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Bacterial Infections: Dibekacin is effective against a wide range of bacterial infections, particularly those caused by gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Acinetobacter species. These infections can affect various parts of the body, including the respiratory tract, urinary tract, skin, soft tissues, and bloodstream.
Respiratory Tract Infections: Dibekacin may be used to treat respiratory tract infections, including pneumonia, bronchitis, and bronchiectasis, particularly when caused by multidrug-resistant gram-negative bacteria.
Urinary Tract Infections: Dibekacin can be effective in treating urinary tract infections (UTIs) caused by susceptible bacteria. This includes infections of the bladder (cystitis) and kidneys (pyelonephritis).
Skin and Soft Tissue Infections: Dibekacin may be used to treat skin and soft tissue infections, including cellulitis, abscesses, and wound infections, particularly when caused by gram-negative bacteria.
Bacterial Meningitis: In some cases, dibekacin may be used in the treatment of bacterial meningitis, particularly when caused by gram-negative bacteria. However, its use in meningitis may be limited due to concerns about penetration into the cerebrospinal fluid and potential neurotoxicity.
Hospital-Acquired Infections: Dibekacin may be used to treat infections acquired in healthcare settings, including ventilator-associated pneumonia and bloodstream infections caused by multidrug-resistant bacteria.
Otitis Externa: Dibekacin may be prescribed for the treatment of otitis externa (swimmer's ear) caused by susceptible bacteria.
Eye Infections: Dibekacin ophthalmic solution may be used to treat bacterial eye infections, such as conjunctivitis (pink eye) and keratitis (corneal inflammation), caused by susceptible bacteria.
Cystic Fibrosis: Dibekacin may be used as part of the treatment regimen for cystic fibrosis patients who have chronic respiratory infections caused by multidrug-resistant gram-negative bacteria.
Precautions and Side Effects: Like other aminoglycoside antibiotics, dibekacin carries a risk of side effects, including nephrotoxicity (kidney damage), ototoxicity (hearing loss or vestibular dysfunction), and neuromuscular blockade. Therefore, it is important to monitor patients closely for signs of toxicity, especially when using high doses or prolonged treatment durations.
Resistance: Overuse or inappropriate use of dibekacin can contribute to the development of antibiotic resistance. Therefore, it should be used judiciously and in accordance with local antimicrobial resistance patterns and guidelines.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
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