Methanobrevibacter smithii: NCBI 2173, [species]

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| ATCC 35061| DSM 861| Methanobrevibacter smithii| Methanobrevibacter smithii Balch and Wolfe 1981| OCM 144| strain PS

1. Digestive processes: Methanobrevibacter smithii is involved in the digestion of dietary carbohydrates in the human gut. It consumes hydrogen produced by other microorganisms during the fermentation of complex carbohydrates and uses it to produce methane. This process helps regulate the microbial ecosystem in the gut and influences the efficiency of energy extraction from the diet.

2. Association with obesity: Some studies have suggested an association between the abundance of Methanobrevibacter smithii in the gut microbiota and obesity. Methane production by Methanobrevibacter smithii may influence energy metabolism and contribute to increased energy harvest from the diet. However, the exact mechanisms underlying this association and whether Methanobrevibacter smithii directly contributes to obesity or is simply a marker of dysbiosis are still under investigation.

3. Inflammatory bowel disease (IBD): Methanobrevibacter smithii has been detected in the gut microbiota of individuals with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. However, its role in the pathogenesis of IBD is not fully understood. Some studies have suggested that methane production by Methanobrevibacter smithii may have anti-inflammatory effects in the gut, while others have proposed that it may exacerbate intestinal inflammation by altering microbial interactions.

4. Hydrogen disposal: Methanobrevibacter smithii plays a role in hydrogen disposal in the gut by consuming hydrogen produced during microbial fermentation. In conditions where excess hydrogen accumulates in the gut, such as small intestinal bacterial overgrowth (SIBO), methane production by Methanobrevibacter smithii may help alleviate symptoms associated with hydrogen accumulation, such as bloating and abdominal discomfort.

5. Potential therapeutic target: Given its abundance and potential role in gut health and disease, Methanobrevibacter smithii has been proposed as a potential therapeutic target for modulating the gut microbiota. Strategies aimed at selectively targeting Methanobrevibacter smithii, such as antimicrobial treatments or dietary interventions, are being investigated for their potential to modulate methane production and improve gastrointestinal health.

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Methanobrevibacter smithii impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart
0.5280044078826904	0.7814189791679382	Methanobrevibacter sp. TLL-48-HuF1	Parent Taxa
0.18625500798225403	0.5536450743675232	Ruminococcus champanellensis	Parent Taxa
0.1726466417312622	0.5503925085067749	Streptococcus suis	Parent Taxa
0.16629742085933685	0.5077996253967285	Phascolarctobacterium succinatutens	Parent Taxa
0.16626204550266266	0.5014746189117432	Phascolarctobacterium sp. Marseille-Q4147	Parent Taxa
0.16025085747241974	0.5451063513755798	Vescimonas fastidiosa	Parent Taxa
0.15516164898872375	0.5176861882209778	Catenibacterium mitsuokai	Parent Taxa
0.15366220474243164	0.470818430185318	Mageeibacillus indolicus	Parent Taxa
0.15177081525325775	0.4738765060901642	Ruminococcus bovis	Parent Taxa
0.15128187835216522	0.4982527792453766	Catenibacterium sp. co_0103	Parent Taxa
0.14327648282051086	0.5212865471839905	Coprococcus catus	Parent Taxa
0.14200574159622192	0.40367212891578674	Cloacibacillus porcorum	Parent Taxa
0.14173851907253265	0.472763329744339	Maliibacterium massiliense	Parent Taxa
0.13949047029018402	0.4718312621116638	Acutalibacter muris	Parent Taxa
0.1394123136997223	0.4987585246562958	Christensenella minuta	Parent Taxa
0.13573047518730164	0.5037612318992615	Subdoligranulum variabile	Parent Taxa
0.12919101119041443	0.4441225528717041	Ruminococcus gauvreauii	Parent Taxa
0.12897531688213348	0.4698907136917114	Novisyntrophococcus fermenticellae	Parent Taxa
0.12775953114032745	0.4900261461734772	Clostridium sp. M62/1	Parent Taxa
0.12670376896858215	0.4576094150543213	Lacrimispora saccharolytica	Parent Taxa
0.12494924664497375	0.4679543375968933	Solibaculum mannosilyticum	Parent Taxa
0.12481235712766647	0.4800162613391876	Coprococcus eutactus	Parent Taxa
0.12422142177820206	0.43989473581314087	Parvimonas micra	Parent Taxa
0.12420035898685455	0.4684390425682068	[Clostridium] hylemonae	Parent Taxa
0.12416590005159378	0.45893973112106323	Clostridium cadaveris	Parent Taxa
0.12408993393182755	0.4682313799858093	Ligilactobacillus ruminis	Parent Taxa
0.12331463396549225	0.4814258813858032	Lawsonibacter asaccharolyticus	Parent Taxa
0.12293138355016708	0.47743260860443115	Butyrivibrio crossotus	Parent Taxa
0.12213483452796936	0.48066672682762146	Akkermansia muciniphila	Parent Taxa
0.12198406457901001	0.4700901210308075	Massilistercora timonensis	Parent Taxa
0.12119438499212265	0.4772699773311615	Faecalitalea cylindroides	Parent Taxa
0.12098953127861023	0.40385252237319946	Chordicoccus furentiruminis	Parent Taxa
0.12015219777822495	0.43659213185310364	Eubacterium sp. c-25	Parent Taxa
0.12012799084186554	0.394155889749527	Desulfovibrio piger	Parent Taxa
0.1190275251865387	0.4742972254753113	Dorea formicigenerans	Parent Taxa
0.11823707818984985	0.3582223951816559	Butyrivibrio fibrisolvens	Parent Taxa
0.11759943515062332	0.4724103510379791	Dorea longicatena	Parent Taxa
0.11715548485517502	0.4660811424255371	Wansuia hejianensis	Parent Taxa
0.11602633446455002	0.46919286251068115	Coprococcus comes	Parent Taxa
0.11267311871051788	0.39808282256126404	Komagataeibacter oboediens	Parent Taxa
0.11265816539525986	0.4594633877277374	Faecalibacterium sp. HTF-F	Parent Taxa
0.11109023541212082	0.34434422850608826	Oxalobacter aliiformigenes	Parent Taxa
0.11107965558767319	0.4232409596443176	Mogibacterium diversum	Parent Taxa
0.11061631143093109	0.45809662342071533	Clostridioides difficile	Parent Taxa
0.11044414341449738	0.4404726028442383	Eubacterium sp. MSJ-33	Parent Taxa
0.11041030287742615	0.3607734143733978	Selenomonas sputigena	Parent Taxa
0.11020725220441818	0.4092369079589844	Lactococcus cremoris	Parent Taxa
0.10903065651655197	0.4608268439769745	Methanosphaera stadtmanae	Parent Taxa
0.10834956914186478	0.4514789581298828	Coprococcus sp. ART55/1	Parent Taxa
0.10823982954025269	0.43211135268211365	Qiania dongpingensis	Parent Taxa
0.10669375211000443	0.4499927759170532	Roseburia hominis	Parent Taxa
0.10660698264837265	0.44980892539024353	Blautia obeum	Parent Taxa
0.10597072541713715	0.44089770317077637	Wujia chipingensis	Parent Taxa
0.1057194396853447	0.4456526041030884	Faecalibacterium sp. I4-1-79	Parent Taxa
0.10538739711046219	0.4452647268772125	Intestinimonas butyriciproducens	Parent Taxa
0.10408321022987366	0.4383475184440613	Oscillibacter hominis	Parent Taxa
0.10373831540346146	0.44374480843544006	Anaerobutyricum hallii	Parent Taxa
0.10370427370071411	0.4145819842815399	Monoglobus pectinilyticus	Parent Taxa
0.10297707468271255	0.34206917881965637	Gallibacterium salpingitidis	Parent Taxa
0.10105973482131958	0.37082764506340027	Treponema peruense	Parent Taxa
0.10104064643383026	0.33235645294189453	Streptococcus canis	Parent Taxa
0.10080358386039734	0.4313846826553345	Faecalibacterium sp. I2-3-92	Parent Taxa

Other bacteria of the same rank impacting Methanobrevibacter smithii

R2	Slope	Tax Name	Parent Chart
0.6063514947891235	0.8934372663497925	Methanobrevibacter sp. TLL-48-HuF1	Parent Taxa
0.386563777923584	0.6144719123840332	Vescimonas fastidiosa	Parent Taxa
0.36339062452316284	0.6475838422775269	Ruminococcus champanellensis	Parent Taxa
0.36235442757606506	0.6931782364845276	Maliibacterium massiliense	Parent Taxa
0.3281245231628418	0.5713106393814087	Clostridium sp. M62/1	Parent Taxa
0.32417866587638855	0.5948930978775024	Christensenella minuta	Parent Taxa
0.30499333143234253	0.5306589007377625	Intestinimonas butyriciproducens	Parent Taxa
0.3014344573020935	0.5958127379417419	Streptococcus suis	Parent Taxa
0.290447473526001	0.5617791414260864	Massilistercora timonensis	Parent Taxa
0.28876715898513794	0.5188427567481995	Coprococcus catus	Parent Taxa
0.2833249270915985	0.5682668685913086	Clostridium cadaveris	Parent Taxa
0.2827427089214325	0.5357070565223694	Faecalitalea cylindroides	Parent Taxa
0.280261367559433	0.6401647925376892	Oxalobacter aliiformigenes	Parent Taxa
0.2726965546607971	0.546201229095459	[Clostridium] hylemonae	Parent Taxa
0.27184176445007324	0.6086581349372864	Chordicoccus furentiruminis	Parent Taxa
0.26865649223327637	0.48222294449806213	Blautia obeum	Parent Taxa
0.2660488486289978	0.5562978982925415	Phascolarctobacterium sp. Marseille-Q4147	Parent Taxa
0.2649714946746826	0.5167205929756165	Wansuia hejianensis	Parent Taxa
0.2642228603363037	0.5156863331794739	Subdoligranulum variabile	Parent Taxa
0.2606571316719055	0.4876137375831604	Coprococcus sp. ART55/1	Parent Taxa
0.25752687454223633	0.5052455067634583	Coprococcus eutactus	Parent Taxa
0.25403833389282227	0.4864130914211273	Lawsonibacter asaccharolyticus	Parent Taxa
0.2529726028442383	0.5969812273979187	Selenomonas sputigena	Parent Taxa
0.16629742085933685	0.3274863064289093	Phascolarctobacterium succinatutens	Parent Taxa
0.15516164898872375	0.29972144961357117	Catenibacterium mitsuokai	Parent Taxa
0.15366220474243164	0.32637253403663635	Mageeibacillus indolicus	Parent Taxa
0.15177081525325775	0.3202750086784363	Ruminococcus bovis	Parent Taxa
0.15128187835216522	0.3036247491836548	Catenibacterium sp. co_0103	Parent Taxa
0.14200574159622192	0.3517848253250122	Cloacibacillus porcorum	Parent Taxa
0.13949047029018402	0.2956363558769226	Acutalibacter muris	Parent Taxa
0.12919101119041443	0.2908904552459717	Ruminococcus gauvreauii	Parent Taxa
0.12897531688213348	0.27447938919067383	Novisyntrophococcus fermenticellae	Parent Taxa
0.12670376896858215	0.2768819034099579	Lacrimispora saccharolytica	Parent Taxa
0.12494924664497375	0.2670116126537323	Solibaculum mannosilyticum	Parent Taxa
0.12422142177820206	0.28238898515701294	Parvimonas micra	Parent Taxa
0.12408993393182755	0.26501840353012085	Ligilactobacillus ruminis	Parent Taxa
0.12293138355016708	0.2574842572212219	Butyrivibrio crossotus	Parent Taxa
0.12213483452796936	0.2540946304798126	Akkermansia muciniphila	Parent Taxa
0.12015219777822495	0.27520468831062317	Eubacterium sp. c-25	Parent Taxa
0.12012799084186554	0.3047727942466736	Desulfovibrio piger	Parent Taxa
0.1190275251865387	0.2509555518627167	Dorea formicigenerans	Parent Taxa
0.11823707818984985	0.33006611466407776	Butyrivibrio fibrisolvens	Parent Taxa
0.11759943515062332	0.24893492460250854	Dorea longicatena	Parent Taxa
0.11602633446455002	0.24728922545909882	Coprococcus comes	Parent Taxa
0.11267311871051788	0.283039391040802	Komagataeibacter oboediens	Parent Taxa
0.11265816539525986	0.24519509077072144	Faecalibacterium sp. HTF-F	Parent Taxa
0.11107965558767319	0.2624501585960388	Mogibacterium diversum	Parent Taxa
0.11061631143093109	0.2414693832397461	Clostridioides difficile	Parent Taxa
0.11044414341449738	0.250740110874176	Eubacterium sp. MSJ-33	Parent Taxa
0.11020725220441818	0.26929938793182373	Lactococcus cremoris	Parent Taxa
0.10903065651655197	0.23659788072109222	Methanosphaera stadtmanae	Parent Taxa
0.10823982954025269	0.25049060583114624	Qiania dongpingensis	Parent Taxa
0.10669375211000443	0.23710103332996368	Roseburia hominis	Parent Taxa
0.10597072541713715	0.24035218358039856	Wujia chipingensis	Parent Taxa
0.1057194396853447	0.23722389340400696	Faecalibacterium sp. I4-1-79	Parent Taxa
0.10408321022987366	0.23744450509548187	Oscillibacter hominis	Parent Taxa
0.10373831540346146	0.23377922177314758	Anaerobutyricum hallii	Parent Taxa
0.10370427370071411	0.25014176964759827	Monoglobus pectinilyticus	Parent Taxa
0.10297707468271255	0.3010416626930237	Gallibacterium salpingitidis	Parent Taxa
0.10105973482131958	0.2725248336791992	Treponema peruense	Parent Taxa
0.10104064643383026	0.30401289463043213	Streptococcus canis	Parent Taxa
0.10080358386039734	0.23367445170879364	Faecalibacterium sp. I2-3-92	Parent Taxa