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Liver Cirrhosis

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Common knowledge amoung some professionals (MD and ND):

  1. Milk Thistle: Milk thistle (Silybum marianum) is a herb that contains the active compound silymarin, known for its antioxidant and anti-inflammatory properties. Some studies suggest that milk thistle may help protect liver cells and possibly improve liver function in certain liver conditions, including cirrhosis. However, conclusive evidence is lacking, and its effectiveness remains uncertain.

  2. Omega-3 Fatty Acids: Omega-3 fatty acids, found in fish oil supplements or fatty fish like salmon, have anti-inflammatory properties that may benefit liver health. They might help reduce inflammation and support overall cardiovascular health.

  3. Vitamin E: Vitamin E is an antioxidant that has been studied for its potential to reduce oxidative stress and inflammation in the liver. Some research suggests that vitamin E supplementation might be beneficial in certain cases of liver disease, but its use should be carefully monitored due to potential side effects and interactions with medications.

  4. Probiotics: While research on probiotics' specific effects on liver cirrhosis is ongoing, maintaining a healthy gut microbiome might indirectly benefit liver health. Probiotics might help in managing complications related to cirrhosis, such as hepatic encephalopathy or gut-related issues.

  5. Multivitamins and Minerals: Nutritional deficiencies are common in individuals with liver cirrhosis due to impaired nutrient absorption. A balanced diet and/or multivitamin supplements prescribed by a healthcare professional can help address deficiencies.


Bacteria/Taxa

The Studies below identify bacteria. Check if it has already been reviewed.

1 πŸ“š
A Metagenomic Meta-analysis Reveals Functional Signatures of Health and Disease in the Human Gut Microbiome.
mSystems (mSystems ) Vol: 4 Issue: 4 Pages: Pub: 2019 Jul-Aug ePub: 2019 May 14 Authors Armour CR,Nayfach S,Pollard KS,Sharpton TJ
2 πŸ“š
A Systematic Review of Microbiota in Cirrhosis: A Change Towards a More Pathogenic Predisposition.
International journal of molecular sciences (Int J Mol Sci ) Vol: 26 Issue: 2 Pages: Pub: 2025 Jan 9 ePub: 2025 Jan 9 Authors Xirouchakis E,Pelekanos A,Xirouchakis S,Kranidioti H,Manolakopoulos S
3 πŸ“š
Akkermansia muciniphila is associated with normal muscle mass and Eggerthella is related with sarcopenia in cirrhosis.
Frontiers in nutrition (Front Nutr ) Vol: 11 Issue: Pages: 1438897 Pub: 2024 ePub: 2024 Oct 30 Authors Efremova I,Alieva A,Maslennikov R,Poluektova E,Zharkova M,Kudryavtseva A,Krasnov G,Zharikov Y,Nerestyuk Y,Karchevskaya A,Ivashkin V
4 πŸ“š
Altered gut microbiome, bile acid composition and metabolome in sarcopenia in liver cirrhosis.
Journal of cachexia, sarcopenia and muscle (J Cachexia Sarcopenia Muscle ) Vol: 14 Issue: 6 Pages: 2676-2691 Pub: 2023 Dec ePub: 2023 Sep 28 Authors Aliwa B,Horvath A,Traub J,Feldbacher N,Habisch H,Fauler G,Madl T,Stadlbauer V
5 πŸ“š
Altered gut microbiota is associated with sleep disturbances in patients with minimal hepatic encephalopathy caused by hepatitis B-related liver cirrhosis.
Expert review of gastroenterology & hepatology (Expert Rev Gastroenterol Hepatol ) Vol: 16 Issue: 8 Pages: 797-807 Pub: 2022 Aug ePub: 2022 Aug 11 Authors Luo M,Hu FR,Xin RJ,Yao L,Hu SJ,Bai FH
6 πŸ“š
Causal effects of gut microbiome on autoimmune liver disease: a two-sample Mendelian randomization study.
BMC medical genomics (BMC Med Genomics ) Vol: 16 Issue: 1 Pages: 232 Pub: 2023 Oct 3 ePub: 2023 Oct 3 Authors Fu Y,Li J,Zhu Y,Chen C,Liu J,Gu S,Zheng Y,Li Y
7 πŸ“š
Causal Relationship Between Gut Microbiota and Liver Cirrhosis: 16S rRNA Sequencing and Mendelian Randomization Analyses.
Journal of clinical and translational hepatology (J Clin Transl Hepatol ) Vol: 12 Issue: 2 Pages: 123-133 Pub: 2024 Feb 28 ePub: 2023 Nov 30 Authors Yuan M,Hu X,Yao L,Chen P,Wang Z,Liu P,Xiong Z,Jiang Y,Li L
8 πŸ“š
Causal relationships between the gut microbiota, inflammatory cytokines, and alcoholic liver disease: a Mendelian randomization analysis.
Frontiers in endocrinology (Front Endocrinol (Lausanne) ) Vol: 15 Issue: Pages: 1442603 Pub: 2024 ePub: 2024 Oct 21 Authors Li S,Zhou C,Liu T,Zhang L,Liu S,Zhao Q,Liu J,Zhao W
9 πŸ“š
Characteristics and Related Factors of Bacterial Infection Among Patients With Cirrhosis.
Materia socio-medica (Mater Sociomed ) Vol: 36 Issue: 1 Pages: 90-96 Pub: 2024 ePub: Authors Lan NN,Lieu DQ,Anh TN,Thuong LH,Tuong TK,Bang MH
10 πŸ“š
Chronic Inflammatory Diseases at Secondary Sites Ensuing Urogenital or Pulmonary Chlamydia Infections.
Microorganisms (Microorganisms ) Vol: 8 Issue: 1 Pages: Pub: 2020 Jan 17 ePub: 2020 Jan 17 Authors Cheok YY,Lee CYQ,Cheong HC,Looi CY,Wong WF
11 πŸ“š
Clostridium paraputrificum in a Middle-Aged Male With Liver Disease.
Journal of investigative medicine high impact case reports (J Investig Med High Impact Case Rep ) Vol: 12 Issue: Pages: 23247096241292213 Pub: 2024 Jan-Dec ePub: Authors Dao KT,D'Assumpcao C,Sharma R,Heidari A
12 πŸ“š
Correlation of liver function with intestinal flora, vitamin deficiency and IL-17A in patients with liver cirrhosis.
Experimental and therapeutic medicine (Exp Ther Med ) Vol: 16 Issue: 5 Pages: 4082-4088 Pub: 2018 Nov ePub: 2018 Aug 29 Authors Mou H,Yang F,Zhou J,Bao C
13 πŸ“š
Dysbiosis of oral microbiota and its association with salivary immunological biomarkers in autoimmune liver disease.
PloS one (PLoS One ) Vol: 13 Issue: 7 Pages: e0198757 Pub: 2018 ePub: 2018 Jul 3 Authors Abe K,Takahashi A,Fujita M,Imaizumi H,Hayashi M,Okai K,Ohira H
14 πŸ“š
Exploring the diagnostic potential of immunoglobulin A-microbiota interplay in liver cirrhosis and spontaneous bacterial peritonitis.
The Kaohsiung journal of medical sciences (Kaohsiung J Med Sci ) Vol: 40 Issue: 9 Pages: 837-851 Pub: 2024 Sep ePub: 2024 Jul 18 Authors Zhang LJ,Huang WQ,Zhang Y,Zhou YL,Xu HM,Zhao C,Nie YQ
15 πŸ“š
Hepatocellular Carcinoma Is Associated With Gut Microbiota Profile and Inflammation in Nonalcoholic Fatty Liver Disease.
Hepatology (Baltimore, Md.) (Hepatology ) Vol: 69 Issue: 1 Pages: 107-120 Pub: 2019 Jan ePub: 2018 Jul 10 Authors Ponziani FR,Bhoori S,Castelli C,Putignani L,Rivoltini L,Del Chierico F,Sanguinetti M,Morelli D,Paroni Sterbini F,Petito V,Reddel S,Calvani R,Camisaschi C,Picca A,Tuccitto A,Gasbarrini A,Pompili M,Mazzaferro V
16 πŸ“š
Identification of Diagnostic Biomarkers for Compensatory Liver Cirrhosis Based on Gut Microbiota and Urine Metabolomics Analyses.
Molecular biotechnology (Mol Biotechnol ) Vol: 66 Issue: 11 Pages: 3164-3181 Pub: 2024 Nov ePub: 2023 Oct 24 Authors Chen Y,Chen S,Xu C,Yu L,Chu S,Bao J,Wang J,Wang J
17 πŸ“š
Implication of the intestinal microbiome in complications of cirrhosis.
World journal of hepatology (World J Hepatol ) Vol: 8 Issue: 27 Pages: 1128-1136 Pub: 2016 Sep 28 ePub: Authors Bhat M,Arendt BM,Bhat V,Renner EL,Humar A,Allard JP
18 πŸ“š
Intestinal microbiota and biliary system diseases.
Frontiers in cellular and infection microbiology (Front Cell Infect Microbiol ) Vol: 14 Issue: Pages: 1362933 Pub: 2024 ePub: 2024 Mar 15 Authors Wang H,Gong J,Chen J,Zhang W,Sun Y,Sun D
19 πŸ“š
Probiotic and glutamine treatments attenuate alcoholic liver disease in a rat model.
Experimental and therapeutic medicine (Exp Ther Med ) Vol: 18 Issue: 6 Pages: 4733-4739 Pub: 2019 Dec ePub: 2019 Oct 23 Authors Huang H,Lin Z,Zeng Y,Lin X,Zhang Y
20 πŸ“š
The causality between gut microbiome and liver cirrhosis: a bi-directional two-sample Mendelian randomization analysis.
Frontiers in microbiology (Front Microbiol ) Vol: 14 Issue: Pages: 1256874 Pub: 2023 ePub: 2023 Oct 18 Authors Xiao QA,Yang YF,Chen L,Xie YC,Li HT,Fu ZG,Han Q,Qin J,Tian J,Zhao WJ,Cai F,Hu YT,Ai LF,Li C,Chen XY,Wang D,Tan YY,Xia X,Zhang XL

Treatment Substances

The Studies below identify substances that has been tried with positive changes (for at least some symptoms in the study). Check if it has already been reviewed.

21 πŸ“š
[Studies on the mechanism of hyperfibrinolysis in liver cirrhosis--changes of plasma t-PA, PAI-1 and active PAI-1 levels in liver cirrhosis].
Rinsho byori. The Japanese journal of clinical pathology (Rinsho Byori ) Vol: 43 Issue: 12 Pages: 1256-60 Pub: 1995 Dec ePub: Authors Matsuura R,Soma M,Maeda Y,Kasakura S
22 πŸ“š
Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 prevents CCl4-induced liver cirrhosis by protecting the intestinal barrier in rats.
Scientific reports (Sci Rep ) Vol: 7 Issue: 1 Pages: 6927 Pub: 2017 Jul 31 ePub: 2017 Jul 31 Authors Shi D,Lv L,Fang D,Wu W,Hu C,Xu L,Chen Y,Guo J,Hu X,Li A,Guo F,Ye J,Li Y,Andayani D,Li L
23 πŸ“š
Anti-inflammatory probiotics HF05 and HF06 synergistically alleviate ulcerative colitis and secondary liver injury.
Food & function (Food Funct ) Vol: 15 Issue: 7 Pages: 3765-3777 Pub: 2024 Apr 2 ePub: 2024 Apr 2 Authors Liu C,Qi X,Liu X,Sun Y,Mao K,Shen G,Ma Y,Li Q
24 πŸ“š
Dietary supplementation of probiotic Lactobacillus modulates metabolic dysfunction-associated steatotic liver disease and intestinal barrier integrity in obesity-induced mice.
Journal of food science (J Food Sci ) Vol: Issue: Pages: Pub: 2024 Oct 25 ePub: 2024 Oct 25 Authors Qayyum N,Ismael M,Haoyue H,Guo H,LΓΌ X
25 πŸ“š
Glucagon-independent renal hyperaemia and hyperfiltration after an oral protein load in Child A liver cirrhosis.
European journal of clinical investigation (Eur J Clin Invest ) Vol: 22 Issue: 1 Pages: 31-7 Pub: 1992 Jan ePub: Authors De Santo NG,Anastasio P,Loguercio C,del Vecchio Blanco C,Capasso G,Coppola S,Bellini L,Spagnuolo G,Federico P,Alfieri R
26 πŸ“š
Lactiplantibacillus plantarum P101 Alleviated Alcohol-Induced Hepatic Lipid Accumulation in Mice via AMPK Signaling Pathway: Gut Microbiota and Metabolomics Analysis.
Probiotics and antimicrobial proteins (Probiotics Antimicrob Proteins ) Vol: Issue: Pages: Pub: 2024 Oct 10 ePub: 2024 Oct 10 Authors Feng X,Wang M,Wen S,Hu L,Lan Y,Xu H
27 πŸ“š
Lactobacillus helveticus attenuates alcoholic liver injury via regulation of gut microecology in mice.
Microbial biotechnology (Microb Biotechnol ) Vol: 17 Issue: 10 Pages: e70016 Pub: 2024 Oct ePub: Authors Lv J,Lang G,Wang Q,Zhao W,Shi D,Zhou Z,Shen Y,Xia H,Han S,Li L
28 πŸ“š
Oligosaccharides derived from Lycium barbarum ameliorate glycolipid metabolism and modulate the gut microbiota community and the faecal metabolites in a type 2 diabetes mouse model: metabolomic bioinformatic analysis.
Food & function (Food Funct ) Vol: 13 Issue: 9 Pages: 5416-5429 Pub: 2022 May 10 ePub: 2022 May 10 Authors Liu H,Zhang Z,Li J,Liu W,Warda M,Cui B,Abd El-Aty AM
29 πŸ“š
Partially hydrolyzed guar gum suppresses binge alcohol-induced liver fat accumulation via gut environment modulation in mice.
Journal of gastroenterology and hepatology (J Gastroenterol Hepatol ) Vol: Issue: Pages: Pub: 2024 Sep 23 ePub: 2024 Sep 23 Authors Morishima S,Abe A,Okamoto S,Kapoor MP,Osumi M,Oda M,Okubo T,Ozeki M,Nishio M,Inoue R
30 πŸ“š
Plasma thrombin-antithrombin III complexes in the diagnosis of primary hepatocellular carcinoma complicating liver cirrhosis.
Cancer (Cancer ) Vol: 67 Issue: 2 Pages: 481-5 Pub: 1991 Jan 15 ePub: Authors Tomiya T,Fujiwara K
31 πŸ“š
Polysaccharides from fermented Asparagus officinalis with Lactobacillus plantarum NCU116 alleviated liver injury via modulation of glutathione homeostasis, bile acid metabolism, and SCFA production.
Food & function (Food Funct ) Vol: 11 Issue: 9 Pages: 7681-7695 Pub: 2020 Sep 23 ePub: Authors Zhang Z,Fan S,Huang D,Xiong T,Nie S,Xie M
32 πŸ“š
Probiotics promote rapid-turnover protein production by restoring gut flora in patients with alcoholic liver cirrhosis.
Hepatology international (Hepatol Int ) Vol: 7 Issue: 2 Pages: 767-74 Pub: 2013 Jun ePub: 2012 Nov 21 Authors Koga H,Tamiya Y,Mitsuyama K,Ishibashi M,Matsumoto S,Imaoka A,Hara T,Nakano M,Ooeda K,Umezaki Y,Sata M
33 πŸ“š
Psychoactive Effects of Lactobacillus johnsonii BS15 on Preventing Memory Dysfunction Induced by Acute Ethanol Exposure Through Modulating Intestinal Microenvironment and Improving Alcohol Metabolic Level.
Frontiers in microbiology (Front Microbiol ) Vol: 13 Issue: Pages: 847468 Pub: 2022 ePub: 2022 Apr 1 Authors Sun N,Zhu B,Xin J,Li L,Gan B,Cao X,Fang J,Pan K,Jing B,Zeng Y,Lv C,Zhao L,Zeng D,Xu P,Wang H,Ni X
34 πŸ“š
Rifaximin-a use is associated with improved muscle mass in patients with cirrhosis.
World journal of hepatology (World J Hepatol ) Vol: 17 Issue: 4 Pages: 104056 Pub: 2025 Apr 27 ePub: Authors Worland T,Hey P,Wong D,Apostolov R,Chan RK,Sinclair M,Gow P
35 πŸ“š
The Impact of Probiotic Bifidobacterium on Liver Diseases and the Microbiota.
Life (Basel, Switzerland) (Life (Basel) ) Vol: 14 Issue: 2 Pages: Pub: 2024 Feb 8 ePub: 2024 Feb 8 Authors Hizo GH,Rampelotto PH
36 πŸ“š
The influence of perilipin 5 deficiency on gut microbiome profiles in murine metabolic dysfunction-associated fatty liver disease (MAFLD) and MAFLD-hepatocellular carcinoma.
Frontiers in cellular and infection microbiology (Front Cell Infect Microbiol ) Vol: 14 Issue: Pages: 1443654 Pub: 2024 ePub: 2024 Oct 14 Authors Krizanac M,Ε tancl P,Mass-Sanchez PB,Karlic R,Moeckel D,Lammers T,Asimakopoulos A,Weiskirchen R
37 πŸ“š
The role of the gut barrier function in the pathophysiology of viral liver cirrhosis.
Hepato-gastroenterology (Hepatogastroenterology ) Vol: 58 Issue: 109 Pages: 1244-7 Pub: 2011 Jul-Aug ePub: Authors Choi Y,Jeon WK,Hwang SJ,Kim BI,Sohn CI,Park DI,Cho YK,Kim HJ,Park JH

Quick Reference

The following items have been cited in the above studies

IDStudiesNameAKA
3172 1   Asparagus officinalis {Asparagus} Garden asparagus,Common asparagus
1753 1   bifidobacterium b (probiotics)
1777 1   Clostridium butyricum MIYAIRI 588 {Miyarisan} Miya,Miya-Pro, Cdactin-O
234 1   Lacticaseibacillus casei {L. casei} Streptobacterium casei,Lactobacillus casei
241 1   Lacticaseibacillus paracasei {L.paracasei} Was also known as Lactobacillus casei subsp. pseudoplantarum
1918 1   lactobacillus helveticus {L. helveticus}
3144 1   Lactobacillus Johnsonii {Lactobacillus Johnsonii} Taxonomy ID: 33959
243 2   Lactobacillus plantarum {L. plantarum} lactobacillus plantarum, Lactobacillus arabinosus
247 1   lactobacillus rhamnosus gg l rhamnosus gg (probiotics)
115 1   lactobacillus rhamnosus gg,bifidobacterium animalis lactis ,lactobacillus paracasei {cvs maximum strength probiotic}
3185 4   Lactococcus lactis {Streptococcus lactis}
236 1   Limosilactobacillus fermentum {L. fermentum} Lactobacillus fermentum
1888 1   Lycium barbarum x Lycium chinense, {Goji Fruit, Juice} Wolfberry,Chinese wolfberry, Matrimony vinem, Himalayan goji, Tibetan goji, Ningxia wolfberry, Chinese boxthorn, Fruktus lycii,Gougizi
1718 1   partially hydrolysed guar gum partially hydrolyzed guar gum
363 1   rifaximin (bang yi, cefaximin-l, colidimin, colidur, coloximina, fatrox, fatroximin, flonorm, fu jie ting, fu te, gastrobiotic, hepaximin, ifaxim, ji li qing, jinxili, lai li qing, lormyx, mai e ke si, mastorange, ou ke shuang, qian er fen, refero, ribolac, rifabac, rifacol, rifadom, rifagut, rifamax, rifax, rixmin, sa fen, spiraxin, targaxan, tixtar, tixteller, trencedia, xi jie, xifushen, zi jun) ,xifaxan

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