Sphingomonadaceae: NCBI 41297, [family]

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| alpha-4 proteobacteria| Sphingomonadaceae| Sphingomonadaceae Kosako et al. 2000| Sphingomonas group| Zymomonas group

1. Environmental interactions: Sphingomonadaceae bacteria play important roles in environmental processes such as biodegradation, bioremediation, and pollutant removal. They are capable of degrading a diverse array of organic compounds, including aromatic hydrocarbons, pesticides, polycyclic aromatic hydrocarbons (PAHs), and industrial chemicals. Their ability to metabolize environmental pollutants can contribute to the detoxification and degradation of contaminants in soil, water, and air, thereby mitigating environmental pollution and promoting ecosystem health.

2. Pathogenic potential: While most members of the family Sphingomonadaceae are considered non-pathogenic or opportunistic environmental bacteria, there have been rare reports of Sphingomonadaceae species causing infections in humans, particularly in immunocompromised individuals or those with underlying health conditions. Infections associated with Sphingomonadaceae bacteria include bloodstream infections, catheter-associated infections, respiratory infections, and infections associated with medical devices. However, such infections are uncommon, and Sphingomonadaceae bacteria are not typically regarded as major human pathogens.

3. Biofilm formation: Sphingomonadaceae bacteria have the ability to form biofilms on biotic and abiotic surfaces, including medical devices such as catheters and implants. Biofilm formation can promote bacterial persistence, resistance to antimicrobial agents, and evasion of host immune responses, increasing the risk of device-associated infections. Understanding the mechanisms of biofilm formation by Sphingomonadaceae bacteria may aid in the development of strategies to prevent and treat biofilm-related infections.

4. Immunomodulatory effects: Some studies suggest that exposure to Sphingomonadaceae bacteria or their components may have immunomodulatory effects on the host immune system. Certain Sphingomonadaceae species produce glycolipid antigens that can activate immune responses, particularly via interactions with specialized immune cells such as natural killer T (NKT) cells. These immunomodulatory effects may have implications for host-microbe interactions, allergic responses, and inflammatory diseases.

5. Plant-microbe interactions: Sphingomonadaceae bacteria are commonly associated with plants and are known to form symbiotic relationships with plant roots. They can promote plant growth, enhance nutrient uptake, and protect plants from pathogens and environmental stressors. Understanding the interactions between Sphingomonadaceae bacteria and plants may have applications in agriculture, horticulture, and environmental remediation.

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Sphingomonadaceae impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart
0.527744472026825	0.9697599411010742	Caulobacteraceae	Parent Taxa
0.2567519247531891	0.6224993467330933	Lysobacteraceae	Parent Taxa

Other bacteria of the same rank impacting Sphingomonadaceae

R2	Slope	Tax Name	Parent Chart
0.43123069405555725	0.768605649471283	Caulobacteraceae	Parent Taxa
0.36333152651786804	0.7333244681358337	Lysobacteraceae	Parent Taxa
0.34758901596069336	0.7072868943214417	Nitrobacteraceae	Parent Taxa
0.29105374217033386	0.6197992563247681	Methylobacteriaceae	Parent Taxa
0.28777989745140076	0.6137744784355164	Burkholderiaceae	Parent Taxa
0.2709364593029022	0.5135101675987244	Oscillospiraceae	Parent Taxa
0.2676941454410553	0.49594566226005554	Pseudomonadaceae	Parent Taxa
0.2669129967689514	0.6299597024917603	Rhizobiaceae	Parent Taxa
0.2549099326133728	0.6081464290618896	Microbacteriaceae	Parent Taxa