Treponema pallidum Details: NCBI 160, gram-negative or unknown [species]

Found in Oral Cavity

For the possible significance see Oral bacteria relative abundance in faeces increases due to gut microbiota depletion and is linked with patient outcomes, 2024

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| "Microspironema pallidum" (Schaudinn and Hoffmann 1905) Stiles and Pfender 1905| "Spirillum pallidum" (Schaudinn and Hoffmann 1905) Mace 1913| "Spirochaeta pallida" Schaudinn and Hoffmann 1905| "Spironema pallidum" (Schaudinn and Hoffmann 1905) Vuillemin 1905| Microspironema pallidum| Spirillum pallidum| Spirochaeta pallida| Spironema pallidum| Treponema pallidum| Treponema pallidum (Schaudinn and Hoffmann 1905) Schaudinn 1905

1. Primary Syphilis: The initial stage of syphilis, known as primary syphilis, is characterized by the development of a painless sore or ulcer called a chancre at the site of infection, typically occurring on the genitals, anus, or mouth. Chancres can go unnoticed, but they are highly infectious. If left untreated, the chancre will heal spontaneously within a few weeks.

2. Secondary Syphilis: Secondary syphilis occurs if the infection is not treated during the primary stage. It is characterized by a variety of symptoms, including skin rash (often on the palms of the hands and soles of the feet), mucous membrane lesions, fever, swollen lymph nodes, sore throat, headache, muscle aches, and fatigue. These symptoms can come and go over several weeks or months.

3. Latent Syphilis: If syphilis remains untreated during the secondary stage, it progresses to the latent stage, during which the bacteria remain in the body without causing symptoms. Latent syphilis can last for years, and individuals may not be aware they are infected unless they undergo syphilis testing.

4. Tertiary Syphilis: In some cases, untreated syphilis can progress to the tertiary stage, which can occur years or even decades after the initial infection. Tertiary syphilis can lead to severe complications affecting multiple organ systems, including the cardiovascular system (e.g., aortic aneurysms), the nervous system (e.g., neurosyphilis, which can cause dementia, paralysis, and sensory deficits), and the skin, bones, and other organs.

5. Congenital Syphilis: Syphilis can be transmitted from a pregnant woman to her fetus during pregnancy or childbirth, resulting in congenital syphilis. Congenital syphilis can cause serious complications in newborns, including stillbirth, prematurity, low birth weight, birth defects, developmental delays, and neurological problems.

6. Increased HIV Transmission: Syphilis infection increases the risk of acquiring or transmitting HIV, the virus that causes AIDS. The genital sores associated with syphilis provide entry points for HIV, and the presence of syphilis infection can increase HIV viral load in co-infected individuals.

7. Screening and Treatment: Early detection and treatment of syphilis are crucial for preventing the progression of the disease and reducing the risk of complications. Syphilis is typically treated with antibiotics, such as penicillin, which are highly effective in curing the infection, especially in the early stages. Individuals diagnosed with syphilis should also be screened for other STIs and HIV.

The above data is from 1000 Healthy Individuals done using Shotgun(10 Millions reads) provide courtesy of Precision Biome.

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Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

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General Substance	Specific Substance	Effect
Amino Acid and similar	2-Amino-5-(carbamoylamino)pentanoic acid {Citrulline}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Amino Acid and similar	Lycopene {Glucosamine (GS)}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Amino Acid and similar	N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide {Melatonin}	2 Studies recorded. The consensus is Decreases📓, Click for details.
Antibiotics, Antivirals etc	doxycycline [CFS]	3 Studies recorded. The consensus is Decreases👶📓, Click for details.
Antibiotics, Antivirals etc	erythromycin [CFS]	1 Studies recorded. The consensus is Decreases📓, Click for details.
Antibiotics, Antivirals etc	metronidazole [CFS]	1 Studies recorded. The consensus is Decreases📓, Click for details.
Common and OTC Supplements	5-Hydroxytryptophan {5-HTP}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Common and OTC Supplements	Boron {Borax}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	dietary fiber	2 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style	Fiber, total dietary	1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style	High-fibre diet {Whole food diet}	1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style	Slow digestible carbohydrates. {Low Glycemic}	2 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	whole-grain diet	1 Studies recorded. The consensus is Decreases📓, Click for details.
Flavonoids, Polyphenols etc	quebracho	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Amorphophallus konjac {Konjaku flour}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	fruit	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	fruit/legume fibre	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Malus domestica {apple}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	pectin {pectin}	2 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	tomato powder	1 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings)	wheat	1 Studies recorded. The consensus is Increases📓, Click for details.
Food Preservatives	Disodium fumarate {Fumaric acid disodium salt}	1 Studies recorded. The consensus is Increases📓, Click for details.
Herb or Spice	Diferuloylmethane {Curcumin}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Herb or Spice	Moringa Oleifera	1 Studies recorded. The consensus is Increases📓, Click for details.
Herb or Spice	Pentadigalloylglucose {Tannic Acid}	1 Studies recorded. The consensus is Increases📓, Click for details.
Miscellaneous, food additives, and other odd items	N-(phosphonomethyl)glycine {glyphosate}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Not Classified	Sodium Fluoride {Toothpaste fluoride}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Prebiotics and similar	Amorphophallus konjac {konjac}	1 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	arabinogalactan {arabinogalactan}	1 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	Carrageenans {Carrageenan}	1 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	partially hydrolysed guar gum	1 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	Poly[β-D-xylopyranose(1->4)] {Xylan}	1 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	Xanthomonas campestris {Xanthan gum}	1 Studies recorded. The consensus is Increases📓, Click for details.
Prescription - Other	helminth infection (prescription)	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	bacillus	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	Bacillus amyloliquefaciens group {B. Amyloliquefaciens}	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	bacillus,lactobacillus,streptococcus,saccharomyces probiotic	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	Bacteroides uniformis {Bacteroides uniformis}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	Escherichia coli Nissle 1917 {Mutaflor}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	Lacticaseibacillus casei {L. casei}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	Ligilactobacillus salivarius {L. salivarius}	1 Studies recorded. The consensus is Increases📓, Click for details.
Sugar and similar	steviol glycosides {Stevia}	1 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	Mixture of Vitamin B? {B Vitamins}	2 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	nicotinic acid {Vitamin B-3}	1 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	Thiamine {Vitamin B1}	1 Studies recorded. The consensus is Increases📓, Click for details.