1
ME/CFS with IBS 0 0.3 0
ME/CFS without IBS 0 0.2 0
membranous nephropathy 0 0
Menopause 0 0.2 0
Metabolic Syndrome 2.1 1.4 0.5
Mood Disorders 2.3 1.7 0.35
multiple chemical sensitivity [MCS] 0.2 0.2
Multiple Sclerosis 1 0.7 0.43
Multiple system atrophy (MSA) 0.4 0.4
myasthenia gravis 0.5 0.2 1.5
neuropathic pain 0.7 -0.7
Neuropathy (all types) 0.1 0.5 -4
neuropsychiatric disorders (PANDAS, PANS) 0.7 0.7
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 1.8 0.4 3.5
NonCeliac Gluten Sensitivity 0.2 0.1 1
Obesity 2.3 2.3 0
obsessive-compulsive disorder 1.7 0.2 7.5
Osteoarthritis 0.7 0.2 2.5
Osteoporosis 0.8 0.2 3
pancreatic cancer 0.5 0 0
Parkinson's Disease 1.9 1.7 0.12
Polycystic ovary syndrome 1.4 0.4 2.5
Postural orthostatic tachycardia syndrome 0 0
Premenstrual dysphoric disorder 0 0
primary biliary cholangitis 0 0.4 0
Primary sclerosing cholangitis 0.4 0.2 1
Psoriasis 0.9 0.4 1.25
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 1.4 0.8 0.75
Rosacea 0.2 -0.2
Schizophrenia 0.7 0.3 1.33
scoliosis 0.7 0.1 6
Sjögren syndrome 0.6 0.3 1
Sleep Apnea 0.4 0.3 0.33
Slow gastric motility / Gastroparesis 0.7 0.7
Small Intestinal Bacterial Overgrowth (SIBO) 1 1
Stress / posttraumatic stress disorder 1.4 0.4 2.5
Systemic Lupus Erythematosus 1.2 0.6 1
Tic Disorder 0 0
Tourette syndrome 0.1 0.1 0
Type 1 Diabetes 1 0.3 2.33
Type 2 Diabetes 2.1 2.1 0
Ulcerative colitis 2.6 1.3 1
Unhealthy Ageing 1.1 0.2 4.5
Vitiligo 0.4 0.2 1

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