Akkermansia: NCBI 239934, [genus]

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| Akkermansia| Akkermansia Derrien et al. 2004

1. Gut Barrier Function: Akkermansia muciniphila plays a role in maintaining gut barrier integrity. It helps in breaking down the mucus layer in the gut and utilizing mucin, a protein found in the mucous layer of the intestines. By regulating the thickness of the mucous layer, it contributes to maintaining a healthy gut lining and barrier function.

2. Metabolic Health: Studies have suggested that higher abundance or supplementation of Akkermansia muciniphila may be associated with improved metabolic health. It has been linked to a reduction in markers of obesity, insulin resistance, and inflammation. This bacterium may also influence lipid metabolism, glucose regulation, and energy homeostasis.

3. Anti-inflammatory Effects: Akkermansia muciniphila has been associated with anti-inflammatory properties, potentially reducing systemic inflammation in the body. Lower levels of inflammation are linked to a reduced risk of various chronic conditions, including metabolic disorders and certain inflammatory diseases.

4. Modulation of Immune Response: Research indicates that Akkermansia muciniphila may have an impact on immune responses by influencing the gut immune system. It can stimulate the production of regulatory T-cells and modulate the balance of immune cells in the gut, contributing to immune homeostasis.

5. Potential Impact on Chronic Diseases: Some studies suggest that Akkermansia muciniphila might have implications for chronic diseases such as obesity, type 2 diabetes, metabolic syndrome, and cardiovascular diseases. However, further research is needed to establish causality and the precise mechanisms involved.

6. Association with Diet: Dietary factors, such as the consumption of certain fibers, polyphenols, and prebiotics, have been linked to an increase in Akkermansia muciniphila abundance. A diet rich in plant-based foods and dietary fibers may promote the growth of this beneficial bacterium.

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Akkermansia impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart
0.326090544462204	0.5748182535171509	Intestinimonas	Parent Taxa
0.26265639066696167	0.5149882435798645	Pusillibacter	Parent Taxa
0.2552238404750824	0.5102517604827881	Vescimonas	Parent Taxa
0.25492846965789795	0.48369812965393066	Methanobrevibacter	Parent Taxa
0.25083285570144653	0.5062537789344788	Ruthenibacterium	Parent Taxa

Other bacteria of the same rank impacting Akkermansia

R2	Slope	Tax Name	Parent Chart
0.33317244052886963	0.591193675994873	Intestinimonas	Parent Taxa
0.3040792644023895	0.6211792826652527	Maliibacterium	Parent Taxa
0.2804373800754547	0.5711729526519775	Christensenella	Parent Taxa
0.2766266167163849	0.5415464639663696	Pusillibacter	Parent Taxa
0.2665981948375702	0.5797567367553711	Acutalibacter	Parent Taxa
0.2649628221988678	0.5328435897827148	Subdoligranulum	Parent Taxa
0.253673255443573	0.547252357006073	Solibaculum	Parent Taxa