Bacteroidota: NCBI 976, [phylum]

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| Bacteroidaeota| Bacteroidaeota Oren et al. 2015| Bacteroides-Cytophaga-Flexibacter group| Bacteroidetes| Bacteroidetes Krieg et al. 2012| Bacteroidota| BCF group| CFB group| CFB group bacteria| Cytophaga-Flexibacter-Bacteroides phylum

1. Gastrointestinal health: Bacteroidota bacteria are predominant members of the human gut microbiota, where they contribute to digestion, metabolism, and the maintenance of gut homeostasis. They help ferment dietary fiber, produce short-chain fatty acids, and compete with potential pathogens for nutrients and colonization sites. Dysbiosis, or an imbalance in the gut microbiota composition, particularly involving Bacteroidota species, has been associated with various gastrointestinal disorders, including inflammatory bowel diseases (such as Crohn's disease and ulcerative colitis), irritable bowel syndrome (IBS), and colorectal cancer.

2. Infections: While most Bacteroidota bacteria are commensal or beneficial, certain species can cause infections, especially in immunocompromised individuals or in association with disruptions to the normal microbiota. Bacteroides fragilis, for example, is a known opportunistic pathogen that can cause infections such as intra-abdominal abscesses, surgical site infections, bloodstream infections (bacteremia), and infections in association with colorectal surgery or trauma. These infections can be serious and may require antibiotic treatment and surgical intervention.

3. Antibiotic resistance: Some Bacteroidota species have developed resistance to multiple antibiotics, making infections caused by these bacteria difficult to treat. Antibiotic-resistant strains of Bacteroides fragilis, for example, have been reported in clinical settings, posing challenges for the management of infections and antimicrobial stewardship efforts.

4. Systemic diseases: Dysbiosis of the gut microbiota, including alterations in Bacteroidota populations, has been implicated in the pathogenesis of systemic diseases beyond the gastrointestinal tract. These diseases may include metabolic disorders such as obesity and type 2 diabetes, cardiovascular diseases, autoimmune conditions, and neurological disorders. While the exact mechanisms underlying these associations are still under investigation, the gut microbiota, including Bacteroidota bacteria, is increasingly recognized as a key player in systemic health and disease.

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Bacteroidota impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart
0.38800597190856934	-0.571660578250885	Acidobacteriota	Parent Taxa
0.2875806987285614	-0.5362669825553894	Bacillota	Parent Taxa

Other bacteria of the same rank impacting Bacteroidota

R2	Slope	Tax Name	Parent Chart
0.2875806987285614	-0.5362640619277954	Bacillota	Parent Taxa