Clostridia: NCBI 186801, [class]

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| Clostridia| Clostridia Rainey 2010

1. Beneficial Roles:

   • Short-Chain Fatty Acid Production: Some Clostridia species play a crucial role in the fermentation of dietary fibers in the colon, producing short-chain fatty acids (SCFAs) such as butyrate. SCFAs are important for maintaining gut health, providing an energy source for colonocytes, and contributing to the regulation of the immune system.

   • Vitamin Synthesis: Certain Clostridia species are involved in the synthesis of vitamins, such as B vitamins (e.g., B12 and folate). These vitamins are essential for various physiological processes in the body.

2. Negative Roles:

   • Pathogenic Species: While many Clostridia species are beneficial, some can be pathogenic and cause diseases. For example, Clostridium difficile is known to cause antibiotic-associated diarrhea and more severe forms of colitis. Infections with pathogenic Clostridia can be challenging to treat and may require specific antimicrobial interventions.

   • Toxin Production: Some pathogenic Clostridia produce toxins that can have detrimental effects on the host. For instance, Clostridium botulinum produces botulinum toxin, which can cause botulism, a serious illness that affects the nervous system.

3. Immune System Regulation:

   • Clostridia species have been implicated in immune system regulation. Certain strains may promote immune tolerance and help prevent inappropriate inflammatory responses, potentially contributing to the maintenance of a healthy immune system.

4. Gut Microbiota Composition:

   • The presence and abundance of Clostridia can influence the overall composition of the gut microbiota. Changes in the relative abundance of Clostridia have been associated with various health conditions, including inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS).

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Clostridia impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart
0.4008309245109558	0.6182522773742676	Alphaproteobacteria	Parent Taxa
0.36990946531295776	0.49461135268211365	Myxococcia	Parent Taxa
0.3563615381717682	0.549689531326294	Spirochaetia	Parent Taxa
0.34589534997940063	0.5227429270744324	Gemmatimonadia	Parent Taxa
0.27781015634536743	0.5268094539642334	Erysipelotrichia	Parent Taxa
0.2774617075920105	0.42836472392082214	Methanomicrobia	Parent Taxa

Other bacteria of the same rank impacting Clostridia

R2	Slope	Tax Name	Parent Chart
0.4631389379501343	0.7403033971786499	Spirochaetia	Parent Taxa
0.42818886041641235	0.6838982105255127	Alphaproteobacteria	Parent Taxa
0.2790038287639618	0.5287362337112427	Erysipelotrichia	Parent Taxa