Eubacteriales Family XIII. Incertae Sedis: NCBI 543314, [family]

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| Clostridiales Family XIII. Incertae Sedis

1. Mucosal Surfaces:

   • Verrucomicrobia bacteria are often found in mucosal surfaces, including the gastrointestinal tract. Their presence in the mucosal environment suggests potential interactions with the host's immune system and other microorganisms in these regions.

2. Akkermansia muciniphila:

   • One of the well-studied genera within Verrucomicrobia is Akkermansia. Akkermansia muciniphila is a species known to inhabit the mucus layer of the intestinal lining. Research has suggested that A. muciniphila may have positive effects on metabolic health, including its potential role in maintaining mucosal integrity and modulating metabolic pathways.

3. Mucus Degradation:

   • Some members of Verrucomicrobia, including Akkermansia species, are specialized in utilizing mucin, a component of the protective mucus layer in the gut. This ability to degrade mucin may influence the gut environment and the interactions between the microbiota and the host.

4. Metabolic Health:

   • Akkermansia muciniphila has been associated with metabolic health benefits in preclinical studies. It has been linked to improvements in glucose metabolism, insulin sensitivity, and lipid metabolism. However, the translation of these findings to human health is an area of ongoing investigation.

5. Immunomodulation:

   • Verrucomicrobia bacteria may play a role in immunomodulation, influencing the host's immune response. The interactions between Verrucomicrobia and the immune system are complex and context-dependent.

6. Associations with Disease:

   • Altered abundances of Verrucomicrobia have been observed in studies of the gut microbiota in various health conditions. Changes in the relative abundance of Verrucomicrobia, including increases or decreases, have been reported in conditions such as inflammatory bowel disease (IBD), obesity, and diabetes. However, the specific contributions of Verrucomicrobia to these conditions are still being explored.

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Eubacteriales Family XIII. Incertae Sedis impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart
0.3743627071380615	0.6555760502815247	Lachnospiraceae	Parent Taxa
0.365782767534256	0.618162989616394	Christensenellaceae	Parent Taxa
0.35706189274787903	0.6378743648529053	Erysipelotrichaceae	Parent Taxa
0.35356155037879944	0.6341038942337036	Eubacteriaceae	Parent Taxa
0.3132804334163666	0.5985933542251587	Peptostreptococcaceae	Parent Taxa
0.31187447905540466	0.5636367201805115	Treponemataceae	Parent Taxa
0.2993534505367279	0.5399907231330872	Gemmatimonadaceae	Parent Taxa
0.28850606083869934	0.5551921725273132	Atopobiaceae	Parent Taxa
0.28617343306541443	0.5379666090011597	Acholeplasmataceae	Parent Taxa
0.2801238000392914	0.5046929121017456	Acetobacteraceae	Parent Taxa
0.2796253561973572	0.5220967531204224	Maliibacteriaceae	Parent Taxa
0.2781633734703064	0.5094577670097351	Cytophagaceae	Parent Taxa
0.27513033151626587	0.5620133280754089	Oscillospiraceae	Parent Taxa
0.26248958706855774	0.5276748538017273	Bruguierivoracaceae	Parent Taxa

Other bacteria of the same rank impacting Eubacteriales Family XIII. Incertae Sedis

R2	Slope	Tax Name	Parent Chart
0.34955477714538574	0.6173096299171448	Christensenellaceae	Parent Taxa
0.33799898624420166	0.607925534248352	Treponemataceae	Parent Taxa
0.3358438014984131	0.5991880297660828	Atopobiaceae	Parent Taxa
0.3081943690776825	0.614137589931488	Maliibacteriaceae	Parent Taxa
0.3071690499782562	0.625419557094574	Acetobacteraceae	Parent Taxa
0.29937899112701416	0.5137268900871277	Lachnospiraceae	Parent Taxa
0.2759236991405487	0.501893162727356	Erysipelotrichaceae	Parent Taxa
0.2742311656475067	0.5010384917259216	Eubacteriaceae	Parent Taxa
0.2532026767730713	0.4789353609085083	Peptostreptococcaceae	Parent Taxa