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Amyotrophic lateral sclerosis (ALS) Motor Neuron

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Common knowledge amoung some professionals (MD and ND):

  1. Antioxidants: Antioxidants such as vitamins C and E have been investigated for their potential to reduce oxidative stress, which is implicated in the progression of ALS. While research has not conclusively shown their effectiveness in slowing ALS progression, maintaining adequate levels of antioxidants through diet or supplements might be beneficial for overall health.

  2. Omega-3 Fatty Acids: Omega-3 fatty acids found in fish oil or certain plant sources possess anti-inflammatory properties. Some studies suggest that omega-3 supplementation might have a potential role in reducing inflammation and oxidative stress, which could be beneficial for individuals with ALS. However, evidence supporting their efficacy is limited.

  3. Vitamin D: Vitamin D deficiency has been associated with a higher risk of ALS. Some studies suggest that maintaining adequate vitamin D levels might have a neuroprotective effect and could potentially influence the risk or progression of ALS. However, more research is needed to establish a clear link.

  4. Probiotics: The gut microbiota's influence on overall health, including neurological conditions, has prompted research into the potential role of probiotics in ALS. While the exact mechanisms are not fully understood, maintaining a healthy gut microbiota through probiotics might have indirect effects on overall health. However, direct evidence linking probiotics to ALS prevention or treatment is lacking.


Bacteria/Taxa

The Studies below identify bacteria. Check if it has already been reviewed.

1 📚
A prospective longitudinal study on the microbiota composition in amyotrophic lateral sclerosis.
BMC medicine (BMC Med ) Vol: 18 Issue: 1 Pages: 153 Pub: 2020 Jun 17 ePub: 2020 Jun 17 Authors Di Gioia D,Bozzi Cionci N,Baffoni L,Amoruso A,Pane M,Mogna L,Gaggìa F,Lucenti MA,Bersano E,Cantello R,De Marchi F,Mazzini L
2 📚
Amyotrophic lateral sclerosis and intestinal microbiota-toward establishing cause and effect.
Gut microbes (Gut Microbes ) Vol: 11 Issue: 6 Pages: 1833-1841 Pub: 2020 Nov 1 ePub: 2020 Jun 5 Authors Gotkine M,Kviatcovsky D,Elinav E
3 📚
Bridging the Gap: Harnessing Plant Bioactive Molecules to Target Gut Microbiome Dysfunctions in Amyotrophic Lateral Sclerosis.
Current issues in molecular biology (Curr Issues Mol Biol ) Vol: 46 Issue: 5 Pages: 4471-4488 Pub: 2024 May 8 ePub: 2024 May 8 Authors Pribac M,Motataianu A,Andone S,Mardale E,Nemeth S
4 📚
Circadian Rhythm Dysfunction Accelerates Disease Progression in a Mouse Model With Amyotrophic Lateral Sclerosis.
Frontiers in neurology (Front Neurol ) Vol: 9 Issue: Pages: 218 Pub: 2018 ePub: 2018 Apr 24 Authors Huang Z,Liu Q,Peng Y,Dai J,Xie Y,Chen W,Long S,Pei Z,Su H,Yao X
5 📚
Cronobacter sakazakii DNA Detection in Cerebrospinal Fluid of a Patient with Amyotrophic Lateral Sclerosis Mimic Syndrome.
Case reports in neurology (Case Rep Neurol ) Vol: 7 Issue: 3 Pages: 238-41 Pub: 2015 Sep-Dec ePub: 2015 Dec 24 Authors Piombo M,Chiarello D,Corbetto M,Di Pino G,Dicuonzo G,Angeletti S,Riva E,De Florio L,Capone F,Di Lazzaro V
6 📚
Cyanobacteria, Cyanotoxins, and Neurodegenerative Diseases: Dangerous Liaisons.
International journal of molecular sciences (Int J Mol Sci ) Vol: 22 Issue: 16 Pages: Pub: 2021 Aug 13 ePub: 2021 Aug 13 Authors Sini P,Dang TBC,Fais M,Galioto M,Padedda BM,Lugliè A,Iaccarino C,Crosio C
7 📚
Evaluation of the Microbial Diversity in Amyotrophic Lateral Sclerosis Using High-Throughput Sequencing.
Frontiers in microbiology (Front Microbiol ) Vol: 7 Issue: Pages: 1479 Pub: 2016 ePub: 2016 Sep 20 Authors Fang X,Wang X,Yang S,Meng F,Wang X,Wei H,Chen T
8 📚
Fungal infection in neural tissue of patients with amyotrophic lateral sclerosis.
Neurobiology of disease (Neurobiol Dis ) Vol: 108 Issue: Pages: 249-260 Pub: 2017 Dec ePub: 2017 Sep 6 Authors Alonso R,Pisa D,Fernández-Fernández AM,Rábano A,Carrasco L
9 📚
Gut inflammation and dysbiosis in human motor neuron disease.
Physiological reports (Physiol Rep ) Vol: 5 Issue: 18 Pages: Pub: 2017 Sep ePub: Authors Rowin J,Xia Y,Jung B,Sun J
10 📚
Is gut microbiota of patients with ALS different from that of healthy individuals?
Turkish journal of medical sciences (Turk J Med Sci ) Vol: 54 Issue: 3 Pages: 579-587 Pub: 2024 ePub: 2024 May 7 Authors Özaydin Aksun Z,Erdogan S,Kalkanci A,Sahin EA,Çuhadar T,Sener HÖ
11 📚
Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model.
Physiological reports (Physiol Rep ) Vol: 3 Issue: 4 Pages: Pub: 2015 Apr ePub: Authors Wu S,Yi J,Zhang YG,Zhou J,Sun J
12 📚
Potential Role of Gut Microbiota in ALS Pathogenesis and Possible Novel Therapeutic Strategies.
Journal of clinical gastroenterology (J Clin Gastroenterol ) Vol: Issue: Pages: Pub: 2018 May 18 ePub: 2018 May 18 Authors Mazzini L,Mogna L,De Marchi F,Amoruso A,Pane M,Aloisio I,Cionci NB,Gaggìa F,Lucenti A,Bersano E,Cantello R,Di Gioia D,Mogna G
13 📚
Specific Bacterial Taxa and Their Metabolite, DHPS, May Be Linked to Gut Dyshomeostasis in Patients with Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.
Nutrients (Nutrients ) Vol: 17 Issue: 9 Pages: Pub: 2025 May 6 ePub: 2025 May 6 Authors Christopher CJ,Morgan KH,Tolleson CM,Trudell R,Fernandez-Romero R,Rice L,Abiodun BA,Vickery Z,Jones KA,Woodall BM,Nagy C,Mieczkowski PA,Bowen G,Campagna SR,Ellis JC
14 📚
The alteration of gut microbiome and metabolism in amyotrophic lateral sclerosis patients.
Scientific reports (Sci Rep ) Vol: 10 Issue: 1 Pages: 12998 Pub: 2020 Aug 3 ePub: 2020 Aug 3 Authors Zeng Q,Shen J,Chen K,Zhou J,Liao Q,Lu K,Yuan J,Bi F
15 📚
The Impact of Microbiota on the Pathogenesis of Amyotrophic Lateral Sclerosis and the Possible Benefits of Polyphenols. An Overview.
Metabolites (Metabolites ) Vol: 11 Issue: 2 Pages: Pub: 2021 Feb 20 ePub: 2021 Feb 20 Authors Casani-Cubel J,Benlloch M,Sanchis-Sanchis CE,Marin R,Lajara-Romance JM,de la Rubia Orti JE

Treatment Substances

The Studies below identify substances that has been tried with positive changes (for at least some symptoms in the study). Check if it has already been reviewed.

Quick Reference

The following items have been cited in the above studies

IDStudiesNameAKA

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