🍽️ valacyclovir hydrochloride,(prescription)

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Antiviral Activity: Valacyclovir is a prodrug of acyclovir, which means it gets converted to acyclovir in the body. Acyclovir is an antiviral medication that works by inhibiting the replication of herpes simplex virus. Valacyclovir is more bioavailable than acyclovir, allowing for less frequent dosing.
Treatment of Genital Herpes: Valacyclovir is commonly used for the treatment of genital herpes outbreaks. It can help reduce the severity and duration of symptoms such as genital sores, pain, and itching. Valacyclovir does not cure genital herpes but can help manage symptoms and reduce the risk of transmission to sexual partners.
Suppression Therapy for Genital Herpes: In individuals with frequent or severe genital herpes outbreaks, valacyclovir may be used as suppressive therapy to reduce the frequency and severity of recurrences. Continuous daily therapy can help prevent outbreaks and reduce the risk of transmission to sexual partners.
Treatment of Cold Sores: Valacyclovir is also used for the treatment of cold sores (herpes labialis) caused by herpes simplex virus type 1. It can help speed up the healing process and reduce the severity of symptoms when taken at the first sign of a cold sore outbreak.
Herpes Zoster (Shingles): Valacyclovir may be used in the treatment of herpes zoster (shingles) in immunocompetent adults to reduce the duration and severity of acute pain and rash associated with the condition. Early initiation of treatment is recommended for maximum benefit.
Prevention of Recurrent Herpes Simplex Virus Infections: For individuals with frequent recurrences of genital herpes or cold sores, valacyclovir may be used as a preventive measure to reduce the frequency of outbreaks. This is known as episodic or intermittent therapy.
Safety and Tolerability: Valacyclovir is generally well-tolerated, with most adverse effects being mild and transient. Common side effects may include headache, nausea, abdominal pain, and dizziness. Rare but serious side effects such as allergic reactions and renal impairment may occur, particularly in individuals with pre-existing kidney problems.
Dosing and Administration: The dosing regimen for valacyclovir depends on the indication being treated or prevented. It is usually taken orally with or without food. Dosage adjustments may be necessary in individuals with impaired renal function to prevent accumulation of the drug and reduce the risk of adverse effects.
Pregnancy and Lactation: Valacyclovir may be used with caution during pregnancy and lactation if the potential benefits outweigh the risks. Pregnant or breastfeeding individuals should consult their healthcare provider before using valacyclovir.
Drug Interactions: Valacyclovir may interact with certain medications, including probenecid and drugs that affect renal function. Concurrent use of valacyclovir with nephrotoxic agents or drugs eliminated primarily by renal excretion may increase the risk of kidney-related side effects.

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Data Contradictions — Limits of Certainity

Impacted of valacyclovir hydrochloride,(prescription) On Probiotics

Rank	Probiotic	Impact
genus	Bifidobacterium	Reduces
species	Akkermansia muciniphila	Reduces
species	Bacteroides uniformis	Reduces
species	Bifidobacterium adolescentis	Reduces
species	Bifidobacterium longum	Reduces
species	Escherichia coli	Reduces
species	Parabacteroides distasonis	Reduces
subspecies	Bifidobacterium longum subsp. infantis	Reduces
subspecies	Bifidobacterium longum subsp. longum	Reduces

Bacteria Impacted by valacyclovir hydrochloride,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

🧙?
📓 Direct Citations	👪👶 Indirect Citations	Taxonomy	Rank	Effect
0	1	Akkermansiaceae	family	Decreases
0	1	Escherichia	genus	Decreases
0	1	Dorea	genus	Decreases
0	1	Roseburia	genus	Decreases
0	1	Parabacteroides	genus	Decreases
0	1	Bacteroides	genus	Decreases
0	1	Bifidobacterium	genus	Decreases
0	1	Clostridioides	genus	Decreases
0	1	Collinsella	genus	Decreases
0	1	Coprococcus	genus	Decreases
0	1	Fusobacterium	genus	Decreases
0	1	Mediterraneibacter	genus	Decreases
0	1	Odoribacter	genus	Decreases
0	1	Phocaeicola	genus	Decreases
0	1	Streptococcus	genus	Decreases
0	1	Veillonella	genus	Decreases
0	1	Clostridium	genus	Decreases
0	1	Enterocloster	genus	Decreases
0	1	Blautia	genus	Decreases
1	0	Akkermansia	genus	Decreases
0	1	Escherichia coli O25:H16	no rank	Decreases
0	1	Clostridium perfringens A	no rank	Decreases
0	1	Clostridium perfringens C	no rank	Decreases
0	1	Clostridium perfringens CPE	no rank	Decreases
0	1	environmental samples	no rank	Decreases
0	1	Escherichia coli O145:H34	no rank	Decreases
0	1	Escherichia coli O16:H48	no rank	Decreases
0	1	unclassified Akkermansia	no rank	Decreases
0	1	Clostridium perfringens D	no rank	Decreases
0	1	Escherichia coli O141:H4	no rank	Decreases
0	1	Clostridium perfringens B	no rank	Decreases
0	1	Escherichia coli O139:H1	no rank	Decreases
0	1	Clostridium perfringens E	no rank	Decreases
0	1	Escherichia coli O80:H26	no rank	Decreases
0	1	Escherichia coli O158:H23	no rank	Decreases
0	1	Escherichia coli O84:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H4	no rank	Decreases
0	1	Escherichia coli O2:K1:H7	no rank	Decreases
0	1	Escherichia coli O78:H51	no rank	Decreases
0	1	Escherichia coli O18ac:H14	no rank	Decreases
0	1	Escherichia coli O85:H1	no rank	Decreases
0	1	Escherichia coli O7:H15	no rank	Decreases
0	1	Escherichia coli O68:H12	no rank	Decreases
0	1	Escherichia coli O55:H7	no rank	Decreases
0	1	Escherichia coli O1:K1:H7	no rank	Decreases
0	1	Escherichia coli O15:H12	no rank	Decreases
0	1	Escherichia coli O170:H18	no rank	Decreases
0	1	Escherichia coli O155:H21	no rank	Decreases
0	1	Escherichia coli O19:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H5	no rank	Decreases
0	1	Escherichia coli O20:H12	no rank	Decreases
0	1	Escherichia coli O111	serogroup	Decreases
0	1	Escherichia coli O121	serogroup	Decreases
0	1	Escherichia coli O155	serogroup	Decreases
0	1	Escherichia coli O177	serogroup	Decreases
0	1	Escherichia coli O26	serogroup	Decreases
0	1	Escherichia coli O3	serogroup	Decreases
0	1	Escherichia coli O5	serogroup	Decreases
0	1	Escherichia coli O86	serogroup	Decreases
0	1	Escherichia coli O91	serogroup	Decreases
0	1	Escherichia coli O103	serogroup	Decreases
0	1	Escherichia coli O78	serogroup	Decreases
0	1	Escherichia coli O43	serogroup	Decreases
0	1	Escherichia coli O119	serogroup	Decreases
0	1	Escherichia coli O157	serogroup	Decreases
0	1	Escherichia coli O145	serogroup	Decreases
0	1	Escherichia coli O1:HNT	serotype	Decreases
0	1	Escherichia coli O10:K5(L):H4	serotype	Decreases
0	1	Escherichia coli O103:H11	serotype	Decreases
0	1	Escherichia coli O103:H25	serotype	Decreases
0	1	Escherichia coli O104:H21	serotype	Decreases
0	1	Escherichia coli O111:H11	serotype	Decreases
0	1	Escherichia coli O111:H8	serotype	Decreases
0	1	Escherichia coli O112ac:H19	serotype	Decreases
0	1	Escherichia coli O114:H49	serotype	Decreases
0	1	Escherichia coli O118:H16	serotype	Decreases
0	1	Escherichia coli O121:H7	serotype	Decreases
0	1	Escherichia coli O123:H11	serotype	Decreases
0	1	Escherichia coli O127:H27	serotype	Decreases
0	1	Escherichia coli O127:H6	serotype	Decreases
0	1	Escherichia coli O128:H2	serotype	Decreases
0	1	Escherichia coli O128ac:H12	serotype	Decreases
0	1	Escherichia coli O145:H25	serotype	Decreases
0	1	Escherichia coli O145:NM	serotype	Decreases
0	1	Escherichia coli O146:H21	serotype	Decreases
0	1	Escherichia coli O153:H2	serotype	Decreases
0	1	Escherichia coli O156:H25	serotype	Decreases
0	1	Escherichia coli O157:H43	serotype	Decreases
0	1	Escherichia coli O157:NM	serotype	Decreases
0	1	Escherichia coli O165:H25	serotype	Decreases
0	1	Escherichia coli O174:H2	serotype	Decreases
0	1	Escherichia coli O174:H21	serotype	Decreases
0	1	Escherichia coli O174:H8	serotype	Decreases
0	1	Escherichia coli O176:H45	serotype	Decreases
0	1	Escherichia coli O177:NM	serotype	Decreases
0	1	Escherichia coli O26:H1	serotype	Decreases
0	1	Escherichia coli O28ac:NM	serotype	Decreases
0	1	Escherichia coli O29:H4	serotype	Decreases
0	1	Escherichia coli O32:H37	serotype	Decreases
0	1	Escherichia coli O6:H16:CFA/II	serotype	Decreases
0	1	Escherichia coli O69:H11	serotype	Decreases
0	1	Escherichia coli O78:H12	serotype	Decreases
0	1	Escherichia coli O79:H7	serotype	Decreases
0	1	Escherichia coli O81:NM	serotype	Decreases
0	1	Escherichia coli O86:H34	serotype	Decreases
0	1	Escherichia coli O91:H14	serotype	Decreases
0	1	Escherichia coli O91:NM	serotype	Decreases
0	1	Escherichia coli ONT:H33	serotype	Decreases
0	1	Escherichia coli O100:H21	serotype	Decreases
0	1	Escherichia coli O121:H19	serotype	Decreases
0	1	Escherichia coli O157:H7	serotype	Decreases
0	1	Escherichia coli O16:H6	serotype	Decreases
0	1	Escherichia coli O89m:H9	serotype	Decreases
0	1	Escherichia coli O111:H-	serotype	Decreases
0	1	Escherichia coli O113:H21	serotype	Decreases
0	1	Escherichia coli H20	serotype	Decreases
0	1	Escherichia coli O150:H6	serotype	Decreases
0	1	Escherichia coli O111:NM	serotype	Decreases
0	1	Escherichia coli O112ab:H8	serotype	Decreases
0	1	Escherichia coli O99:H6	serotype	Decreases
0	1	Escherichia coli O26:H11	serotype	Decreases
0	1	Escherichia coli O145:H28	serotype	Decreases
0	1	Escherichia coli O126:H45	serotype	Decreases
0	1	Escherichia coli O2:H6	serotype	Decreases
0	1	Escherichia coli O7:H4	serotype	Decreases
0	1	Escherichia coli O1:H42	serotype	Decreases
0	1	Escherichia coli O25:NM	serotype	Decreases
0	1	Escherichia coli O25:H1	serotype	Decreases
0	1	Escherichia coli O7:K1	serotype	Decreases
0	1	Escherichia coli O125ac:K+:H10	serotype	Decreases
0	1	Escherichia coli O6:K2:H1	serotype	Decreases
0	1	Escherichia coli O152:H23	serotype	Decreases
0	1	Escherichia coli O15:H18	serotype	Decreases
0	1	Escherichia coli O39:NM	serotype	Decreases
0	1	Escherichia coli O44:H18	serotype	Decreases
0	1	Escherichia coli O2:K2:H1	serotype	Decreases
0	1	Escherichia coli O8:H8	serotype	Decreases
0	1	Escherichia coli O89m:H10	serotype	Decreases
0	1	Escherichia coli O10:H32	serotype	Decreases
0	1	Escherichia coli O6:H16	serotype	Decreases
0	1	Escherichia coli O157:H-	serotype	Decreases
0	1	Escherichia coli O45:H2	serotype	Decreases
0	1	Escherichia coli O103:H2	serotype	Decreases
0	1	Escherichia coli O167:H26	serotype	Decreases
0	1	Escherichia coli O104:H4	serotype	Decreases
0	1	Escherichia coli O83:H1	serotype	Decreases
0	1	Escherichia coli O9:H10	serotype	Decreases
0	1	Escherichia coli O78:H4	serotype	Decreases
0	1	Escherichia coli O139:H28	serotype	Decreases
1	0	Coprococcus comes	species	Decreases
1	0	Bacteroides caccae	species	Decreases
1	0	Escherichia coli	species	Decreases
1	0	Bacteroides ovatus	species	Decreases
1	0	Streptococcus salivarius	species	Decreases
1	0	Bacteroides xylanisolvens	species	Decreases
1	0	Fusobacterium nucleatum	species	Decreases
0	1	Akkermansia massiliensis	species	Decreases
0	1	Candidatus Akkermansia intestinavium	species	Decreases
1	0	Parabacteroides merdae	species	Decreases
1	0	[Ruminococcus] torques	species	Decreases
1	0	Veillonella parvula	species	Decreases
1	0	Clostridium perfringens	species	Decreases
1	0	Odoribacter splanchnicus	species	Decreases
1	0	Roseburia intestinalis	species	Decreases
1	0	Dorea formicigenerans	species	Decreases
1	0	Bifidobacterium adolescentis	species	Decreases
1	0	Enterocloster bolteae	species	Decreases
1	0	Collinsella aerofaciens	species	Decreases
1	0	Bifidobacterium longum	species	Decreases
1	0	Bacteroides uniformis	species	Decreases
1	0	Clostridioides difficile	species	Decreases
1	0	Parabacteroides distasonis	species	Decreases
1	0	Akkermansia muciniphila	species	Decreases
1	0	Blautia obeum	species	Decreases
1	0	Phocaeicola vulgatus	species	Decreases
1	0	Streptococcus parasanguinis	species	Decreases
0	1	Akkermansia glycaniphila	species	Decreases
0	1	Bifidobacterium longum subsp. longum	subspecies	Decreases
0	1	Bifidobacterium longum subsp. infantis	subspecies	Decreases
0	1	Bifidobacterium longum subsp. suis	subspecies	Decreases
0	1	Fusobacterium nucleatum subsp. nucleatum	subspecies	Decreases
0	1	Bifidobacterium longum subsp. suillum	subspecies	Decreases

Impact of valacyclovir hydrochloride,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition	Positive Impact	Negative Impact	Benefit Ratio Impact
Acne	0.6	0.5	0.2
ADHD	3.1	0.6	4.17
Age-Related Macular Degeneration and Glaucoma	1.1	0.4	1.75
Allergic Rhinitis (Hay Fever)	2.8	1.4	1
Allergies	3.7	2.4	0.54
Allergy to milk products	1.6	1.6	0
Alopecia (Hair Loss)	1.1		1.1
Alzheimer's disease	4.7	4.2	0.12
Amyotrophic lateral sclerosis (ALS) Motor Neuron	2.9	1.1	1.64
Ankylosing spondylitis	3.3	0.6	4.5
Anorexia Nervosa	1.3	1.7	-0.31
Antiphospholipid syndrome (APS)	1		1
Asthma	4.1	1.9	1.16
Atherosclerosis	1.6	1.5	0.07
Atrial fibrillation	2.6	1.6	0.63
Autism	5.6	5.5	0.02
Autoimmune Disease	1.2	1	0.2
Barrett esophagus cancer	0.6	0.3	1
benign prostatic hyperplasia	0.6	0.3	1
Biofilm	1.4		1.4
Bipolar Disorder	1.5	1.1	0.36
Brain Trauma	0.9	1.1	-0.22
Breast Cancer	1.4		1.4
Cancer (General)	0.9	1.4	-0.56
Carcinoma	4.1	2.3	0.78
Celiac Disease	1.9	2.4	-0.26
Cerebral Palsy	1.4	1	0.4
Chronic Fatigue Syndrome	2.8	3.5	-0.25
Chronic Kidney Disease	3.3	1.4	1.36
Chronic Lyme	0.1	0.8	-7
Chronic Obstructive Pulmonary Disease (COPD)	2	1.7	0.18
Chronic Urticaria (Hives)	1.9	0.1	18
Coagulation / Micro clot triggering bacteria	1.8	1	0.8
Cognitive Function	2.8	1.6	0.75
Colorectal Cancer	6.4	2.4	1.67
Constipation	1.4	1.1	0.27
Coronary artery disease	1.7	1.8	-0.06
COVID-19	5	5.1	-0.02
Crohn's Disease	5.8	3.5	0.66
Cushing's Syndrome (hypercortisolism)		0.3	-0.3
cystic fibrosis	1.1	1.4	-0.27
d-lactic acidosis (one form of brain fog)	0.5		0.5
deep vein thrombosis	2.4	1.1	1.18
Denture Wearers Oral Shifts	1.1		1.1
Depression	6.8	6.3	0.08
Dermatomyositis	0.3	0.3	0
Eczema	1.7	1.8	-0.06
Endometriosis	3.4	1.9	0.79
Eosinophilic Esophagitis	0.3	0.6	-1
Epilepsy	2.9	1.5	0.93
erectile dysfunction	1.4	0.3	3.67
Fibromyalgia	2.5	2.5	0
Functional constipation / chronic idiopathic constipation	3.8	3	0.27
gallstone disease (gsd)	2.7	1.2	1.25
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	0.9	0.3	2
Generalized anxiety disorder	2.4	2.1	0.14
giant cell arteritis		0.2	-0.2
Glioblastoma		0.3	-0.3
Gout	1.8	1.1	0.64
Graves' disease	1.6	3	-0.88
Gulf War Syndrome	0.9	0.4	1.25
Halitosis	1.5	0.3	4
Hashimoto's thyroiditis	2.7	0.9	2
Heart Failure	3	1	2
hemorrhagic stroke	1.3		1.3
Hidradenitis Suppurativa	0.9	0.3	2
High Histamine/low DAO	1.5	0.3	4
hypercholesterolemia (High Cholesterol)	1	0.1	9
hyperglycemia	2.2	1.2	0.83
Hyperlipidemia (High Blood Fats)	0.6	0.3	1
hypersomnia		0.4	-0.4
hypertension (High Blood Pressure	3.5	2.4	0.46
Hypothyroidism	0	0.7	0
Hypoxia	3.1	0.3	9.33
IgA nephropathy (IgAN)	1.3	2	-0.54
Inflammatory Bowel Disease	4.7	4.2	0.12
Insomnia	2.2	1.6	0.38
Intelligence	1.3		1.3
Intracranial aneurysms	1.1	0.9	0.22
Irritable Bowel Syndrome	5.2	3.4	0.53
ischemic stroke	2.4	1.4	0.71
Liver Cirrhosis	5.6	4.2	0.33
Long COVID	4.6	3.9	0.18
Low bone mineral density		0.8	-0.8
Lung Cancer	1.1	0.8	0.38
Lymphoma	0.6		0.6
Mast Cell Issues / mastitis	1.2	0.6	1
ME/CFS with IBS	0.6	1.5	-1.5
ME/CFS without IBS	0.5	1.4	-1.8
membranous nephropathy	0.3		0.3
Menopause	0.9	0.6	0.5
Metabolic Syndrome	5.7	4.7	0.21
Mood Disorders	6.2	4.9	0.27
multiple chemical sensitivity [MCS]	0.9	0.1	8
Multiple Sclerosis	4	2.9	0.38
Multiple system atrophy (MSA)	0.1	0.4	-3
myasthenia gravis	0.9	0.7	0.29
neuropathic pain		1.9	-1.9
Neuropathy (all types)	0.5	1.9	-2.8
neuropsychiatric disorders (PANDAS, PANS)	1.1		1.1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	4.3	2.3	0.87
NonCeliac Gluten Sensitivity	1.1	0.6	0.83
Obesity	7.4	5.9	0.25
obsessive-compulsive disorder	2.9	2.5	0.16
Osteoarthritis	1.6	0.9	0.78
Osteoporosis	1.9	1.6	0.19
pancreatic cancer	2	0.6	2.33
Parkinson's Disease	5.6	4	0.4
Polycystic ovary syndrome	3.8	2.1	0.81
Postural orthostatic tachycardia syndrome	0.2	0.6	-2
Premenstrual dysphoric disorder	0.7	0.4	0.75
primary biliary cholangitis	1.2	1.1	0.09
Primary sclerosing cholangitis	2	1.2	0.67
Psoriasis	2	1.7	0.18
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	4.5	3.5	0.29
Rosacea	0.5	1	-1
Schizophrenia	4.5	2.5	0.8
scoliosis	0.8		0.8
Sjögren syndrome	2.3	2	0.15
Sleep Apnea	1.6	1.3	0.23
Slow gastric motility / Gastroparesis	1.1	0.3	2.67
Small Intestinal Bacterial Overgrowth (SIBO)	2.1	0.1	20
Stress / posttraumatic stress disorder	3.1	2.2	0.41
Systemic Lupus Erythematosus	3.1	1.3	1.38
Tic Disorder	0.6	1.2	-1
Tourette syndrome	0.9	0.3	2
Type 1 Diabetes	3.1	2.3	0.35
Type 2 Diabetes	6	5	0.2
Ulcerative colitis	4.4	2.9	0.52
Unhealthy Ageing	2.8	1.9	0.47
Vitiligo	1.3	1.6	-0.23

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