Clostridioides difficile: NCBI 1496, [species]

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| "Bacillus difficilis" Hall and O'Toole 1935| "Peptoclostridium difficile" Yutin and Galperin 2013| AS 1.2184| ATCC 9689| Bacillus difficilis| BCRC 10642| CCRC 10642| CCRC:10642| CCUG 4938| CIP 104282| Clostridioides difficile| Clostridioides difficile (Hall and O'Toole 1935) Lawson et al. 2016| Clostridium difficile| Clostridium difficile (Hall and O'Toole 1935) Prevot 1938 (Approved Lists 1980)| Clostridium difficle| Clostridium sp. HMSC19D05| DSM 1296| DSMZ 1296| JCM 1296| LMG 15861| LMG:15861| NCIMB 10666| NCTC 11209| Peptoclostridium difficile

1. Infection and Symptoms:

   • Clostridioides difficile infection (CDI) can result in symptoms ranging from mild diarrhea to severe colitis. Common symptoms include watery diarrhea, abdominal pain, fever, and loss of appetite.

2. Risk Factors:

   • Antibiotic use is a major risk factor for CDI. The use of broad-spectrum antibiotics can disrupt the normal gut microbiota, allowing C. difficile to proliferate and produce toxins that damage the colon lining.

3. Healthcare-Associated Infections:

   • CDI is often associated with healthcare settings, including hospitals and long-term care facilities. The bacterium can spread easily in healthcare environments, and individuals with weakened immune systems or underlying health conditions are at higher risk of severe infections.

4. Toxin Production:

   • C. difficile produces toxins, particularly toxins A and B, which are responsible for the damage to the colon lining and the development of symptoms. Toxins produced by C. difficile play a central role in the pathogenesis of the infection.

5. Recurrence:

   • Recurrent CDI is a challenging aspect of the infection. Some individuals may experience multiple episodes of CDI, requiring additional treatment and management strategies.

6. Pseudomembranous Colitis:

   • Severe cases of CDI can lead to a condition known as pseudomembranous colitis, characterized by the formation of pseudomembranes on the colon lining. This condition can result in severe inflammation and complications.

7. Treatment:

   • Treatment of CDI typically involves discontinuing the use of the implicated antibiotics and administering specific antibiotics targeting C. difficile, such as metronidazole or vancomycin. Fecal microbiota transplantation (FMT) is also considered in recurrent cases.

8. Prevention:

   • Preventive measures include infection control practices in healthcare settings, appropriate use of antibiotics, and maintaining good hand hygiene.

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

Legend

• The interactions are based on data from 1000 healthy individuals using shotgun 10M reads Precision Biome, a provider in full conformity to EU regulations for health information
• The width of the lines indicates R² (the coefficient of determination)
• Green indicates positive slope
• Red indicates negative
• Interactions are not two way because incidence of each bacteria are different

Clostridioides difficile impacts on other bacteria of the same rank

R2	Slope	Tax Name	Parent Chart
0.4395354390144348	0.6554350256919861	Wansuia hejianensis	Parent Taxa
0.43784821033477783	0.6498387455940247	Marvinbryantia formatexigens	Parent Taxa
0.4299079477787018	0.6228504180908203	Novisyntrophococcus fermenticellae	Parent Taxa
0.41897132992744446	0.580672562122345	Ruminococcus gauvreauii	Parent Taxa
0.416536808013916	0.6154337525367737	Qiania dongpingensis	Parent Taxa
0.414457231760025	0.719889223575592	Bifidobacterium eulemuris	Parent Taxa
0.41442087292671204	0.6290757060050964	Massilistercora timonensis	Parent Taxa
0.41212376952171326	0.6373124122619629	Subdoligranulum variabile	Parent Taxa
0.41131946444511414	0.6189189553260803	[Clostridium] hylemonae	Parent Taxa
0.40918266773223877	0.6200386881828308	Lachnoclostridium phocaeense	Parent Taxa
0.4022619426250458	0.6312905550003052	Enterococcus faecium	Parent Taxa
0.401706725358963	0.5813283324241638	Acutalibacter muris	Parent Taxa
0.4009152054786682	0.6302332878112793	Clostridium sp. M62/1	Parent Taxa
0.3995188772678375	0.6130006313323975	Christensenella minuta	Parent Taxa
0.3943260610103607	0.6278693079948425	Coprococcus catus	Parent Taxa
0.39128977060317993	0.6256579756736755	Blautia obeum	Parent Taxa
0.3875442147254944	0.6141031384468079	Oscillibacter hominis	Parent Taxa
0.38751575350761414	0.5983204245567322	Solibaculum mannosilyticum	Parent Taxa
0.3858673572540283	0.5873892307281494	Clostridium cadaveris	Parent Taxa
0.3847784101963043	0.6132519245147705	Vescimonas fastidiosa	Parent Taxa
0.3847474753856659	0.6086342930793762	Longicatena caecimuris	Parent Taxa
0.38398250937461853	0.5979989767074585	Ligilactobacillus ruminis	Parent Taxa
0.38330498337745667	0.6162367463111877	Faecalitalea cylindroides	Parent Taxa
0.38328036665916443	0.5858041644096375	Eubacterium callanderi	Parent Taxa
0.3798554241657257	0.5740342736244202	Blautia liquoris	Parent Taxa
0.3766099810600281	0.6024268269538879	[Eubacterium] hominis	Parent Taxa
0.3756522536277771	0.5604740977287292	Eubacterium sp. c-25	Parent Taxa
0.3728819489479065	0.6093866229057312	Anaerotruncus colihominis	Parent Taxa
0.37023115158081055	0.586860716342926	Flintibacter sp. KGMB00164	Parent Taxa
0.3695709705352783	0.5654039978981018	Eubacterium limosum	Parent Taxa
0.3680599331855774	0.5662548542022705	Lacrimispora saccharolytica	Parent Taxa
0.36610257625579834	0.5999600887298584	Enterocloster asparagiformis	Parent Taxa
0.36546626687049866	0.6046345233917236	Dorea longicatena	Parent Taxa
0.3641516864299774	0.6023106575012207	Dorea formicigenerans	Parent Taxa
0.36261653900146484	0.6012231111526489	[Clostridium] scindens	Parent Taxa
0.3597666621208191	0.5999278426170349	Roseburia hominis	Parent Taxa
0.35967519879341125	0.5972163677215576	Intestinimonas butyriciproducens	Parent Taxa
0.3593733012676239	0.5465441346168518	Maliibacterium massiliense	Parent Taxa
0.35883498191833496	0.5715763568878174	Catenibacterium mitsuokai	Parent Taxa
0.35744673013687134	0.5874021649360657	Blautia hansenii	Parent Taxa
0.3560965955257416	0.5805479884147644	Amedibacterium intestinale	Parent Taxa
0.3539695739746094	0.5911371111869812	Faecalibacterium duncaniae	Parent Taxa
0.35235321521759033	0.5934180617332458	Ruthenibacterium lactatiformans	Parent Taxa
0.3519990146160126	0.5780743956565857	Blautia pseudococcoides	Parent Taxa
0.3504105508327484	0.5894752740859985	[Ruminococcus] lactaris	Parent Taxa
0.3499736785888672	0.5498130917549133	Eubacterium maltosivorans	Parent Taxa
0.34978756308555603	0.5914632678031921	Coprococcus comes	Parent Taxa
0.34967848658561707	0.5907250046730042	Blautia sp. SC05B48	Parent Taxa
0.3495490252971649	0.5913848876953125	Anaerobutyricum hallii	Parent Taxa
0.3459866940975189	0.5701815485954285	Pectobacterium parmentieri	Parent Taxa
0.344110906124115	0.5812970995903015	Blautia argi	Parent Taxa
0.3421027958393097	0.5466922521591187	Monoglobus pectinilyticus	Parent Taxa
0.3408353328704834	0.5828874111175537	Hungatella hathewayi	Parent Taxa
0.3376023471355438	0.5232737064361572	Streptococcus pasteurianus	Parent Taxa
0.33403974771499634	0.5577552914619446	Clostridium sp. SY8519	Parent Taxa
0.33229494094848633	0.5690709948539734	Blautia producta	Parent Taxa
0.3277319073677063	0.5659688711166382	Butyrivibrio crossotus	Parent Taxa
0.32708805799484253	0.5695189833641052	Vescimonas coprocola	Parent Taxa
0.32678303122520447	0.5180035829544067	Parvimonas micra	Parent Taxa
0.3258381485939026	0.5680336952209473	Pusillibacter faecalis	Parent Taxa
0.32335364818573	0.566382884979248	Enterocloster clostridioformis	Parent Taxa
0.3211691081523895	0.4941847026348114	Mageeibacillus indolicus	Parent Taxa
0.32006964087486267	0.5161815881729126	Enterococcus cecorum	Parent Taxa
0.3188868463039398	0.5570548176765442	Coprococcus eutactus	Parent Taxa
0.31832388043403625	0.5396797060966492	Lachnoanaerobaculum gingivalis	Parent Taxa
0.3177223205566406	0.5637009739875793	[Clostridium] innocuum	Parent Taxa
0.3174520432949066	0.5421745181083679	Eubacterium sp. MSJ-33	Parent Taxa
0.3142434358596802	0.5596029758453369	Faecalibacterium sp. I4-3-84	Parent Taxa
0.3141796886920929	0.5167874693870544	Mogibacterium diversum	Parent Taxa
0.31414204835891724	0.5580075979232788	Faecalibacterium sp. I3-3-89	Parent Taxa
0.31193193793296814	0.5557780861854553	Faecalibacterium sp. I4-1-79	Parent Taxa
0.3092721998691559	0.5179649591445923	Ruminococcus champanellensis	Parent Taxa
0.3057911694049835	0.5329993963241577	Proteiniphilum saccharofermentans	Parent Taxa
0.30398228764533997	0.5438803434371948	Faecalibacterium sp. I2-3-92	Parent Taxa
0.3026186227798462	0.5290464162826538	Streptococcus suis	Parent Taxa
0.30085477232933044	0.5451305508613586	Faecalibacterium sp. HTF-F	Parent Taxa
0.30030879378318787	0.5432162284851074	Faecalibacterium sp. IP-3-29	Parent Taxa
0.2984837293624878	0.49960264563560486	Emergencia timonensis	Parent Taxa
0.2977534234523773	0.5564574599266052	Pantoea sp. At-9b	Parent Taxa
0.296755850315094	0.5630251169204712	Pectobacterium carotovorum	Parent Taxa
0.29642242193222046	0.5421655774116516	Coprococcus sp. ART55/1	Parent Taxa
0.2960245907306671	0.5415499806404114	Lawsonibacter asaccharolyticus	Parent Taxa
0.29272347688674927	0.5412053465843201	Anaerostipes hadrus	Parent Taxa
0.2904113531112671	0.5372081398963928	Eubacterium ventriosum	Parent Taxa
0.28970786929130554	0.5005977749824524	Catenibacterium sp. co_0103	Parent Taxa
0.288340300321579	0.4895602762699127	Campylobacter coli	Parent Taxa
0.28631335496902466	0.528036892414093	Faecalibacterium sp. IP-1-18	Parent Taxa
0.28365689516067505	0.4710915684700012	Intestinibaculum porci	Parent Taxa
0.2834549844264984	0.532569408416748	Blautia wexlerae	Parent Taxa
0.2832857072353363	0.450762540102005	Treponema peruense	Parent Taxa
0.28122061491012573	0.44701796770095825	Chordicoccus furentiruminis	Parent Taxa
0.2791244387626648	0.4776403605937958	Phascolarctobacterium succinatutens	Parent Taxa
0.2789883613586426	0.5195999145507812	Faecalibacterium sp. I3-3-33	Parent Taxa
0.27631571888923645	0.525717556476593	[Ruminococcus] torques	Parent Taxa
0.27137210965156555	0.4865489900112152	Klebsiella sp. WP8-S18-ESBL-06	Parent Taxa
0.27053403854370117	0.4478439688682556	Komagataeibacter oboediens	Parent Taxa
0.26963508129119873	0.4585764706134796	Ruminococcus bovis	Parent Taxa
0.2694252133369446	0.5104068517684937	Wujia chipingensis	Parent Taxa
0.26843690872192383	0.45499011874198914	Pseudomonas extremaustralis	Parent Taxa
0.2677696645259857	0.46204638481140137	Phascolarctobacterium sp. Marseille-Q4147	Parent Taxa
0.2645655870437622	0.44322633743286133	Clostridium sp. C1	Parent Taxa
0.261990487575531	0.4251859486103058	Clostridium sp. MD294	Parent Taxa
0.25936034321784973	0.5029405355453491	Sellimonas intestinalis	Parent Taxa
0.2592165172100067	0.5092909336090088	Roseburia intestinalis	Parent Taxa
0.2524243891239166	0.44966375827789307	Lactococcus cremoris	Parent Taxa
0.25119978189468384	0.42781394720077515	Corynebacterium durum	Parent Taxa
0.25118523836135864	0.36154502630233765	Helicobacter canadensis	Parent Taxa
0.24345152080059052	0.4913405478000641	Ruminococcus bicirculans (ex Wegman et al. 2014)	Parent Taxa
0.24142812192440033	0.4906487762928009	Akkermansia muciniphila	Parent Taxa
0.23808753490447998	0.4833701550960541	Roseburia rectibacter	Parent Taxa
0.2358318269252777	0.48289164900779724	Faecalibacillus intestinalis	Parent Taxa
0.23238441348075867	0.4818315804004669	Dysosmobacter welbionis	Parent Taxa
0.2315242886543274	0.41364598274230957	Pseudobutyrivibrio xylanivorans	Parent Taxa
0.23054175078868866	0.3800104856491089	Allocoprobacillus halotolerans	Parent Taxa
0.22840873897075653	0.3672514855861664	Ruminococcus albus	Parent Taxa
0.22799940407276154	0.38700875639915466	Actinomyces oris	Parent Taxa
0.2277909368276596	0.3958606719970703	Actinomyces naeslundii	Parent Taxa
0.22593742609024048	0.4752967655658722	Enterocloster bolteae	Parent Taxa
0.22577621042728424	0.3704705536365509	Treponema denticola	Parent Taxa
0.225470170378685	0.46508821845054626	Blautia parvula	Parent Taxa
0.22439411282539368	0.47360357642173767	Simiaoa sunii	Parent Taxa
0.22412987053394318	0.4303095042705536	Turicibacter bilis	Parent Taxa
0.22266341745853424	0.45108678936958313	Adlercreutzia equolifaciens	Parent Taxa
0.2216903418302536	0.4282890260219574	Candidatus Nanosynbacter sp. HMT-352	Parent Taxa
0.21660509705543518	0.3972642123699188	Butyricicoccus sp. GAM44	Parent Taxa
0.21123388409614563	0.4310811758041382	Romboutsia ilealis	Parent Taxa
0.2087390273809433	0.383039653301239	Fannyhessea vaginae	Parent Taxa
0.20819006860256195	0.45642900466918945	Faecalibacterium prausnitzii	Parent Taxa
0.20710629224777222	0.43715018033981323	Streptococcus agalactiae	Parent Taxa
0.2067815661430359	0.407621294260025	Romboutsia sp. 13368	Parent Taxa
0.20198620855808258	0.33992981910705566	Butyrivibrio fibrisolvens	Parent Taxa
0.19887994229793549	0.43923744559288025	Clostridium perfringens	Parent Taxa
0.19787317514419556	0.35205844044685364	Faecalibaculum rodentium	Parent Taxa
0.19470472633838654	0.42906105518341064	Streptococcus sanguinis	Parent Taxa
0.19099275767803192	0.4115939140319824	Actinomyces pacaensis	Parent Taxa
0.18959343433380127	0.4244636595249176	Gordonibacter pamelaeae	Parent Taxa
0.18783316016197205	0.335414856672287	Gallibacterium salpingitidis	Parent Taxa
0.18360954523086548	0.42805325984954834	Lachnospira eligens	Parent Taxa
0.1831769347190857	0.38125839829444885	Romboutsia sp. CE17	Parent Taxa
0.17921288311481476	0.37740591168403625	Gordonibacter urolithinfaciens	Parent Taxa
0.17891757190227509	0.42308539152145386	Flavonifractor plautii	Parent Taxa
0.17813991010189056	0.3338174521923065	Parolsenella massiliensis	Parent Taxa
0.1779610514640808	0.30913376808166504	Aminipila luticellarii	Parent Taxa
0.17653867602348328	0.36091676354408264	Campylobacter jejuni	Parent Taxa
0.17602606117725372	0.38682180643081665	Gemella sanguinis	Parent Taxa
0.17468951642513275	0.32946982979774475	Selenomonas sputigena	Parent Taxa
0.17117202281951904	0.31885579228401184	Phoenicibacter congonensis	Parent Taxa
0.1694028377532959	0.3775091767311096	Adlercreutzia hattorii	Parent Taxa
0.16935759782791138	0.31985998153686523	Saccharomyces cerevisiae	Parent Taxa
0.16903002560138702	0.31974977254867554	Cloacibacillus porcorum	Parent Taxa
0.16533730924129486	0.32116955518722534	Olsenella sp. oral taxon 807	Parent Taxa
0.1652631014585495	0.32371801137924194	Anaerostipes rhamnosivorans	Parent Taxa
0.1648242473602295	0.3117940127849579	Bacillus paralicheniformis	Parent Taxa
0.1620582938194275	0.3700607717037201	Streptococcus lutetiensis	Parent Taxa
0.16177427768707275	0.40110448002815247	Alistipes communis	Parent Taxa
0.1613747626543045	0.306432843208313	Murdochiella vaginalis	Parent Taxa
0.15995793044567108	0.3874608874320984	Anaerostipes caccae	Parent Taxa
0.1554933786392212	0.394136905670166	Thomasclavelia ramosa	Parent Taxa
0.15333746373653412	0.2972573935985565	Streptococcus canis	Parent Taxa
0.15266740322113037	0.3851385712623596	Alistipes senegalensis	Parent Taxa
0.15200072526931763	0.32460474967956543	Lactococcus lactis	Parent Taxa
0.15168988704681396	0.37021422386169434	Alistipes dispar	Parent Taxa
0.14745038747787476	0.3673034608364105	Alistipes ihumii	Parent Taxa
0.14676935970783234	0.299455463886261	Taranisvirus taranis	Parent Taxa
0.14610856771469116	0.278674453496933	Aeromonas salmonicida	Parent Taxa
0.14553144574165344	0.3368995487689972	uncultured Alistipes sp.	Parent Taxa
0.14509235322475433	0.2899300456047058	Arachnia propionica	Parent Taxa
0.14449718594551086	0.36642053723335266	Alistipes indistinctus	Parent Taxa
0.14373867213726044	0.2791345715522766	Actinomyces sp. oral taxon 171	Parent Taxa
0.14356385171413422	0.27588558197021484	Treponema phagedenis	Parent Taxa
0.1421860158443451	0.27707764506340027	Trueperella pyogenes	Parent Taxa
0.1416889727115631	0.3274581730365753	Thomasclavelia spiroformis	Parent Taxa
0.14132045209407806	0.2897210121154785	Streptococcus parasuis	Parent Taxa
0.1408620923757553	0.275358647108078	Proteiniclasticum sp. QWL-01	Parent Taxa
0.1406121402978897	-0.31822943687438965	Staphylococcus lugdunensis	Parent Taxa
0.14004449546337128	0.2896200120449066	Megasphaera stantonii	Parent Taxa
0.1389666050672531	0.2743697166442871	Actinomyces sp. oral taxon 169	Parent Taxa
0.13714367151260376	0.272747278213501	Eggerthella sp. YY7918	Parent Taxa
0.1353033483028412	0.3657643795013428	Alistipes shahii	Parent Taxa
0.1345798224210739	0.27252453565597534	Candidatus Minimicrobia vallesae	Parent Taxa
0.13196857273578644	0.3633795380592346	Mediterraneibacter gnavus	Parent Taxa
0.13092301785945892	0.2620670795440674	Arabiibacter massiliensis	Parent Taxa
0.12848646938800812	0.3550902307033539	Schaalia odontolytica	Parent Taxa
0.12788817286491394	0.34228160977363586	Streptococcus gordonii	Parent Taxa
0.127750962972641	0.2737146317958832	Pyramidobacter piscolens	Parent Taxa
0.1268826425075531	-0.3638061583042145	Corynebacterium kefirresidentii	Parent Taxa
0.1257098913192749	0.3436727523803711	Granulicatella adiacens	Parent Taxa
0.12447834014892578	0.3526100516319275	Alistipes finegoldii	Parent Taxa
0.12419653683900833	0.2558012008666992	Brachyspira pilosicoli	Parent Taxa
0.1236652359366417	0.26899856328964233	Actinomyces sp. oral taxon 414	Parent Taxa
0.12344726920127869	0.2580116391181946	Enterococcus saigonensis	Parent Taxa
0.1229436993598938	0.27390018105506897	Raoultibacter timonensis	Parent Taxa
0.12148715555667877	-0.3117283284664154	Staphylococcus capitis	Parent Taxa
0.12133809179067612	0.2545276880264282	Caproicibacterium amylolyticum	Parent Taxa
0.1210726723074913	0.2752021551132202	Dialister succinatiphilus	Parent Taxa
0.11970139294862747	0.32315319776535034	Alistipes sp. dk3624	Parent Taxa
0.1193506121635437	0.2958187162876129	Eggerthella guodeyinii	Parent Taxa
0.11735979467630386	0.29218852519989014	Rothia dentocariosa	Parent Taxa
0.11679219454526901	0.25294092297554016	Caproicibacterium lactatifermentans	Parent Taxa
0.11537963151931763	0.272756963968277	Turicibacter sanguinis	Parent Taxa
0.11481858044862747	0.24919277429580688	Caproicibacter fermentans	Parent Taxa
0.11399699002504349	0.32897213101387024	Butyricimonas virosa	Parent Taxa
0.11310958117246628	0.26762664318084717	Brigitvirus brigit	Parent Taxa
0.11161613464355469	0.2505941092967987	Oxalobacter aliiformigenes	Parent Taxa
0.11061631143093109	0.2414693832397461	Methanobrevibacter smithii	Parent Taxa
0.10969944298267365	0.3158320188522339	Barnesiella viscericola	Parent Taxa
0.10921610891819	0.259318470954895	Turicibacter sp. H121	Parent Taxa
0.10821731388568878	0.2639690041542053	Gemella morbillorum	Parent Taxa
0.10796725004911423	0.2383001148700714	Treponema putidum	Parent Taxa
0.10699314624071121	0.2783280611038208	Terrisporobacter hibernicus	Parent Taxa
0.10580550879240036	0.3020919859409332	Alistipes megaguti	Parent Taxa
0.10534755140542984	0.24700769782066345	Treponema succinifaciens	Parent Taxa
0.1049029678106308	0.2391379326581955	Anaerocolumna cellulosilytica	Parent Taxa
0.10484880208969116	0.2360699623823166	Filifactor alocis	Parent Taxa
0.10429050028324127	0.322844535112381	Alistipes onderdonkii	Parent Taxa
0.10414545983076096	0.2339554727077484	Leuconostoc mesenteroides	Parent Taxa
0.10389959812164307	0.2698220908641815	Lancefieldella parvula	Parent Taxa
0.10332399606704712	0.23776181042194366	Pauljensenia hongkongensis	Parent Taxa
0.10327892005443573	0.32121679186820984	Odoribacter splanchnicus	Parent Taxa
0.10315528512001038	0.2398623377084732	Thermocaproicibacter melissae	Parent Taxa
0.10224834829568863	0.23160161077976227	Ligilactobacillus agilis	Parent Taxa
0.10131264477968216	0.24848194420337677	Streptococcus mutans	Parent Taxa
0.10129661113023758	0.24701900780200958	Methanobrevibacter sp. TLL-48-HuF1	Parent Taxa
0.1012129932641983	-0.23908263444900513	Staphylococcus epidermidis	Parent Taxa
0.1011212095618248	-0.23548001050949097	Staphylococcus hominis	Parent Taxa
0.10074607282876968	0.234805628657341	Actinomyces sp. HMT 175	Parent Taxa
0.1005326509475708	0.2306877225637436	Bulleidia sp. zg-1006	Parent Taxa
0.10032490640878677	0.22959209978580475	Cellulosilyticum sp. WCF-2	Parent Taxa

Other bacteria of the same rank impacting Clostridioides difficile

R2	Slope	Tax Name	Parent Chart
0.4395354390144348	0.6706010699272156	Wansuia hejianensis	Parent Taxa
0.43784821033477783	0.6737797856330872	Marvinbryantia formatexigens	Parent Taxa
0.4299079477787018	0.6902266144752502	Novisyntrophococcus fermenticellae	Parent Taxa
0.41897132992744446	0.721527636051178	Ruminococcus gauvreauii	Parent Taxa
0.416536808013916	0.6768182516098022	Qiania dongpingensis	Parent Taxa
0.41442087292671204	0.6587774753570557	Massilistercora timonensis	Parent Taxa
0.41212376952171326	0.6466588973999023	Subdoligranulum variabile	Parent Taxa
0.41131946444511414	0.6645772457122803	[Clostridium] hylemonae	Parent Taxa
0.40918266773223877	0.6599308848381042	Lachnoclostridium phocaeense	Parent Taxa
0.4022619426250458	0.6372057199478149	Enterococcus faecium	Parent Taxa
0.401706725358963	0.6910152435302734	Acutalibacter muris	Parent Taxa
0.4009152054786682	0.6361377239227295	Clostridium sp. M62/1	Parent Taxa
0.3995188772678375	0.6517429947853088	Christensenella minuta	Parent Taxa
0.3943260610103607	0.6280384063720703	Coprococcus catus	Parent Taxa
0.39128977060317993	0.6254052519798279	Blautia obeum	Parent Taxa
0.3875442147254944	0.6310734748840332	Oscillibacter hominis	Parent Taxa
0.38751575350761414	0.6476725935935974	Solibaculum mannosilyticum	Parent Taxa
0.3858673572540283	0.6569193601608276	Clostridium cadaveris	Parent Taxa
0.3847784101963043	0.6274393796920776	Vescimonas fastidiosa	Parent Taxa
0.3847474753856659	0.6321488618850708	Longicatena caecimuris	Parent Taxa
0.38398250937461853	0.6421123147010803	Ligilactobacillus ruminis	Parent Taxa
0.38330498337745667	0.62200927734375	Faecalitalea cylindroides	Parent Taxa
0.38328036665916443	0.6542807221412659	Eubacterium callanderi	Parent Taxa
0.3798554241657257	0.6617295145988464	Blautia liquoris	Parent Taxa
0.3766099810600281	0.6251547336578369	[Eubacterium] hominis	Parent Taxa
0.3756522536277771	0.6702401638031006	Eubacterium sp. c-25	Parent Taxa
0.3728819489479065	0.6118971705436707	Anaerotruncus colihominis	Parent Taxa
0.37023115158081055	0.6308671832084656	Flintibacter sp. KGMB00164	Parent Taxa
0.3695709705352783	0.6536405682563782	Eubacterium limosum	Parent Taxa
0.3680599331855774	0.6499898433685303	Lacrimispora saccharolytica	Parent Taxa
0.36610257625579834	0.6102115511894226	Enterocloster asparagiformis	Parent Taxa
0.36546626687049866	0.6044416427612305	Dorea longicatena	Parent Taxa
0.3641516864299774	0.6045911312103271	Dorea formicigenerans	Parent Taxa
0.36261653900146484	0.6031314134597778	[Clostridium] scindens	Parent Taxa
0.3597666621208191	0.5996832251548767	Roseburia hominis	Parent Taxa
0.35967519879341125	0.6022527813911438	Intestinimonas butyriciproducens	Parent Taxa
0.3593733012676239	0.657537579536438	Maliibacterium massiliense	Parent Taxa
0.35883498191833496	0.627798855304718	Catenibacterium mitsuokai	Parent Taxa
0.35744673013687134	0.6085213422775269	Blautia hansenii	Parent Taxa
0.3560965955257416	0.6133801341056824	Amedibacterium intestinale	Parent Taxa
0.3539695739746094	0.5987944006919861	Faecalibacterium duncaniae	Parent Taxa
0.35235321521759033	0.5937689542770386	Ruthenibacterium lactatiformans	Parent Taxa
0.3519990146160126	0.6089164614677429	Blautia pseudococcoides	Parent Taxa
0.3504105508327484	0.5944448113441467	[Ruminococcus] lactaris	Parent Taxa
0.3499736785888672	0.6365321278572083	Eubacterium maltosivorans	Parent Taxa
0.34978756308555603	0.5913935303688049	Coprococcus comes	Parent Taxa
0.34967848658561707	0.5919479727745056	Blautia sp. SC05B48	Parent Taxa
0.3495490252971649	0.5910685658454895	Anaerobutyricum hallii	Parent Taxa
0.344110906124115	0.5919708013534546	Blautia argi	Parent Taxa
0.3421027958393097	0.6257685422897339	Monoglobus pectinilyticus	Parent Taxa
0.3408353328704834	0.5847361087799072	Hungatella hathewayi	Parent Taxa
0.3376023471355438	0.6451736092567444	Streptococcus pasteurianus	Parent Taxa
0.33403974771499634	0.5989001989364624	Clostridium sp. SY8519	Parent Taxa
0.33229494094848633	0.5839252471923828	Blautia producta	Parent Taxa
0.3277319073677063	0.5790634751319885	Butyrivibrio crossotus	Parent Taxa
0.32708805799484253	0.5743234157562256	Vescimonas coprocola	Parent Taxa
0.32678303122520447	0.6308509707450867	Parvimonas micra	Parent Taxa
0.3258381485939026	0.5736247301101685	Pusillibacter faecalis	Parent Taxa
0.32335364818573	0.5709100365638733	Enterocloster clostridioformis	Parent Taxa
0.3211691081523895	0.6498969197273254	Mageeibacillus indolicus	Parent Taxa
0.32006964087486267	0.6200717687606812	Enterococcus cecorum	Parent Taxa
0.3188868463039398	0.5724514126777649	Coprococcus eutactus	Parent Taxa
0.31832388043403625	0.5898385047912598	Lachnoanaerobaculum gingivalis	Parent Taxa
0.3177223205566406	0.563636302947998	[Clostridium] innocuum	Parent Taxa
0.3174520432949066	0.5855163335800171	Eubacterium sp. MSJ-33	Parent Taxa
0.3142434358596802	0.5615471601486206	Faecalibacterium sp. I4-3-84	Parent Taxa
0.3141796886920929	0.607947587966919	Mogibacterium diversum	Parent Taxa
0.31414204835891724	0.5629709362983704	Faecalibacterium sp. I3-3-89	Parent Taxa
0.31193193793296814	0.5612526535987854	Faecalibacterium sp. I4-1-79	Parent Taxa
0.3092721998691559	0.5970909595489502	Ruminococcus champanellensis	Parent Taxa
0.30398228764533997	0.5589138865470886	Faecalibacterium sp. I2-3-92	Parent Taxa
0.3026186227798462	0.5720077157020569	Streptococcus suis	Parent Taxa
0.30085477232933044	0.5518949031829834	Faecalibacterium sp. HTF-F	Parent Taxa
0.30030879378318787	0.552834689617157	Faecalibacterium sp. IP-3-29	Parent Taxa
0.2984837293624878	0.5974422693252563	Emergencia timonensis	Parent Taxa
0.29642242193222046	0.5467378497123718	Coprococcus sp. ART55/1	Parent Taxa
0.2960245907306671	0.5466247200965881	Lawsonibacter asaccharolyticus	Parent Taxa
0.29272347688674927	0.5408732295036316	Anaerostipes hadrus	Parent Taxa
0.2904113531112671	0.5405937433242798	Eubacterium ventriosum	Parent Taxa
0.28970786929130554	0.5787238478660583	Catenibacterium sp. co_0103	Parent Taxa
0.288340300321579	0.588978111743927	Campylobacter coli	Parent Taxa
0.28631335496902466	0.5422222018241882	Faecalibacterium sp. IP-1-18	Parent Taxa
0.28365689516067505	0.6021268367767334	Intestinibaculum porci	Parent Taxa
0.2834549844264984	0.5322404503822327	Blautia wexlerae	Parent Taxa
0.2832857072353363	0.6284587979316711	Treponema peruense	Parent Taxa
0.28122061491012573	0.6291036009788513	Chordicoccus furentiruminis	Parent Taxa
0.2791244387626648	0.5843819975852966	Phascolarctobacterium succinatutens	Parent Taxa
0.2789883613586426	0.536929190158844	Faecalibacterium sp. I3-3-33	Parent Taxa
0.27631571888923645	0.5255972743034363	[Ruminococcus] torques	Parent Taxa
0.27053403854370117	0.6040809750556946	Komagataeibacter oboediens	Parent Taxa
0.26963508129119873	0.5879828333854675	Ruminococcus bovis	Parent Taxa
0.2694252133369446	0.527863621711731	Wujia chipingensis	Parent Taxa
0.2677696645259857	0.5795298218727112	Phascolarctobacterium sp. Marseille-Q4147	Parent Taxa
0.2645655870437622	0.5969085097312927	Clostridium sp. C1	Parent Taxa
0.261990487575531	0.616178572177887	Clostridium sp. MD294	Parent Taxa
0.25936034321784973	0.515687882900238	Sellimonas intestinalis	Parent Taxa
0.2592165172100067	0.5089752674102783	Roseburia intestinalis	Parent Taxa
0.2524243891239166	0.5613625645637512	Lactococcus cremoris	Parent Taxa
0.25119978189468384	0.5871706008911133	Corynebacterium durum	Parent Taxa
0.24345152080059052	0.49548429250717163	Ruminococcus bicirculans (ex Wegman et al. 2014)	Parent Taxa
0.24142812192440033	0.4920589327812195	Akkermansia muciniphila	Parent Taxa
0.23808753490447998	0.4925573766231537	Roseburia rectibacter	Parent Taxa
0.2358318269252777	0.4883742034435272	Faecalibacillus intestinalis	Parent Taxa
0.23238441348075867	0.48229384422302246	Dysosmobacter welbionis	Parent Taxa
0.2315242886543274	0.5597160458564758	Pseudobutyrivibrio xylanivorans	Parent Taxa
0.23054175078868866	0.6066721081733704	Allocoprobacillus halotolerans	Parent Taxa
0.22840873897075653	0.6219409704208374	Ruminococcus albus	Parent Taxa
0.22799940407276154	0.5891324281692505	Actinomyces oris	Parent Taxa
0.2277909368276596	0.5754320621490479	Actinomyces naeslundii	Parent Taxa
0.22593742609024048	0.4753607511520386	Enterocloster bolteae	Parent Taxa
0.22577621042728424	0.6094309091567993	Treponema denticola	Parent Taxa
0.225470170378685	0.4847900867462158	Blautia parvula	Parent Taxa
0.22439411282539368	0.47380155324935913	Simiaoa sunii	Parent Taxa
0.22412987053394318	0.5208573341369629	Turicibacter bilis	Parent Taxa
0.22266341745853424	0.4936154782772064	Adlercreutzia equolifaciens	Parent Taxa
0.2216903418302536	0.5176185369491577	Candidatus Nanosynbacter sp. HMT-352	Parent Taxa
0.21660509705543518	0.5452418923377991	Butyricicoccus sp. GAM44	Parent Taxa
0.21123388409614563	0.49000951647758484	Romboutsia ilealis	Parent Taxa
0.2087390273809433	0.5449541211128235	Fannyhessea vaginae	Parent Taxa
0.20819006860256195	0.4561280608177185	Faecalibacterium prausnitzii	Parent Taxa
0.20710629224777222	0.4737646281719208	Streptococcus agalactiae	Parent Taxa
0.2067815661430359	0.5072884559631348	Romboutsia sp. 13368	Parent Taxa
0.20198620855808258	0.5941997170448303	Butyrivibrio fibrisolvens	Parent Taxa
0.19887994229793549	0.45278459787368774	Clostridium perfringens	Parent Taxa
0.19787317514419556	0.5620463490486145	Faecalibaculum rodentium	Parent Taxa
0.19470472633838654	0.4537925720214844	Streptococcus sanguinis	Parent Taxa
0.19099275767803192	0.46403202414512634	Actinomyces pacaensis	Parent Taxa
0.18959343433380127	0.44666588306427	Gordonibacter pamelaeae	Parent Taxa
0.18783316016197205	0.5600025057792664	Gallibacterium salpingitidis	Parent Taxa
0.18360954523086548	0.42894089221954346	Lachnospira eligens	Parent Taxa
0.1831769347190857	0.4804535210132599	Romboutsia sp. CE17	Parent Taxa
0.17921288311481476	0.474854439496994	Gordonibacter urolithinfaciens	Parent Taxa
0.17891757190227509	0.4228876233100891	Flavonifractor plautii	Parent Taxa
0.17813991010189056	0.5336446762084961	Parolsenella massiliensis	Parent Taxa
0.1779610514640808	0.5756765604019165	Aminipila luticellarii	Parent Taxa
0.17653867602348328	0.4891395568847656	Campylobacter jejuni	Parent Taxa
0.17602606117725372	0.4550572335720062	Gemella sanguinis	Parent Taxa
0.17468951642513275	0.5302140116691589	Selenomonas sputigena	Parent Taxa
0.17117202281951904	0.5368320941925049	Phoenicibacter congonensis	Parent Taxa
0.1694028377532959	0.44873833656311035	Adlercreutzia hattorii	Parent Taxa
0.16935759782791138	0.5294741988182068	Saccharomyces cerevisiae	Parent Taxa
0.16903002560138702	0.5286321640014648	Cloacibacillus porcorum	Parent Taxa
0.16533730924129486	0.5147976279258728	Olsenella sp. oral taxon 807	Parent Taxa
0.1652631014585495	0.5105156302452087	Anaerostipes rhamnosivorans	Parent Taxa
0.1648242473602295	0.5286318063735962	Bacillus paralicheniformis	Parent Taxa
0.1620582938194275	0.43792346119880676	Streptococcus lutetiensis	Parent Taxa
0.16177427768707275	0.4033220410346985	Alistipes communis	Parent Taxa
0.1613747626543045	0.5266236066818237	Murdochiella vaginalis	Parent Taxa
0.15995793044567108	0.41283631324768066	Anaerostipes caccae	Parent Taxa
0.1554933786392212	0.3945161700248718	Thomasclavelia ramosa	Parent Taxa
0.15333746373653412	0.5158407092094421	Streptococcus canis	Parent Taxa
0.15266740322113037	0.39639604091644287	Alistipes senegalensis	Parent Taxa
0.15200072526931763	0.46826401352882385	Lactococcus lactis	Parent Taxa
0.15168988704681396	0.40973544120788574	Alistipes dispar	Parent Taxa
0.14745038747787476	0.40144023299217224	Alistipes ihumii	Parent Taxa
0.14676935970783234	0.4901208281517029	Taranisvirus taranis	Parent Taxa
0.14610856771469116	0.524298369884491	Aeromonas salmonicida	Parent Taxa
0.14553144574165344	0.43197277188301086	uncultured Alistipes sp.	Parent Taxa
0.14509235322475433	0.5004391670227051	Arachnia propionica	Parent Taxa
0.14449718594551086	0.3943479359149933	Alistipes indistinctus	Parent Taxa
0.14373867213726044	0.5149440169334412	Actinomyces sp. oral taxon 171	Parent Taxa
0.14356385171413422	0.520374596118927	Treponema phagedenis	Parent Taxa
0.1421860158443451	0.5131630897521973	Trueperella pyogenes	Parent Taxa
0.1416889727115631	0.43269333243370056	Thomasclavelia spiroformis	Parent Taxa
0.14132045209407806	0.4877811372280121	Streptococcus parasuis	Parent Taxa
0.1408620923757553	0.5115585923194885	Proteiniclasticum sp. QWL-01	Parent Taxa
0.1406121402978897	-0.4418577551841736	Staphylococcus lugdunensis	Parent Taxa
0.14004449546337128	0.4835456907749176	Megasphaera stantonii	Parent Taxa
0.1389666050672531	0.5064939856529236	Actinomyces sp. oral taxon 169	Parent Taxa
0.13714367151260376	0.5028232336044312	Eggerthella sp. YY7918	Parent Taxa
0.1353033483028412	0.36991941928863525	Alistipes shahii	Parent Taxa
0.1345798224210739	0.4938264489173889	Candidatus Minimicrobia vallesae	Parent Taxa
0.13196857273578644	0.3631700575351715	Mediterraneibacter gnavus	Parent Taxa
0.13092301785945892	0.49957823753356934	Arabiibacter massiliensis	Parent Taxa
0.12848646938800812	0.36184173822402954	Schaalia odontolytica	Parent Taxa
0.12788817286491394	0.37363436818122864	Streptococcus gordonii	Parent Taxa
0.127750962972641	0.4667304754257202	Pyramidobacter piscolens	Parent Taxa
0.1268826425075531	-0.34876441955566406	Corynebacterium kefirresidentii	Parent Taxa
0.1257098913192749	0.36578369140625	Granulicatella adiacens	Parent Taxa
0.12447834014892578	0.3530198335647583	Alistipes finegoldii	Parent Taxa
0.12419653683900833	0.48551976680755615	Brachyspira pilosicoli	Parent Taxa
0.1236652359366417	0.4597245454788208	Actinomyces sp. oral taxon 414	Parent Taxa
0.12344726920127869	0.4784562289714813	Enterococcus saigonensis	Parent Taxa
0.1229436993598938	0.44886314868927	Raoultibacter timonensis	Parent Taxa
0.12148715555667877	-0.3897212743759155	Staphylococcus capitis	Parent Taxa
0.12133809179067612	0.47671863436698914	Caproicibacterium amylolyticum	Parent Taxa
0.1210726723074913	0.439940869808197	Dialister succinatiphilus	Parent Taxa
0.11970139294862747	0.37041687965393066	Alistipes sp. dk3624	Parent Taxa
0.1193506121635437	0.4034586250782013	Eggerthella guodeyinii	Parent Taxa
0.11735979467630386	0.4016577899456024	Rothia dentocariosa	Parent Taxa
0.11679219454526901	0.4617370367050171	Caproicibacterium lactatifermentans	Parent Taxa
0.11537963151931763	0.4230125844478607	Turicibacter sanguinis	Parent Taxa
0.11481858044862747	0.460762083530426	Caproicibacter fermentans	Parent Taxa
0.11399699002504349	0.34652477502822876	Butyricimonas virosa	Parent Taxa
0.11310958117246628	0.42263948917388916	Brigitvirus brigit	Parent Taxa
0.11161613464355469	0.445406049489975	Oxalobacter aliiformigenes	Parent Taxa
0.11061631143093109	0.45809662342071533	Methanobrevibacter smithii	Parent Taxa
0.10969944298267365	0.34733477234840393	Barnesiella viscericola	Parent Taxa
0.10921610891819	0.42116594314575195	Turicibacter sp. H121	Parent Taxa
0.10821731388568878	0.4099622070789337	Gemella morbillorum	Parent Taxa
0.10796725004911423	0.45307257771492004	Treponema putidum	Parent Taxa
0.10699314624071121	0.38441380858421326	Terrisporobacter hibernicus	Parent Taxa
0.10580550879240036	0.3502427041530609	Alistipes megaguti	Parent Taxa
0.10534755140542984	0.4264950156211853	Treponema succinifaciens	Parent Taxa
0.1049029678106308	0.43867138028144836	Anaerocolumna cellulosilytica	Parent Taxa
0.10484880208969116	0.4441429376602173	Filifactor alocis	Parent Taxa
0.10429050028324127	0.3230362832546234	Alistipes onderdonkii	Parent Taxa
0.10414545983076096	0.445150762796402	Leuconostoc mesenteroides	Parent Taxa
0.10389959812164307	0.38506704568862915	Lancefieldella parvula	Parent Taxa
0.10332399606704712	0.4345693290233612	Pauljensenia hongkongensis	Parent Taxa
0.10327892005443573	0.3215240240097046	Odoribacter splanchnicus	Parent Taxa
0.10315528512001038	0.43006035685539246	Thermocaproicibacter melissae	Parent Taxa
0.10224834829568863	0.4414837658405304	Ligilactobacillus agilis	Parent Taxa
0.10131264477968216	0.4077264070510864	Streptococcus mutans	Parent Taxa
0.10129661113023758	0.41007617115974426	Methanobrevibacter sp. TLL-48-HuF1	Parent Taxa
0.1012129932641983	-0.42333894968032837	Staphylococcus epidermidis	Parent Taxa
0.1011212095618248	-0.4294258654117584	Staphylococcus hominis	Parent Taxa
0.10074607282876968	0.42906156182289124	Actinomyces sp. HMT 175	Parent Taxa
0.1005326509475708	0.4357954263687134	Bulleidia sp. zg-1006	Parent Taxa
0.10032490640878677	0.43697020411491394	Cellulosilyticum sp. WCF-2	Parent Taxa