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Common knowledge amoung some professionals (MD and ND):
Omega-3 Fatty Acids: Omega-3 supplements containing EPA and DHA have been studied for their potential benefits in mental health. Some research suggests that omega-3 fatty acids might have a role in supporting brain function and possibly reducing symptoms of anxiety, but evidence is mixed.
Magnesium: Magnesium is an essential mineral that plays a role in various bodily functions, including relaxation and stress reduction. Some individuals with anxiety might have lower levels of magnesium, and supplementation might help, although more research is needed to establish its effectiveness.
L-Theanine: L-theanine is an amino acid found in tea leaves that may have calming effects. Some studies suggest that L-theanine might help promote relaxation and reduce anxiety, but further research is needed to confirm its efficacy for GAD.
Probiotics: The gut-brain connection is an area of ongoing research in mental health. Some studies suggest that probiotics might influence the gut microbiota, which could potentially impact mood and anxiety. However, their specific role in managing GAD requires further investigation.
The Studies below identify bacteria. Check if it has already been reviewed.
| 1 | 📚 |
<i>Lactobacillus mucosae</i> and <i>Bifidobacterium longum</i> Synergistically Alleviate Immobilization Stress-Induced Anxiety/Depression in Mice by Suppressing Gut Dysbiosis.
Journal of microbiology and biotechnology (J Microbiol Biotechnol ) Vol: 29 Issue: 9 Pages: 1369-1374 Pub: 2019 Sep 28 ePub: Authors Han SK,Kim DH |
| 2 | 📚 |
Altered gut microbiota profile in patients with generalized anxiety disorder.
Journal of psychiatric research (J Psychiatr Res ) Vol: 104 Issue: Pages: 130-136 Pub: 2018 Sep ePub: 2018 Jul 18 Authors Jiang HY,Zhang X,Yu ZH,Zhang Z,Deng M,Zhao JH,Ruan B |
| 3 | 📚 |
Connection of pre-competition anxiety with gut microbiota and metabolites in wrestlers with varying sports performances based on brain-gut axis theory.
BMC microbiology (BMC Microbiol ) Vol: 24 Issue: 1 Pages: 147 Pub: 2024 Apr 27 ePub: 2024 Apr 27 Authors Fu P,Wang C,Zheng S,Qiao L,Gao W,Gong L |
| 4 | 📚 |
Desulfovibrio confers resilience to the comorbidity of pain and anxiety in a mouse model of chronic inflammatory pain.
Psychopharmacology (Psychopharmacology (Berl) ) Vol: 240 Issue: 1 Pages: 87-100 Pub: 2023 Jan ePub: 2022 Nov 28 Authors Wu Z,Liu H,Yan E,Zhang X,Wang Y,Huang C,He T,Miao L,Yang L,Jiang R,Qi C,Liu C,Wang D,Yang C |
| 5 | 📚 |
Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice.
Mucosal immunology (Mucosal Immunol ) Vol: 11 Issue: 5 Pages: 1386-1397 Pub: 2018 Sep ePub: 2018 Jun 4 Authors Jang HM,Lee HJ,Jang SE,Han MJ,Kim DH |
| 6 | 📚 |
Experiencing social exclusion changes gut microbiota composition.
Translational psychiatry (Transl Psychiatry ) Vol: 12 Issue: 1 Pages: 254 Pub: 2022 Jun 17 ePub: 2022 Jun 17 Authors Kim CS,Shin GE,Cheong Y,Shin JH,Shin DM,Chun WY |
| 7 | 📚 |
Exploring the Association between Anxiety, Depression, and Gut Microbiota during Pregnancy: Findings from a Pregnancy Cohort Study in Shijiazhuang, Hebei Province, China.
Nutrients (Nutrients ) Vol: 16 Issue: 10 Pages: Pub: 2024 May 12 ePub: 2024 May 12 Authors Chi R,Li M,Zhang M,Zhang N,Zhang G,Cui L,Ma G |
| 8 | 📚 |
Fluoxetine ameliorates dysbiosis in a depression model induced by chronic unpredicted mild stress in mice.
International journal of medical sciences (Int J Med Sci ) Vol: 16 Issue: 9 Pages: 1260-1270 Pub: 2019 ePub: 2019 Sep 7 Authors Sun L,Zhang H,Cao Y,Wang C,Zhao C,Wang H,Cui G,Wang M,Pan Y,Shi Y,Nie Y |
| 9 | 📚 |
Gastrointestinal Microbiota & Symptoms of Depression and Anxiety in Anorexia Nervosa-A Re-Analysis of the MICROBIAN Longitudinal Study.
Nutrients (Nutrients ) Vol: 16 Issue: 6 Pages: Pub: 2024 Mar 19 ePub: 2024 Mar 19 Authors Ketel J,Bosch-Bruguera M,Auchter G,Cuntz U,Zipfel S,Enck P,Mack I |
| 10 | 📚 |
Gut Microbiome: A Potential Indicator for Differential Diagnosis of Major Depressive Disorder and General Anxiety Disorder.
Frontiers in psychiatry (Front Psychiatry ) Vol: 12 Issue: Pages: 651536 Pub: 2021 ePub: 2021 Sep 13 Authors Dong Z,Shen X,Hao Y,Li J,Li H,Xu H,Yin L,Kuang W |
| 11 | 📚 |
High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats.
Biological research (Biol Res ) Vol: 57 Issue: 1 Pages: 23 Pub: 2024 May 6 ePub: 2024 May 6 Authors de Noronha SISR,de Moraes LAG,Hassell JE Jr,Stamper CE,Arnold MR,Heinze JD,Foxx CL,Lieb MM,Cler KE,Karns BL,Jaekel S,Loupy KM,Silva FCS,Chianca-Jr DA,Lowry CA,de Menezes RC |
| 12 | 📚 |
Immobilization stress-induced Escherichia coli causes anxiety by inducing NF-?B activation through gut microbiota disturbance.
Scientific reports (Sci Rep ) Vol: 8 Issue: 1 Pages: 13897 Pub: 2018 Sep 17 ePub: 2018 Sep 17 Authors Jang HM,Lee KE,Lee HJ,Kim DH |
| 13 | 📚 |
Improving precision management of anxiety disorders: a Mendelian randomization study targeting specific gut microbiota and associated metabolites.
Frontiers in microbiology (Front Microbiol ) Vol: 15 Issue: Pages: 1380912 Pub: 2024 ePub: 2024 Apr 9 Authors Xu MM,Qiu WH,Ma QY,Yu ZY,Yang WM,Hu TN,Guo Y,Chen XY |
| 14 | 📚 |
Induction of anxiety-like behavior in mice during the initial stages of infection with the agent of murine colonic hyperplasia Citrobacter rodentium.
Physiology & behavior (Physiol Behav ) Vol: 89 Issue: 3 Pages: 350-7 Pub: 2006 Oct 30 ePub: 2006 Aug 2 Authors Lyte M,Li W,Opitz N,Gaykema RP,Goehler LE |
| 15 | 📚 |
Ingestion of Mycobacterium vaccae decreases anxiety-related behavior and improves learning in mice.
Behavioural processes (Behav Processes ) Vol: 96 Issue: Pages: 27-35 Pub: 2013 Jun ePub: 2013 Feb 27 Authors Matthews DM,Jenks SM |
| 16 | 📚 |
Microbiome-gut-brain axis in cancer treatment-related psychoneurological toxicities and symptoms: a systematic review.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (Support Care Cancer ) Vol: 29 Issue: 2 Pages: 605-617 Pub: 2021 Feb ePub: 2020 Sep 12 Authors Song BC,Bai J |
| 17 | 📚 |
Perturbations in Gut Microbiota Composition in Psychiatric Disorders: A Review and Meta-analysis.
JAMA psychiatry (JAMA Psychiatry ) Vol: 78 Issue: 12 Pages: 1343-1354 Pub: 2021 Dec 1 ePub: Authors Nikolova VL,Smith MRB,Hall LJ,Cleare AJ,Stone JM,Young AH |
| 18 | 📚 |
Probiotic Supplement Preparation Relieves Test Anxiety by Regulating Intestinal Microbiota in College Students.
Disease markers (Dis Markers ) Vol: 2021 Issue: Pages: 5597401 Pub: 2021 ePub: 2021 Apr 20 Authors Qin Q,Liu H,Yang Y,Wang Y,Xia C,Tian P,Wei J,Li S,Chen T |
| 19 | 📚 |
Reproducible microbiome composition signatures of anxiety and depressive symptoms.
Computational and structural biotechnology journal (Comput Struct Biotechnol J ) Vol: 21 Issue: Pages: 5326-5336 Pub: 2023 ePub: 2023 Oct 18 Authors Kouraki A,Kelly A,Vijay A,Gohir S,Astbury S,Georgopoulos V,Millar B,Walsh DA,Ferguson E,Menni C,Valdes AM |
| 20 | 📚 |
Review article: bugs, inflammation and mood-a microbiota-based approach to psychiatric symptoms in inflammatory bowel diseases.
Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther ) Vol: 52 Issue: 2 Pages: 247-266 Pub: 2020 Jul ePub: 2020 Jun 11 Authors Thomann AK,Mak JWY,Zhang JW,Wuestenberg T,Ebert MP,Sung JJY,Bernstein ÇN,Reindl W,Ng SC |
| 21 | 📚 |
Supplementation of Sesamin Alleviates Stress-Induced Behavioral and Psychological Disorders via Reshaping the Gut Microbiota Structure.
Journal of agricultural and food chemistry (J Agric Food Chem ) Vol: 67 Issue: 45 Pages: 12441-12451 Pub: 2019 Nov 13 ePub: 2019 Nov 1 Authors Wang Q,Jia M,Zhao Y,Hui Y,Pan J,Yu H,Yan S,Dai X,Liu X,Liu Z |
| 22 | 📚 |
Taxonomic and Metabolic Signatures of Gut Microbiota for Assessing the Severity of Depression and Anxiety in Major Depressive Disorder Patients.
Neuroscience (Neuroscience ) Vol: 496 Issue: Pages: 179-189 Pub: 2022 Aug 1 ePub: 2022 Jun 21 Authors Zhang X,Hou Y,Li Y,Wei W,Cai X,Shao H,Yuan Y,Zheng X |
| 23 | 📚 |
The Gut Microbiome in Anxiety Disorders.
Current psychiatry reports (Curr Psychiatry Rep ) Vol: 27 Issue: 5 Pages: 347-361 Pub: 2025 May ePub: 2025 Apr 12 Authors Butler MI,Kittel-Schneider S,Wagner-Skacel J,Mörkl S,Clarke G |
| 24 | 📚 |
The gut microbiome in social anxiety disorder: evidence of altered composition and function.
Translational psychiatry (Transl Psychiatry ) Vol: 13 Issue: 1 Pages: 95 Pub: 2023 Mar 20 ePub: 2023 Mar 20 Authors Butler MI,Bastiaanssen TFS,Long-Smith C,Morkl S,Berding K,Ritz NL,Strain C,Patangia D,Patel S,Stanton C,O`Mahony SM,Cryan JF,Clarke G,Dinan TG |
The Studies below identify substances that has been tried with positive changes (for at least some symptoms in the study). Check if it has already been reviewed.
| 25 | 📚 |
Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress.
Neuroscience (Neuroscience ) Vol: 310 Issue: Pages: 561-77 Pub: 2015 Dec 3 ePub: 2015 Sep 25 Authors Liang S,Wang T,Hu X,Luo J,Li W,Wu X,Duan Y,Jin F |
| 26 | 📚 |
Anti-anxiety Properties of Selected Medicinal Plants.
Current pharmaceutical biotechnology (Curr Pharm Biotechnol ) Vol: 23 Issue: 8 Pages: 1041-1060 Pub: 2022 ePub: Authors Khan A,Akram M,Thiruvengadam M,Daniyal M,Zakki SA,Munir N,Zainab R,Heydari M,Mosavat SH,Rebezov M,Shariati MA |
| 27 | 📚 |
Anxiolytic and hyperlocomotive effects of aqueous extract of Nigella sativa L. seeds in rats.
Pakistan journal of pharmaceutical sciences (Pak J Pharm Sci ) Vol: 27 Issue: 5 Spec no Pages: 1547-52 Pub: 2014 Sep ePub: Authors Bano F,Ahmed A,Parveen T,Haider S |
| 28 | 📚 |
Bifidobacterium breve M-16V regulates the autonomic nervous system via the intestinal environment: A double-blind, placebo-controlled study.
Behavioural brain research (Behav Brain Res ) Vol: 460 Issue: Pages: 114820 Pub: 2024 Mar 5 ePub: 2023 Dec 20 Authors Mutoh N,Moriya M,Xu C,Kato K,Arai S,Iwabuchi N,Tanaka M,Jinghua Y,Itamura R,Sakatani K,Warisawa S |
| 29 | 📚 |
Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds.
Journal of agricultural and food chemistry (J Agric Food Chem ) Vol: 63 Issue: 32 Pages: 7108-23 Pub: 2015 Aug 19 ePub: 2015 Aug 5 Authors Friedman M |
| 30 | 📚 |
Cloning, prokaryotic expression and functional analysis of squalene synthase (SQS) in Magnolia officinalis.
Protein expression and purification (Protein Expr Purif ) Vol: 120 Issue: Pages: 28-34 Pub: 2016 Apr ePub: 2015 Dec 13 Authors Zha L,Liu S,Su P,Yuan Y,Huang L |
| 31 | 📚 |
Effects of chronic treatment with new strains of Lactobacillus plantarum on cognitive, anxiety- and depressive-like behaviors in male mice.
PloS one (PLoS One ) Vol: 15 Issue: 6 Pages: e0234037 Pub: 2020 ePub: 2020 Jun 19 Authors Barros-Santos T,Silva KSO,Libarino-Santos M,Elisangela Gouveia Cata-Preta,Reis HS,Tamura EK,de Oliveira-Lima AJ,Berro LF,Uetanabaro APT,Marinho EAV |
| 32 | 📚 |
Green tea effects on cognition, mood and human brain function: A systematic review.
Phytomedicine : international journal of phytotherapy and phytopharmacology (Phytomedicine ) Vol: 34 Issue: Pages: 26-37 Pub: 2017 Oct 15 ePub: 2017 Jul 27 Authors Mancini E,Beglinger C,Drewe J,Zanchi D,Lang UE,Borgwardt S |
| 33 | 📚 |
Ingestion of Lactobacillus helveticus WHH1889 improves depressive and anxiety symptoms induced by chronic unpredictable mild stress in mice.
Beneficial microbes (Benef Microbes ) Vol: 13 Issue: 6 Pages: 473-488 Pub: 2022 Dec 7 ePub: 2022 Nov 15 Authors Gao K,Chen CL,Ke XQ,Yu YX,Chen S,Liu GC,Wang HF,Li YJ |
| 34 | 📚 |
Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat.
Science China. Life sciences (Sci China Life Sci ) Vol: 57 Issue: 3 Pages: 327-335 Pub: 2014 Mar ePub: 2014 Feb 19 Authors Luo J,Wang T,Liang S,Hu X,Li W,Jin F |
| 35 | 📚 |
Lactiplantibacillus plantarum as a promising adjuvant for neurological disorders therapy through the brain-gut axis and related action pathways.
Critical reviews in food science and nutrition (Crit Rev Food Sci Nutr ) Vol: Issue: Pages: 1-13 Pub: 2023 Nov 11 ePub: 2023 Nov 11 Authors Duarte Luiz J,Manassi C,Magnani M,Cruz AGD,Pimentel TC,Verruck S |
| 36 | 📚 |
Lion's Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model.
Behavioral sciences (Basel, Switzerland) (Behav Sci (Basel) ) Vol: 12 Issue: 7 Pages: Pub: 2022 Jul 15 ePub: 2022 Jul 15 Authors Rodriguez MN,Lippi SLP |
| 37 | 📚 |
Lipid and Energy Metabolism of the Gut Microbiota Is Associated with the Response to Probiotic Bifidobacterium breve Strain for Anxiety and Depressive Symptoms in Schizophrenia.
Journal of personalized medicine (J Pers Med ) Vol: 11 Issue: 10 Pages: Pub: 2021 Sep 30 ePub: 2021 Sep 30 Authors Yamamura R,Okubo R,Katsumata N,Odamaki T,Hashimoto N,Kusumi I,Xiao J,Matsuoka YJ |
| 38 | 📚 |
Magnolol and Honokiol Attenuate Apoptosis of Enterotoxigenic Escherichia Coli-Induced Intestinal Epithelium by Maintaining Secretion and Absorption Homeostasis and Protecting Mucosal Integrity.
Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit ) Vol: 24 Issue: Pages: 3348-3356 Pub: 2018 May 21 ePub: 2018 May 21 Authors Deng Y,Han X,Tang S,Li C,Xiao W,Tan Z |
| 39 | 📚 |
Novel Multi-Strain E3 Probiotic Formulation Improved Mental Health Symptoms and Sleep Quality in Hong Kong Chinese.
Nutrients (Nutrients ) Vol: 15 Issue: 24 Pages: Pub: 2023 Dec 8 ePub: 2023 Dec 8 Authors Chan HHY,Siu PLK,Choy CT,Chan UK,Zhou J,Wong CH,Lee YW,Chan HW,Tsui JCC,Loo SKF,Tsui SKW |
| 40 | 📚 |
Overcoming Anxiety Disorder by Probiotic Lactiplantibacillus plantarum LZU-J-TSL6 through Regulating Intestinal Homeostasis.
Foods (Basel, Switzerland) (Foods ) Vol: 11 Issue: 22 Pages: Pub: 2022 Nov 11 ePub: 2022 Nov 11 Authors Liu G,Khan I,Li Y,Yang Y,Lu X,Wang Y,Li J,Zhang C |
| 41 | 📚 |
Pre-Gestational intake of Lactobacillus helveticus NS8 has anxiolytic effects in adolescent Sprague Dawley offspring.
Brain and behavior (Brain Behav ) Vol: 10 Issue: 9 Pages: e01714 Pub: 2020 Sep ePub: 2020 Jul 17 Authors Niu Y,Liang S,Wang T,Hu X,Li W,Wu X,Jin F |
| 42 | 📚 |
Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota.
Neurobiology of stress (Neurobiol Stress ) Vol: 14 Issue: Pages: 100294 Pub: 2021 May ePub: 2021 Jan 12 Authors Ma T,Jin H,Kwok LY,Sun Z,Liong MT,Zhang H |
| 43 | 📚 |
Probiotics may be useful for drug-induced liver dysfunction in patients with depression - A secondary analysis of a randomized clinical trial.
Clinical nutrition ESPEN (Clin Nutr ESPEN ) Vol: 63 Issue: Pages: 604-614 Pub: 2024 Oct ePub: 2024 Jul 30 Authors Gawlik-Kotelnicka O,Burzynski J,Rogalski J,Skowronska A,Strzelecki D |
| 44 | 📚 |
Release of an anti-anxiety peptide in casein hydrolysate with Aspergillus oryzae protease.
Food & function (Food Funct ) Vol: 13 Issue: 20 Pages: 10449-10460 Pub: 2022 Oct 17 ePub: 2022 Oct 17 Authors Takeuchi Y,Fukunaga M,Iwatani S,Miyanaga K,Adachi T,Yamamoto N |
| 45 | 📚 |
Saffron extract (Safr'Inside™) improves anxiety related behaviour in a mouse model of low-grade inflammation through the modulation of the microbiota and gut derived metabolites.
Food & function (Food Funct ) Vol: 13 Issue: 23 Pages: 12219-12233 Pub: 2022 Nov 28 ePub: 2022 Nov 28 Authors Pontifex MG,Connell E,Le Gall G,Pourtau L,Gaudout D,Angeloni C,Zallocco L,Ronci M,Giusti L,Müller M,Vauzour D |
| 46 | 📚 |
The anxiolytic effect of probiotics: A systematic review and meta-analysis of the clinical and preclinical literature.
PloS one (PLoS One ) Vol: 13 Issue: 6 Pages: e0199041 Pub: 2018 ePub: 2018 Jun 20 Authors Reis DJ,Ilardi SS,Punt SEW |
| 47 | 📚 |
The benefits of ashwagandha (Withania somnifera) supplements on brain function and sports performance.
Frontiers in nutrition (Front Nutr ) Vol: 11 Issue: Pages: 1439294 Pub: 2024 ePub: 2024 Aug 2 Authors Guo S,Rezaei MJ |
The following items have been cited in the above studies
| ID | Studies | Name | AKA |
|---|---|---|---|
| 216 | 1 | aspergillus oryzae {koji} | Koji mould,Japanese koji mold,Rice koji |
| 1737 | 1 | bifidobacterium bifidum {B. bifidum} | |
| 1943 | 2 | Bifidobacterium breve {B. breve} | |
| 50 | 1 | bifidobacterium longum {B.Longum } | May include Bifidobacterium longum subsp. infantis and Bifidobacterium longum subsp. longum |
| 110 | 1 | coptis chinensis {Chinese goldthread } | Coptide chinois,Golden thread,Yellowroot,Cankerroot,Mouth root,Huang Lian |
| 2966 | 1 | Crocus sativus {Saffron} | Zafran,Kesar,Azafrán,Safran,Zafferano |
| 176 | 1 | green tea | |
| 4521 | 2 | Hericium erinaceus {Lion's Mane Mushroom } | Yamabushitake (Japanese), Bearded Tooth Fungus, Monkey's Head Mushroom, Hedgehog Mushroom, Old Man's Beard,Bearded Hedgehog |
| 201 | 1 | Hypericum perforatum {St. John's Wort} | Goatweed,Klamath weed,Tipton's weed,Rosin rose,Hypericum,Millepertuis,Johanniskraut |
| 230 | 1 | lactobacillus acidophilus {L. acidophilus} | Bacillus acidophilus |
| 1918 | 6 | lactobacillus helveticus {L. helveticus} | |
| 243 | 5 | Lactobacillus plantarum {L. plantarum} | lactobacillus plantarum, Lactobacillus arabinosus |
| 115 | 1 | lactobacillus rhamnosus gg,bifidobacterium animalis lactis ,lactobacillus paracasei {cvs maximum strength probiotic} | |
| 276 | 2 | magnolia officinalis {magnolia bark} | Hu-bak, Magnolol,Houpo |
| 1719 | 1 | Nigella sativa {black cumin} | black seed, black caraway, kalonji,fennel flower |
| 2973 | 1 | Valeriana officinalis {Valerian} | member of Caprifoliaceae or honeysuckle family |
| 23 | 2 | Withania somnifera {Ashwagandha} | Indian Ginseng,Indian Winter Cherry |
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