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🍽️ repaglinide,(prescription)

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  1. Type 2 Diabetes Mellitus: Repaglinide belongs to the class of medications known as meglitinides, which stimulate insulin secretion from pancreatic beta cells. It helps lower blood glucose levels by increasing insulin release, particularly in response to meals. By improving insulin action, repaglinide helps control blood sugar levels in patients with type 2 diabetes.

  2. Glucose Control: Repaglinide is effective in lowering both fasting and postprandial (after-meal) blood glucose levels. It helps prevent hyperglycemia (high blood sugar) by promoting the uptake of glucose into cells and reducing the production of glucose by the liver.

  3. Mealtime Dosage: Repaglinide is typically taken before each main meal to mimic the physiological insulin response to food intake. It has a rapid onset of action, reaching peak blood levels within 1 hour of administration, which helps control the rise in blood glucose levels after meals.

  4. HbA1c Reduction: Treatment with repaglinide has been shown to decrease glycosylated hemoglobin (HbA1c) levels, a marker of long-term glucose control. Lowering HbA1c levels reduces the risk of diabetes-related complications such as cardiovascular disease, kidney damage, and nerve damage.

  5. Weight Neutrality: Unlike some other diabetes medications such as sulfonylureas, which may cause weight gain, repaglinide is considered weight neutral or may even lead to modest weight loss in some individuals. This can be beneficial for patients who are overweight or obese.

  6. Hypoglycemia: The most common side effect of repaglinide is hypoglycemia (low blood sugar), especially if taken without adequate food intake or if the meal is delayed. Patients should be educated about the symptoms of hypoglycemia and instructed on appropriate self-management techniques, such as consuming glucose-containing snacks.

  7. Adverse Effects: In addition to hypoglycemia, other potential side effects of repaglinide include gastrointestinal disturbances (such as nausea, diarrhea, or constipation), headache, dizziness, and upper respiratory tract infections. These side effects are usually mild and transient.

  8. Renal and Hepatic Impairment: Caution is advised when using repaglinide in patients with renal or hepatic impairment, as the drug is primarily metabolized by the liver and excreted by the kidneys. Dose adjustments may be necessary in patients with impaired liver or kidney function to prevent potential adverse effects.

  9. Drug Interactions: Repaglinide metabolism may be affected by certain medications, such as gemfibrozil, clopidogrel, and some antifungal agents, leading to increased blood levels of repaglinide and a higher risk of hypoglycemia. Patients should inform their healthcare provider about all medications they are taking before starting repaglinide therapy.

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Impacted of repaglinide,(prescription) On Probiotics

Bacteria Impacted by repaglinide,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

Impact of repaglinide,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

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