Actinomyces: NCBI 1654, [genus]

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| "Actinocladothrix" Affanassieff and Schulz 1889| "Discomyces" Rivolta 1878| Actinocladothrix| Actinomyces| Actinomyces Harz 1877 (Approved Lists 1980) emend. Nouioui et al. 2018| Discomyces

1. Normal Flora:

   • Many Actinomyces species are part of the normal microbial flora in the oral cavity, gastrointestinal tract, and genital tract of humans. In these settings, they contribute to the balance of the microbiota and may have beneficial roles.

2. Pathogenic Potential:

   • While Actinomyces species are generally commensal, some can become opportunistic pathogens. Actinomyces species can cause infections, most notably actinomycosis. Actinomycosis is a chronic suppurative and granulomatous infection that can occur in various body sites, including the cervicofacial area, thorax, abdomen, and pelvis.

3. Actinomycosis:

   • Actinomycosis is characterized by the formation of abscesses, draining sinuses, and the presence of characteristic sulfur granules in the affected tissues. The condition often arises due to disruption of mucosal barriers, allowing Actinomyces to invade deeper tissues. Cervicofacial actinomycosis is one of the more common forms.

4. Dental Health:

   • Actinomyces species are commonly found in dental plaque and can be involved in dental caries and periodontal diseases. Maintaining good oral hygiene is important to prevent the overgrowth of potentially pathogenic bacteria.

5. Pelvic Inflammatory Disease (PID):

   • In the genital tract, Actinomyces species have been associated with pelvic inflammatory disease (PID), particularly in women with intrauterine devices (IUDs). This is considered a rare complication.

6. Endocarditis:

   • Actinomyces species have been implicated in infective endocarditis, particularly in individuals with pre-existing heart valve abnormalities.

7. Treatment:

   • Actinomycosis is typically treated with prolonged courses of antibiotics, often involving penicillin or other beta-lactam antibiotics. Surgical drainage and debridement may be necessary in severe cases.

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Actinomyces impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart
0.5100573897361755	0.5965017676353455	Pauljensenia	Parent Taxa
0.451811820268631	0.699061393737793	Schaalia	Parent Taxa
0.3938109576702118	0.6210650205612183	Mogibacterium	Parent Taxa
0.3701249361038208	0.5278635621070862	Arachnia	Parent Taxa
0.35495656728744507	0.5595033168792725	Coriobacterium	Parent Taxa
0.35459575057029724	0.536226212978363	Sphingobium	Parent Taxa
0.354133278131485	0.561259925365448	Olsenella	Parent Taxa
0.3216458559036255	0.60169917345047	Dorea	Parent Taxa
0.3198001980781555	0.555547297000885	Arthrobacter	Parent Taxa
0.2916581630706787	0.5077950954437256	Lancefieldella	Parent Taxa
0.2846357822418213	0.4781525731086731	Xiamenia	Parent Taxa
0.2776153087615967	0.5442346930503845	Wansuia	Parent Taxa
0.2747887372970581	0.498018354177475	Dermacoccus	Parent Taxa
0.26969969272613525	0.5758753418922424	Tetragenococcus	Parent Taxa
0.2665337920188904	0.5488486886024475	Anaerobutyricum	Parent Taxa
0.261752188205719	0.5300359725952148	Subdoligranulum	Parent Taxa
0.255331814289093	0.5120925903320312	Delftia	Parent Taxa
0.2549165189266205	0.45909786224365234	Arabiibacter	Parent Taxa

Other bacteria of the same rank impacting Actinomyces

R2	Slope	Tax Name	Parent Chart
0.4694967567920685	0.7738725543022156	Pauljensenia	Parent Taxa
0.43402746319770813	0.6434168219566345	Schaalia	Parent Taxa
0.42035943269729614	0.7352756857872009	Olsenella	Parent Taxa
0.39570584893226624	0.7257746458053589	Arachnia	Parent Taxa
0.39393380284309387	0.673882246017456	Mogibacterium	Parent Taxa
0.3844972252845764	0.7080547213554382	Lancefieldella	Parent Taxa
0.2702433466911316	0.5001805424690247	Dorea	Parent Taxa
0.2585841417312622	0.5096228122711182	Corynebacterium	Parent Taxa
0.2567412853240967	0.571993350982666	Propionibacterium	Parent Taxa
0.25040003657341003	0.5458798408508301	Candidatus Nanosynbacter	Parent Taxa