Electrolyte Supplements: Some individuals with POTS might experience electrolyte imbalances due to fluid shifts or inadequate intake. Supplements containing electrolytes like sodium, potassium, magnesium, and fluids might help in managing symptoms related to hydration and blood pressure regulation. However, their use should be guided by healthcare providers.

Compression Stockings: While not supplements, compression stockings or garments are sometimes used to help improve blood flow and reduce pooling in the lower extremities, which might assist in managing symptoms of POTS, particularly orthostatic intolerance.

Salt Supplementation: Some individuals with POTS might be advised to increase their salt intake to help manage symptoms related to blood pressure regulation and volume. However, this should be done under medical supervision and guidance.

Probiotics: While not directly related to POTS, some research suggests that probiotics might influence gut health, which might indirectly impact overall health. Gut health is being explored in relation to various autonomic nervous system disorders, although specific effects on POTS require further research.

Vitamin Supplements: In some cases, individuals with POTS might have deficiencies in certain vitamins or minerals. Supplementation with vitamins such as B12, folate, or others might be recommended if deficiencies are identified through testing.