Megasphaera Details: NCBI 906, gram-negative or unknown [genus]

Found in Oral Cavity

For the possible significance see Oral bacteria relative abundance in faeces increases due to gut microbiota depletion and is linked with patient outcomes, 2024

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| Megasphaera| Megasphaera Rogosa 1971 (Approved Lists 1980) emend. Marchandin et al. 2003

1. Anaerobic Fermentation:

   • Megasphaera species are generally anaerobic bacteria, and they are capable of fermenting a variety of substrates. In the gut, they participate in the fermentation of dietary fibers and complex carbohydrates.

2. Short-Chain Fatty Acid Production:

   • As part of their metabolic activities, Megasphaera bacteria can produce short-chain fatty acids (SCFAs) during the fermentation process. SCFAs, such as acetate, propionate, and butyrate, have been associated with various health benefits, including providing an energy source for colonic cells and influencing immune function.

3. Role in the Rumen of Ruminant Animals:

   • Some Megasphaera species are found in the rumen of ruminant animals, where they contribute to the digestion of fibrous plant materials through fermentation. The breakdown of complex carbohydrates in the rumen is important for the nutrition of ruminants.

4. Metabolism of Lactate:

   • Certain Megasphaera species are known for their ability to metabolize lactate. This characteristic is of interest in various environments, including the human gut, where the balance of lactate-producing and lactate-utilizing bacteria can influence gut health.

5. Influence on Gut Microbiota Composition:

   • The presence and abundance of Megasphaera species can contribute to the overall composition and diversity of the gut microbiota. Changes in the relative abundance of Megasphaera may be associated with specific dietary patterns or health conditions.

6. Associations with Gastrointestinal Disorders:

   • Some studies have investigated the association between Megasphaera and gastrointestinal disorders. For example, shifts in the abundance of Megasphaera have been observed in conditions such as irritable bowel syndrome (IBS).

Visuals of 1 Interactions with other bacteria of the same rank

The above data is from 1000 Healthy Individuals done using Shotgun(10 Millions reads) provide courtesy of Precision Biome.

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Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

More Information

Statistics

NCBI

Data Punk

End Products Produced

Lab Reporting

Different labs use different software to read the sample. See this post for more details.
One lab may say you have none, another may say you have a lot! - This may be solely due to the software they are using to estimate.
We deem lab specific values using values from the KM method for each specific lab to be the most reliable.

Desired Levels Suggestions for Megasphaera

• Lab Low and High are calculated using the formula that most labs use: Mean - 1.95 Standard Deviation to Mean + 1.95 Standard Deviation

These are values that are computed from lab specific samples and are in percentage

Lab	Frequency	Average	Median	Minimum	Maximum	Std.Dev.	Skew	25 - 75 Percentile	5 - 95 Percentile	Lab Ranges	Box-Plot-Whiskers	Harmonic Mean	Geometric Mean	Obs.
BiomeSight	0.9201	0.1211	0.017	0.001	14.304	0.7371	0.4236	0.008 - 0.037	0.002 - 0.1656	-1.3163 - 1.5585	-0.0355 - 0.0805	0.0086	0.0181	3409
BiomeSightRdp	0.4074	0.0079	0.002	0.001	0.037	0.0108	1.6439	0.002 - 0.008	0.0015 - 0.027	-0.0131 - 0.0289	-0.007 - 0.017	0.0027	0.0042	11
custom	0.1277	0.5738	0.011	0.0036	3.4	1.3846	1.2194	0.0073 - 0.011	0.0042 - 2.5527	-2.1261 - 3.2737	0.0016 - 0.0166	0.0084	0.0215	6
es-xenogene	0.9091	0.0106	0.008	0.001	0.03	0.0088	0.8829	0.0043 - 0.0155	0.001 - 0.03	-0.0066 - 0.0278	-0.0126 - 0.0324	0.0034	0.0066	20
Medivere	1	0.0531	0.0105	0.0047	0.3014	0.1096	1.1666	0.0099 - 0.0177	0.0062 - 0.2166	-0.1606 - 0.2668	-0.002 - 0.0296	0.0112	0.0172	7
Thorne	0.9418	0.0078	0.0036	0.0002	0.2083	0.0198	0.64	0.0022 - 0.0061	0.001 - 0.0165	-0.0308 - 0.0465	-0.0036 - 0.0119	0.0024	0.0039	178
Thryve	0.675	0.1288	0.0044	0.0001	21.361	1.0026	0.3723	0.0025 - 0.0089	0.0012 - 0.2263	-1.8262 - 2.0839	-0.0071 - 0.0185	0.0028	0.0061	837
uBiome	0.6553	0.3544	0.0229	0.0019	20.703	1.4091	0.7057	0.0076 - 0.0862	0.0031 - 1.5894	-2.3934 - 3.1021	-0.1103 - 0.2041	0.0112	0.0335	517
Vitract	0.3084	0.0024	0.0024	0.0024	0.0024		0	0.0024 - 0.0024	0.0024 - 0.0024	-	0.0024 - 0.0024	0.5928	0.0024	247

External Reference Ranges for Megasphaera

Megasphaera (NCBI 906) per million

Source of Ranges	Low Boundary	High Boundary	Low Boundary %age	High Boundary %age
Metagenomics	0	0	0	0
PrecisionBiome	3.7364141462603584E-05	0.0052459510043263435	0	0
Thorne (20/80%ile)	46.46	105.02	0.0046	0.0105

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Data Contradictions — Limits of Certainity

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General Substance	Specific Substance	Effect
Amino Acid and similar	(2S)-2-amino-4-carbamoylbutanoic acid {Glutamine}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Amino Acid and similar	2-hydroxyethyl)trimethylazanium {choline}	1 Studies recorded. The consensus is Decreases👶, Click for details.
Amino Acid and similar	N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide {Melatonin}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Amino Acid and similar	pyrrolidine-2-carboxylic acid {proline}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Antibiotics, Antivirals etc	rifaximin	2 Studies recorded. The consensus is Decreases📓, Click for details.
Antibiotics, Antivirals etc	trimethoprim	1 Studies recorded. The consensus is Decreases📓, Click for details.
Antibiotics, Antivirals etc	vancomycin (antibiotic)[CFS]	1 Studies recorded. The consensus is Increases👶, Click for details.
Common and OTC Supplements	1,4-a-D-glucan branched {Amylopectin}	1 Studies recorded. The consensus is Increases👶, Click for details.
Common and OTC Supplements	5-Hydroxytryptophan {5-HTP}	1 Studies recorded. The consensus is Increases👶, Click for details.
Common and OTC Supplements	chlorhexidine	1 Studies recorded. The consensus is Decreases📓, Click for details.
Common and OTC Supplements	sodium butyrate	1 Studies recorded. The consensus is Increases👶, Click for details.
Diet Style	Amylum {Starch}	1 Studies recorded. The consensus is Increases👶, Click for details.
Diet Style	dietary fiber	1 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	Fiber, total dietary	1 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	high carbohydrate diet	1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style	High-fibre diet {Whole food diet}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	hypocaloric hyperproteic diet	2 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	low protein diet	1 Studies recorded. The consensus is Increases👶, Click for details.
Diet Style	Pisum sativum {pea}	1 Studies recorded. The consensus is Increases👶, Click for details.
Diet Style	Slow digestible carbohydrates. {Low Glycemic}	3 Studies recorded. The consensus is Increases👪📓, Click for details.
Diet Style	Traditional Mediterranean diet {Mediterranean diet}	1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style	whole-grain diet	3 Studies recorded. The consensus is Increases👪📓, Click for details.
Flavonoids, Polyphenols etc	Camellia sinensis {oolong tea}	1 Studies recorded. The consensus is Increases👪, Click for details.
Flavonoids, Polyphenols etc	glutathione	1 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	Abstention from eating {Fasting}	1 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	amaranthus {amaranth}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Amorphophallus konjac {Konjaku flour}	1 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	Avena sativa {Oats}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Avena sativa x Hordeum vulgare {barley,oat}	3 Studies recorded. The consensus is Increases👪📓, Click for details.
Food (excluding seasonings)	Bovine Milk Products {Dairy}	4 Studies recorded. The consensus is Increases👶📓, Click for details.
Food (excluding seasonings)	Caffeine	2 Studies recorded. The consensus is Decreases👶, Click for details.
Food (excluding seasonings)	Citrus aurantiifolia {Lime}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Citrus limon {Lemon}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Coffee	3 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	Cola aspartame {Diet Cola}	2 Studies recorded. The consensus is Decreases👶, Click for details.
Food (excluding seasonings)	Cucurbita pepo {Pumpkin}	2 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	eicosapentaenoic acid (EPA),docosahexaenoic acid (DHA) {Fish Oil}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	fruit	1 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings)	fruit/legume fibre	1 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings)	Gallus domesticus {Chicken}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Garcinia mangostana {Mangosteen}	1 Studies recorded. The consensus is Increases👪, Click for details.
Food (excluding seasonings)	gliadin, glutenin etc {Gluten}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Hordeum vulgare {Barley}	2 Studies recorded. The consensus is Increases👪📓, Click for details.
Food (excluding seasonings)	Hydrastis canadensis {Goldenseal}	2 Studies recorded. The consensus is Increases👶📓, Click for details.
Food (excluding seasonings)	kefir	1 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings)	Morus {Mulberry }	1 Studies recorded. The consensus is Decreases👶, Click for details.
Food (excluding seasonings)	olive oil {olive oil}	2 Studies recorded. The consensus is Increases👶📓, Click for details.
Food (excluding seasonings)	oolong teas	2 Studies recorded. The consensus is Decreases👶, Click for details.
Food (excluding seasonings)	Orange Juice	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Oryza sativa {Rice}	1 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	Outer Layers of Triticum aestivum {Wheat Bran}	1 Studies recorded. The consensus is Increases👪, Click for details.
Food (excluding seasonings)	pectin {pectin}	1 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	Prunus dulcis {Almonds}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	pseudo-cereals {amaranth,quinoa, taro,buckwheat}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	refined wheat breads	1 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	tea	2 Studies recorded. The consensus is Decreases👶, Click for details.
Food (excluding seasonings)	vegetable	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	wheat	1 Studies recorded. The consensus is Increases👪, Click for details.
Food (excluding seasonings)	yogurt	6 Studies recorded. The consensus is Increases👶📓, Click for details.
Food (excluding seasonings)	Zea mays {maize}	1 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	β-lactoglobulin {Whey}	2 Studies recorded. The consensus is Decreases👶, Click for details.
Food Preservatives	2H-1?6,2-benzothiazol-1,1,3-trione {Saccharin}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Herb or Spice	5,6-dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium {Berberine}	2 Studies recorded. The consensus is Increases👶📓, Click for details.
Herb or Spice	Boswellia serrata {Boswellia}	1 Studies recorded. The consensus is Decreases👶, Click for details.
Herb or Spice	Camellia Linnaeus {camellia}	2 Studies recorded. The consensus is Decreases👶, Click for details.
Herb or Spice	Codonopsis pilosula {Dangshen}	1 Studies recorded. The consensus is Decreases👶, Click for details.
Herb or Spice	Cymbopogon citratus {Lemongrass}	1 Studies recorded. The consensus is Increases👪, Click for details.
Herb or Spice	Ginkgo biloba {Ginkgo}	1 Studies recorded. The consensus is Increases👶, Click for details.
Herb or Spice	Polygonatum kingianum {Solomon's Seal}	1 Studies recorded. The consensus is Increases📓, Click for details.
Herb or Spice	Shen Ling Bai Zhu San {参苓白术散}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Miscellaneous, food additives, and other odd items	Tobacco consumption {Smoking}	1 Studies recorded. The consensus is Increases👶, Click for details.
Prebiotics and similar	(2->1)-beta-D-fructofuranan {Inulin}	4 Studies recorded. The consensus is Increases👶📓, Click for details.
Prebiotics and similar	a-Gluco-oligosaccharides {GOS}	1 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	Amorphophallus konjac {konjac}	1 Studies recorded. The consensus is Increases👶, Click for details.
Prebiotics and similar	Carrageenans {Carrageenan}	1 Studies recorded. The consensus is Increases👶, Click for details.
Prebiotics and similar	High-amylose maize starch {HAMS}	1 Studies recorded. The consensus is Increases👶, Click for details.
Prebiotics and similar	partially hydrolysed guar gum	1 Studies recorded. The consensus is Increases👶, Click for details.
Prebiotics and similar	ß-glucan {Beta-Glucan}	2 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	xylooligosaccharide	1 Studies recorded. The consensus is Decreases👶, Click for details.
Prescription - Other	candida albicans (prescription)	1 Studies recorded. The consensus is Increases📓, Click for details.
Prescription - Other	chemotherapy (prescription)	1 Studies recorded. The consensus is Decreases📓, Click for details.
Prescription - Other	Enterococcus faecalis {Streptococcus faecalis}	1 Studies recorded. The consensus is Decreases👶, Click for details.
Prescription - Other	metformin (prescription)	1 Studies recorded. The consensus is Increases👶, Click for details.
Prescription - Other	Morphine	1 Studies recorded. The consensus is Increases👶, Click for details.
Prescription - Other	proton-pump inhibitors (prescription)	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	aspergillus oryzae {koji}	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	bacillus	6 Studies recorded. The consensus is Increases👶📓, Click for details.
Probiotics	Bacillus amyloliquefaciens group {B. Amyloliquefaciens}	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	bacillus licheniformis {b. licheniformis}	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	bacillus subtilis {B.Subtilis }	2 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	bacillus subtilis,lactobacillus acidophilus	3 Studies recorded. The consensus is Increases👶📓, Click for details.
Probiotics	bacillus,lactobacillus,streptococcus,saccharomyces probiotic	8 Studies recorded. The consensus is Increases👶📓, Click for details.
Probiotics	bifidobacterium	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	Bifidobacterium animalis subsp. lactis {B. Lactis}	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	bifidobacterium longum {B.Longum }	2 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	bifidobacterium longum,lactobacillus helveticus	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	Clostridium butyricum MIYAIRI 588 {Miyarisan}	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	enterococcus faecium {E. faecium}	2 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	Escherichia coli Nissle 1917 {Mutaflor}	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	Heyndrickxia coagulans {B. coagulans}	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	Lacticaseibacillus paracasei {L.paracasei}	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	Lacticaseibacillus paracasei shirota {Yakult}	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	lactobacillus acidophilus {L. acidophilus}	3 Studies recorded. The consensus is Increases👶📓, Click for details.
Probiotics	Lactobacillus delbrueckii subsp. bulgaricus {L bulgaricus}	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	lactobacillus paracasei,lactobacillus acidophilus,bifidobacterium animalis	3 Studies recorded. The consensus is Increases👶📓, Click for details.
Probiotics	Lactobacillus plantarum {L. plantarum}	1 Studies recorded. The consensus is Decreases👶, Click for details.
Probiotics	lactobacillus rhamnosus gg,bifidobacterium animalis lactis ,lactobacillus paracasei {cvs maximum strength probiotic}	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	Lactococcus lactis {Streptococcus lactis}	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	Lentilactobacillus kefiri {Kefibios}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	Limosilactobacillus reuteri {L. Reuteri}	2 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	pediococcus acidilactic {RBB9 PEDIOCOCCUS ACIDILACTI}	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	Probiotic Mixture 1 {Japanese Vet Probiotic}	4 Studies recorded. The consensus is Increases👶📓, Click for details.
Probiotics	Probiotic Mixture 2 {Vetafarm Probotic}	3 Studies recorded. The consensus is Increases👶📓, Click for details.
Probiotics	Saccharomyces cerevisiae var boulardii {S. boulardii}	1 Studies recorded. The consensus is Decreases👶, Click for details.
Sugar and similar	Lactose {Milk Sugar}	1 Studies recorded. The consensus is Increases📓, Click for details.
Sugar and similar	Polydextrose {polydextrose}	1 Studies recorded. The consensus is Increases📓, Click for details.
Sugar and similar	synthetic disaccharide derivative of lactose {Lactulose}	1 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol {Vitamin A}	2 Studies recorded. The consensus is Decreases📓, Click for details.
Vitamins, Minerals and similar	alpha-tocopherol {Vitamin E}	2 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	ascorbic acid {Vitamin C}	1 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	Mixture of Vitamin B? {B Vitamins}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Vitamins, Minerals and similar	Riboflavin {Vitamin B2}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Vitamins, Minerals and similar	vitamin d	3 Studies recorded. The consensus is Decreases📓, Click for details.

Food Groups Containing the Megasphaera bacteria

This is base on Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome. See that paper for details on foods groups.

1. dairy : 100% of Highest
2. alcohol : 70.2756416% of Highest

Foods Containing the Megasphaera bacteria

Data comes from FoodMicrobionet. For the meaning of weight, see that site. The bacteria does not need to be alive to have an effect.

Robiola di Roccaverano Cheese (Italy) Weight: 0.4187 Trentingrana Cheese (Italy) Weight: 0.2168 Nunu, Ghana Weight: 0.05382 Malaysian fermented fish sauce Weight: 0.02306 Butter cheese, cow milk Weight: 0.006204 Sausage, Cyprus: Limassol Weight: 0.003483