Lachnospiraceae: NCBI 186803, [family]

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| Lachnospiraceae| Lachnospiraceae Rainey 2010

1. Short-Chain Fatty Acid Production:

   • Like many bacteria in the gut microbiota, some members of the Lachnospiraceae family are involved in the fermentation of dietary fibers, producing short-chain fatty acids (SCFAs) as byproducts. SCFAs, such as butyrate, have been associated with various health benefits, including providing energy for colonocytes, maintaining gut barrier function, and exhibiting anti-inflammatory properties.

2. Metabolism of Complex Carbohydrates:

   • Lachnospiraceae bacteria are known for their ability to metabolize complex carbohydrates. This metabolic activity contributes to the breakdown of dietary fibers and the production of beneficial metabolites in the gut.

3. Gut Microbiota Composition:

   • The abundance of Lachnospiraceae and its relative balance with other bacterial groups are important for maintaining a healthy gut microbiota. Changes in the abundance of Lachnospiraceae have been associated with various health conditions, including inflammatory bowel diseases (IBD) and metabolic disorders.

4. Potential Anti-Inflammatory Effects:

   • Some species within the Lachnospiraceae family have been associated with anti-inflammatory effects. By promoting the production of butyrate, these bacteria may contribute to a more balanced immune response and help mitigate excessive inflammation in the gut.

5. Impact on Intestinal Health:

   • Lachnospiraceae bacteria contribute to the overall health of the intestines. They play a role in maintaining the structural integrity of the gut lining and influencing the mucus layer, which acts as a protective barrier.

6. Associations with Disease:

   • While certain members of Lachnospiraceae are associated with health benefits, changes in the abundance of specific species within this family have been linked to various diseases. For example, alterations in the composition of Lachnospiraceae have been reported in conditions such as obesity, diabetes, and inflammatory bowel diseases.

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Lachnospiraceae impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart
0.4784475564956665	0.6893715858459473	Peptostreptococcaceae	Parent Taxa
0.45975011587142944	0.6471198201179504	Pseudoalteromonadaceae	Parent Taxa
0.40015682578086853	0.6277698278427124	Erysipelotrichaceae	Parent Taxa
0.3945136070251465	0.6220701932907104	Eubacteriaceae	Parent Taxa
0.3883951008319855	0.5303351283073425	Acetobacteraceae	Parent Taxa
0.3436148166656494	0.5396366119384766	Treponemataceae	Parent Taxa
0.32663410902023315	0.5260768532752991	Christensenellaceae	Parent Taxa
0.3243282437324524	0.5694990158081055	Oscillospiraceae	Parent Taxa
0.31198740005493164	0.5583872199058533	Clostridiaceae	Parent Taxa
0.29937899112701416	0.5137268900871277	Eubacteriales Family XIII. Incertae Sedis	Parent Taxa
0.2937387228012085	0.43275871872901917	Micromonosporaceae	Parent Taxa
0.26697105169296265	0.41803622245788574	Gemmatimonadaceae	Parent Taxa
0.26413071155548096	0.5114501118659973	Eggerthellaceae	Parent Taxa

Other bacteria of the same rank impacting Lachnospiraceae

R2	Slope	Tax Name	Parent Chart
0.4832307994365692	0.6979016065597534	Peptostreptococcaceae	Parent Taxa
0.4464785158634186	0.7284923791885376	Treponemataceae	Parent Taxa
0.4320790469646454	0.7142361998558044	Christensenellaceae	Parent Taxa
0.41365766525268555	0.7377282977104187	Acetobacteraceae	Parent Taxa
0.4117968678474426	0.6473752856254578	Erysipelotrichaceae	Parent Taxa
0.4089176058769226	0.6463330388069153	Eubacteriaceae	Parent Taxa
0.3743627071380615	0.6555760502815247	Eubacteriales Family XIII. Incertae Sedis	Parent Taxa
0.34350425004959106	0.6631491184234619	Maliibacteriaceae	Parent Taxa
0.3243282437324524	0.5694974660873413	Oscillospiraceae	Parent Taxa
0.3130010962486267	0.5600237250328064	Clostridiaceae	Parent Taxa
0.2868766188621521	0.5796103477478027	Bacillaceae	Parent Taxa
0.26702961325645447	0.5198068618774414	Eggerthellaceae	Parent Taxa