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Common knowledge amoung some professionals (MD and ND):
Glucosamine and Chondroitin Sulfate: These are commonly used supplements for osteoarthritis. Glucosamine and chondroitin are components of cartilage and might help in maintaining or repairing joint tissue. Some studies suggest that they might provide modest relief from OA symptoms, although results are mixed. They are often taken together in supplement form.
Omega-3 Fatty Acids: Omega-3 fatty acids found in fish oil or certain plant-based sources may have anti-inflammatory properties that could potentially benefit individuals with OA by reducing inflammation and joint pain. Some evidence suggests they might help in managing symptoms.
Turmeric/Curcumin: Turmeric contains curcumin, a compound with anti-inflammatory properties. Some studies suggest that curcumin supplements might have a role in reducing inflammation and providing pain relief for individuals with OA, although more research is needed.
Vitamin D and Calcium: Adequate levels of vitamin D and calcium are important for bone health. While they are not specific treatments for OA, maintaining optimal levels might support overall bone and joint health.
Probiotics: While not directly related to joint health, maintaining a healthy gut microbiome might indirectly influence overall health and potentially impact inflammation. Some research suggests that probiotics might have a role in reducing inflammation, which could benefit individuals with OA. However, specific strains, dosages, and their effects on OA require further research.
The Studies below identify bacteria. Check if it has already been reviewed.
| 1 | 📚 |
Assessment of fecal Akkermansia muciniphila in patients with osteoporosis and osteopenia: a pilot study.
Journal of diabetes and metabolic disorders (J Diabetes Metab Disord ) Vol: 20 Issue: 1 Pages: 279-284 Pub: 2021 Jun ePub: 2021 Jan 23 Authors Keshavarz Azizi Raftar S,Hoseini Tavassol Z,Amiri M,Ejtahed HS,Zangeneh M,Sadeghi S,Ashrafian F,Kariman A,Khatami S,Siadat SD |
| 2 | 📚 |
Association between gut microbiota, bone metabolism, and fracture risk in postmenopausal Japanese women.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (Osteoporos Int ) Vol: 32 Issue: 1 Pages: 145-156 Pub: 2021 Jan ePub: 2020 Nov 25 Authors Ozaki D,Kubota R,Maeno T,Abdelhakim M,Hitosugi N |
| 3 | 📚 |
Association of gut microbiota composition and function with an aged rat model of senile osteoporosis using 16S rRNA and metagenomic sequencing analysis.
Aging (Aging (Albany NY) ) Vol: 12 Issue: 11 Pages: 10795-10808 Pub: 2020 Jun 2 ePub: 2020 Jun 2 Authors Ma S,Qin J,Hao Y,Fu L |
| 4 | 📚 |
Autophagy-induced osteoblast-derived exosomes maintain bone formation and prevent osteoporosis by remodeling gut microbiota-metabolism.
Biomedical journal (Biomed J ) Vol: Issue: Pages: 100870 Pub: 2025 May 6 ePub: 2025 May 6 Authors Chen L,Lu L,Fan C,Zhu X,Pan L,Tang S,Wang Y,Peng Y,You L |
| 5 | 📚 |
Changes in the gut microbiota of osteoporosis patients based on 16S rRNA gene sequencing: a systematic review and meta-analysis.
Journal of Zhejiang University. Science. B (J Zhejiang Univ Sci B ) Vol: 23 Issue: 12 Pages: 1002-1013 Pub: 2022 Dec 15 ePub: Authors Huang R,Liu P,Bai Y,Huang J,Pan R,Li H,Su Y,Zhou Q,Ma R,Zong S,Zeng G |
| 6 | 📚 |
Characterization of Intestinal Flora in Osteoporosis Patients Based on 16S rDNA Sequencing.
International journal of general medicine (Int J Gen Med ) Vol: 17 Issue: Pages: 4311-4324 Pub: 2024 ePub: 2024 Sep 23 Authors Sun M,Liu Y,Tang S,Li Y,Zhang R,Mao L |
| 7 | 📚 |
Clinical correlation between intestinal flora profiles and the incidence of postmenopausal osteoporosis.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol ) Vol: 41 Issue: 1 Pages: 2465587 Pub: 2025 Dec ePub: 2025 Feb 14 Authors Zhu C,Zhang Y,Pan Y,Zhang Z,Liu Y,Lin X,Cai J,Xiong Z,Pan Y,Nie H |
| 8 | 📚 |
Gut microbiome and osteoporosis: a review.
Bone & joint research (Bone Joint Res ) Vol: 9 Issue: 8 Pages: 524-530 Pub: 2020 Aug ePub: 2020 Aug 2 Authors Li S,Mao Y,Zhou F,Yang H,Shi Q,Meng B |
| 9 | 📚 |
Gut Microbiome Reveals Specific Dysbiosis in Primary Osteoporosis.
Frontiers in cellular and infection microbiology (Front Cell Infect Microbiol ) Vol: 10 Issue: Pages: 160 Pub: 2020 ePub: 2020 Apr 21 Authors Xu Z,Xie Z,Sun J,Huang S,Chen Y,Li C,Sun X,Xia B,Tian L,Guo C,Li F,Pi G |
| 10 | 📚 |
Gut microbiota alterations associated with reduced bone mineral density in older adults.
Rheumatology (Oxford, England) (Rheumatology (Oxford) ) Vol: 58 Issue: 12 Pages: 2295-2304 Pub: 2019 Dec 1 ePub: Authors Das M,Cronin O,Keohane DM,Cormac EM,Nugent H,Nugent M,Molloy C,O`Toole PW,Shanahan F,Molloy MG,Jeffery IB |
| 11 | 📚 |
Gut microbiota alterations in postmenopausal women with osteoporosis and osteopenia from Shanghai, China.
PeerJ (PeerJ ) Vol: 12 Issue: Pages: e17416 Pub: 2024 ePub: 2024 May 31 Authors Ji J,Gu Z,Li N,Dong X,Wang X,Yao Q,Zhang Z,Zhang L,Cao L |
| 12 | 📚 |
Gut-bone axis research: unveiling the impact of gut microbiota on postmenopausal osteoporosis and osteoclasts through Mendelian randomization.
Frontiers in endocrinology (Front Endocrinol (Lausanne) ) Vol: 15 Issue: Pages: 1419566 Pub: 2024 ePub: 2024 May 31 Authors Xiao H,Wang Y,Chen Y,Chen R,Yang C,Geng B,Xia Y |
| 13 | 📚 |
Novel microbiota-related gene set enrichment analysis identified osteoporosis associated gut microbiota from autoimmune diseases.
Journal of bone and mineral metabolism (J Bone Miner Metab ) Vol: 39 Issue: 6 Pages: 984-996 Pub: 2021 Nov ePub: 2021 Aug 2 Authors Cao RR,He P,Lei SF |
| 14 | 📚 |
Osteoporosis in postmenopausal women is associated with disturbances in gut microbiota and migration of peripheral immune cells.
BMC musculoskeletal disorders (BMC Musculoskelet Disord ) Vol: 25 Issue: 1 Pages: 791 Pub: 2024 Oct 7 ePub: 2024 Oct 7 Authors Ma Z,Liu Y,Shen W,Yang J,Wang T,Li Y,Ma J,Zhang X,Wang H |
| 15 | 📚 |
Perturbations in gut microbiota composition in osteoporosis: a systematic review and meta-analysis.
Journal of bone and mineral metabolism (J Bone Miner Metab ) Vol: 42 Issue: 5 Pages: 551-563 Pub: 2024 Sep ePub: 2024 Jun 12 Authors Cao Y,Gao Y,Huang J |
| 16 | 📚 |
Ruptured mycotic aneurysm of intercostal arteries associated with vertebral osteomyelitis: a case report.
Journal of cardiothoracic surgery (J Cardiothorac Surg ) Vol: 18 Issue: 1 Pages: 145 Pub: 2023 Apr 17 ePub: 2023 Apr 17 Authors Tsukamoto M,Morimoto T,Yoshihara T,Mawatari M |
| 17 | 📚 |
Staphylococcus simulans as an authentic pathogenic agent of osteoarticular infections.
Infection (Infection ) Vol: 39 Issue: 5 Pages: 473-6 Pub: 2011 Oct ePub: 2011 Aug 10 Authors Mallet M,Loiez C,Melliez H,Yazdanpanah Y,Senneville E,Lemaire X |
| 18 | 📚 |
The Characteristics of Gut Microbiota and Its Relation with Diet in Postmenopausal Osteoporosis.
Calcified tissue international (Calcif Tissue Int ) Vol: 115 Issue: 4 Pages: 393-404 Pub: 2024 Oct ePub: 2024 Jul 26 Authors Chen T,Meng F,Wang N,Hao Y,Fu L |
| 19 | 📚 |
The gut microbiota alteration and the key bacteria in Astragalus polysaccharides (APS)-improved osteoporosis.
Food research international (Ottawa, Ont.) (Food Res Int ) Vol: 138 Issue: Pt B Pages: 109811 Pub: 2020 Dec ePub: 2020 Oct 21 Authors Liu J,Liu J,Liu L,Zhang G,Zhou A,Peng X |
| 20 | 📚 |
The Lachnospiraceae-butyric acid axis and its role in glucocorticoid-associated osteonecrosis.
Journal of translational medicine (J Transl Med ) Vol: 22 Issue: 1 Pages: 1015 Pub: 2024 Nov 11 ePub: 2024 Nov 11 Authors Guo M,He S,Song W,Mai J,Yuan X,Huang Y,Xi H,Sun G,Chen Y,Du B,Liu X |
| 21 | 📚 |
The Osteoporosis/Microbiota Linkage: The Role of miRNA.
International journal of molecular sciences (Int J Mol Sci ) Vol: 21 Issue: 23 Pages: Pub: 2020 Nov 24 ePub: 2020 Nov 24 Authors De Martinis M,Ginaldi L,Allegra A,Sirufo MM,Pioggia G,Tonacci A,Gangemi S |
The Studies below identify substances that has been tried with positive changes (for at least some symptoms in the study). Check if it has already been reviewed.
| 22 | 📚 |
2'-Fucosyllactose ameliorates aging-related osteoporosis by restoring gut microbial and innate immune homeostasis.
Journal of advanced research (J Adv Res ) Vol: Issue: Pages: Pub: 2024 Nov 14 ePub: 2024 Nov 14 Authors Li A,Kou R,Wang J,Zhang B,Zhang Y,Liu J,Hu Y,Wang S |
| 23 | 📚 |
Bifidobacterium improves oestrogen-deficiency-induced osteoporosis in mice by modulating intestinal immunity.
Food & function (Food Funct ) Vol: 15 Issue: 4 Pages: 1840-1851 Pub: 2024 Feb 19 ePub: 2024 Feb 19 Authors Zhang J,Liang X,Tian X,Zhao M,Mu Y,Yi H,Zhang Z,Zhang L |
| 24 | 📚 |
Chemical constituents and biological properties of Pu-erh tea.
Food research international (Ottawa, Ont.) (Food Res Int ) Vol: 154 Issue: Pages: 110899 Pub: 2022 Apr ePub: 2021 Dec 15 Authors Wang S,Qiu Y,Gan RY,Zhu F |
| 25 | 📚 |
Curcumin Ameliorated Glucocorticoid-Induced Osteoporosis While Modulating the Gut Microbiota and Serum Metabolome.
Journal of agricultural and food chemistry (J Agric Food Chem ) Vol: Issue: Pages: Pub: 2025 Mar 26 ePub: 2025 Mar 26 Authors Li S,Zhang Y,Ding S,Chang J,Liu G,Hu S |
| 26 | 📚 |
Effect of probiotics on postmenopausal bone health: a preclinical meta-analysis.
The British journal of nutrition (Br J Nutr ) Vol: 131 Issue: 4 Pages: 567-580 Pub: 2024 Feb 28 ePub: 2023 Oct 23 Authors Bose S,Sharan K |
| 27 | 📚 |
Evaluation of Functional Components of Lactobacillus plantarum AR495 on Ovariectomy-Induced Osteoporosis in Mice And RAW264.7 Cells.
Foods (Basel, Switzerland) (Foods ) Vol: 13 Issue: 19 Pages: Pub: 2024 Sep 29 ePub: 2024 Sep 29 Authors Chen Z,Shao J,Yang Y,Wang G,Xiong Z,Song X,Ai L,Xia Y,Zhu B |
| 28 | 📚 |
Exogenous melatonin prevents type 1 diabetes mellitus-induced bone loss, probably by inhibiting senescence.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (Osteoporos Int ) Vol: 33 Issue: 2 Pages: 453-466 Pub: 2022 Feb ePub: 2021 Sep 14 Authors Gong Z,Da W,Tian Y,Zhao R,Qiu S,Wu Q,Wen K,Shen L,Zhou R,Tao L,Zhu Y |
| 29 | 📚 |
Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis.
Nutrients (Nutrients ) Vol: 14 Issue: 13 Pages: Pub: 2022 Jun 23 ePub: 2022 Jun 23 Authors Yang SY,Fang CJ,Chen YW,Chen WP,Lee LY,Chen CC,Lin YY,Liu SC,Tsai CH,Huang WC,Wu YC,Tang CH |
| 30 | 📚 |
Inhibitory effects of Colocasia antiquorum var. esculenta varnish on inflammation and alveolar bone loss in a rat ligature-induced periodontitis model.
Dental materials journal (Dent Mater J ) Vol: 44 Issue: 1 Pages: 86-92 Pub: 2025 Jan 31 ePub: 2024 Dec 28 Authors Moon SH,Shin SJ,Shim GY,Kim HJ,Oh S,Kim SH,Bae JM |
| 31 | 📚 |
Lactobacillus plantarum LP45 inhibits the RANKL/OPG signaling pathway and prevents glucocorticoid-induced osteoporosis.
Food & nutrition research (Food Nutr Res ) Vol: 67 Issue: Pages: Pub: 2023 ePub: 2023 Mar 24 Authors Jiang X,Qi X,Xie C |
| 32 | 📚 |
Lactobacillus Reuteri 6475 Prevents Bone Loss in a Clinically Relevant Oral Model of Glucocorticoid-Induced Osteoporosis in Male CD-1 Mice.
JBMR plus (JBMR Plus ) Vol: 7 Issue: 12 Pages: e10805 Pub: 2023 Dec ePub: 2023 Aug 13 Authors Chargo NJ,Schepper JD,Rios-Arce N,Kang HJ,Gardinier JD,Parameswaran N,McCabe LR |
| 33 | 📚 |
Lactobacillus rhamnosus GG Promotes Intestinal Vitamin D Absorption by Upregulating Vitamin D Transporters in Senile Osteoporosis.
Calcified tissue international (Calcif Tissue Int ) Vol: 111 Issue: 2 Pages: 162-170 Pub: 2022 Aug ePub: 2022 May 26 Authors Cheng J,Zhai J,Zhong W,Zhao J,Zhou L,Wang B |
| 34 | 📚 |
Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model.
Journal of cellular physiology (J Cell Physiol ) Vol: 229 Issue: 11 Pages: 1822-30 Pub: 2014 Nov ePub: Authors Britton RA,Irwin R,Quach D,Schaefer L,Zhang J,Lee T,Parameswaran N,McCabe LR |
| 35 | 📚 |
Role of the Microbiome in Regulating Bone Metabolism and Susceptibility to Osteoporosis.
Calcified tissue international (Calcif Tissue Int ) Vol: 110 Issue: 3 Pages: 273-284 Pub: 2022 Mar ePub: 2021 Dec 6 Authors Cronin O,Lanham-New SA,Corfe BM,Gregson CL,Darling AL,Ahmadi KR,Gibson PS,Tobias JH,Ward KA,Traka MH,Rossi M,Williams C,Harvey NC,Cooper C,Whelan K,Uitterlinden AG,O`Toole PW,Ohlsson C,Compston JE,Ralston SH |
| 36 | 📚 |
Soy-whey dual-protein alleviates osteoporosis of ovariectomized rats via regulating bone fat metabolism through gut-liver-bone axis.
Nutrition (Burbank, Los Angeles County, Calif.) (Nutrition ) Vol: 103-104 Issue: Pages: 111723 Pub: 2022 Nov-Dec ePub: 2022 May 6 Authors Zhang J,Zhang Q,Liu H,Liu X,Yu Y,Han D,He X,Zeng P,Wang J |
| 37 | 📚 |
Specific targeting of inflammatory osteoclastogenesis by the probiotic yeast S. boulardii CNCM I-745 reduces bone loss in osteoporosis.
eLife (Elife ) Vol: 12 Issue: Pages: Pub: 2023 Feb 27 ePub: 2023 Feb 27 Authors Madel MB,Halper J,Ibáñez L,Claire L,Rouleau M,Boutin A,Mahler A,Pontier-Bres R,Ciucci T,Topi M,Hue C,Amiaud J,Iborra S,Sancho D,Heymann D,Garchon HJ,Czerucka D,Apparailly F,Duroux-Richard I,Wakkach A,Blin-Wakkach C |
| 38 | 📚 |
Study on the relationship between tea polyphenols alleviating osteoporosis and the changes of microorganism-metabolite-intestinal barrier.
Microbial pathogenesis (Microb Pathog ) Vol: 188 Issue: Pages: 106564 Pub: 2024 Mar ePub: 2024 Feb 1 Authors Wen X,Wu P,Li F,Pi G |
| 39 | 📚 |
Vanillin Promotes Osteoblast Differentiation, Mineral Apposition, and Antioxidant Effects in Pre-Osteoblasts.
Pharmaceutics (Pharmaceutics ) Vol: 16 Issue: 4 Pages: Pub: 2024 Apr 1 ePub: 2024 Apr 1 Authors Yun HM,Kim E,Kwon YJ,Park KR |
The following items have been cited in the above studies
| ID | Studies | Name | AKA |
|---|---|---|---|
| 32 | 2 | bacillus subtilis {B.Subtilis } | Hay bacillus, grass bacillus,Vibrio subtilis |
| 1755 | 1 | bacillus,lactobacillus,streptococcus,saccharomyces probiotic | |
| 1753 | 1 | bifidobacterium | b (probiotics) |
| 46 | 1 | Bifidobacterium animalis subsp. lactis {B. Lactis} | Includes BB-12, DN-173 010 ,Bifidobacterium Regularis,Bifidus Regularis |
| 1737 | 1 | bifidobacterium bifidum {B. bifidum} | |
| 459 | 1 | Camellia sinensis {oolong tea} | Blue Tea,Qingcha,Wulong |
| 4537 | 1 | Colocasia esculenta {Taro} | Elephant Ears,Dasheen,Green Taro,Malanga,Caladium,Eddo |
| 1824 | 1 | Diferuloylmethane {Curcumin} | Extract from Turmeric (which contains other chemicals) |
| 4521 | 1 | Hericium erinaceus {Lion's Mane Mushroom } | Yamabushitake (Japanese), Bearded Tooth Fungus, Monkey's Head Mushroom, Hedgehog Mushroom, Old Man's Beard,Bearded Hedgehog |
| 1674 | 1 | Human milk oligosaccharides (prebiotic, Holigos, Stachyose) | Stachyose,2'-Fucosyllactose ,2'-FL |
| 243 | 3 | Lactobacillus plantarum {L. plantarum} | lactobacillus plantarum, Lactobacillus arabinosus |
| 247 | 1 | lactobacillus rhamnosus gg | l rhamnosus gg (probiotics) |
| 245 | 2 | Limosilactobacillus reuteri {L. Reuteri} | Lactobacillus fermentum subsp. reuteri |
| 282 | 1 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide {Melatonin} | a hormone primarily produced by the pineal gland |
| 338 | 1 | polyphenols | |
| 4562 | 1 | Vanillin {Vanilla} | Vanilla planifolia |
| 430 | 1 | β-lactoglobulin {Whey} | Liquid byproduct of cheese or casein manufacture, Lactalbumin, Whey protein / isolates / hydrolysates |
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