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Common knowledge amoung some professionals (MD and ND):
Vitamin D: Some research suggests a possible link between vitamin D deficiency and a higher risk of seizures in people with epilepsy. Maintaining adequate vitamin D levels might have potential benefits, but evidence supporting vitamin D supplementation specifically for epilepsy is limited.
Omega-3 Fatty Acids: Omega-3 supplements, particularly those containing EPA and DHA, may have anti-inflammatory properties and potential neurological benefits. Some studies suggest that omega-3 supplementation might have a positive effect on seizure control, but more research is needed.
Vitamin B6: Pyridoxine (vitamin B6) supplementation might be considered for certain types of epilepsy, such as pyridoxine-dependent epilepsy. However, its use should be guided by healthcare professionals and is specific to certain forms of epilepsy.
Ketogenic Diet: While not a supplement, the ketogenic diet, which is high in fats, adequate in protein, and low in carbohydrates, has shown some effectiveness in reducing seizures, especially in children with certain types of epilepsy that are resistant to medications. It's a specialized diet that should be supervised by healthcare professionals and registered dietitians.
Probiotics: The role of probiotics in managing epilepsy is an area of ongoing research. Some studies suggest a potential link between gut health and neurological conditions, but their specific role in epilepsy management requires further investigation.
The Studies below identify bacteria. Check if it has already been reviewed.
| 1 | 📚 |
A meta-analysis of the changes in the Gut microbiota in patients with intractable epilepsy compared to healthy controls.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci ) Vol: 120 Issue: Pages: 213-220 Pub: 2024 Feb ePub: 2024 Jan 29 Authors Yang R,Liu J,Diao L,Wei L,Luo H,Cai L |
| 2 | 📚 |
Alteration of Gut Microbiota in Patients With Epilepsy and the Potential Index as a Biomarker.
Frontiers in microbiology (Front Microbiol ) Vol: 11 Issue: Pages: 517797 Pub: 2020 ePub: 2020 Sep 18 Authors Gong X,Liu X,Chen C,Lin J,Li A,Guo K,An D,Zhou D,Hong Z |
| 3 | 📚 |
Altered composition of the gut microbiome in patients with drug-resistant epilepsy.
Epilepsy research (Epilepsy Res ) Vol: 147 Issue: Pages: 102-107 Pub: 2018 Nov ePub: 2018 Sep 24 Authors Peng A,Qiu X,Lai W,Li W,Zhang L,Zhu X,He S,Duan J,Chen L |
| 4 | 📚 |
Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet.
Epilepsy research (Epilepsy Res ) Vol: 145 Issue: Pages: 163-168 Pub: 2018 Sep ePub: 2018 Jun 28 Authors Zhang Y,Zhou S,Zhou Y,Yu L,Zhang L,Wang Y |
| 5 | 📚 |
Altered intestinal microbiota composition with epilepsy and concomitant diarrhea and potential indicator biomarkers in infants.
Frontiers in microbiology (Front Microbiol ) Vol: 13 Issue: Pages: 1081591 Pub: 2022 ePub: 2023 Jan 11 Authors Liu T,Jia F,Guo Y,Wang Q,Zhang X,Chang F,Xie Y |
| 6 | 📚 |
Association between seizure reduction during ketogenic diet treatment of epilepsy and changes in circulatory metabolites and gut microbiota composition.
EBioMedicine (EBioMedicine ) Vol: 109 Issue: Pages: 105400 Pub: 2024 Nov ePub: 2024 Nov 4 Authors Dahlin M,Wheelock CE,Prast-Nielsen S |
| 7 | 📚 |
Bacillus subtilis plays a role in the inhibition of transporter ABCB1 in Caco-2 cells.
Epilepsy research (Epilepsy Res ) Vol: 183 Issue: Pages: 106925 Pub: 2022 Jul ePub: 2022 Apr 14 Authors Dai Y,Wang M,Zhong D,Xu X |
| 8 | 📚 |
Bacterial meningitis and epilepsy.
Epilepsia (Epilepsia ) Vol: 49 Suppl 6 Issue: Pages: 8-12 Pub: 2008 Aug ePub: Authors Murthy JM,Prabhakar S |
| 9 | 📚 |
Can the Gut Microbiota Serve as a Guide to the Diagnosis and Treatment of Childhood Epilepsy?
Pediatric neurology (Pediatr Neurol ) Vol: 145 Issue: Pages: 11-21 Pub: 2023 Aug ePub: 2023 Apr 14 Authors Türay S,Cangür S,Kahraman G,Kayabasi E,Çetiner ÖF,Aydin B,Öztürk CE |
| 10 | 📚 |
Change in intestinal flora after treatment in children with focal epilepsy.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi ) Vol: 24 Issue: 3 Pages: 290-296 Pub: 2022 Mar 15 ePub: Authors Gong SZ,Qiu J,Wu LW,Tan LH |
| 11 | 📚 |
Changes and significance of gut microbiota in children with focal epilepsy before and after treatment.
Frontiers in cellular and infection microbiology (Front Cell Infect Microbiol ) Vol: 12 Issue: Pages: 965471 Pub: 2022 ePub: 2022 Nov 3 Authors Zhou C,Gong S,Xiang S,Liang L,Hu X,Huang R,Liao Z,Ma Y,Xiao Z,Qiu J |
| 12 | 📚 |
Changes in gut flora in patients with epilepsy: a systematic review and meta-analysis.
Frontiers in microbiology (Front Microbiol ) Vol: 15 Issue: Pages: 1480022 Pub: 2024 ePub: 2024 Nov 14 Authors He X,Zhang Y |
| 13 | 📚 |
Correlations between gastrointestinal and oral microbiota in children with cerebral palsy and epilepsy.
Frontiers in pediatrics (Front Pediatr ) Vol: 10 Issue: Pages: 988601 Pub: 2022 ePub: 2022 Nov 4 Authors Huang C,Chu C,Peng Y,Zhang N,Yang Z,You J,Wei F |
| 14 | 📚 |
Genetically proxied gut microbiota, gut metabolites with risk of epilepsy and the subtypes: A bi-directional Mendelian randomization study.
Frontiers in molecular neuroscience (Front Mol Neurosci ) Vol: 15 Issue: Pages: 994270 Pub: 2022 ePub: 2022 Nov 3 Authors Ouyang Y,Chen Y,Wang G,Song Y,Zhao H,Xiao B,Yang Z,Long L |
| 15 | 📚 |
Gut Bacteria Seize Control of the Brain to Prevent Epilepsy.
Cell host & microbe (Cell Host Microbe ) Vol: 24 Issue: 1 Pages: 3-5 Pub: 2018 Jul 11 ePub: Authors Dooling SW,Costa-Mattioli M |
| 16 | 📚 |
Gut Bacterial Dysbiosis in Children with Intractable Epilepsy.
Journal of clinical medicine (J Clin Med ) Vol: 10 Issue: 1 Pages: Pub: 2020 Dec 22 ePub: 2020 Dec 22 Authors Lee K,Kim N,Shim JO,Kim GH |
| 17 | 📚 |
Gut flora and metabolism are altered in epilepsy and partially restored after ketogenic diets.
Microbial pathogenesis (Microb Pathog ) Vol: 155 Issue: Pages: 104899 Pub: 2021 Jun ePub: 2021 Apr 21 Authors Gong X,Cai Q,Liu X,An D,Zhou D,Luo R,Peng R,Hong Z |
| 18 | 📚 |
Gut Microbial Characteristics of Adult Patients With Epilepsy.
Frontiers in neuroscience (Front Neurosci ) Vol: 16 Issue: Pages: 803538 Pub: 2022 ePub: 2022 Feb 16 Authors Dong L,Zheng Q,Cheng Y,Zhou M,Wang M,Xu J,Xu Z,Wu G,Yu Y,Ye L,Feng Z |
| 19 | 📚 |
Gut Microbiome Distinguishes Patients With Epilepsy From Healthy Individuals.
Frontiers in microbiology (Front Microbiol ) Vol: 12 Issue: Pages: 696632 Pub: 2021 ePub: 2022 Jan 7 Authors Cui G,Liu S,Liu Z,Chen Y,Wu T,Lou J,Wang H,Zou Y,Sun Y,Rao B,Ren Z,Lian Y,Jiang Y |
| 20 | 📚 |
Gut Microbiota and Epilepsy: A Systematic Review on Their Relationship and Possible Therapeutics.
ACS chemical neuroscience (ACS Chem Neurosci ) Vol: 11 Issue: 21 Pages: 3488-3498 Pub: 2020 Nov 4 ePub: 2020 Oct 16 Authors Arulsamy A,Tan QY,Balasubramaniam V,O`Brien TJ,Shaikh MF |
| 21 | 📚 |
Higher levels of Bifidobacteria and tumor necrosis factor in children with drug-resistant epilepsy are associated with anti-seizure response to the ketogenic diet.
EBioMedicine (EBioMedicine ) Vol: 80 Issue: Pages: 104061 Pub: 2022 Jun ePub: 2022 May 19 Authors Dahlin M,Singleton SS,David JA,Basuchoudhary A,Wickström R,Mazumder R,Prast-Nielsen S |
| 22 | 📚 |
Idiopathic epilepsy in dogs is associated with dysbiotic faecal microbiota.
Animal microbiome (Anim Microbiome ) Vol: 7 Issue: 1 Pages: 31 Pub: 2025 Mar 27 ePub: 2025 Mar 27 Authors Silvestrino M,Pirolo M,Bianco A,Castellana S,Del Sambro L,Tarallo VD,Guardabassi L,Zatelli A,Gernone F |
| 23 | 📚 |
Is Gut Microbiota a Key Player in Epilepsy Onset? A Longitudinal Study in Drug-Naive Children.
Frontiers in cellular and infection microbiology (Front Cell Infect Microbiol ) Vol: 11 Issue: Pages: 749509 Pub: 2021 ePub: 2021 Dec 3 Authors Ceccarani C,Viganò I,Ottaviano E,Redaelli MG,Severgnini M,Vignoli A,Borghi E |
| 24 | 📚 |
Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy.
World journal of gastroenterology (World J Gastroenterol ) Vol: 23 Issue: 33 Pages: 6164-6171 Pub: 2017 Sep 7 ePub: Authors Xie G,Zhou Q,Qiu CZ,Dai WK,Wang HP,Li YH,Liao JX,Lu XG,Lin SF,Ye JH,Ma ZY,Wang WJ |
| 25 | 📚 |
Medication-resistant epilepsy is associated with a unique gut microbiota signature.
Epilepsia (Epilepsia ) Vol: Issue: Pages: Pub: 2025 Mar 22 ePub: 2025 Mar 22 Authors Riva A,Sahin E,Volpedo G,Catania NT,Venara I,Biagioli V,Balagura G,Amadori E,De Caro C,Cerulli Irelli E,Di Bonaventura C,Zara F,Sezerman OU,Russo E,Striano P |
| 26 | 📚 |
Mild Encephalopathy/Encephalitis with Reversible Splenial Lesion in a Patient with Salmonella typhi Infection: An Unusual Presentation with Excellent Prognosis.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine (Indian J Crit Care Med ) Vol: 23 Issue: 12 Pages: 584-586 Pub: 2019 Dec ePub: Authors Chopra P,Bhatia RS,Chopra R |
| 27 | 📚 |
Susceptibility to epilepsy after traumatic brain injury is associated with preexistent gut microbiome profile.
Epilepsia (Epilepsia ) Vol: 63 Issue: 7 Pages: 1835-1848 Pub: 2022 Jul ePub: 2022 Apr 16 Authors Medel-Matus JS,Lagishetty V,Santana-Gomez C,Shin D,Mowrey W,Staba RJ,Galanopoulou AS,Sankar R,Jacobs JP,Mazarati AM |
| 28 | 📚 |
The comparison of gut microbiota between different types of epilepsy in children.
Microbial cell factories (Microb Cell Fact ) Vol: 24 Issue: 1 Pages: 64 Pub: 2025 Mar 14 ePub: 2025 Mar 14 Authors Fang S,Hu N,Zhou C,You J,Wu L,Pan X,Xiao Z,Qiu J |
| 29 | 📚 |
The gut microbiome in epilepsy.
Microbial pathogenesis (Microb Pathog ) Vol: 139 Issue: Pages: 103853 Pub: 2020 Feb ePub: 2019 Nov 13 Authors Safak B,Altunan B,Topçu B,Eren Topkaya A |
| 30 | 📚 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Cell (Cell ) Vol: 173 Issue: 7 Pages: 1728-1741.e13 Pub: 2018 Jun 14 ePub: 2018 May 24 Authors Olson CA,Vuong HE,Yano JM,Liang QY,Nusbaum DJ,Hsiao EY |
The Studies below identify substances that has been tried with positive changes (for at least some symptoms in the study). Check if it has already been reviewed.
| 31 | 📚 |
A six-month prospective, randomised, double-blinded, placebo-controlled, crossover, dietary trial design to investigate the potential of psychobiotics on seizure semiology and comorbidities in canine epilepsy: study protocol.
BMC veterinary research (BMC Vet Res ) Vol: 19 Issue: 1 Pages: 57 Pub: 2023 Mar 3 ePub: 2023 Mar 3 Authors Schmidt T,Meller S,Meyerhoff N,Twele F,Zanghi B,Volk HA |
| 32 | 📚 |
About gladiators and a sacred disease.
Biomedical journal (Biomed J ) Vol: 45 Issue: 1 Pages: 1-8 Pub: 2022 Feb ePub: 2022 Mar 23 Authors Kattner AA |
| 33 | 📚 |
An Overview of the Neuropharmacological Potential of Thymoquinone and its Targeted Delivery Prospects for CNS Disorder.
Current drug metabolism (Curr Drug Metab ) Vol: 23 Issue: 6 Pages: 447-459 Pub: 2022 ePub: Authors Verma R,Sartaj A,Qizilbash FF,Ghoneim MM,Alshehri S,Imam SS,Kala C,Alam MS,Gilani SJ,Taleuzzaman M |
| 34 | 📚 |
Anticonvulsant activities of Sambucus nigra.
European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci ) Vol: 20 Issue: 14 Pages: 3123-6 Pub: 2016 Jul ePub: Authors Ataee R,Falahati A,Ebrahimzadeh MA,Shokrzadeh M |
| 35 | 📚 |
Association between seizure reduction during ketogenic diet treatment of epilepsy and changes in circulatory metabolites and gut microbiota composition.
EBioMedicine (EBioMedicine ) Vol: 109 Issue: Pages: 105400 Pub: 2024 Nov ePub: 2024 Nov 4 Authors Dahlin M,Wheelock CE,Prast-Nielsen S |
| 36 | 📚 |
Effect of arctigenin on neurological diseases: A review.
Journal of ethnopharmacology (J Ethnopharmacol ) Vol: 315 Issue: Pages: 116642 Pub: 2023 Oct 28 ePub: 2023 May 24 Authors Li M,Jiang H,Wang Y,Xu Z,Xu H,Chen Y,Zhu J,Lin Z,Zhang M |
| 37 | 📚 |
Preventive and therapeutic impact of probiotic supplementation on behavior and inflammatory responses in the PTZ-induced chemical kindling in rats.
Psychopharmacology (Psychopharmacology (Berl) ) Vol: 242 Issue: 4 Pages: 783-792 Pub: 2025 Apr ePub: 2025 Feb 18 Authors Tahmasebi S,Bonab SF,Ghafouri-Fard S,Eslami S |
| 38 | 📚 |
The Effects of G2013 (a-L-guluronic Acid) in a Pentylenetetrazole-induced Kindling Animal Model of Epilepsy.
Innovations in clinical neuroscience (Innov Clin Neurosci ) Vol: 17 Issue: 4-6 Pages: 9-12 Pub: 2020 Apr 1 ePub: Authors Tahmasebi S,Azizi G,Miladi H,Shafiei E,Kamali AN,Hamedifar H,Fayyaz F,Rasouli SE,Kalvandi M,Mohammadi H,Hassannia H,Eslami S,Hamid KM,Mirshafiey A |
The following items have been cited in the above studies
| ID | Studies | Name | AKA |
|---|---|---|---|
| 2952 | 1 | Arctium lappa {Burdock Root} | Lappa,Beggar's buttons,Thorny burr,Happy major,Fox's clote,Cockle buttons,Love leaves,Philanthropium,Personata,Clot-bur |
| 46 | 1 | Bifidobacterium animalis subsp. lactis {B. Lactis} | Includes BB-12, DN-173 010 ,Bifidobacterium Regularis,Bifidus Regularis |
| 50 | 2 | bifidobacterium longum {B.Longum } | May include Bifidobacterium longum subsp. infantis and Bifidobacterium longum subsp. longum |
| 215 | 2 | ketogenic diet | |
| 1918 | 1 | lactobacillus helveticus {L. helveticus} | |
| 245 | 1 | Limosilactobacillus reuteri {L. Reuteri} | Lactobacillus fermentum subsp. reuteri |
| 1719 | 1 | Nigella sativa {black cumin} | black seed, black caraway, kalonji,fennel flower |
| 2863 | 1 | Sambucus nigra L. ssp. canadensis {Elderberry} | Sweet elder,Wild elder,Flor sauco,Tree of music,Danewort,Walewort,New Mexican elderberry,Velvet-leaf elder,Hairy blue elderberry,Dwarf elder,Common elder |
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