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ADHD

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Common knowledge amoung some professionals (MD and ND):

  1. Omega-3 Fatty Acids: Omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) found in fish oil, have been investigated for their potential benefits in improving cognitive function and reducing symptoms of ADHD. Some studies suggest that omega-3 supplementation might have a modest positive effect on attention and behavior in some individuals with ADHD.

  2. Probiotics and Gut-Brain Axis: Research into the gut-brain axis, the connection between the gut microbiota and brain function, is ongoing. Some studies have suggested that imbalances in the gut microbiome may be linked to certain neurological conditions, including ADHD. While there's limited direct evidence for the use of probiotics in treating ADHD, maintaining a healthy gut microbiota through probiotics and a balanced diet might have indirect benefits on overall health, including mental health.

  3. Zinc: Some studies have explored the role of zinc in ADHD. Zinc is an essential mineral involved in neurotransmitter function and cognitive processes. While evidence is mixed, some research suggests that zinc supplementation may benefit a subset of individuals with ADHD who have lower zinc levels.

  4. Iron: Iron is important for brain function and cognitive development. Low iron levels have been associated with attention problems in children. However, iron supplementation should only be used when there is a diagnosed iron deficiency, as excessive iron intake can be harmful.

  5. Multivitamins and Minerals: Ensuring adequate intake of essential vitamins and minerals through a balanced diet or supplements may support overall health. While there's limited evidence supporting their direct effect on ADHD symptoms, deficiencies in certain nutrients may contribute to behavioral issues or affect cognitive function.


Bacteria/Taxa

The Studies below identify bacteria. Check if it has already been reviewed.

1 📚
A Systematic Review of the Microbiome in Children With Neurodevelopmental Disorders.
Frontiers in neurology (Front Neurol ) Vol: 10 Issue: Pages: 727 Pub: 2019 ePub: 2019 Jul 30 Authors Lacorte E,Gervasi G,Bacigalupo I,Vanacore N,Raucci U,Parisi P
2 📚
Anti-Basal Ganglia Antibodies and Streptococcal Infection in ADHD.
Journal of attention disorders (J Atten Disord ) Vol: 22 Issue: 9 Pages: 864-871 Pub: 2018 Jul ePub: 2015 Apr 16 Authors Aguilera-Albesa S,Crespo-Eguílaz N,Del Pozo JL,Villoslada P,Sánchez-Carpintero R
3 📚
Association between Gut Microbiota and Emotional-Behavioral Symptoms in Children with Attention-Deficit/Hyperactivity Disorder.
Journal of personalized medicine (J Pers Med ) Vol: 12 Issue: 10 Pages: Pub: 2022 Oct 2 ePub: 2022 Oct 2 Authors Lee MJ,Lai HC,Kuo YL,Chen VC
4 📚
Current Limitations for the Assessment of the Role of the Gut Microbiome for Attention Deficit Hyperactivity Disorder (ADHD).
Frontiers in psychiatry (Front Psychiatry ) Vol: 11 Issue: Pages: 623 Pub: 2020 ePub: 2020 Jun 26 Authors Hiergeist A,Gessner J,Gessner A
5 📚
Group A Streptococcal Infections Are Associated With Increased Risk of Pediatric Neuropsychiatric Disorders: A Taiwanese Population-Based Cohort Study.
The Journal of clinical psychiatry (J Clin Psychiatry ) Vol: 77 Issue: 7 Pages: e848-54 Pub: 2016 Jul ePub: Authors Wang HC,Lau CI,Lin CC,Chang A,Kao CH
6 📚
Gut microbiome differences in children with Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder and effects of probiotic supplementation: A randomized controlled trial.
Research in developmental disabilities (Res Dev Disabil ) Vol: 161 Issue: Pages: 105003 Pub: 2025 Apr 3 ePub: 2025 Apr 3 Authors Novau-Ferré N,Papandreou C,Rojo-Marticella M,Canals-Sans J,Bulló M
7 📚
Gut microbiome in ADHD and its relation to neural reward anticipation.
PloS one (PLoS One ) Vol: 12 Issue: 9 Pages: e0183509 Pub: 2017 ePub: 2017 Sep 1 Authors Aarts E,Ederveen THA,Naaijen J,Zwiers MP,Boekhorst J,Timmerman HM,Smeekens SP,Netea MG,Buitelaar JK,Franke B,van Hijum SAFT,Arias Vasquez A
8 📚
Gut Microbiota and Clinical Manifestations in Thai Pediatric Patients with Attention-Deficit Hyperactivity Disorder.
Journal of personalized medicine (J Pers Med ) Vol: 14 Issue: 7 Pages: Pub: 2024 Jul 10 ePub: 2024 Jul 10 Authors Panpetch J,Kiatrungrit K,Tuntipopipat S,Tangphatsornruang S,Mhuantong W,Chongviriyaphan N
9 📚
Gut microbiota and dietary patterns in children with attention-deficit/hyperactivity disorder.
European child & adolescent psychiatry (Eur Child Adolesc Psychiatry ) Vol: 29 Issue: 3 Pages: 287-297 Pub: 2020 Mar ePub: 2019 May 22 Authors Wang LJ,Yang CY,Chou WJ,Lee MJ,Chou MC,Kuo HC,Yeh YM,Lee SY,Huang LH,Li SC
10 📚
Gut microbiota profiles in treatment-naïve children with attention deficit hyperactivity disorder.
Behavioural brain research (Behav Brain Res ) Vol: 347 Issue: Pages: 408-413 Pub: 2018 Jul 16 ePub: 2018 Mar 23 Authors Jiang HY,Zhou YY,Zhou GL,Li YC,Yuan J,Li XH,Ruan B
11 📚
Gut microbiota signature in treatment-naïve attention-deficit/hyperactivity disorder.
Translational psychiatry (Transl Psychiatry ) Vol: 11 Issue: 1 Pages: 382 Pub: 2021 Jul 8 ePub: 2021 Jul 8 Authors Richarte V,Sánchez-Mora C,Corrales M,Fadeuilhe C,Vilar-Ribó L,Arribas L,Garcia E,Rosales-Ortiz SK,Arias-Vasquez A,Soler-Artigas M,Ribasés M,Ramos-Quiroga JA
12 📚
Identifying psychiatric disorder-associated gut microbiota using microbiota-related gene set enrichment analysis.
Briefings in bioinformatics (Brief Bioinform ) Vol: Issue: Pages: Pub: 2019 Apr 5 ePub: 2019 Apr 5 Authors Cheng S,Han B,Ding M,Wen Y,Ma M,Zhang L,Qi X,Cheng B,Li P,Kafle OP,Liang X,Liu L,Du Y,Zhao Y,Zhang F
13 📚
Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms.
Microorganisms (Microorganisms ) Vol: 8 Issue: 3 Pages: Pub: 2020 Mar 13 ePub: 2020 Mar 13 Authors Szopinska-Tokov J,Dam S,Naaijen J,Konstanti P,Rommelse N,Belzer C,Buitelaar J,Franke B,Aarts E,Arias Vasquez A
14 📚
Neonatal Cardiac and Respiratory Arrest During Linezolid Therapy: A Case Report.
Cureus (Cureus ) Vol: 16 Issue: 9 Pages: e69480 Pub: 2024 Sep ePub: 2024 Sep 15 Authors Song W,Qi J,Fan S,Xiao J,Li M
15 📚
Reduced microbiome alpha diversity in young patients with ADHD.
PloS one (PLoS One ) Vol: 13 Issue: 7 Pages: e0200728 Pub: 2018 ePub: 2018 Jul 12 Authors Prehn-Kristensen A,Zimmermann A,Tittmann L,Lieb W,Schreiber S,Baving L,Fischer A
16 📚
Septic arthritis of the knee caused by antibiotic-resistant Acinetobacter baumannii in a gout patient: a rare case report.
Archives of orthopaedic and trauma surgery (Arch Orthop Trauma Surg ) Vol: 130 Issue: 3 Pages: 381-4 Pub: 2010 Mar ePub: 2009 Aug 26 Authors Duan X,Yang L,Xia P
17 📚
Systematic review of gut microbiota and attention-deficit hyperactivity disorder (ADHD).
Annals of general psychiatry (Ann Gen Psychiatry ) Vol: 20 Issue: 1 Pages: 12 Pub: 2021 Feb 16 ePub: 2021 Feb 16 Authors Sukmajaya AC,Lusida MI,Soetjipto,Setiawati Y

Treatment Substances

The Studies below identify substances that has been tried with positive changes (for at least some symptoms in the study). Check if it has already been reviewed.

18 📚
A Pilot Randomized Control Trial With the Probiotic Strain Lactobacillus rhamnosus GG (LGG) in ADHD: Children and Adolescents Report Better Health-Related Quality of Life.
Frontiers in psychiatry (Front Psychiatry ) Vol: 11 Issue: Pages: 181 Pub: 2020 ePub: 2020 Mar 17 Authors Kumperscak HG,Gricar A,Ülen I,Micetic-Turk D
19 📚
A randomised, placebo-controlled, 24-week, study of low-dose extended-release methylphenidate in adults with attention-deficit/hyperactivity disorder.
European archives of psychiatry and clinical neuroscience (Eur Arch Psychiatry Clin Neurosci ) Vol: 259 Issue: 2 Pages: 120-9 Pub: 2009 Mar ePub: 2009 Jan 22 Authors Rösler M,Fischer R,Ammer R,Ose C,Retz W
20 📚
A systematic review of the beneficial effects of prebiotics, probiotics, and synbiotics on ADHD.
Neuropsychopharmacology reports (Neuropsychopharmacol Rep ) Vol: Issue: Pages: Pub: 2024 Apr 16 ePub: 2024 Apr 16 Authors Allahyari P,Abbas Torki S,Aminnezhad Kavkani B,Mahmoudi Z,Mousavi Hoseini MS,Moradi M,Alami F,Keshavarz Mohammadian M,Bahoo Sele Bani S,Abbasi Mobarakeh K,Shafaei H,Khoshdooz S,Hajipour A,Doaei S,Gholamalizadeh M
21 📚
Add-On Bifidobacterium Bifidum Supplement in Children with Attention-Deficit/Hyperactivity Disorder: A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial.
Nutrients (Nutrients ) Vol: 16 Issue: 14 Pages: Pub: 2024 Jul 13 ePub: 2024 Jul 13 Authors Wang LJ,Tsai CS,Chou WJ,Kuo HC,Huang YH,Lee SY,Dai HY,Yang CY,Li CJ,Yeh YT
22 📚
Assessment of probiotic strain Lactobacillus acidophilus LB supplementation as adjunctive management of attention-deficit hyperactivity disorder in children and adolescents: a randomized controlled clinical trial.
BMC psychiatry (BMC Psychiatry ) Vol: 23 Issue: 1 Pages: 823 Pub: 2023 Nov 9 ePub: 2023 Nov 9 Authors Elhossiny RM,Elshahawy HH,Mohamed HM,Abdelmageed RI
23 📚
Complementary medicines (herbal and nutritional products) in the treatment of Attention Deficit Hyperactivity Disorder (ADHD): a systematic review of the evidence.
Complementary therapies in medicine (Complement Ther Med ) Vol: 19 Issue: 4 Pages: 216-27 Pub: 2011 Aug ePub: 2011 Jul 26 Authors Sarris J,Kean J,Schweitzer I,Lake J
24 📚
Crocus sativus L. Versus Methylphenidate in Treatment of Children with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind Pilot Study.
Journal of child and adolescent psychopharmacology (J Child Adolesc Psychopharmacol ) Vol: 29 Issue: 3 Pages: 205-212 Pub: 2019 Apr ePub: 2019 Feb 11 Authors Baziar S,Aqamolaei A,Khadem E,Mortazavi SH,Naderi S,Sahebolzamani E,Mortezaei A,Jalilevand S,Mohammadi MR,Shahmirzadi M,Akhondzadeh S
25 📚
Eating Patterns and Dietary Interventions in ADHD: A Narrative Review.
Nutrients (Nutrients ) Vol: 14 Issue: 20 Pages: Pub: 2022 Oct 16 ePub: 2022 Oct 16 Authors Pinto S,Correia-de-Sá T,Sampaio-Maia B,Vasconcelos C,Moreira P,Ferreira-Gomes J
26 📚
Emerging Role and Place of Probiotics in the Management of Pediatric Neurodevelopmental Disorders.
Euroasian journal of hepato-gastroenterology (Euroasian J Hepatogastroenterol ) Vol: 12 Issue: 2 Pages: 102-108 Pub: 2022 Jul-Dec ePub: Authors Khanna HN,Roy S,Shaikh A,Bandi V
27 📚
Herbal medicines in children with attention deficit hyperactivity disorder (ADHD): A systematic review.
Complementary therapies in medicine (Complement Ther Med ) Vol: 30 Issue: Pages: 14-23 Pub: 2017 Feb ePub: 2016 Nov 18 Authors Anheyer D,Lauche R,Schumann D,Dobos G,Cramer H
28 📚
Herbal medicines in the treatment of children and adolescents with attention-deficit/hyperactivity disorder (ADHD): An updated systematic review of clinical trials.
Avicenna journal of phytomedicine (Avicenna J Phytomed ) Vol: 13 Issue: 4 Pages: 338-353 Pub: 2023 Jul-Aug ePub: Authors Golsorkhi H,Qorbani M,Sabbaghzadegan S,Dadmehr M
29 📚
Iranian Traditional Medicine for Treatment of Attention Deficit Disorder with Hyperactivity in Children: A Systematic Review of Randomized Controlled Trials.
Iranian journal of public health (Iran J Public Health ) Vol: 53 Issue: 2 Pages: 280-292 Pub: 2024 Feb ePub: Authors Noorazar SG,Mirzaei M,Kalejahi P
30 📚
Ketogenic diet ameliorates attention deficit hyperactivity disorder in rats via regulating gut microbiota.
PloS one (PLoS One ) Vol: 18 Issue: 8 Pages: e0289133 Pub: 2023 ePub: 2023 Aug 16 Authors Liu Y,Yang C,Meng Y,Dang Y,Yang L
31 📚
Lactiplantibacillus plantarum as a promising adjuvant for neurological disorders therapy through the brain-gut axis and related action pathways.
Critical reviews in food science and nutrition (Crit Rev Food Sci Nutr ) Vol: Issue: Pages: 1-13 Pub: 2023 Nov 11 ePub: 2023 Nov 11 Authors Duarte Luiz J,Manassi C,Magnani M,Cruz AGD,Pimentel TC,Verruck S
32 📚
Low Doses of Melatonin to Improve Sleep in Children with ADHD: An Open-Label Trial.
Children (Basel, Switzerland) (Children (Basel) ) Vol: 10 Issue: 7 Pages: Pub: 2023 Jun 28 ePub: 2023 Jun 28 Authors Checa-Ros A,Muñoz-Hoyos A,Molina-Carballo A,Viejo-Boyano I,Chacín M,Bermúdez V,D'Marco L
33 📚
Novel and complementary treatment approaches in attention-deficit/hyperactivity disorder.
Current opinion in pediatrics (Curr Opin Pediatr ) Vol: Issue: Pages: Pub: 2024 Jun 11 ePub: 2024 Jun 11 Authors Caterfino A,Krishna S,Chen V
34 📚
Nutritional supplements for the treatment of ADHD.
Child and adolescent psychiatric clinics of North America (Child Adolesc Psychiatr Clin N Am ) Vol: 23 Issue: 4 Pages: 883-97 Pub: 2014 Oct ePub: 2014 Aug 12 Authors Bloch MH,Mulqueen J
35 📚
Randomised controlled trial of the effects of kefir on behaviour, sleep and the microbiome in children with ADHD: a study protocol.
BMJ open (BMJ Open ) Vol: 13 Issue: 12 Pages: e071063 Pub: 2023 Dec 7 ePub: 2023 Dec 7 Authors Lawrence K,Fibert P,Hobbs J,Myrissa K,Toribio-Mateas MA,Quadt F,Cotter PD,Gregory AM
36 📚
Randomized, Double-Blind, Placebo-Controlled Acute Comparator Trials of Lisdexamfetamine and Extended-Release Methylphenidate in Adolescents With Attention-Deficit/Hyperactivity Disorder.
CNS drugs (CNS Drugs ) Vol: 31 Issue: 11 Pages: 999-1014 Pub: 2017 Nov ePub: Authors Newcorn JH,Nagy P,Childress AC,Frick G,Yan B,Pliszka S
37 📚
Selecting Effective Herbal Medicines for Attention-Deficit/Hyperactivity Disorder via Text Mining of Donguibogam.
Evidence-based complementary and alternative medicine : eCAM (Evid Based Complement Alternat Med ) Vol: 2019 Issue: Pages: 1798364 Pub: 2019 ePub: 2019 Jun 4 Authors Bae HW,Lee SY,Kim SJ,Shin HK,Choi BT,Baek JU
38 📚
Sleep disturbance in children with attention-deficit hyperactivity disorder: relationship with melatonin and behavior.
Neurological research (Neurol Res ) Vol: Issue: Pages: 1-9 Pub: 2024 Jun 4 ePub: 2024 Jun 4 Authors de Souza ALDM,Giacheti CM,Do Couto MCH,Galina Spilla CS,da Silva NC,Proença M,Pinato L
39 📚
Treatments for ADHD in Children and Adolescents: A Systematic Review.
Pediatrics (Pediatrics ) Vol: 153 Issue: 4 Pages: Pub: 2024 Apr 1 ePub: Authors Peterson BS,Trampush J,Maglione M,Bolshakova M,Rozelle M,Miles J,Pakdaman S,Brown M,Yagyu S,Motala A,Hempel S
40 📚
Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother ) Vol: 143 Issue: Pages: 112175 Pub: 2021 Nov ePub: 2021 Sep 27 Authors Paul S,Chakraborty S,Anand U,Dey S,Nandy S,Ghorai M,Saha SC,Patil MT,Kandimalla R,Procków J,Dey A

Quick Reference

The following items have been cited in the above studies

IDStudiesNameAKA
316 2   alpha-linolenic acid {Omega-3} ALA. Plant based, Flaxseed, otherwise see Fish oil NOT a-Lipoic acid (also ALA)
1737 1   bifidobacterium bifidum {B. bifidum}
50 1   bifidobacterium longum {B.Longum } May include Bifidobacterium longum subsp. infantis and Bifidobacterium longum subsp. longum
51 1   Bifidobacterium longum subsp. longum BB536 {BB536} Morinaga BB536, robiotic BB536
1916 1   Citrus limon {Lemon} Citron,Limón,Zitrone,Limão
2966 3   Crocus sativus {Saffron} Zafran,Kesar,Azafrán,Safran,Zafferano
297 2   Escherichia coli Nissle 1917 {Mutaflor} In use since 1917
207 2   Ferrum {Iron Supplements} Ferrous Sulfate,Ferrous Gluconate,Ferrous Fumarate,Iron Polysaccharide,Carbonyl Iron,Heme Iron Polypeptide
1766 2   Ginkgo biloba {Ginkgo} Ginkgo, gingko, maidenhair tree,Japanese silver apricot
215 1   ketogenic diet
241 1   Lacticaseibacillus paracasei {L.paracasei} Was also known as Lactobacillus casei subsp. pseudoplantarum
230 1   lactobacillus acidophilus {L. acidophilus} Bacillus acidophilus
243 2   Lactobacillus plantarum {L. plantarum} lactobacillus plantarum, Lactobacillus arabinosus
247 3   lactobacillus rhamnosus gg l rhamnosus gg (probiotics)
245 1   Limosilactobacillus reuteri {L. Reuteri} Lactobacillus fermentum subsp. reuteri
259 1   lincomycin (bio-cox / lincomix, clordelin inyectable, deccox / lincomycin, decoquinate lincomycin, enzalin, ivomec for swine and lincomix, linco, linco spectin, lincocin, lincocin forte, lincocine, lincofan, lincofarm, linco-feed, lincoject, lincomicina, lincomicina andromaco, lincomicina genamérica, lincomicina genfar, lincomicina l.ch., lincomicina mintlab, lincomicina vitalis, lincomicina winthrop, lincomix / maxiban, lincomix / nicarmix 25, lincomix, lincomycin 30% zoetis, lincomycin bayer, lincomycin sparhawk, lincoplus, linco-sol, linco-spectin, lincyn, linkomed, linkomicin, linkomisin-ie, linkosol, linosin, lintropsin, medoglycin, nichomycin, nolipo, pritalinc, sacox / lincomix, safe guard, zencocin, albiotic, albiotic formula, amlin, ascolinic, avatec / lincomix, aviosan, bacto-link, banminth / lincomix, biolincom, cillimicina, coban / lincomix, concentrat vo 61 lincomycine spectinomycine, coyden / lincomix, duobiotic ls, emdactilin, ethilin, formicina, frademicina, galactis, hu gu, l spec vmd, licomycin, licoxin, like, linc. oral, lincoban, lincocin neo, lincocina, lincodox, lincohem, lincomed, lincomeis, lincomicina 11% intervet, lincomicina 11% vetoquinol, lincomicina luper, lincomicina mk, lincomicina normon, lincomix / amprol plus, lincomix / bonaid, lincomix / deccox, lincomix / robenz, lincomix / stenorol, lincomix / zoamix, lincomycin - sine, lincomycin - spectinomycin phibro, lincomycin, lincomycin 20%, lincomycin actavis, lincomycin ccpc, lincomycin chi sheng, lincomycin hcl astar, lincomycin hcl li ta, lincomycin hcl root, lincomycin hcl ta fong, lincomycin hcl tai yu, lincomycin hcl winston, lincomycin hydrochloride biopharm, lincomycin hydrochloride nichi-iko, lincomycin hydrochloride np, lincomycin hydrochloride quo vademus, lincomycin hydrochloride rup borisov, lincomycin hydrochloride sic bhfz, lincomycin indo farma, lincomycin new chemical, lincomycin shing poong, lincomycin sinton, lincomycin siu guan, lincomycin standard, lincomycin swiss pharm, lincomycin union, lincomycin vmd, lincomycin y f chem, lincomycin ying yuan, lincomycin yung shin, lincomycin zoetis, lincomycine, lincomycine franvet, lincomycine spectinomycine franvet, lincomycine-spectinomycine, lincomycine-spectinomycine-vmd, lincomycine-vmd, lincomycin-spectinomycin agri, lincomycin-suzhou no 6 pharm, lincophar, lincopharm, lincosol, lincospectin, linco-spectin forte, lingo, linmycin, linspec, lizpion, l-s 50, macramid, micospectone, myasone, mycoxin, neloren, nicarbazin lincomycin, omicin, pecasolin, pelancocin, percocyn, pneumospectin, pyanosid, sintolin, specin, speclinx 50, spectolin, spectoliphen, spectoliphen veaux, ovins, porcins, spectovet, tamcocin, tismamisin, ultralinc, vualin)
2818 1   long-term, moderate-intensity exercise {exercise} Shifts not seen with short-term, high-intensity exercise
2972 3   Methylphenidate
1028 1   modafinil,(prescription) (alertec, alertex, altasomil, aspendos, forcilin, intensit, mentix, modafinil aurobindo, modafinil biogaran, modafinil bluefish, modafinil chanelle, modafinil eg, modafinil generis, modafinil genus, modafinil medochemie, modafinil mylan, modafinil orchid, modafinil teva, modafinil wynn, modafinil-acino, modafinil-neuraxpharm, modanil, modasomil, modavigil, modiodal, modiwake, movigil, provigil, resotyl, stavigile, vigia, vigicer, vigil, vigimax, zalux)
282 3   N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide {Melatonin} a hormone primarily produced by the pineal gland
2961 1   Panax ... {Ginseng} Asian or Korean ginseng,American ginseng,Renshen,Baiguo
2938 2   Pycnogenol
23 1   Withania somnifera {Ashwagandha} Indian Ginseng,Indian Winter Cherry
441 2   Zinc {Zinc Supplements} Zinc sulfate,Zinc acetate,Zinc gluconate,Zinc picolinate,Zinc citrate,Zinc oxide,Zinc monomethionine

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