Akkermansiaceae: NCBI 1647988, [family]

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| Akkermansiaceae| Akkermansiaceae Hedlund and Derrien 2012

1. Mucin Degradation:

   • Akkermansia muciniphila is recognized for its ability to degrade mucin, a component of the protective mucus layer that lines the gut. The degradation of mucin by Akkermansia may have implications for gut health and the maintenance of the intestinal barrier.

2. Gut Barrier Function:

   • Akkermansia muciniphila has been associated with the maintenance of a healthy gut barrier. The mucin layer serves as a protective barrier, and its integrity is crucial for preventing the penetration of harmful substances and pathogens into the gut mucosa.

3. Metabolic Effects:

   • Some studies suggest that Akkermansia muciniphila may have metabolic benefits. It has been associated with improvements in metabolic parameters such as insulin sensitivity, glucose metabolism, and lipid profile in animal models. These findings have led to investigations into the potential role of Akkermansia in metabolic disorders, including obesity and type 2 diabetes.

4. Anti-Inflammatory Effects:

   • Akkermansia muciniphila has been studied for its potential anti-inflammatory properties. It may modulate immune responses and reduce inflammation in the gut. Chronic inflammation in the gut is associated with various diseases, and maintaining a balanced immune response is crucial for overall health.

5. Associations with Diet:

   • Diet plays a role in shaping the composition of the gut microbiota, including the abundance of Akkermansia muciniphila. Diets rich in certain fibers, such as those found in fruits and vegetables, have been associated with increased abundance of Akkermansia.

6. Potential Therapeutic Applications:

   • Due to its beneficial properties, researchers are exploring the therapeutic potential of Akkermansia muciniphila for various health conditions, including metabolic disorders, inflammatory bowel diseases, and other inflammatory conditions.

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Akkermansiaceae impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart

Other bacteria of the same rank impacting Akkermansiaceae

R2	Slope	Tax Name	Parent Chart
0.3040792644023895	0.6211792826652527	Maliibacteriaceae	Parent Taxa
0.2804373800754547	0.5711729526519775	Christensenellaceae	Parent Taxa