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Functional constipation / chronic idiopathic constipation

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Common knowledge amoung some professionals (MD and ND):

  1. Fiber Supplements: Fiber is known to promote regular bowel movements and alleviate constipation. Supplements containing soluble fiber (psyllium husk, methylcellulose) or insoluble fiber might help improve stool consistency and bowel regularity. However, it's essential to increase fiber intake gradually and ensure adequate hydration to prevent discomfort.

  2. Probiotics: Probiotics are beneficial bacteria that might support gut health. Some research suggests that certain probiotics, especially strains like Bifidobacterium and Lactobacillus, might have a role in improving bowel habits and stool consistency. However, the specific strains, dosages, and their effectiveness for constipation require further investigation.

  3. Magnesium: Magnesium supplements might have a mild laxative effect by drawing water into the intestines and softening stools. However, excessive magnesium intake can cause diarrhea or other side effects, so it's crucial to use magnesium supplements cautiously and under medical guidance.

  4. Prune Juice or Prune Extract: Prunes and prune juice contain sorbitol and fiber, which can help soften stools and promote bowel movements. Some individuals find relief from constipation by including prunes or prune juice in their diet.

  5. Osmotic Laxatives: These are over-the-counter medications that help draw water into the intestines to soften stools and ease constipation. Examples include polyethylene glycol (PEG) and lactulose. These should be used under the guidance of a healthcare professional.


Bacteria/Taxa

The Studies below identify bacteria. Check if it has already been reviewed.

1 πŸ“š
Acupoint Massage Therapy Alters the Composition of Gut Microbiome in Functional Constipation Patients.
Evidence-based complementary and alternative medicine : eCAM (Evid Based Complement Alternat Med ) Vol: 2021 Issue: Pages: 1416236 Pub: 2021 ePub: 2021 Jan 12 Authors Chen H,Tan PS,Li CP,Chen BZ,Xu YQ,He YQ,Ke X
2 πŸ“š
Altered gut microbial profile is associated with differentially expressed fecal microRNAs in patients with functional constipation.
Frontiers in microbiology (Front Microbiol ) Vol: 14 Issue: Pages: 1323877 Pub: 2023 ePub: 2024 Jan 11 Authors Yao J,Yan X,Li Y,Chen Y,Xiao X,Zhou S,Zhang W,Wang L,Chen M,Zeng F,Li Y
3 πŸ“š
Analysis of Gut Microbiome and Metabolite Characteristics in Patients with Slow Transit Constipation.
Digestive diseases and sciences (Dig Dis Sci ) Vol: Issue: Pages: Pub: 2020 Aug 7 ePub: 2020 Aug 7 Authors Tian H,Chen Q,Yang B,Qin H,Li N
4 πŸ“š
Antipsychotic-induced gastrointestinal hypomotility and the alteration in gut microbiota in patients with schizophrenia.
Brain, behavior, and immunity (Brain Behav Immun ) Vol: 99 Issue: Pages: 119-129 Pub: 2022 Jan ePub: 2021 Sep 24 Authors Xu Y,Shao M,Fang X,Tang W,Zhou C,Hu X,Zhang X,Su KP
5 πŸ“š
Assessing the causal effects of Eubacterium and Rumphococcus on constipation: a Mendelian randomized study.
Frontiers in microbiology (Front Microbiol ) Vol: 15 Issue: Pages: 1376232 Pub: 2024 ePub: 2024 Jul 31 Authors Zhang X,Chen J,He F,Du W,Yu X
6 πŸ“š
Bowel Habits, Obesity, Intestinal Microbiota and Their Influence on Hemorrhoidal Disease: a Mendelian Randomization Study.
Clinical and experimental gastroenterology (Clin Exp Gastroenterol ) Vol: 17 Issue: Pages: 157-164 Pub: 2024 ePub: 2024 May 10 Authors Yu M,Shang Y,Han L,Yu X
7 πŸ“š
Characterization of gut contractility and microbiota in patients with severe chronic constipation.
PloS one (PLoS One ) Vol: 15 Issue: 7 Pages: e0235985 Pub: 2020 ePub: 2020 Jul 17 Authors Yarullina DR,Shafigullin MU,Sakulin KA,Arzamastseva AA,Shaidullov IF,Markelova MI,Grigoryeva TV,Karpukhin OY,Sitdikova GF
8 πŸ“š
Characterization of Microbiota in Children with Chronic Functional Constipation.
PloS one (PLoS One ) Vol: 11 Issue: 10 Pages: e0164731 Pub: 2016 ePub: 2016 Oct 19 Authors de Meij TG,de Groot EF,Eck A,Budding AE,Kneepkens CM,Benninga MA,van Bodegraven AA,Savelkoul PH
9 πŸ“š
Consumption of Wheat Peptides Improves Functional Constipation: A Translational Study in Humans and Mice.
Molecular nutrition & food research (Mol Nutr Food Res ) Vol: 66 Issue: 19 Pages: e2200313 Pub: 2022 Oct ePub: 2022 Aug 9 Authors Wang Q,Shen F,Zhang J,Cai H,Pan Y,Sun T,Gong Y,Du J,Zhong H,Feng F
10 πŸ“š
Gut Environment and Dietary Habits in Healthy Japanese Adults and their Association with Bowel Movement.
Digestion (Digestion ) Vol: Issue: Pages: 1-11 Pub: 2019 Aug 21 ePub: 2019 Aug 21 Authors Tanabe A,Adachi K,Yamaguchi Y,Izawa S,Yamamoto S,Hijikata Y,Ebi M,Funaki Y,Ogasawara N,Goto C,Sasaki M,Kasugai K
11 πŸ“š
Gut Microbiota Altered in Mild Cognitive Impairment Compared With Normal Cognition in Sporadic Parkinson's Disease.
Frontiers in neurology (Front Neurol ) Vol: 11 Issue: Pages: 137 Pub: 2020 ePub: 2020 Feb 25 Authors Ren T,Gao Y,Qiu Y,Jiang S,Zhang Q,Zhang J,Wang L,Zhang Y,Wang L,Nie K
12 πŸ“š
Gut Microbiota and Chronic Constipation: A Review and Update.
Frontiers in medicine (Front Med (Lausanne) ) Vol: 6 Issue: Pages: 19 Pub: 2019 ePub: 2019 Feb 12 Authors Ohkusa T,Koido S,Nishikawa Y,Sato N
13 πŸ“š
Gut Microbiota and Metabolite Profiles Associated With Functional Constipation Severity.
Microbiology and immunology (Microbiol Immunol ) Vol: 69 Issue: 2 Pages: 85-95 Pub: 2025 Feb ePub: 2024 Dec 1 Authors Wang J,He J,Liu D,Zhang T,Wu Y,Xie M
14 πŸ“š
Gut Microbiota Composition Changes in Constipated Women of Reproductive Age.
Frontiers in cellular and infection microbiology (Front Cell Infect Microbiol ) Vol: 10 Issue: Pages: 557515 Pub: 2020 ePub: 2021 Jan 21 Authors Li H,Chen J,Ren X,Yang C,Liu S,Bai X,Shan S,Dong X
15 πŸ“š
High Oscillospira abundance indicates constipation and low BMI in the Guangdong Gut Microbiome Project.
Scientific reports (Sci Rep ) Vol: 10 Issue: 1 Pages: 9364 Pub: 2020 Jun 9 ePub: 2020 Jun 9 Authors Chen YR,Zheng HM,Zhang GX,Chen FL,Chen LD,Yang ZC
16 πŸ“š
Inhibitory Effect of Lactococcus lactis subsp. lactis HFY14 on Diphenoxylate-Induced Constipation in Mice by Regulating the VIP-cAMP-PKA-AQP3 Signaling Pathway.
Drug design, development and therapy (Drug Des Devel Ther ) Vol: 15 Issue: Pages: 1971-1980 Pub: 2021 ePub: 2021 May 11 Authors Tan Q,Hu J,Zhou Y,Wan Y,Zhang C,Liu X,Long X,Tan F,Zhao X
17 πŸ“š
Irritable Bowel Syndrome, Particularly the Constipation-Predominant Form, Involves an Increase in <i>Methanobrevibacter smithii</i>, Which Is Associated with Higher Methane Production.
Gut and liver (Gut Liver ) Vol: 10 Issue: 6 Pages: 932-938 Pub: 2016 Nov 15 ePub: Authors Ghoshal U,Shukla R,Srivastava D,Ghoshal UC
18 πŸ“š
Moringa oleifera leaf alleviates functional constipation via regulating the gut microbiota and the enteric nervous system in mice.
Frontiers in microbiology (Front Microbiol ) Vol: 14 Issue: Pages: 1315402 Pub: 2023 ePub: 2023 Dec 20 Authors Gao X,Yang W,Li S,Liu S,Yang W,Song S,Sheng J,Zhao Y,Tian Y
19 πŸ“š
Multi-omics analyses demonstrate the modulating role of gut microbiota on the associations of unbalanced dietary intake with gastrointestinal symptoms in children with autism spectrum disorder.
Gut microbes (Gut Microbes ) Vol: 15 Issue: 2 Pages: 2281350 Pub: 2023 Dec ePub: 2023 Nov 27 Authors Li H,Liu C,Huang S,Wang X,Cao M,Gu T,Ou X,Pan S,Lin Z,Wang X,Zhu Y,Jing J
20 πŸ“š
Potential role of fecal microbiota in patients with constipation.
Therapeutic advances in gastroenterology (Therap Adv Gastroenterol ) Vol: 13 Issue: Pages: 1756284820968423 Pub: 2020 ePub: 2020 Oct 31 Authors Tian Y,Zuo L,Guo Q,Li J,Hu Z,Zhao K,Li C,Li X,Zhou J,Zhou Y,Li XA
21 πŸ“š
Progranulin inhibits autophagy to facilitate intracellular colonization of Helicobacter pylori through the PGRN/mTOR/DCN axis in gastric epithelial cells.
Frontiers in cellular and infection microbiology (Front Cell Infect Microbiol ) Vol: 14 Issue: Pages: 1425367 Pub: 2024 ePub: 2024 Jul 31 Authors Liu L,Xiang M,Zhou J,Ren Z,Shi W,Du X,Fu X,Li P,Wang H
22 πŸ“š
The composition of intestinal microbiota and its association with functional constipation of the elderly patients.
Future microbiology (Future Microbiol ) Vol: 15 Issue: Pages: 163-175 Pub: 2020 Feb ePub: 2020 Feb 21 Authors Guo M,Yao J,Yang F,Liu W,Bai H,Ma J,Ma X,Zhang J,Fang Y,Miao Y,Sun J,Zhang Y,Zhao H
23 πŸ“š
The oral cavity and intestinal microbiome in children with functional constipation.
Scientific reports (Sci Rep ) Vol: 14 Issue: 1 Pages: 8283 Pub: 2024 Apr 9 ePub: 2024 Apr 9 Authors Kwiatkowska M,Golebiewski M,Sikora M,Rycharska EL,Krogulska A
24 πŸ“š
Unveiling the gut microbiota composition and functionality associated with constipation through metagenomic analyses.
Scientific reports (Sci Rep ) Vol: 7 Issue: 1 Pages: 9879 Pub: 2017 Aug 29 ePub: 2017 Aug 29 Authors Mancabelli L,Milani C,Lugli GA,Turroni F,Mangifesta M,Viappiani A,Ticinesi A,Nouvenne A,Meschi T,van Sinderen D,Ventura M

Treatment Substances

The Studies below identify substances that has been tried with positive changes (for at least some symptoms in the study). Check if it has already been reviewed.

25 πŸ“š
Bacillus coagulans (PROBACI) in treating constipation-dominant functional bowel disorders.
Medicine (Medicine (Baltimore) ) Vol: 99 Issue: 19 Pages: e20098 Pub: 2020 May ePub: Authors Chang CW,Chen MJ,Shih SC,Chang CW,Chiau JC,Lee HC,Lin YS,Lin WC,Wang HY
26 πŸ“š
Bacillus Subtilis (BG01-4(TM)) Improves Self-Reported Symptoms for Constipation, Indigestion, and Dyspepsia: A Phase 1/2A Randomized Controlled Trial.
Nutrients (Nutrients ) Vol: 15 Issue: 21 Pages: Pub: 2023 Oct 24 ePub: 2023 Oct 24 Authors Patch C,Pearce AJ,Cheng M,Boyapati R,Brenna JT
27 πŸ“š
Bifidobacterium lactis TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice.
Frontiers in nutrition (Front Nutr ) Vol: 9 Issue: Pages: 890314 Pub: 2022 ePub: 2022 Jun 29 Authors Tang T,Wang J,Jiang Y,Zhu X,Zhang Z,Wang Y,Shu X,Deng Y,Zhang F
28 πŸ“š
Comparative effects of different enzymatic hydrolysates of konjac glucomannan on gut flora and constipation in rats.
Food & function (Food Funct ) Vol: 13 Issue: 16 Pages: 8717-8729 Pub: 2022 Aug 15 ePub: 2022 Aug 15 Authors Chang XY,Liu YY,Hu MM,Liu YQ,Jiang CH,Wang Q,Jin QM,Zhang DJ,Yin ZQ,Zhang J
29 πŸ“š
Effect of Bacillus coagulans Unique IS2 with Lactulose on Functional Constipation in Adults: a Double-Blind Placebo Controlled Study.
Probiotics and antimicrobial proteins (Probiotics Antimicrob Proteins ) Vol: 15 Issue: 2 Pages: 379-386 Pub: 2023 Apr ePub: 2021 Oct 2 Authors Venkataraman R,Shenoy R,Ahire JJ,Neelamraju J,Madempudi RS
30 πŸ“š
Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial.
Scientific reports (Sci Rep ) Vol: 14 Issue: 1 Pages: 22384 Pub: 2024 Sep 27 ePub: 2024 Sep 27 Authors Kwon H,Nam EH,Kim H,Jo H,Bang WY,Lee M,Shin H,Kim D,Kim J,Kim H,Lee J,Jung YH,Yang J,Won DD,Shin M
31 πŸ“š
Effect of Lactobacillus reuteri (DSM 17938) on methane production in patients affected by functional constipation: a retrospective study.
European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci ) Vol: 21 Issue: 7 Pages: 1702-1708 Pub: 2017 Apr ePub: Authors Ojetti V,Petruzziello C,Migneco A,Gnarra M,Gasbarrini A,Franceschi F
32 πŸ“š
Effect of the ingestion of a symbiotic yogurt on the bowel habits of women with functional constipation.
Acta gastroenterologica Latinoamericana (Acta Gastroenterol Latinoam ) Vol: 38 Issue: 1 Pages: 16-25 Pub: 2008 Mar ePub: Authors De Paula JA,Carmuega E,Weill R
33 πŸ“š
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review.
Journal of clinical gastroenterology (J Clin Gastroenterol ) Vol: 52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017 Issue: Pages: S10-S26 Pub: 2018 Nov/Dec ePub: Authors Wegh CAM,Benninga MA,Tabbers MM
34 πŸ“š
Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial.
Gut microbes (Gut Microbes ) Vol: 9 Issue: 3 Pages: 236-251 Pub: 2018 ePub: 2018 Feb 8 Authors Ibarra A,Latreille-Barbier M,Donazzolo Y,Pelletier X,Ouwehand AC
35 πŸ“š
Effects of a probiotic fermented milk on functional constipation: a randomized, double-blind, placebo-controlled study.
Journal of gastroenterology and hepatology (J Gastroenterol Hepatol ) Vol: 28 Issue: 7 Pages: 1141-7 Pub: 2013 Jul ePub: Authors Mazlyn MM,Nagarajah LH,Fatimah A,Norimah AK,Goh KL
36 πŸ“š
Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial.
Gut microbes (Gut Microbes ) Vol: 15 Issue: 1 Pages: 2197837 Pub: 2023 Jan-Dec ePub: Authors Lai H,Li Y,He Y,Chen F,Mi B,Li J,Xie J,Ma G,Yang J,Xu K,Liao X,Yin Y,Liang J,Kong L,Wang X,Li Z,Shen Y,Dang S,Zhang L,Wu Q,Zeng L,Shi L,Zhang X,Tian T,Liu X
37 πŸ“š
Effects of garlic-derived fructan and oligofructose mixtures on intestinal health and constipation relief in mice.
Journal of the science of food and agriculture (J Sci Food Agric ) Vol: 104 Issue: 12 Pages: 7476-7487 Pub: 2024 Sep ePub: 2024 May 14 Authors Xie C,Gao W,Liang X,Chye FY
38 πŸ“š
Effects of long-term administration of Lactobacillus reuteri DSM-17938 on circulating levels of 5-HT and BDNF in adults with functional constipation.
Beneficial microbes (Benef Microbes ) Vol: 10 Issue: 2 Pages: 137-147 Pub: 2019 Mar 13 ePub: 2018 Dec 21 Authors Riezzo G,Chimienti G,Orlando A,D`Attoma B,Clemente C,Russo F
39 πŸ“š
Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials.
European journal of pediatrics (Eur J Pediatr ) Vol: Issue: Pages: Pub: 2024 May 29 ePub: 2024 May 29 Authors Yang WC,Zeng BS,Liang CS,Hsu CW,Su KP,Wu YC,Tu YK,Lin PY,Stubbs B,Chen TY,Chen YW,Shiue YL,Zeng BY,Suen MW,Hung CM,Wu MK,Tseng PT
40 πŸ“š
Efficacy of a mixture of probiotic agents as complementary therapy for chronic functional constipation in childhood.
Italian journal of pediatrics (Ital J Pediatr ) Vol: 43 Issue: 1 Pages: 24 Pub: 2017 Mar 7 ePub: 2017 Mar 7 Authors Russo M,Giugliano FP,Quitadamo P,Mancusi V,Miele E,Staiano A
41 πŸ“š
Fructooligosaccharides for Relieving Functional Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Foods (Basel, Switzerland) (Foods ) Vol: 13 Issue: 24 Pages: Pub: 2024 Dec 11 ePub: 2024 Dec 11 Authors Zhen H,Qian H,Liu X,Tan C
42 πŸ“š
Herbal Medicine for the Management of Laxative Activity.
Current pharmaceutical biotechnology (Curr Pharm Biotechnol ) Vol: 23 Issue: 10 Pages: 1269-1283 Pub: 2022 ePub: Authors Akram M,Thiruvengadam M,Zainab R,Daniyal M,Bankole MM,Rebezov M,Shariati MA,Okuskhanova E
43 πŸ“š
Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial.
Journal of digestive diseases (J Dig Dis ) Vol: 20 Issue: 9 Pages: 435-446 Pub: 2019 Sep ePub: 2019 Aug 1 Authors Martoni CJ,Evans M,Chow CT,Chan LS,Leyer G
44 πŸ“š
Industrial Application and Health Prospective of Fig (Ficus carica) By-Products.
Molecules (Basel, Switzerland) (Molecules ) Vol: 28 Issue: 3 Pages: Pub: 2023 Jan 18 ePub: 2023 Jan 18 Authors Rasool IFU,Aziz A,Khalid W,Koraqi H,Siddiqui SA,Al-Farga A,Lai WF,Ali A
45 πŸ“š
Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology (Turk J Gastroenterol ) Vol: 28 Issue: 5 Pages: 388-393 Pub: 2017 Sep ePub: 2017 Jul 13 Authors BastΓΌrk A,Artan R,Atalay A,Yilmaz A
46 πŸ“š
Irritable Bowel Syndrome.
Current treatment options in gastroenterology (Curr Treat Options Gastroenterol ) Vol: 5 Issue: 4 Pages: 267-278 Pub: 2002 Aug ePub: Authors Sach JA,Chang L
47 πŸ“š
Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5-hydroxytryptamine hormone release.
Nutrition (Burbank, Los Angeles County, Calif.) (Nutrition ) Vol: 84 Issue: Pages: 111112 Pub: 2021 Apr ePub: 2020 Dec 13 Authors Lu Y,Zhang J,Zhang Z,Liang X,Liu T,Yi H,Gong P,Wang L,Yang W,Zhang X,Zhang L,Yang L,Shi H
48 πŸ“š
Lack of Benefit of Lactobacillus reuteri DSM 17938 as an Addition to the Treatment of Functional Constipation.
Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr ) Vol: 67 Issue: 6 Pages: 763-766 Pub: 2018 Dec ePub: Authors JadreΕ‘in O,Sila S,Trivic I,MiΕ‘ak Z,Hojsak I,Kolacek S
49 πŸ“š
Lacticaseibacillus paracasei NCU-04 relieves constipation and the depressive-like behaviors induced by loperamide in mice through the microbiome-gut-brain axis.
Current research in food science (Curr Res Food Sci ) Vol: 9 Issue: Pages: 100875 Pub: 2024 ePub: 2024 Oct 4 Authors Li S,Li Y,Cai Y,Yan Z,Wei J,Zhang H,Yue F,Chen T
50 πŸ“š
Lacticaseibacillus rhamnosus LRJ-1 alleviates constipation through promoting gut Bacteroides-derived ?-aminobutyric acid production.
Current research in food science (Curr Res Food Sci ) Vol: 9 Issue: Pages: 100924 Pub: 2024 ePub: 2024 Nov 12 Authors Xia T,Huang F,Yun F,Liu Y,Wang T,Wang S,Jin S,Ma X,Wang W,He J,Teng K,Zhong J
51 πŸ“š
Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial.
The Journal of pediatrics (J Pediatr ) Vol: 184 Issue: Pages: 101-105.e1 Pub: 2017 May ePub: 2017 Mar 8 Authors Wojtyniak K,Horvath A,Dziechciarz P,Szajewska H
52 πŸ“š
Lactobacillus paracasei Relieves Constipation by Acting on the Acetic Acid-5-HT-Intestinal Motility Pathway.
Foods (Basel, Switzerland) (Foods ) Vol: 12 Issue: 22 Pages: Pub: 2023 Nov 20 ePub: 2023 Nov 20 Authors Wang L,Yang S,Mei C,Tang N,Wang J,Yu Q,Wang G,Wu G,Zhao J,Chen W
53 πŸ“š
Lactobacillus rhamnosus Strains Relieve Loperamide-Induced Constipation via Different Pathways Independent of Short-Chain Fatty Acids.
Frontiers in cellular and infection microbiology (Front Cell Infect Microbiol ) Vol: 10 Issue: Pages: 423 Pub: 2020 ePub: 2020 Aug 19 Authors Wang G,Yang S,Sun S,Si Q,Wang L,Zhang Q,Wu G,Zhao J,Zhang H,Chen W
54 πŸ“š
Latilactobacillus sakei Furu2019 and stachyose as probiotics, prebiotics, and synbiotics alleviate constipation in mice.
Frontiers in nutrition (Front Nutr ) Vol: 9 Issue: Pages: 1039403 Pub: 2022 ePub: 2023 Jan 5 Authors Guo Y,Song L,Huang Y,Li X,Xiao Y,Wang Z,Ren Z
55 πŸ“š
Moringa oleifera leaf alleviates functional constipation via regulating the gut microbiota and the enteric nervous system in mice.
Frontiers in microbiology (Front Microbiol ) Vol: 14 Issue: Pages: 1315402 Pub: 2023 ePub: 2023 Dec 20 Authors Gao X,Yang W,Li S,Liu S,Yang W,Song S,Sheng J,Zhao Y,Tian Y
56 πŸ“š
Network meta-analysis of probiotics, prebiotics, and synbiotics for the treatment of chronic constipation in adults.
European journal of nutrition (Eur J Nutr ) Vol: 63 Issue: 6 Pages: 1999-2010 Pub: 2024 Sep ePub: 2024 May 2 Authors Deng X,Liang C,Zhou L,Shang X,Hui X,Hou L,Wang Y,Liu W,Liang S,Yao L,Yang K,Li X
57 πŸ“š
Pediococcus pentosaceus B49 from human colostrum ameliorates constipation in mice.
Food & function (Food Funct ) Vol: 11 Issue: 6 Pages: 5607-5620 Pub: 2020 Jun 24 ePub: Authors Huang J,Li S,Wang Q,Guan X,Qian L,Li J,Zheng Y,Lin B
58 πŸ“š
Positive effect of Bifidobacterium animalis subsp. lactis VHProbi YB11 in improving gastrointestinal movement of mice having constipation.
Frontiers in microbiology (Front Microbiol ) Vol: 13 Issue: Pages: 1040371 Pub: 2022 ePub: 2022 Dec 2 Authors Cui H,Wang Q,Feng C,Guo C,Zhang J,Bu X,Duan Z
59 πŸ“š
Prebiotics Improved the Defecation Status via Changes in the Microbiota and Short-chain Fatty Acids in Hemodialysis Patients.
The Kobe journal of medical sciences (Kobe J Med Sci ) Vol: 66 Issue: 1 Pages: E12-E21 Pub: 2020 Apr 1 ePub: 2020 Apr 1 Authors Miyoshi M,Shiroto A,Kadoguchi H,Usami M,Hori Y
60 πŸ“š
Prevention of loperamide induced constipation in mice by KGM and the mechanisms of different gastrointestinal tract microbiota regulation.
Carbohydrate polymers (Carbohydr Polym ) Vol: 256 Issue: Pages: 117418 Pub: 2021 Mar 15 ePub: 2020 Nov 21 Authors Zhang Q,Zhong D,Sun R,Zhang Y,Pegg RB,Zhong G
61 πŸ“š
Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice.
Scientific reports (Sci Rep ) Vol: 14 Issue: 1 Pages: 1131 Pub: 2024 Jan 11 ePub: 2024 Jan 11 Authors Cheng S,Cui H,Zhang J,Wang Q,Duan Z
62 πŸ“š
Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial.
JAMA pediatrics (JAMA Pediatr ) Vol: 168 Issue: 3 Pages: 228-33 Pub: 2014 Mar ePub: Authors Indrio F,Di Mauro A,Riezzo G,Civardi E,Intini C,Corvaglia L,Ballardini E,Bisceglia M,Cinquetti M,Brazzoduro E,Del Vecchio A,Tafuri S,Francavilla R
63 πŸ“š
Randomised double blind placebo controlled trial on Lactobacillus reuteri DSM 17938: improvement in symptoms and bowel habit in functional constipation.
Beneficial microbes (Benef Microbes ) Vol: 9 Issue: 1 Pages: 51-60 Pub: 2018 Jan 29 ePub: 2017 Oct 12 Authors Riezzo G,Orlando A,D`Attoma B,Linsalata M,Martulli M,Russo F
64 πŸ“š
Review article: inhibition of methanogenic archaea by statins as a targeted management strategy for constipation and related disorders.
Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther ) Vol: 43 Issue: 2 Pages: 197-212 Pub: 2016 Jan ePub: 2015 Nov 11 Authors Gottlieb K,Wacher V,Sliman J,Pimentel M
65 πŸ“š
Synbiotic yogurt containing konjac mannan oligosaccharides and Bifidobacterium animalis ssp. lactis BB12 alleviates constipation in mice by modulating the stem cell factor (SCF)/c-Kit pathway and gut microbiota.
Journal of dairy science (J Dairy Sci ) Vol: 104 Issue: 5 Pages: 5239-5255 Pub: 2021 May ePub: 2021 Mar 2 Authors Li T,Yan Q,Wen Y,Liu J,Sun J,Jiang Z
66 πŸ“š
Systematic review of randomised controlled trials: probiotics for functional constipation.
World journal of gastroenterology (World J Gastroenterol ) Vol: 16 Issue: 1 Pages: 69-75 Pub: 2010 Jan 7 ePub: Authors Chmielewska A,Szajewska H
67 πŸ“š
Systematic review: probiotics for functional constipation in children.
European journal of pediatrics (Eur J Pediatr ) Vol: 176 Issue: 9 Pages: 1155-1162 Pub: 2017 Sep ePub: 2017 Aug 1 Authors Wojtyniak K,Szajewska H
68 πŸ“š
The effect of Lactobacillus reuteri supplementation in adults with chronic functional constipation: a randomized, double-blind, placebo-controlled trial.
Journal of gastrointestinal and liver diseases : JGLD (J Gastrointestin Liver Dis ) Vol: 23 Issue: 4 Pages: 387-91 Pub: 2014 Dec ePub: Authors Ojetti V,Ianiro G,Tortora A,D`Angelo G,Di Rienzo TA,BibbΓ² S,Migneco A,Gasbarrini A
69 πŸ“š
The effect of probiotics as a treatment for constipation in elderly people: A systematic review.
Archives of gerontology and geriatrics (Arch Gerontol Geriatr ) Vol: 71 Issue: Pages: 142-149 Pub: 2017 Jul ePub: 2017 Apr 14 Authors MartΓ­nez-MartΓ­nez MI,Calabuig-TolsΓ‘ R,Cauli O
70 πŸ“š
The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials.
The American journal of clinical nutrition (Am J Clin Nutr ) Vol: 100 Issue: 4 Pages: 1075-84 Pub: 2014 Oct ePub: 2014 Aug 6 Authors Dimidi E,Christodoulides S,Fragkos KC,Scott SM,Whelan K
71 πŸ“š
The effectiveness of Lactobacillus reuteri DSM 17938 as an adjunct to macrogol in the treatment of functional constipation in children. A randomized, double-blind, placebo-controlled, multicentre trial.
Clinics and research in hepatology and gastroenterology (Clin Res Hepatol Gastroenterol ) Vol: 42 Issue: 5 Pages: 494-500 Pub: 2018 Oct ePub: 2018 Apr 9 Authors Wegner A,Banaszkiewicz A,Kierkus J,Landowski P,Korlatowicz-Bilar A,Wiecek S,Kwiecien J,Gawronska A,Dembinski L,Czaja-Bulsa G,Socha P
72 πŸ“š
The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial.
BMC nephrology (BMC Nephrol ) Vol: 23 Issue: 1 Pages: 259 Pub: 2022 Jul 22 ePub: 2022 Jul 22 Authors Lydia A,Indra TA,Rizka A,Abdullah M
73 πŸ“š
The role of a probiotics mixture in the treatment of childhood constipation: a pilot study.
Nutrition journal (Nutr J ) Vol: 6 Issue: Pages: 17 Pub: 2007 Aug 4 ePub: 2007 Aug 4 Authors Bekkali NL,Bongers ME,Van den Berg MM,Liem O,Benninga MA

Quick Reference

The following items have been cited in the above studies

IDStudiesNameAKA
7 1   allium sativum {garlic} garlic,allium sativum,allium
1881 4   Amorphophallus konjac {konjac} Glucomannan,Devil's Tongue,Voodoo Lily,Snake Palm,Corpse Flower,Konjac mannan
32 1   bacillus subtilis {B.Subtilis } Hay bacillus, grass bacillus,Vibrio subtilis
33 1   bacillus subtilis,lactobacillus acidophilus
3008 1   Bifidobacterium animalis {B. animalis} Bifidobacterium longum subsp. animalis biotype a,Bifidobacterium animalis subsp. lactis
46 3   Bifidobacterium animalis subsp. lactis {B. Lactis} Includes BB-12, DN-173 010 ,Bifidobacterium Regularis,Bifidus Regularis
1737 1   bifidobacterium bifidum {B. bifidum}
49 1   bifidobacterium infantis {B. infantis}
1757 1   bifidobacterium lactis,streptococcus thermophilus probiotic b lactis,streptococcus thermophilus probiotic
50 2   bifidobacterium longum {B.Longum } May include Bifidobacterium longum subsp. infantis and Bifidobacterium longum subsp. longum
51 1   Bifidobacterium longum subsp. longum BB536 {BB536} Morinaga BB536, robiotic BB536
1756 1   enterococcus faecium {E. faecium} Was Streptococcus faecium, sometimes Enterococcus lactis
4565 1   ficus carica {fig}
150 2   fructo-oligosaccharides fos,(fos),fructooligosaccharide,fructooligosaccharides,oligofructose
29 3   Heyndrickxia coagulans {B. coagulans} Was Bacillus coagulans,AKA Weizmannia faecalis,lactobacillus sporogenes
1674 1   Human milk oligosaccharides (prebiotic, Holigos, Stachyose) Stachyose,2'-Fucosyllactose ,2'-FL
234 5   Lacticaseibacillus casei {L. casei} Streptobacterium casei,Lactobacillus casei
241 4   Lacticaseibacillus paracasei {L.paracasei} Was also known as Lactobacillus casei subsp. pseudoplantarum
246 12   Lacticaseibacillus rhamnosus {l. rhamnosus} lactobacillus rhamnosus, Lactobacillus casei subsp. rhamnosus
230 1   lactobacillus acidophilus {L. acidophilus} Bacillus acidophilus
1918 1   lactobacillus helveticus {L. helveticus}
1731 1   lactobacillus paracasei,lactobacillus acidophilus,bifidobacterium animalis l paracasei,l acidophilus,bifidobacterium animalis (probiotics)
243 3   Lactobacillus plantarum {L. plantarum} lactobacillus plantarum, Lactobacillus arabinosus
247 2   lactobacillus rhamnosus gg l rhamnosus gg (probiotics)
115 2   lactobacillus rhamnosus gg,bifidobacterium animalis lactis ,lactobacillus paracasei {cvs maximum strength probiotic}
1773 1   Latilactobacillus sakei {Lactobacillus sakei} Lactobacillus bavaricus
245 8   Limosilactobacillus reuteri {L. Reuteri} Lactobacillus fermentum subsp. reuteri
1367 1   lovastatin,(prescription) (advicor, ai le ting, altoprev, apo-lovastatin, asacor, aterkey, cholilysis, colesvir, delipic, deolip, du le, elstin, gengxian, holetar, jun ning, justin, le huo, lefuxin, leslipid, liferzit, lipdaune, lipdip, lipidless, lipopres, liporedux, liposcler, liprox, lipus, lofacol, lostatin, lostin, lotivas, lotyn, lovabeta, lovachol, lovacol, lovacor, lovadac, lovadura, lovahexal, lovapen, lovast, lovasta, lovastan, lovastatin - 1 a pharma, lovastatin actavis, lovastatin al, lovastatin alternova, lovastatin domesco, lovastatin hexal, lovastatin laropharm, lovastatin ratiopharm, lovastatin sanis health, lovastatin stada, lovastatina, lovastatina andromaco, lovastatina anglopharma, lovastatina arena, lovastatina bexal, lovastatina bussié, lovastatina cinfa, lovastatina cuve, lovastatina edigen, lovastatina farmandina, lovastatina genericos juventus, lovastatina generis, lovastatina genfar, lovastatina germed, lovastatina interpharma, lovastatina jaba, lovastatina kern pharma, lovastatina l.ch., lovastatina la santé, lovastatina labesfal, lovastatina lareq, lovastatina mabo, lovastatina mepha, lovastatina mintlab, lovastatina mk, lovastatina mylan, lovastatina normon, lovastatina pasteur, lovastatina pensa, lovastatina qualigen, lovastatina ratiopharm, lovastatina sandoz, lovastatina teva, lovastatina tevagen, lovastatina vir, lovastatina winthrop, lovastatin-ct, lovastatin-ratiopharm, lovasterol, lovastin, lovastin g.m., lovastmed, lovastrol, lovatex, lovatin, lovatop, lovatrol, lovinacor, lowchol, lowlipid, lowsta, lozutin, luo zhi da, luohuaning, medostatin, medovascin, medovaskin, meixinjie, mevacor, mevastin, ming wei xin, misodomin, nabicortin, nergadan, pms-lovastatin, rextat, riva-lovastatin, rovacor, sancos, sandoz lovastatin, su xin, taucor, tavacor, xin lu, xue qing)
4425 1   Moringa Oleifera Moringa
1718 1   partially hydrolysed guar gum partially hydrolyzed guar gum
2830 1   Pediococcus pentosaceus {P. pentosaceus} Lactobacillus sp. SL-1
361 1   Rheum × hybridum {Rhubarb} Rhei or Dahuang
388 1   statins (prescription)
1709 2   synthetic disaccharide derivative of lactose {Lactulose} Consists of one molecule of galactose and one molecule of fructose. Constulose, Enulose, Generlac, and Kristalose

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