Verrucomicrobiales: NCBI 48461, [order]

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| Verrucomicrobiales| Verrucomicrobiales Ward-Rainey et al. 1996 emend. Yoon et al. 2008| Verrucosimicrobiales

1. Akkermansia muciniphila and Gut Health:

   • Akkermansia muciniphila, a species within the order Verrucomicrobiales, is often associated with gut health. It resides in the mucus layer of the intestinal tract and has been studied for its potential contributions to mucin degradation and maintenance of gut barrier function.

2. Mucin Degradation and Barrier Function:

   • Akkermansia muciniphila has the ability to degrade mucin, a glycoprotein that forms the protective mucus layer in the intestines. This activity may contribute to the turnover of the mucus layer and the maintenance of the mucosal barrier.

3. Butyrate Production:

   • Akkermansia muciniphila has been linked to the production of short-chain fatty acids (SCFAs), including butyrate. Butyrate has anti-inflammatory effects and serves as an energy source for the cells lining the colon.

4. Metabolic Health:

   • Some studies have explored the potential impact of Akkermansia muciniphila on metabolic health. Higher abundance of this bacterium has been associated with improvements in metabolic parameters, such as reduced adiposity and improved glucose metabolism. However, the precise mechanisms and causation are still areas of ongoing research.

5. Anti-Inflammatory Effects:

   • Akkermansia muciniphila has been associated with anti-inflammatory effects in the gut. It may play a role in regulating immune responses and contributing to a balanced inflammatory environment.

6. Potential Therapeutic Applications:

   • Due to its associations with gut health and metabolic parameters, Akkermansia muciniphila has garnered interest as a potential therapeutic target. Some studies have explored the use of this bacterium or its products in interventions aimed at improving metabolic and inflammatory conditions.

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Verrucomicrobiales impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart

Other bacteria of the same rank impacting Verrucomicrobiales

R2	Slope	Tax Name	Parent Chart