Clostridioides: NCBI 1870884, [genus]

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| Clostridioides| Clostridioides Lawson et al. 2016

1. Clostridioides difficile (C. difficile):

   • C. difficile is a Gram-positive, anaerobic bacterium that can cause infections in the colon, particularly in individuals who have taken antibiotics, which disrupt the normal balance of the gut microbiota.

2. Clostridioides difficile Infection (CDI):

   • Clostridioides difficile infection (CDI) is a common healthcare-associated infection. It can cause symptoms ranging from mild diarrhea to severe colitis. In severe cases, CDI can lead to complications such as pseudomembranous colitis and toxic megacolon.

3. Risk Factors:

   • Individuals at an increased risk for CDI include those who have recently taken antibiotics, are elderly, have underlying health conditions, or are hospitalized. The use of broad-spectrum antibiotics can disrupt the normal gut microbiota, allowing C. difficile to proliferate.

4. Transmission:

   • C. difficile is typically transmitted via the fecal-oral route. Spores shed in the feces can persist in the environment and can be spread to others or to surfaces. Healthcare settings are common sites for C. difficile transmission.

5. Toxin Production:

   • C. difficile produces toxins, including toxins A and B, which contribute to the development of symptoms. These toxins can cause damage to the lining of the colon.

6. Recurrence:

   • Recurrent cases of CDI can occur, where individuals experience multiple episodes of infection. Managing and preventing recurrences can be challenging.

7. Treatment:

   • Treatment of CDI often involves discontinuing the use of the implicated antibiotic, if possible, and administration of specific antibiotics effective against C. difficile. Fecal microbiota transplantation (FMT) is another approach used for recurrent cases.

8. Prevention:

   • Preventive measures include proper hand hygiene, infection control practices in healthcare settings, judicious use of antibiotics, and environmental cleaning to reduce the spread of C. difficile spores.

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Clostridioides impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart
0.42694032192230225	0.6227548122406006	Pseudoalteromonas	Parent Taxa
0.37617287039756775	0.647060215473175	Sodalis	Parent Taxa
0.36214277148246765	0.5981205105781555	Lachnoclostridium	Parent Taxa
0.3593469262123108	0.601485013961792	Dorea	Parent Taxa
0.35645049810409546	0.60157710313797	Blautia	Parent Taxa
0.3515680134296417	0.5714758038520813	Wansuia	Parent Taxa
0.34357550740242004	0.5700228810310364	Subdoligranulum	Parent Taxa
0.33793845772743225	0.5849916338920593	Anaerobutyricum	Parent Taxa
0.3366210460662842	0.5851057171821594	Anaerostipes	Parent Taxa
0.3352724611759186	0.5493119359016418	Marvinbryantia	Parent Taxa
0.33503156900405884	0.5682534575462341	Faecalitalea	Parent Taxa
0.33290207386016846	0.5797013640403748	Coprococcus	Parent Taxa
0.33273693919181824	0.5772396922111511	Eubacterium	Parent Taxa
0.3326520323753357	0.5713832974433899	Anaerotruncus	Parent Taxa
0.327697217464447	0.5730454921722412	Ruthenibacterium	Parent Taxa
0.3262631893157959	0.5691438913345337	Vescimonas	Parent Taxa
0.3104572296142578	0.5528573989868164	Hungatella	Parent Taxa
0.3003033697605133	0.5386369228363037	Intestinimonas	Parent Taxa
0.2997835874557495	0.5265661478042603	Oscillibacter	Parent Taxa
0.29686787724494934	0.5102713108062744	Christensenella	Parent Taxa
0.28558269143104553	0.5354188084602356	Ruminococcus	Parent Taxa
0.2733602523803711	0.487312376499176	Massilistercora	Parent Taxa
0.27334532141685486	0.4721497893333435	Novisyntrophococcus	Parent Taxa
0.27321186661720276	0.4913657605648041	Catenibacterium	Parent Taxa
0.27097922563552856	0.49521058797836304	Ligilactobacillus	Parent Taxa
0.27047568559646606	0.4915633797645569	Longicatena	Parent Taxa
0.26672640442848206	0.5205676555633545	Roseburia	Parent Taxa
0.2635181248188019	0.5175109505653381	Clostridium	Parent Taxa
0.2634085416793823	0.5032236576080322	Pusillibacter	Parent Taxa
0.2583020031452179	0.4345977306365967	Halomonas	Parent Taxa
0.2578400671482086	0.5122112035751343	Faecalibacterium	Parent Taxa

Other bacteria of the same rank impacting Clostridioides

R2	Slope	Tax Name	Parent Chart
0.41537365317344666	0.6864084005355835	Marvinbryantia	Parent Taxa
0.4108474552631378	0.6739202737808228	Wansuia	Parent Taxa
0.3888072669506073	0.6874317526817322	Novisyntrophococcus	Parent Taxa
0.3839913606643677	0.6449669599533081	Subdoligranulum	Parent Taxa
0.3767754137516022	0.6576480269432068	Massilistercora	Parent Taxa
0.37537840008735657	0.6198135614395142	Lachnoclostridium	Parent Taxa
0.3699018359184265	0.6578090786933899	Christensenella	Parent Taxa
0.3662673830986023	0.6651288270950317	Qiania	Parent Taxa
0.3642835319042206	0.6228168606758118	Faecalitalea	Parent Taxa
0.35784459114074707	0.6313877701759338	Oscillibacter	Parent Taxa
0.3575422167778015	0.5985853672027588	Dorea	Parent Taxa
0.35526061058044434	0.6346911191940308	Longicatena	Parent Taxa
0.3523522615432739	0.6058024764060974	Anaerotruncus	Parent Taxa
0.3504355251789093	0.6461380124092102	Solibaculum	Parent Taxa
0.34918078780174255	0.6652405858039856	Acutalibacter	Parent Taxa
0.34754350781440735	0.5869705677032471	Blautia	Parent Taxa
0.34577253460884094	0.6383275389671326	Treponema	Parent Taxa
0.3446059226989746	0.630643367767334	Catenibacterium	Parent Taxa
0.33980250358581543	0.6447532773017883	Lacrimispora	Parent Taxa
0.33567479252815247	0.5857122540473938	Vescimonas	Parent Taxa
0.33481454849243164	0.5806305408477783	Eubacterium	Parent Taxa
0.33475586771965027	0.5960156917572021	Intestinimonas	Parent Taxa
0.3320222795009613	0.5807709097862244	Ruthenibacterium	Parent Taxa
0.3311355412006378	0.5738056898117065	Anaerobutyricum	Parent Taxa
0.3290404677391052	0.6096554398536682	Ligilactobacillus	Parent Taxa
0.3285820186138153	0.5726940035820007	Coprococcus	Parent Taxa
0.32722896337509155	0.5822713375091553	Hungatella	Parent Taxa
0.32657983899116516	0.5687780976295471	Anaerostipes	Parent Taxa
0.32657912373542786	0.6157421469688416	Amedibacterium	Parent Taxa
0.3219105899333954	0.6171878576278687	Flintibacter	Parent Taxa
0.3187859058380127	0.6373664140701294	Maliibacterium	Parent Taxa
0.30239662528038025	0.5682185292243958	Pusillibacter	Parent Taxa
0.3023575246334076	0.5769771337509155	Butyrivibrio	Parent Taxa
0.29665374755859375	0.607024610042572	Monoglobus	Parent Taxa
0.29569971561431885	0.615436851978302	Parvimonas	Parent Taxa
0.2894150912761688	0.6163226962089539	Mageeibacillus	Parent Taxa
0.2883923351764679	0.5793585181236267	Lachnoanaerobaculum	Parent Taxa
0.2840310335159302	0.5387080907821655	Ruminococcus	Parent Taxa
0.2724153399467468	0.5389235615730286	Lawsonibacter	Parent Taxa
0.2648702561855316	0.567781388759613	Mogibacterium	Parent Taxa
0.2569424510002136	0.5045948624610901	Roseburia	Parent Taxa
0.2550943195819855	0.5820749998092651	Chordicoccus	Parent Taxa
0.2526998817920685	0.4997989237308502	Clostridium	Parent Taxa
0.25240570306777954	0.5663763284683228	Emergencia	Parent Taxa
0.2502894103527069	0.5747137069702148	Komagataeibacter	Parent Taxa