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🍽️ Rapamycin

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  1. Immunosuppression: Rapamycin is primarily used as an immunosuppressant medication to prevent rejection in organ transplantation, particularly kidney transplantation. It inhibits the activity of T lymphocytes, a type of white blood cell involved in the immune response, thereby reducing the risk of rejection.

  2. Anti-proliferative Properties: Rapamycin has anti-proliferative properties, meaning it inhibits the growth and proliferation of cells. This property is exploited in the treatment of certain cancers, including renal cell carcinoma (RCC) and neuroendocrine tumors (NETs).

  3. Coronary Stent Coating: Rapamycin is also used in drug-eluting stents (DES) deployed during percutaneous coronary intervention (PCI) procedures to prevent restenosis, the re-narrowing of arteries after stent placement. The drug-coated stents release rapamycin locally to inhibit the proliferation of smooth muscle cells in the arterial wall.

  4. Lymphangioleiomyomatosis (LAM): Rapamycin has shown efficacy in the treatment of lymphangioleiomyomatosis, a rare lung disease characterized by the abnormal proliferation of smooth muscle cells in the lung tissue. It helps to stabilize lung function and reduce symptoms in patients with LAM.

  5. Tuberous Sclerosis Complex (TSC): Rapamycin is also used in the treatment of tuberous sclerosis complex, a genetic disorder characterized by the growth of benign tumors in various organs, including the brain, kidneys, heart, eyes, lungs, and skin. It can reduce the size of tumors associated with TSC and improve symptoms.

  6. Sirolimus-eluting Devices: Apart from drug-eluting stents, sirolimus has been incorporated into other medical devices, such as drug-eluting balloons and drug-eluting implants, for various applications in interventional cardiology and other fields.

  7. Potential Anti-aging Effects: Rapamycin has been investigated for its potential anti-aging effects in preclinical studies. Some research suggests that rapamycin may extend lifespan and delay the onset of age-related diseases in certain model organisms, although further studies are needed to determine its safety and efficacy for anti-aging purposes in humans.

  8. Side Effects: Common side effects of rapamycin include immunosuppression-related complications such as increased susceptibility to infections, as well as metabolic disturbances, gastrointestinal symptoms, skin reactions, and potential adverse effects on renal function and lipid metabolism. Patients receiving rapamycin therapy require close monitoring for these side effects.

  9. Drug Interactions: Rapamycin may interact with other medications, particularly those metabolized by the cytochrome P450 system, potentially leading to altered drug concentrations and effects. Patients should inform their healthcare providers about all medications, supplements, and herbal products they are taking to minimize the risk of drug interactions.

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Check for interactions on Supp.AI   |   📚 PubMed Citations

⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of Rapamycin On Probiotics

Rank Probiotic Impact
species Akkermansia muciniphila Increases
species Bacteroides uniformis Increases
species Christensenella minuta Increases
species Limosilactobacillus reuteri Increases
species Streptococcus thermophilus Increases

Bacteria Impacted by Rapamycin

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Terriglobia class Increases
0 1 Vicinamibacteria class Increases
0 1 Blastocatellia class Increases
0 1 Holophagae class Increases
0 1 Solibacteres class Increases
0 1 Thermoanaerobaculia class Increases
1 1 Peptostreptococcaceae family Decreases
0 1 Streptococcaceae family Increases
0 1 Bacillaceae family Increases
0 1 Bacteroidaceae family Increases
0 1 Coprobacillaceae family Increases
0 1 Fusobacteriaceae family Increases
0 1 Peptococcaceae family Increases
0 1 Porphyromonadaceae family Increases
0 1 Pseudoalteromonadaceae family Increases
0 1 Selenomonadaceae family Increases
0 1 Veillonellaceae family Increases
0 1 Akkermansiaceae family Increases
0 1 Christensenellaceae family Increases
1 0 Lachnospiraceae family Increases
1 0 Prevotellaceae family Increases
1 0 Romboutsia genus Decreases
0 1 Clostridioides genus Decreases
0 1 Acetoanaerobium genus Decreases
0 1 Asaccharospora genus Decreases
0 1 Criibacterium genus Decreases
0 1 Intestinibacter genus Decreases
0 1 Mediannikoviicoccus genus Decreases
0 1 Peptoanaerobacter genus Decreases
0 1 Proteocatella genus Decreases
0 1 Sporacetigenium genus Decreases
0 1 Paeniclostridium genus Decreases
0 1 Terrisporobacter genus Decreases
0 1 Peptacetobacter genus Decreases
0 1 Tepidibacter genus Decreases
0 1 Filifactor genus Decreases
0 1 Anaerotignum genus Increases
0 1 Anaeropeptidivorans genus Increases
0 1 Anaeromicropila genus Increases
0 1 Chordicoccus genus Increases
0 1 Pseudoprevotella genus Increases
0 1 Tyzzerella genus Increases
0 1 Hoylesella genus Increases
0 1 Anaerocolumna genus Increases
0 1 Enterocloster genus Increases
0 1 Pseudobutyrivibrio genus Increases
0 1 Sporofaciens genus Increases
0 1 Lachnospira genus Increases
0 1 Wujia genus Increases
0 1 Simiaoa genus Increases
0 1 Sellimonas genus Increases
0 1 Herbinix genus Increases
0 1 Qiania genus Increases
0 1 Lacrimispora genus Increases
0 1 Novisyntrophococcus genus Increases
0 1 Lachnoanaerobaculum genus Increases
0 1 Butyrivibrio genus Increases
0 1 Mediterraneibacter genus Increases
0 1 Roseburia genus Increases
0 1 Lachnoclostridium genus Increases
0 1 Wansuia genus Increases
0 1 Acetatifactor genus Increases
0 1 Acetitomaculum genus Increases
0 1 Agathobacter genus Increases
0 1 Alloprevotella genus Increases
0 1 Anaerobium genus Increases
0 1 Anaerosacchariphilus genus Increases
0 1 Anaerosporobacter genus Increases
0 1 Anaerotaenia genus Increases
0 1 Anthropogastromicrobium genus Increases
0 1 Bariatricus genus Increases
0 1 Brotaphodocola genus Increases
0 1 Butyribacter genus Increases
0 1 Candidatus Epulonipiscium genus Increases
0 1 Catenibacillus genus Increases
0 1 Catonella genus Increases
0 1 Claveliimonas genus Increases
0 1 Cuneatibacter genus Increases
0 1 Diplocloster genus Increases
0 1 Eisenbergiella genus Increases
0 1 Extibacter genus Increases
0 1 Faecalicatena genus Increases
0 1 Faecalimonas genus Increases
0 1 Frisingicoccus genus Increases
0 1 Fusicatenibacter genus Increases
0 1 Gallintestinimicrobium genus Increases
0 1 Gluceribacter genus Increases
0 1 Hallella genus Increases
0 1 Hespellia genus Increases
0 1 Hominifimenecus genus Increases
0 1 Hominisplanchenecus genus Increases
0 1 Hoministercoradaptatus genus Increases
0 1 Hominiventricola genus Increases
0 1 Jingyaoa genus Increases
0 1 Johnsonella genus Increases
0 1 Jutongia genus Increases
0 1 Kineothrix genus Increases
0 1 Lachnobacterium genus Increases
0 1 Lachnotalea genus Increases
0 1 Lientehia genus Increases
0 1 Limosilactobacillus genus Increases
0 1 Luxibacter genus Increases
0 1 Marseilla genus Increases
0 1 Massiliprevotella genus Increases
0 1 Merdimonas genus Increases
0 1 Metaprevotella genus Increases
0 1 Mobilitalea genus Increases
0 1 Moryella genus Increases
0 1 Muricomes genus Increases
0 1 Murimonas genus Increases
0 1 Niameybacter genus Increases
0 1 Oliverpabstia genus Increases
0 1 Oribacterium genus Increases
0 1 Parablautia genus Increases
0 1 Pararoseburia genus Increases
0 1 Parasporobacterium genus Increases
0 1 Porcincola genus Increases
0 1 Prevotellamassilia genus Increases
0 1 Robinsoniella genus Increases
0 1 Sakamotonia genus Increases
0 1 Schaedlerella genus Increases
0 1 Shuttleworthella genus Increases
0 1 Sporobacterium genus Increases
0 1 Stomatobaculum genus Increases
0 1 Suonthocola genus Increases
0 1 Syntrophococcus genus Increases
0 1 Waltera genus Increases
0 1 Zhenhengia genus Increases
0 1 Marvinbryantia genus Increases
0 1 Coprococcus genus Increases
0 1 Anaerostipes genus Increases
0 1 Dorea genus Increases
0 1 Anaerobutyricum genus Increases
0 1 Prevotella genus Increases
0 1 Segatella genus Increases
0 1 Leyella genus Increases
0 1 Blautia genus Increases
1 1 Peptostreptococcus genus Increases
1 1 Peptoclostridium genus Increases
1 0 Akkermansia genus Increases
1 0 Bacteroides genus Increases
1 0 Christensenella genus Increases
1 0 Dialister genus Increases
1 0 Fusobacterium genus Increases
1 0 Oceanobacillus genus Increases
1 0 Paraprevotella genus Increases
1 0 Peptococcus genus Increases
1 0 Porphyromonas genus Increases
1 0 Pseudoalteromonas genus Increases
1 0 Selenomonas genus Increases
1 0 Sharpea genus Increases
1 0 Streptococcus genus Increases
0 1 environmental samples no rank Decreases
0 1 Peptostreptococcaceae incertae sedis no rank Decreases
0 1 unclassified Peptostreptococcaceae no rank Decreases
0 1 unclassified Romboutsia no rank Decreases
0 1 Acidobacteriota incertae sedis no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 Lachnospiraceae incertae sedis no rank Increases
0 1 unclassified Akkermansia no rank Increases
0 1 unclassified Bacteroides no rank Increases
0 1 unclassified Christensenella no rank Increases
0 1 unclassified Dialister no rank Increases
0 1 unclassified Fusobacterium no rank Increases
0 1 unclassified Lachnospiraceae no rank Increases
0 1 unclassified Oceanobacillus no rank Increases
0 1 unclassified Paraprevotella no rank Increases
0 1 unclassified Peptococcus no rank Increases
0 1 unclassified Peptostreptococcus no rank Increases
0 1 unclassified Porphyromonas no rank Increases
0 1 unclassified Prevotellaceae no rank Increases
0 1 unclassified Pseudoalteromonas no rank Increases
0 1 unclassified Selenomonas no rank Increases
0 1 unclassified Streptococcus no rank Increases
0 2 Eubacteriales order Decreases
0 1 Bacteroidales order Increases
1 0 Acidobacteriota phylum Increases
0 1 Romboutsia ilealis species Decreases
0 1 Romboutsia hominis species Decreases
0 1 Faecalimicrobium dakarense species Decreases
0 1 Romboutsia lituseburensis species Decreases
0 1 Romboutsia sedimentorum species Decreases
0 1 Romboutsia timonensis species Decreases
0 1 Streptococcus ferus species Increases
0 1 Bacteroides zoogleoformans species Increases
0 1 Fusobacterium vincentii species Increases
0 1 Streptococcus sobrinus species Increases
0 1 Streptococcus iniae species Increases
0 1 Bacteroides coprosuis species Increases
0 1 Bacteroides heparinolyticus species Increases
0 1 Streptococcus pyogenes species Increases
0 1 Streptococcus ruminantium species Increases
0 1 Streptococcus parasuis species Increases
0 1 Fusobacterium necrophorum species Increases
0 1 Streptococcus canis species Increases
0 1 Streptococcus infantarius species Increases
0 1 Akkermansia glycaniphila species Increases
0 1 Streptococcus urinalis species Increases
0 1 Streptococcus suis species Increases
0 1 Streptococcus alactolyticus species Increases
0 1 Streptococcus equinus species Increases
0 1 Bacteroides zhangwenhongii species Increases
0 1 Streptococcus agalactiae species Increases
0 1 Streptococcus acidominimus species Increases
0 1 Bacteroides nordii species Increases
0 1 Bacteroides stercoris species Increases
0 1 Streptococcus porcinus species Increases
0 1 Dialister pneumosintes species Increases
0 1 Streptococcus pasteurianus species Increases
0 1 Bacteroides cellulosilyticus species Increases
0 1 Streptococcus lutetiensis species Increases
0 1 Porphyromonas crevioricanis species Increases
0 1 Bacteroides intestinalis species Increases
0 1 Bacteroides caccae species Increases
0 1 Streptococcus pluranimalium species Increases
0 1 Fusobacterium periodonticum species Increases
0 1 Streptococcus pseudoporcinus species Increases
0 1 Streptococcus himalayensis species Increases
0 1 Streptococcus gallolyticus species Increases
0 1 Fusobacterium canifelinum species Increases
0 1 Streptococcus uberis species Increases
0 1 Fusobacterium hominis species Increases
0 1 Fusobacterium animalis species Increases
0 1 Fusobacterium hwasookii species Increases
0 1 Streptococcus macedonicus species Increases
0 1 Streptococcus parauberis species Increases
0 1 Bacteroides eggerthii species Increases
0 1 Porphyromonas endodontalis species Increases
0 1 Streptococcus cristatus species Increases
0 1 Streptococcus periodonticum species Increases
0 1 Streptococcus ruminicola species Increases
0 1 Streptococcus milleri species Increases
0 1 Fusobacterium pseudoperiodonticum species Increases
0 1 Streptococcus mutans species Increases
0 1 Fusobacterium nucleatum species Increases
0 1 Porphyromonas cangingivalis species Increases
0 1 Bacteroides helcogenes species Increases
0 1 Bacteroides faecis species Increases
0 1 Bacteroides salyersiae species Increases
0 1 Streptococcus merionis species Increases
0 1 Fusobacterium polymorphum species Increases
0 1 Fusobacterium gonidiaformans species Increases
0 1 Fusobacterium varium species Increases
0 1 Streptococcus toyakuensis species Increases
0 1 Streptococcus rubneri species Increases
0 1 Fusobacterium ulcerans species Increases
0 1 Streptococcus koreensis species Increases
0 1 Bacteroides faecium species Increases
0 1 Bacteroides humanifaecis species Increases
0 1 Streptococcus ratti species Increases
0 1 Bacteroides caecimuris species Increases
0 1 Bacteroides thetaiotaomicron species Increases
0 1 Streptococcus pseudopneumoniae species Increases
0 1 Streptococcus sanguinis species Increases
0 1 Streptococcus ilei species Increases
0 1 Bacteroides xylanisolvens species Increases
0 1 Streptococcus gwangjuense species Increases
0 1 Streptococcus oriscaviae species Increases
0 1 Streptococcus infantis species Increases
0 1 Streptococcus troglodytae species Increases
0 1 Bacteroides fragilis species Increases
0 1 Streptococcus pneumoniae species Increases
0 1 Selenomonas ruminantium species Increases
0 1 Bacteroides luhongzhouii species Increases
0 1 Streptococcus gordonii species Increases
0 1 Bacteroides uniformis species Increases
0 1 Streptococcus mitis species Increases
0 1 Porphyromonas gingivalis species Increases
0 1 Bacteroides ovatus species Increases
0 1 Streptococcus vestibularis species Increases
0 1 Streptococcus oralis species Increases
0 1 Streptococcus lactarius species Increases
0 1 Dialister succinatiphilus species Increases
0 1 Streptococcus australis species Increases
0 1 Akkermansia massiliensis species Increases
0 1 Bacteroides acidifaciens species Increases
0 1 Bacteroides caecigallinarum species Increases
0 1 Bacteroides caecimuri species Increases
0 1 Bacteroides chinchillae species Increases
0 1 Bacteroides clarus species Increases
0 1 Bacteroides congonensis species Increases
0 1 Bacteroides cutis species Increases
0 1 Bacteroides denticanum species Increases
0 1 Bacteroides difficilis species Increases
0 1 Bacteroides faecalis species Increases
0 1 Bacteroides faecichinchillae species Increases
0 1 Bacteroides finegoldii species Increases
0 1 Bacteroides fluxus species Increases
0 1 Bacteroides galacturonicus species Increases
0 1 Bacteroides gallinaceum species Increases
0 1 Bacteroides gallinarum species Increases
0 1 Bacteroides graminisolvens species Increases
0 1 Bacteroides ihuae species Increases
0 1 Bacteroides ilei species Increases
0 1 Bacteroides koreensis species Increases
0 1 Bacteroides kribbi species Increases
0 1 Bacteroides luti species Increases
0 1 Bacteroides mediterraneensis species Increases
0 1 Bacteroides muris (ex Fokt et al. 2023) species Increases
0 1 Bacteroides ndongoniae species Increases
0 1 Bacteroides oleiciplenus species Increases
0 1 Bacteroides parvus species Increases
0 1 Bacteroides propionicifaciens species Increases
0 1 Bacteroides propionicigenes species Increases
0 1 Bacteroides pyogenes species Increases
0 1 Bacteroides reticulotermitis species Increases
0 1 Bacteroides rhinocerotis species Increases
0 1 Bacteroides rodentium species Increases
0 1 Bacteroides sp species Increases
0 1 Bacteroides sp. C13EG172 species Increases
0 1 Bacteroides stercorirosoris species Increases
0 1 Bacteroides timonensis species Increases
0 1 Candidatus Akkermansia intestinavium species Increases
0 1 Candidatus Bacteroides intestinigallinarum species Increases
0 1 Christensenella hongkongensis species Increases
0 1 Christensenella intestinihominis species Increases
0 1 Christensenella massiliensis species Increases
0 1 Christensenella timonensis species Increases
0 1 Dialister invisus species Increases
0 1 Dialister micraerophilus species Increases
0 1 Dialister propionicifaciens species Increases
0 1 Fusobacterium equinum species Increases
0 1 Fusobacterium gastrosuis species Increases
0 1 Fusobacterium naviforme species Increases
0 1 Fusobacterium necrogenes species Increases
0 1 Fusobacterium perfoetens species Increases
0 1 Fusobacterium russii species Increases
0 1 Fusobacterium simiae species Increases
0 1 Oceanobacillus caeni species Increases
0 1 Oceanobacillus iheyensis species Increases
0 1 Oceanobacillus jeddahense species Increases
0 1 Oceanobacillus kimchii species Increases
0 1 Oceanobacillus locisalsi species Increases
0 1 Oceanobacillus luteolus species Increases
0 1 Oceanobacillus neutriphilus species Increases
0 1 Oceanobacillus oncorhynchi species Increases
0 1 Oceanobacillus picturae species Increases
0 1 Oceanobacillus profundus species Increases
0 1 Oceanobacillus zhaokaii species Increases
0 1 Peptoclostridium litorale species Increases
0 1 Peptococcus niger species Increases
0 1 Peptococcus simiae species Increases
0 1 Peptostreptococcus anaerobius species Increases
0 1 Peptostreptococcus canis species Increases
0 1 Peptostreptococcus russellii species Increases
0 1 Peptostreptococcus stomatis species Increases
0 1 Porphyromonas bennonis species Increases
0 1 Porphyromonas bobii species Increases
0 1 Porphyromonas canis species Increases
0 1 Porphyromonas canoris species Increases
0 1 Porphyromonas catoniae species Increases
0 1 Porphyromonas circumdentaria species Increases
0 1 Porphyromonas gulae species Increases
0 1 Porphyromonas levii species Increases
0 1 Porphyromonas macacae species Increases
0 1 Porphyromonas pasteri species Increases
0 1 Porphyromonas pogonae species Increases
0 1 Porphyromonas uenonis species Increases
0 1 Porphyromonas vaginalis species Increases
0 1 Pseudoalteromonas agarivorans species Increases
0 1 Pseudoalteromonas aliena species Increases
0 1 Pseudoalteromonas arabiensis species Increases
0 1 Pseudoalteromonas arctica species Increases
0 1 Pseudoalteromonas atlantica species Increases
0 1 Pseudoalteromonas byunsanensis species Increases
0 1 Pseudoalteromonas carrageenovora species Increases
0 1 Pseudoalteromonas denitrificans species Increases
0 1 Pseudoalteromonas donghaensis species Increases
0 1 Pseudoalteromonas espejiana species Increases
0 1 Pseudoalteromonas gracilis species Increases
0 1 Pseudoalteromonas haloplanktis species Increases
0 1 Pseudoalteromonas issachenkonii species Increases
0 1 Pseudoalteromonas luteoviolacea species Increases
0 1 Pseudoalteromonas marina species Increases
0 1 Pseudoalteromonas nigrifaciens species Increases
0 1 Pseudoalteromonas ostreae species Increases
0 1 Pseudoalteromonas phenolica species Increases
0 1 Pseudoalteromonas piratica species Increases
0 1 Pseudoalteromonas rhizosphaerae species Increases
0 1 Pseudoalteromonas rubra species Increases
0 1 Pseudoalteromonas ruthenica species Increases
0 1 Pseudoalteromonas shioyasakiensis species Increases
0 1 Pseudoalteromonas spongiae species Increases
0 1 Pseudoalteromonas tetraodonis species Increases
0 1 Pseudoalteromonas translucida species Increases
0 1 Pseudoalteromonas tunicata species Increases
0 1 Pseudoalteromonas viridis species Increases
0 1 Pseudoalteromonas xiamenensis species Increases
0 1 Selenomonas artemidis species Increases
0 1 Selenomonas bovis species Increases
0 1 Selenomonas dianae species Increases
0 1 Selenomonas felix species Increases
0 1 Selenomonas flueggei species Increases
0 1 Selenomonas genomosp. P5 species Increases
0 1 Selenomonas infelix species Increases
0 1 Selenomonas lacticifex species Increases
0 1 Selenomonas noxia species Increases
0 1 Sharpea azabuensis species Increases
0 1 Streptococcus azizii species Increases
0 1 Streptococcus caballi species Increases
0 1 Streptococcus castoreus species Increases
0 1 Streptococcus chenjunshii species Increases
0 1 Streptococcus chosunense species Increases
0 1 Streptococcus criceti species Increases
0 1 Streptococcus cuniculipharyngis species Increases
0 1 Streptococcus danieliae species Increases
0 1 Streptococcus dentapri species Increases
0 1 Streptococcus dentasini species Increases
0 1 Streptococcus dentirousetti species Increases
0 1 Streptococcus devriesei species Increases
0 1 Streptococcus didelphis species Increases
0 1 Streptococcus downei species Increases
0 1 Streptococcus entericus species Increases
0 1 Streptococcus fryi species Increases
0 1 Streptococcus gallinaceus species Increases
0 1 Streptococcus halichoeri species Increases
0 1 Streptococcus halotolerans species Increases
0 1 Streptococcus henryi species Increases
0 1 Streptococcus hongkongensis species Increases
0 1 Streptococcus hyointestinalis species Increases
0 1 Streptococcus hyovaginalis species Increases
0 1 Streptococcus ictaluri species Increases
0 1 Streptococcus macacae species Increases
0 1 Streptococcus marimammalium species Increases
0 1 Streptococcus marmotae species Increases
0 1 Streptococcus massiliensis species Increases
0 1 Streptococcus minor species Increases
0 1 Streptococcus orisasini species Increases
0 1 Streptococcus orisratti species Increases
0 1 Streptococcus orisuis species Increases
0 1 Streptococcus ovis species Increases
0 1 Streptococcus panodentis species Increases
0 1 Streptococcus pantholopis species Increases
0 1 Streptococcus pasteuri species Increases
0 1 Streptococcus peroris species Increases
0 1 Streptococcus phocae species Increases
0 1 Streptococcus plurextorum species Increases
0 1 Streptococcus porci species Increases
0 1 Streptococcus porcorum species Increases
0 1 Streptococcus respiraculi species Increases
0 1 Streptococcus rupicaprae species Increases
0 1 Streptococcus seminale species Increases
0 1 Streptococcus shenyangsis species Increases
0 1 Streptococcus sinensis species Increases
0 1 Streptococcus symci species Increases
0 1 Streptococcus thoraltensis species Increases
0 1 Streptococcus timonensis species Increases
0 1 Streptococcus troglodytidis species Increases
0 1 Streptococcus ursoris species Increases
0 1 Streptococcus vaginalis species Increases
0 1 Streptococcus viridans species Increases
0 1 Streptococcus vulneris species Increases
0 1 Streptococcus xiaochunlingii species Increases
0 1 Porphyromonas somerae species Increases
0 1 Streptococcus thermophilus species Increases
0 1 Porphyromonas asaccharolytica species Increases
0 1 Fusobacterium mortiferum species Increases
0 1 Streptococcus parasanguinis species Increases
0 1 Streptococcus salivarius species Increases
0 1 Dialister hominis species Increases
0 1 Dialister massiliensis species Increases
0 1 Selenomonas sputigena species Increases
0 1 Paraprevotella xylaniphila species Increases
0 1 Paraprevotella clara species Increases
0 1 Pseudoalteromonas piscicida species Increases
0 1 Akkermansia muciniphila species Increases
0 1 Christensenella minuta species Increases
1 0 Limosilactobacillus reuteri species Increases
0 1 Peptoclostridium acidaminophilum species Increases
0 1 Pseudoalteromonas distincta group species group Increases
0 1 Streptococcus anginosus group species group Increases
0 1 Streptococcus dysgalactiae group species group Increases
0 1 Limosilactobacillus reuteri SD2112 strain Increases
0 1 Limosilactobacillus reuteri TD1 strain Increases
0 1 Limosilactobacillus reuteri subsp. murium subspecies Increases
0 1 Limosilactobacillus reuteri subsp. reuteri subspecies Increases
0 1 Limosilactobacillus reuteri subsp. rodentium subspecies Increases
0 1 Limosilactobacillus reuteri subsp. suis subspecies Increases

Impact of Rapamycin on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.5 -0.5
Acne 0.9 1.2 -0.33
ADHD 2.4 4.9 -1.04
Age-Related Macular Degeneration and Glaucoma 0.6 0.6 0
Allergic Rhinitis (Hay Fever) 3.3 2.8 0.18
Allergies 6.5 5.2 0.25
Allergy to milk products 1.9 3.1 -0.63
Alopecia (Hair Loss) 1.8 -1.8
Alzheimer's disease 7.9 10.4 -0.32
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2 5.4 -1.7
Ankylosing spondylitis 4.4 5.5 -0.25
Anorexia Nervosa 3.6 2.6 0.38
Antiphospholipid syndrome (APS) 1 -1
Asthma 4.8 7.1 -0.48
Atherosclerosis 1.5 2.4 -0.6
Atrial fibrillation 3.1 4.8 -0.55
Autism 11.3 9.8 0.15
Autoimmune Disease 1 1.3 -0.3
Barrett esophagus cancer 0.9 0.6 0.5
benign prostatic hyperplasia 0.9 0.9
Biofilm 2.3 -2.3
Bipolar Disorder 2.2 2.4 -0.09
Brain Trauma 2.1 1.5 0.4
Breast Cancer 1.2 1.9 -0.58
Cancer (General) 0.9 1.8 -1
Carcinoma 2.8 5.3 -0.89
Celiac Disease 6 2.9 1.07
Cerebral Palsy 2 2.2 -0.1
Chronic Fatigue Syndrome 4.3 4 0.07
Chronic Kidney Disease 3.5 2.2 0.59
Chronic Lyme 0.9 0.9
Chronic Obstructive Pulmonary Disease (COPD) 4.5 5.4 -0.2
Chronic Urticaria (Hives) 1.4 0.6 1.33
Coagulation / Micro clot triggering bacteria 3.2 2.2 0.45
Cognitive Function 2.9 4.7 -0.62
Colorectal Cancer 4.7 11.2 -1.38
Constipation 1.9 1.7 0.12
Coronary artery disease 4.2 3 0.4
COVID-19 10.2 9.5 0.07
Crohn's Disease 8.4 9.9 -0.18
Cushing's Syndrome (hypercortisolism) 0.6 0.6
cystic fibrosis 1.3 1.3
d-lactic acidosis (one form of brain fog) 0.8 -0.8
deep vein thrombosis 3.2 2.5 0.28
Denture Wearers Oral Shifts 2.1 -2.1
Depression 12.2 15.1 -0.24
Dermatomyositis 1.2 1.2 0
Eczema 2.7 1.8 0.5
Endometriosis 2.2 3.8 -0.73
Eosinophilic Esophagitis 1.2 1 0.2
Epilepsy 4.5 7.2 -0.6
erectile dysfunction 0.1 2.2 -21
Fibromyalgia 2 1.3 0.54
Functional constipation / chronic idiopathic constipation 4.7 4.9 -0.04
gallstone disease (gsd) 1.5 1.9 -0.27
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 2.6 1.8 0.44
Generalized anxiety disorder 3.9 4.4 -0.13
giant cell arteritis 0.3 -0.3
Glioblastoma 2.1 2.1
Gout 2.5 5 -1
Graves' disease 5 2.3 1.17
Gulf War Syndrome 2.1 1.9 0.11
Halitosis 1.2 5.4 -3.5
Hashimoto's thyroiditis 3.3 4.9 -0.48
Heart Failure 3.2 4 -0.25
hemorrhagic stroke 1.8 -1.8
Hemorrhoidal disease, Hemorrhoids, Piles 0.2 0.2
Hidradenitis Suppurativa 0.9 3.2 -2.56
High Histamine/low DAO 0.9 0.3 2
hypercholesterolemia (High Cholesterol) 1.8 0.6 2
hyperglycemia 2.5 2.1 0.19
Hyperlipidemia (High Blood Fats) 0.9 0.8 0.13
hypersomnia 1 0.7 0.43
hypertension (High Blood Pressure 5.4 9 -0.67
Hypothyroidism 2.2 1.8 0.22
Hypoxia 1 2.1 -1.1
IgA nephropathy (IgAN) 3.3 4.3 -0.3
Inflammatory Bowel Disease 8.7 6.1 0.43
Insomnia 5.2 5.4 -0.04
Intelligence 1.8 2.3 -0.28
Intracranial aneurysms 0.6 2.4 -3
Irritable Bowel Syndrome 6.5 10.4 -0.6
ischemic stroke 3.6 3.7 -0.03
Liver Cirrhosis 5.2 7.7 -0.48
Long COVID 11.8 8.8 0.34
Low bone mineral density 1.3 0.5 1.6
Lung Cancer 2.2 0.1 21
Mast Cell Issues / mastitis 2.6 1.4 0.86
ME/CFS with IBS 0.6 0.6 0
ME/CFS without IBS 0.9 0.6 0.5
membranous nephropathy 1.2 -1.2
Menopause 0.9 1.2 -0.33
Metabolic Syndrome 8.9 11.7 -0.31
Mood Disorders 10.1 14.5 -0.44
multiple chemical sensitivity [MCS] 0.4 2.5 -5.25
Multiple Sclerosis 4.4 6.5 -0.48
Multiple system atrophy (MSA) 0.4 1.5 -2.75
myasthenia gravis 0.3 1.7 -4.67
neuropathic pain 2.8 2.8
Neuropathy (all types) 1.5 2.8 -0.87
neuropsychiatric disorders (PANDAS, PANS) 0.6 0.9 -0.5
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 7.6 6.8 0.12
NonCeliac Gluten Sensitivity 0.9 1.6 -0.78
Obesity 11.7 11 0.06
obsessive-compulsive disorder 4.7 4 0.18
Osteoarthritis 2.4 3.6 -0.5
Osteoporosis 4.2 3.2 0.31
pancreatic cancer 2.8 2 0.4
Parkinson's Disease 8.6 11.1 -0.29
Peanut Allergy 1.2 1.2
Polycystic ovary syndrome 6.2 7.5 -0.21
Postural orthostatic tachycardia syndrome 0.3 0.3 0
Premenstrual dysphoric disorder 0.3 0.7 -1.33
primary biliary cholangitis 1.4 2.4 -0.71
Primary sclerosing cholangitis 2.6 2.1 0.24
Psoriasis 3.5 3.5 0
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 5.9 9.6 -0.63
Rosacea 0.9 0.9 0
Schizophrenia 6.4 8 -0.25
scoliosis 0.4 0.9 -1.25
sensorineural hearing loss 0.6 0.2 2
Sjögren syndrome 2.8 1.5 0.87
Sleep Apnea 2.1 2.7 -0.29
Slow gastric motility / Gastroparesis 0.4 1 -1.5
Small Intestinal Bacterial Overgrowth (SIBO) 3.6 -3.6
Stress / posttraumatic stress disorder 2.5 4.2 -0.68
Systemic Lupus Erythematosus 4 4.6 -0.15
Tic Disorder 1.6 1 0.6
Tourette syndrome 0.6 1.8 -2
Type 1 Diabetes 3.3 6.3 -0.91
Type 2 Diabetes 8.2 9.5 -0.16
Ulcerative colitis 8.1 6.6 0.23
Unhealthy Ageing 2.4 2.8 -0.17
Vitiligo 1.8 2.1 -0.17

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