Treponema denticola: NCBI 158, [species]

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| "Spirillum dentium" (Miller 1889) Sternberg 1892| "Spirochaeta ambigua" Seguin and Vinzent 1936| "Spirochaeta comandonii" Seguin and Vinzent 1936| "Spirochaeta dentium" (Miller 1889) Migula 1895| "Spirochaeta microdentium" (Noguchi 1912) Heim 1922| "Spirochaeta orthodonta" Hoffmann 1920| "Spirochaete denticola" Flugge 1886| "Spirochaete dentium" Miller 1889| "Spironema dentium" (Miller 1889) Gross 1912| "Treponema ambiguum" (Seguin and Vinzent 1936) Prevot 1940| "Treponema comandonii" (Seguin and Vinzent 1936) Prevot 1940| "Treponema dentium" (Miller 1889) Dobell 1912| "Treponema dentium-stenogyratum" Pettit 1928| "Treponema microdentium" Noguchi 1912| "Treponema orthodontum" (Hoffmann 1920) Noguchi 1928| ATCC 35405| CIP 103919| DSM 14222| JCM 8153| Spirillum dentium| Spirochaeta ambigua| Spirochaeta comandonii| Spirochaeta dentium| Spirochaeta microdentium| Spirochaeta orthodonta| Spirochaete denticola| Spirochaete dentium| Spironema dentium| Treponema ambiguum| Treponema comandonii| Treponema denticola| Treponema denticola (ex Brumpt 1925) Chan et al. 1993| Treponema denticola (ex Flugge 1886) Chan et al. 1993| Treponema dentium| Treponema dentium-stenogyratum| Treponema microdentium| Treponema orthodontum

1. Periodontal Diseases: Treponema denticola is considered one of the major pathogens implicated in the development and progression of periodontal diseases, including gingivitis and periodontitis. These diseases involve inflammation and infection of the tissues surrounding the teeth, including the gums (gingiva) and supporting structures such as the periodontal ligament and alveolar bone.

2. Biofilm Formation: Treponema denticola is known to form biofilms in the oral cavity, particularly in periodontal pockets and on the surfaces of teeth and dental plaque. Biofilms provide a protective environment for bacteria, making them more resistant to antimicrobial agents and host immune responses. This can contribute to the chronicity and severity of periodontal infections.

3. Tissue Destruction: Treponema denticola produces enzymes and toxins that can degrade periodontal tissues, including collagenases and proteases that contribute to the breakdown of connective tissue and bone resorption. This tissue destruction is a hallmark feature of periodontal diseases and can lead to tooth mobility, tooth loss, and systemic complications if left untreated.

4. Inflammatory Response: The presence of Treponema denticola and other periodontal pathogens can stimulate an immune response in the host, leading to the production of pro-inflammatory cytokines and inflammatory mediators. Chronic inflammation in the periodontal tissues can exacerbate tissue damage and contribute to systemic inflammation, which has been linked to various systemic conditions such as cardiovascular disease, diabetes, and adverse pregnancy outcomes.

5. Association with Systemic Health: While the primary impact of Treponema denticola is on oral health and periodontal diseases, there is emerging evidence suggesting potential associations between periodontal infections and systemic health conditions. Chronic periodontitis has been linked to an increased risk of cardiovascular disease, diabetes mellitus, respiratory infections, adverse pregnancy outcomes, and other systemic conditions. While the exact mechanisms underlying these associations are not fully understood, it is believed that systemic dissemination of oral bacteria and their inflammatory byproducts may play a role.

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Treponema denticola impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart
0.5123293995857239	0.7522159814834595	Treponema putidum	Parent Taxa
0.3779006898403168	0.7068090438842773	Dorea formicigenerans	Parent Taxa
0.3704959452152252	0.6989120841026306	Coprococcus catus	Parent Taxa
0.3503352999687195	0.679236114025116	Blautia obeum	Parent Taxa
0.34908148646354675	0.678085446357727	Dorea longicatena	Parent Taxa
0.3481026589870453	0.6796603202819824	Vescimonas fastidiosa	Parent Taxa
0.3392513394355774	0.6685999035835266	Coprococcus comes	Parent Taxa
0.3263499140739441	0.6564928889274597	Blautia sp. SC05B48	Parent Taxa
0.317732036113739	0.6487216353416443	Vescimonas coprocola	Parent Taxa
0.31374111771583557	0.6451778411865234	Subdoligranulum variabile	Parent Taxa
0.3068773150444031	0.6362779140472412	Cloacibacterium caeni	Parent Taxa
0.3045026361942291	0.5831905603408813	Pectobacterium carotovorum	Parent Taxa
0.2962406575679779	0.6274133920669556	Wansuia hejianensis	Parent Taxa
0.29393747448921204	0.6220427751541138	Anaerobutyricum hallii	Parent Taxa
0.2881890535354614	0.6349093317985535	Corynebacterium vitaeruminis	Parent Taxa
0.2813322842121124	0.6087993383407593	[Ruminococcus] torques	Parent Taxa
0.2797989845275879	0.6162240505218506	Companilactobacillus alimentarius	Parent Taxa
0.2775256931781769	0.5784079432487488	Salmonella bongori	Parent Taxa
0.27629154920578003	0.5619195103645325	Pantoea sp. At-9b	Parent Taxa
0.27070924639701843	0.5987976789474487	Intestinimonas butyriciproducens	Parent Taxa
0.2688084840774536	0.6120274662971497	Skunavirus fd13	Parent Taxa
0.2680559456348419	0.5945993065834045	Ruthenibacterium lactatiformans	Parent Taxa
0.266583651304245	0.5939884185791016	Eubacterium ventriosum	Parent Taxa
0.2647928297519684	0.5905174612998962	Roseburia hominis	Parent Taxa
0.2605840861797333	0.5886272192001343	Oscillibacter hominis	Parent Taxa
0.2571539282798767	0.5836979746818542	Clostridium sp. M62/1	Parent Taxa
0.2565537095069885	0.5839093923568726	Ruminococcus champanellensis	Parent Taxa
0.25619685649871826	0.5827800631523132	Faecalibacillus intestinalis	Parent Taxa

Other bacteria of the same rank impacting Treponema denticola

R2	Slope	Tax Name	Parent Chart
0.3965951204299927	0.7351640462875366	Treponema putidum	Parent Taxa